Dr. Mohammad Azhar Aziz
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Dr. Mohammad Azhar Aziz

Researcher
King Abdullah International Medical Research Center, Saudi Arabia

Highest Degree
Ph.D. in Biotechnology from Jawaharlal Nehru University, India

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Area of Interest:

Biomedical Sciences
100%
Colorectal Cancer
62%
Cancer Biology
90%
Glycobiology
75%
Clinical Immunology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Deeb, A.M., Z. Yousef, M. Al-Johani and M.A. Aziz, 2018. Effect of sampling procedure on the quality control metrics of cytoscan HD array for studying cytogenetic aspects of colorectal cancer. Int. J. Health Sci., 12: 49-55.
    PubMed  |  Direct Link  |  
  2. Alhumaid, A., Z. Yousef, B. Haafiz, S. AlGhamdi and M.A. Aziz, 2018. Emerging paradigms in coorectal cancer liver metastasis. Crit. Rev. Oncol./Hematol., 132: 39-50.
  3. Bouchama, A., M.A. Aziz, S. Al Mahri, M.N. Gabere and M. Al Dlamy et al., 2017. A model of exposure to extreme environmental heat uncovers the human transcriptome to heat stress. Scient. Rep., Vol. 7. 10.1038/s41598-017-09819-5.
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  4. Aziz, M.A., Z. Yousef, A.M. Saleh, S. Mohammad and B. Al Knawy, 2017. Towards personalized medicine of colorectal cancer. Crit. Rev. Oncol./Hematol., 118: 70-78.
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  5. Aziz, M.A., 2017. Application of DNA microarrays in cytogenetics. Int. J. Cell Sci. Mol. Biol., Vol. 2. 10.19080/IJCSMB.2017.02.555578.
    CrossRef  |  Direct Link  |  
  6. Alhawiti, N.M., S. Al Mahri, M.A. Aziz, S.S. Malik and S. Mohammad, 2017. TXNIP in metabolic regulation: Physiological role and therapeutic outlook. Curr. Drug Targets, 18: 1095-1103.
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  7. Saleh, A.M., M.O. Taha, M.A. Aziz, M.A. Qudah, R.A. Tayeh and S.A. Rizvi, 2016. Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells. Cancer Lett., 375: 199-208.
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  8. Saleh, A.M., M.A. Aziz, I.M. Abdou, M.O. Taha and M.A. Al-Qudah et al., 2016. Cytotoxic activity of the novel heterocyclic compound G-11 is primarily mediated through intrinsic apoptotic pathway. Apoptosis, 21: 873-886.
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  9. Gabere, M.N., M.A. Hussein and M.A. Aziz, 2016. Filtered selection coupled with support vector machines generate a functionally relevant prediction model for colorectal cancer. Onco Targets Ther., 9: 3313-3325.
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  10. Saleh, A.M., M.M. El-Abadelah, M.A. Aziz, M.O. Taha, A. Nasr and S.A. Rizvi, 2015. Antiproliferative activity of the isoindigo 5′-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase. Cancer Lett., 361: 251-261.
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  11. Saleh, A.M., A. Aljada, M.M. El-Abadelah, S.S. Sabri, J.A. Zahra, A. Nasr and M.A. Aziz, 2015. The pyridone-annelated isoindigo (5 ‘-Cl) induces apoptosis, dysregulation of mitochondria and formation of ROS in leukemic HL-60 cells. Cell. Physiol. Biochem., 35: 1958-1974.
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  12. Saleh, A.M., A. Aljada, M.M. El-Abadelah, M.O. Taha, S.S. Sabri, J.A. Zahra and M.A. Aziz, 2015. The anticancer activity of the substituted pyridone-annelated isoindigo (5′-Cl) Involves G0/G1 cell cycle arrest and inactivation of CDKs in the promyelocytic leukemia cell line HL-60. Cell. Physiol. Biochem., 35: 1943-1957.
    CrossRef  |  
  13. Aziz, M.A., S. Periyasamy, Z. Yousef, A. Deeb and M. AlOtaibi, 2014. Colorectal cancer driver genes identified by patient specific comparison of cytogenetic microarray. Genomics Data, 2: 29-31.
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  14. Aziz, M.A., S. Periyasamy, Z. Al Yousef, I. AlAbdulkarim, M. Al Otaibi, A. Alfahed and G. Alasiri, 2014. Integrated exon level expression analysis of driver genes explain their role in colorectal cancer. PLoS One, Vol. 9. 10.1371/journal.pone.0110134.
    CrossRef  |  Direct Link  |  
  15. Aziz, M.A., M. AlOtaibi, A. AlAbdulrahman, M. AlDrees and I. AlAbdulkarim, 2014. Mucin family genes are downregulated in colorectal cancer patients. J. Carcinogenesis Mutagenesis, Vol. S10. 10.4172/2157-2518.S10-009.
    CrossRef  |  Direct Link  |  
  16. Eldai, H., S. Periyasamy, S. Al Qarni, M. Al Rodayyan and S.M. Mustafa et al., 2013. Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner. PLoS One, Vol. 8. 10.1371/journal.pone.0076251.
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  17. Dabir, S., A. Kluge, M.A. Aziz, J.A. Houghton and A. Dowlati, 2011. Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors. Cancer Biol. Ther., 12: 139-151.
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  18. Shi, T., T. Mazumdar, J. DeVecchio, Z.H. Duan, A. Agyeman, M. Aziz and J.A. Houghton, 2010. cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PLoS One, Vol. 5. 10.1371/journal.pone.0013054.
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  19. Aziz, M.A., J.E. Schupp and T.J. Kinsella, 2009. Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs. Cancer Biol. Ther., 8: 1156-1163.
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  20. Seo, Y., T. Yan, X. Zeng, M.A. Aziz and T.J. Kinsella, 2008. Essential role of DNA base excision repair on survival in an acidic tumor microenvironment. Int. J. Radiat. Oncol. Biol. Phys., 72: S23-S24.
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  21. Gurkan, E., Schupp J.E., M.A. Aziz, T.J. Kinsella and K.A. Loparo, 2007. Probabilistic modeling of DNA mismatch repair effects on cell cycle dynamics and iododeoxyuridine-DNA incorporation. Cancer Res., 67: 10993-11000.
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  22. Aziz, M.A., S. Midha, S.M. Waheed and R. Bhatnagar, 2007. Oral vaccines: New needs, new possibilities. BioEssays, 29: 591-604.
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  23. Midha, S., R. Mishra, M.A. Aziz, M. Sharma, A. Mishra, P. Khandelwal and R. Bhatnagar, 2005. Cloning, expression and characterization of recombinant nitric oxide synthase-like protein from Bacillus anthracis. Biochem. Biophys. Res. Commun., 336: 346-356.
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  24. Aziz, M.A., D. Sikriwal, S. Singh, S. Jarugula, P.A. Kumar and R. Bhatnagar, 2005. Transformation of an edible crop with the pagA gene of Bacillus anthracis. Faseb J., 19: 1501-1503.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Singh, S., M.A. Aziz, P. Khandelwal, R. Bhat and R. Bhatnagar, 2004. The osmoprotectants glycine and its methyl derivatives prevent the thermal inactivation of protective antigen of Bacillus anthracis. Biochem. Biophys. Res. Commun., 316: 559-564.
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  26. Singh, S., A. Singh, M.A. Aziz, S.M. Waheed, R. Bhat and R. Bhatnagar, 2004. Thermal inactivation of protective antigen of Bacillus anthracis and its prevention by polyol osmolytes. Biochem. Biophys. Res. Commun., 322: 1029-1037.
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  27. Aziz, M.A., S. Singh, P. Annand-Kumar and R. Bhatnagar, 2002. Expression of protective antigen in transgenic plants: A step towards edible vaccine against anthrax. Biochem. Biophys. Res. Commun., 299: 345-451.
    PubMed  |  Direct Link  |  
  28. Tayyab, S., S.K. Haq, M.A. Aziz, M.M. Khan and S. Muzammil, 1999. Effect of lysine modification on the conformation and indomethacin binding properties of human serum albumin. Int. J. Biol. Macromol., 26: 173-180.
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