Dr. Amir Hossein Sakhteman
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Dr. Amir Hossein Sakhteman

Associate Professor
Shiraz University of Medical Sciences, Iran

Highest Degree
Ph.D. in Medicinal Chemistry from Tehran University of Medical Sciences, Tehran, Iran

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Area of Interest:

Biomedical Sciences
100%
Medicinal Chemistry
62%
Drug Design
90%
Bioassays
75%
Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sakhteman, A., N. Edraki, B. Hemmateenejad, R. Miri, A. Foroumadi, A. Shafiee and M. Khoshneviszadeh, 2017. In silico screening of IL-1β production inhibitors using chemometric tools. Iran. J. Pharmaceut. Res., 16: 513-524.
    PubMed  |  Direct Link  |  
  2. Parhizkar, E., S. Daneshamouz, S. Mohammadi-Samani, A. Sakhteman, G. Parhizkar, M. Omidi and F. Ahmadi, 2017. Synthesis and in vitro assessment of novel water-soluble dextran-docetaxel conjugates as potential pH sensitive system for tumor-targeted delivery. J. Applied Polym. Sci., Vol. 134, No. 43. 10.1002/app.45457.
    CrossRef  |  Direct Link  |  
  3. Parhizkar, E., M. Ghazali, F. Ahmadi and A. Sakhteman, 2017. PLS-LS-SVM based modeling of ATR-IR as a robust method in detection and qualification of alprazolam. Spectrochim. Acta Part A: Mol. Biomol. Spectrosc., 173: 87-92.
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  4. Mojaddami, A., A. Sakhteman, M. Fereidoonnezhad, Z. Faghih and A. Najdian et al., 2017. Binding mode of triazole derivatives as aromatase inhibitors based on docking, protein ligand interaction fingerprinting and molecular dynamics simulation studies. Res. Pharmaceut. Sci., 12: 21-30.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Ghorbani, M., A. Gohari, A. Sakhteman and Z. Rezaei, 2017. In silico analysis of drug resistance in HIV-reverse transcriptase inhibitors. Acta Med. Mediterr., 33: 745-749.
    Direct Link  |  
  6. Ghafouri, H., M. Ranjbar and A. Sakhteman, 2017. 3D-QSAR studies of some reversible Acetyl cholinesterase inhibitors based on CoMFA and ligand protein interaction fingerprints using PC-LS-SVM and PLS-LS-SVM. Comput. Biol. Chem., 69: 19-27.
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  7. Fereidoonnezhad, M., Z. Faghih, A. Mojaddami, Z. Rezaei and A. Sakhteman, 2017. A comparative QSAR analysis, molecular docking and PLIF studies of some N-arylphenyl-2,2-dichloroacetamide analogues as anticancer agents. Iran. J. Pharmaceut. Res., 16: 981-998.
    PubMed  |  Direct Link  |  
  8. Sakhteman, A., M. Khoddami, M. Negahdaripour, A. Mehdizadeh, M. Tatar and Y. Ghasemi, 2016. Exploring 3D structure of human gonadotropin hormone receptor at antagonist state using homology modeling, molecular dynamic simulation and cross-docking studies. J. Mol. Model., Vol. 22, No. 9. 10.1007/s00894-016-3091-0.
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  9. Sakhteman, A. and B. Zare, 2016. Modelface: An Application Programming Interface (API) for homology modeling studies using Modeller software. Iran. J. Pharmaceut. Res., 15: 801-807.
    PubMed  |  Direct Link  |  
  10. Sadeghian-Rizi, S., A. Sakhteman and F. Hassanzadeh, 2016. A Quantitative Structure-Activity Relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors. Res. Pharmaceut. Sci., 11: 445-453.
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  11. Mohammadi, M., F. Nejatollahi, A. Sakhteman and N. Zarei, 2016. Insilico analysis of three different tag polypeptides with dual roles in scFv antibodies. J. Theoret. Biol., 402: 100-106.
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  12. Khoshneviszadeh, M. and A. Sakhteman, 2016. Exploring Quantitative Structure-Activity Relationship (QSAR) models for some biologically active catechol structures using PC-LS-SVM and PC-ANFIS. Applied Biol. Chem., 59: 433-441.
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  13. Fereidoonnezhad, M., Z. Faghih, A. Mojaddami, A.H. Sakhteman and Z. Rezaei, 2016. A comparative docking studies of dichloroacetate analogues on four isozymes of pyruvate dehydrogenase kinase in humans. Indian J. Pharmaceut. Educ. Res., 50: S32-S38.
    Direct Link  |  
  14. Zarshenas, M.M., S. Amirhossein, E. Hamed and M. Mahmoodreza, 2015. Trachyspermum ammi hydrosol, an almost pure source of thymol; analysis of the recovered essential oil from different samples. Int. J. Pharmacogn. Phytochem. Res., 7: 457-460.
    Direct Link  |  
  15. Shafii, N., M. Khoobi, M. Amini, A. Sakhteman and H. Nadri et al., 2015. Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors. J. Enzyme Inhibit. Med. Chem., 30: 389-395.
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  16. Khoddami, M., H. Nadri, A. Moradi and A. Sakhteman, 2015. Homology modeling, molecular dynamic simulation and docking based binding site analysis of human dopamine (D4) receptor. J. Mol. Model., Vol. 21, No. 2. 10.1007/s00894-015-2579-3.
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  17. Akrami, H., B.F. Mirjalili, M. Khoobi, H. Nadri and A. Moradi et al., 2014. Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling. Eur. J. Med. Chem., 84: 375-381.
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  18. Salarian, A.A., A. Asadi-Eskandar, A. Sakhteman and K. Abdi, 2013. Synthesis and docking studies of some 3-amino-6-(thiophen-2-yl)thieno[2,3-b]pyridine derivatives. Asian J. Chem., 25: 1275-1278.
  19. Razavi, S.F., M. Khoobi, H. Nadri, A. Sakhteman and A. Moradi et al., 2013. Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors. Eur. J. Med. Chem., 64: 252-259.
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  20. Nadri, H., M. Pirali-Hamedani, A. Moradi, A. Sakhteman and A. Vahidi et al., 2013. 5,6-Dimethoxybenzofuran-3-one derivatives: A novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety. DARU J. Pharmaceut. Sci., Vol. 21. 10.1186/2008-2231-21-15.
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  21. Khoobi, M., M. Alipour, A. Sakhteman, H. Nadri and A. Moradi et al., 2013. Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors. Eur. J. Med. Chem., 68: 260-269.
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  22. Khoobi, M., M. Alipour, A. Moradi, A. Sakhteman and H. Nadri et al., 2013. Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase. Eur. J. Med. Chem., 68: 291-300.
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  23. Hosseinzadeh, N., M. Hasani, A. Foroumadi, H. Nadri and S. Emami et al., 2013. 5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents. Med. Chem. Res., 22: 2293-2302.
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  24. Asadipour, A., M. Alipour, M. Jafari, M. Khoobi and S. Emami et al., 2013. Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. Eur. J. Med. Chem., 70: 623-630.
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  25. Alipour, M., M. Khoobi, H. Nadri, A. Sakhteman and A. Moradi et al., 2013. Synthesis of some new 3-C oumaranone and coumarin derivatives as dual inhibitors of acetyl- and butyrylcholinesterase. Arch. Pharm., 346: 577-587.
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  26. Mozaffari, S., S. Ghasemi, H. Baher, H. Khademi and M. Amini et al., 2012. Synthesis and evaluation of some novel methylene-bridged aryl semicarbazones as potential anticonvulsant agents. Med. Chem. Res., 21: 3797-3808.
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  27. Assadieskandar, A., M. Amini, M. Salehi, H. Sadeghian and M. Alimardani et al., 2012. Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors. Bioorg. Med. Chem., 20: 7160-7166.
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  28. Alipour, M., M. Khoobi, A. Foroumadi, H. Nadri and A. Moradi et al., 2012. Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors. Bioorg. Med. Chem., 20: 7214-7222.
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  29. Sakhteman, A., M. Sharifzadeh, A. Moradi, H. Nadri and K. Tabrizian et al., 2011. Antinociceptive activity of some 1,4-substituted piperidine derivatives using tail flick method in mice. Afr. J. Pharm. Pharmacol., 5: 352-357.
    Direct Link  |  
  30. Sakhteman, A., M. Lahtela-Kakkonen and A. Poso, 2011. Studying the catechol binding cavity in comparative models of human dopamine D2 receptor. J. Mol. Graph. Modell., 29: 685-692.
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  31. Asli, M.A.M., L. Firoozpour, V. Sheibani, D.N. Sarkandi and A. Sakhteman et al., 2011. Synthesis of 1-benzyl-4-[2-(3-thienylcarbonylamino)ethyl]piperidine as a novel potential cholinesterase inhibitor. Asian J. Chem., 23: 2487-2490.
  32. Sakhteman, A., A. Foroumadi, M. Sharifzadeh, M. Amanlou, F. Rayatnia and A. Shafiee, 2009. Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives. Bioorg. Med. Chem., 17: 6908-6913.
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  33. Foroumadi, A., S. Sedaghat, S. Emami, M. Yazdanian and M.H. Moshafi et al., 2009. Synthesis and structure-activity relationship study of 2-substituted-5-(5-nitro-2-thienyl)-1,3,4-thiadiazoles as anti-Helicobacter pylori agents. Lett. Drug Des. Discov., 6: 468-474.
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  34. Foroumadi, A., V. Sheibani, A. Sakhteman, M. Rameshk and M. Abbasi et al., 2007. Synthesis and anticonvulsant activity of novel 2-amino-5-[4-chloro-2-(2-chlorophenoxy) phenyl]-1,3,4-thiadiazole derivatives. DARU J. Pharmaceut. Sci., 15: 89-93.
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  35. Foroumadi, A., A. Sakhteman, Z. Sharifzadeh, N. Mohammadhosseini and B. Hemmateenejad et al., 2007. Synthesis, antituberculosis activity and QSAR study of some novel 2-(nitroaryl)-5-(nitrobenzylsulfinyl and sulfonyl)-1,3,4-thiadiazole derivatives. DARU J. Pharmaceut. Sci., 15: 218-226.
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  36. Foroumadi, A., Z. Kargar, A. Sakhteman, Z. Sharifzadeh, R. Feyzmohammadi, M. Kazemi and A. Shafiee, 2006. Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates. Bioorg. Med. Chem. Lett., 16: 1164-1167.
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