Dr. Sameer E. Al-Harthi
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Dr. Sameer E. Al-Harthi

Assistant Professor
King Abdulaziz University, Saudi Arabia

Highest Degree
Ph.D. in Clinical Pharmacology from University of Glasgow, UK

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Area of Interest:

Biomedical Sciences
100%
Pharmacology
62%
Pharmacy
90%
Medicine
75%
Cardiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Osman, A.M.M., S.E. Al-Harthy, R.M. Mohamed, E.A. Huwait, H.M. Al-Kreathy, M. Alkhaled and M.M. Sayed-Ahmed, 2019. Dimethyl sulfoxide potentiates the anticancer activity of cisplatin against the growth of lung cancer cells. Int. J. Pharmacol., 15: 586-592.
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  2. AlQahtani, A.A., Abdel-Moneim M. Osman, H.M. Al-Kreathy and S.E. Al-Harthy et al., 2019. Chemosensitizing effects of marine astaxanthin on the anti-cancer activity of doxorubicin in tumor bearing mice. Int. J. Cancer Res., 15: 1-8.
    CrossRef  |  Direct Link  |  
  3. AlQahtani, A.A., A.M.M. Osman, Z.A. Damanhouri, H.M. Al-Kreathy and H.S. Al-Malky et al., 2019. Cardioprotective effect of marine astaxanthin on doxorubicin-induced cardiotoxicity in normal rats. J. Pharm. Res. Int., 27: 1-11.
    CrossRef  |  Direct Link  |  
  4. Al-Zahrani, Y.A., M.A.A.A. Sattar, S.E. Alharthi and H.M. Alkreathy, 2019. Neuroprotective role of vitamin D3 against insulin resistance and diabetic induced memory dysfunction in rats. Int. J. Pharmacol., 15: 724-730.
    CrossRef  |  Direct Link  |  
  5. Al-Zahrani, Y.A., M.A.A.A. Sattar, S.E. Al-Harthi and H.M. Alkreathy, 2019. Neuroprotective effect of different doses of vitamine D3 in diabetic-induced Alzheimer rat model. J. Pharmaceut. Res. Int., 26: 1-11.
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  6. Al-Harthy, S.E., M.S. Al-Motairi, H.M. Al-Kreathy, F.O. Kamel and M.M. Sayed-Ahmed et al., 2019. Enhancement of doxorubicin cytotoxicity by verapamil in human breast cancer cells. J. Pharm. Res. Int., 27: 1-10.
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  7. Turcot, V., Y. Lu, H.M. Highland, C. Schurmann and A.E. Justice et al., 2018. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat. Genet., 50: 26-41.
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  8. Melguizo-Sanchis, D., Y. Xu, D. Taheem, M. Yu and K. Tilgner et al., 2018. iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. Cell Death Dis., Vol. 9. 10.1038/s41419-017-0141-1.
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  9. Kamarudin, T.A., S. Bojic, J. Collin, M. Yu and S. Alharthi et al., 2018. Differences in the activity of endogenous bone morphogenetic protein signaling impact on the ability of induced pluripotent stem cells to differentiate to corneal epithelial-like cells. Stem Cells, 36: 337-348.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Buskin, A., L. Zhu, V. Chichagova, B. Basu and S. Mozaffari-Jovin et al., 2018. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat. Commun., Vol. 9. 10.1038/s41467-018-06448-y.
    CrossRef  |  Direct Link  |  
  11. Osman, A.M.M., H.M. Al-Kreathy, A. Al-Zahrani, O.A. Ahmed and W.S. Ramadan et al., 2017. Enhancement of efficacy and reduced toxicity of cisplatin through Self Nanoemulsifying Drug Delivery System (SNEDDS). Int. J. Pharmacol., 13: 292-302.
    CrossRef  |  Direct Link  |  
  12. Khan, L.M., F.O. Kamel, H.M. Alkreathy, S.E. Al-Harthi, O.I. Saadah, A.M.M. Osman and M.A. Allibaih, 2017. Benefits of medication antidote signals for the detection of potential adverse drug reactions over contemporary methods of pharmacovigilance in hospitalized children. Int. J. Pharmacol., 13: 64-73.
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  13. Hallam, D., J. Collin, S. Bojic, V. Chichagova and A. Buskin et al., 2017. An induced pluripotent stem cell patient specific model of complement factor H (Y402H) polymorphism displays characteristic features of age-related macular degeneration and indicates a beneficial role for UV light exposure. Stem Cells, 35: 2305-2320.
    CrossRef  |  Direct Link  |  
  14. Al-Aama, J.Y., N.A. Shaik, B. Banaganapalli, M.A. Salama and O. Rashidi et al., 2017. Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients. PLoS ONE, Vol. 12. 10.1371/journal.pone.0176664.
    CrossRef  |  Direct Link  |  
  15. Adam, S., D.M. Sanchis, G. El-Kamah, S. Samarasinghe, S. Alharthi, L. Armstrong and M. Lako, 2017. Concise review: Getting to the core of inherited bone marrow failures. Stem Cells, 35: 284-298.
    CrossRef  |  Direct Link  |  
  16. Mohamed, A.B.O., S.I. Hindawi, S. Al-Harthi, Q. Alam and M.Z. Alam et al., 2016. Allelic variance among ABO blood group genotypes in a population from the Western region of Saudi Arabia. Blood Res., 51: 274-278.
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  17. Khan, L.M., S.E. Al-Harthi, A.M.M. Osman, M.A.A.A. Sattar and A.S. Ali, 2016. Dilemmas of the causality assessment tools in the diagnosis of adverse drug reactions. Saudi Pharmaceut. J., 24: 485-493.
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  18. Saadah, O.I., S.E. Al-Harthi, J.A. Al-Mughales, Y.Y. Bin-Taleb and R.S. Baeshen, 2015. Serum interleukin-33 level in Saudi children with inflammatory bowel disease. Int. J. Clin. Exp. Pathol., 8: 16000-16006.
    PubMed  |  Direct Link  |  
  19. Saadah, O.I., N.A. Shaik, B. Banaganapalli, M.A. Salama and S.E. Al-Harthi et al., 2015. Replication of GWAS coding SNPs implicates MMEL1 as a potential susceptibility locus among Saudi Arabian celiac disease patients. Dis. Markers, Vol. 2015. 10.1155/2015/351673.
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  20. Osman, A.M.M., S.A. Telity, Z.A. Damanhouri, S.E. Al-Harthy and H.M. Al-Kreathy et al., 2015. Chemosensitizing and nephroprotective effect of resveratrol in cisplatin-treated animals. Cancer Cell Int., Vol. 15. 10.1186/s12935-014-0152-2.
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  21. Osman, A.M.M., H.S. Al-Malki, S.E. Al-Harthi, A.A. El-Hanafy, H.M. Elashmaoui and M.F. Elshal, 2015. Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells. Mol. Med. Rep., 12: 1368-1374.
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  22. Osman, A.M.M., A.A. Ali, Z.A. Damanhouri, S.E. Al-Harthy and M.F. ElShal et al., 2015. Dimethylsulfoxide excerbates cisplatin-induced cytotoxicity in Ehrlich ascites carcinoma cells. Cancer Cell Int., Vol. 15. 10.1186/s12935-015-0258-1.
    CrossRef  |  Direct Link  |  
  23. Khan, L.M., S.E. Al-Harthi, H.M. Alkreathy, A.M.M. Osman and A.S. Ali, 2015. Detection of adverse drug reactions by medication antidote signals and comparison of their sensitivity with common methods of ADR detection. Saudi Pharmaceut. J., 23: 515-522.
    CrossRef  |  Direct Link  |  
  24. Al-Zahrani, Y.A., S.E. Al-Harthi, L.M. Khan, H.M. El-Bassossy, S.M. Edris and M.A.A.A. Sattar, 2015. The possible antianginal effect of allopurinol in vasopressin-induced ischemic model in rats. Saudi Pharmaceut. J., 23: 487-498.
    CrossRef  |  Direct Link  |  
  25. Al-Salmi, A.A., M.A. Sattar, L.M. Khan and S.E. Al-Harthi, 2015. Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents. Afr. J. Pharm. Pharmacol., 9: 806-817.
    Direct Link  |  
  26. Al-Harthi, S.E., L.M. Khan, A.M. Osman, M.A. Alim, O.I. Saadah, A.A. Almohammadi, F.M. Khan and F.O. Kamel, 2015. Perceptions and knowledge regarding antimicrobial stewardship among clinicians in Jeddah, Saudi Arabia. Saudi Med. J., 36: 813-820.
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  27. Al-Harthi, S.E., O.M. Alarabi, W.S. Ramadan, M.N. Alaama and H.M. Al-Kreathy et al., 2014. Amelioration of doxorubicin-induced cardiotoxicity by resveratrol. Mol. Med. Rep., 10: 1455-1460.
    CrossRef  |  Direct Link  |  
  28. Osman, A.M.M., S.E. Al-Harthi, O.M. AlArabi, M.F. Elshal and W.S. Ramadan et al., 2013. Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin-treated animals. Cancer Cell Int., Vol. 13. 10.1186/1475-2867-13-52.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Khan, L.M., S.E. Al-Harthi and O.I. Saadah, 2013. Adverse drug reactions in hospitalized pediatric patients of saudi arabian university hospital and impact of pharmacovigilance in reporting ADR. Saudi Pharm. J., 21: 261-266.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Saadah, O.I., H.H. Sindi, Y. Bin-Talib, S. Al-Harthi and J. Al-Mughales, 2012. Entecavir treatment of children 2-16 years of age with chronic hepatitis B infection. Arab J. Gastroenterol., 13: 41-44.
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  31. Osman, A.M., M.H. Bayoumi, E. Sameer, A. Al-Harthi, A. Zoheir, Damanhouri and M.F. ElShal, 2012. Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell line. Cancer Cell Int., 12: 47-52.
  32. Lawan, A., E. Torrance, S. Al-Harthi, M. Shweash and S. Alnasser et al., 2012. MKP-2: Out of the DUSP-bin and back into the limelight. Biochem. Soc. Trans., 40: 235-239.
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  33. Khan, L.M., S.E. Al-Harthi, O.I. Saadah, A.B. Al-Amoudi and M.I. Sulaiman et al., 2012. Impact of pharmacovigilance on adverse drug reactions reporting in hospitalized internal medicine patients at Saudi Arabian teaching hospital. Saudi Med. J., 33: 863-868.
    PubMed  |  Direct Link  |  
  34. Lawan, A., S. Al-Harthi, L. Cadalbert, A.G. McCluskey and M. Shweash et al., 2011. Deletion of the Dual Specific Phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP Kinase Phosphatase-2 (MKP-2) in proliferation and cell survival. J. Biol. Chem., 286: 12933-12943.
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  35. Al-Mutairi, M., S. Al-Harthi, L. Cadalbert and R. Plevin, 2010. Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells. Br. J. Pharmacol., 161: 782-798.
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