Dr. Kumarappan Chidambaram
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Dr. Kumarappan Chidambaram

Assistant Professor
Department of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Saudi Arabia

Highest Degree
Ph.D. in Pharmacology from Jadavpur University, Jadavpur, Kolkata, India

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Biography

Dr. Kumarappan is currently working as an Assistant Professor at the Department of Pharmacology at King Khalid University. He is a member of ACCP, AALAS, and ISE. He has published extensively in type2 diabetes mellitus and natural products. Dr Kumar's research is focused on the mechanism underlying the development of metabolic syndrome and developing therapeutics to develop therapeutics.

Area of Interest:

Pharmacology and Toxicology
100%
Metabolic Syndrome
62%
Animal Models
90%
Toxicological Research
75%
Systematic Review
55%

Research Publications in Numbers

Books
1
Chapters
2
Articles
110
Abstracts
20

Selected Publications

  1. Thayumanavan, G., S. Jeyabalan, S. Fuloria, M. Sekar and M. Ravi et al., 2022. Silibinin and naringenin against bisphenol A-induced neurotoxicity in zebrafish model-potential flavonoid molecules for new drug design, development, and therapy for neurological disorders. Molecules, Vol. 27. 10.3390/molecules27082572.
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  2. Ravindhiran, R., R. Krishnamurthy, K. Sivarajan, J.N. Sekar, K. Chidambaram, A.M. Alqahtani and K. Dhandapani, 2022. Pharmacokinetic profile of sarcin and thionin from Aspergillus giganteus and in vitro validation against human fungal pathogen. Biosci. Rep., Vol. 42. 10.1042/BSR20220229.
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  3. Rana, T., T. Behl, M. Shamsuzzaman, S. Singh and N. Sharma et al., 2022. Exploring the role of astrocytic dysfunction and AQP4 in depression. Cell. Signalling, Vol. 96. 10.1016/j.cellsig.2022.110359.
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  4. Rahman, M.M., M.R. Islam, S. Shohag, M.E. Hossain and M.S. Rahaman et al., 2022. The multifunctional role of herbal products in the management of diabetes and obesity: A comprehensive review. Molecules, Vol. 27. 10.3390/molecules27051713.
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  5. Rahamathulla, M., U. Hani, A. Alqahtani, H.V. Gangadharappa and B.M. Yasmin et al., 2022. 23 factorial design and optimization of effervescent floating matrix tablet of neratinib. J. Pharm. Innovation, 17: 1451-1462.
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  6. Munjal, A., R. Khandia, S. Paladhi, M. Pandey and A. Parihar et al., 2022. Evaluating the effects of hypotensive drug valsartan on angiogenesis and associated breast ductal carcinoma cell metastasis. Int. J. Pharmacol., 18: 817-825.
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  7. Morais, S.R., K. Chitra, S. Jeyabalan, L.S. Wong and M. Sekar et al., 2022. Anticancer potential of Spirastrella pachyspira (marine sponge) against SK-BR-3 human breast cancer cell line and in silico analysis of its bioactive molecule sphingosine. Front. Mar. Sci., Vol. 9. 10.3389/fmars.2022.950880.
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  8. Mitra, S., M.S. Lami, A. Ghosh, R. Das and T.E. Tallei et al., 2022. Hormonal therapy for gynecological cancers: How far has science progressed toward clinical applications? Cancers, Vol. 14. 10.3390/cancers14030759.
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  9. Mehta, J., K. Utkarsh, S. Fuloria, T. Singh and M. Sekar et al., 2022. Antibacterial potential of Bacopa monnieri (L.) Wettst. and its bioactive molecules against uropathogens-an in silico study to identify potential lead molecule(s) for the development of new drugs to treat urinary tract infections. Molecules, Vol. 27. 10.3390/molecules27154971.
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  10. Manivasagan, P., A. Joe, H.W. Han, T. Thambi and M. Selvaraj et al., 2022. Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy. Mater. Today Bio, Vol. 13. 10.1016/j.mtbio.2021.100197.
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  11. Mahadevana, N., M. Goyalb, V. Rajalakshimia, N.A. Khana and K. Chidambaram, 2022. Hepatoprotective effect of combined extracts of Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa on carbon tetrachloride and paracetamol-induced hepatotoxicity in rats. Indian J. Tradit. Knowl., 21: 545-551.
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  12. Kandhasamy, D.M., P.M. Mareeswaran, S. Chellappan, D. Namasivayam, A. Aldahish and K. Chidambaram, 2022. Synthesis and photoluminescence properties of MoS2/graphene heterostructure by liquid-phase exfoliation. ACS Omega, 7: 629-637.
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  13. Islam, M.R., F. Islam, M.H. Nafady, M. Akter and S. Mitra et al., 2022. Natural small molecules in breast cancer treatment: Understandings from a therapeutic viewpoint. Molecules, Vol. 27. 10.3390/molecules27072165.
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  14. Ilango, K.B., S. Gowthaman, K.I. Seramaan, K. Chidambaram, M.F. Bayan, M. Rahamathulla and C. Balakumar, 2022. Mucilage of Coccinia grandis as an efficient natural polymer-based pharmaceutical excipient. Polymers, Vol. 14. 10.3390/polym14010215.
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  15. Gnanaraj, C., M. Sekar, S. Fuloria, S.S. Swain and S.H. Gan et al., 2022. In silico molecular docking analysis of karanjin against Alzheimer’s and Parkinson’s diseases as a potential natural lead molecule for new drug design, development and therapy. Molecules, Vol. 27. 10.3390/molecules27092834.
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  16. Gautam, A.K., P. Kumar, R. Raj, D. Kumar and B. Bhattacharya et al., 2022. Preclinical evaluation of dimethyl itaconate against hepatocellular carcinoma via activation of the e/iNOS-mediated NF-κB-dependent apoptotic pathway. Front. Pharmacol., Vol. 12. 10.3389/fphar.2021.823285.
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  17. Fuloria, S., M. Sekar, F.S. Khattulanuar, S.H. Gan and N.N.I.M. Rani et al., 2022. Chemistry, biosynthesis and pharmacology of viniferin: Potential resveratrol-derived molecules for new drug discovery, development and therapy. Molecules, Vol. 27. 10.3390/molecules27165072.
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  18. Fuloria, S., J. Mehta, M.P. Talukdar, M. Sekar and S.H. Gan et al., 2022. Synbiotic effects of fermented rice on human health and wellness: A natural beverage that boosts immunity. Front. Microbiol., Vol. 13. 10.3389/fmicb.2022.950913.
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  19. Fuloria, S., J. Mehta, A. Chandel, M. Sekar and N.N.I.M. Rani et al., 2022. A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Front. Pharmacol., Vol. 13. 10.3389/fphar.2022.820806.
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  20. Bayan, M.F., S.M. Marji, M.S. Salem, M.Y. Begum, K. Chidambaram and B. Chandrasekaran, 2022. Development of polymeric-based formulation as potential smart colonic drug delivery system. Polymers, Vol. 14. 10.3390/polym14173697.
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  21. Anand, S., P.S. Rajinikanth, D.K. Arya, P. Pandey, R.K. Gupta, R. Sankhwar and K. Chidambaram, 2022. Multifunctional biomimetic nanofibrous scaffold loaded with asiaticoside for rapid diabetic wound healing. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14020273.
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  22. Anand, S., P. Pandey, M.Y. Begum, K. Chidambaram and D.K. Arya et al., 2022. Electrospun biomimetic multifunctional nanofibers loaded with ferulic acid for enhanced antimicrobial and wound-healing activities in STZ-induced diabetic rats. Pharmaceuticals, Vol. 15. 10.3390/ph15030302.
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  23. Alqahtani, T., R. Khandia, N. Puranik, A.M. Alqahtani and Y. Alghazwani et al., 2022. Codon usage is influenced by compositional constraints in genes associated with dementia. Front. Genet., Vol. 13. 10.3389/fgene.2022.884348.
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  24. Alqahtani, A., K. Chidambara, K. Asseri, K. Venkatesan and A.A. Qure et al., 2022. Renoprotective and in silico modeling studies of febuxostat in gentamicin induced nephrotoxic rats. Int. J. Pharmacol., 18: 994-1003.
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  25. Paulsamy, P., V. Easwaran, R. Ashraf, S.H. Alshahrani and K. Venkatesan et al., 2021. Association of maternal observation and motivation (MOM) program with m-health support on maternal and newborn health. Healthcare, Vol. 9. 10.3390/healthcare9121629.
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  26. Paulsamy, P., R. Ashraf, S.H. Alshahrani, K. Periannan and A.A. Qureshi et al., 2021. Social support, self-care behaviour and self-efficacy in patients with type 2 diabetes during the COVID-19 pandemic: A cross-sectional study. Healthcare, Vol. 9. 10.3390/healthcare9111607.
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  27. Paulsamy, P., K. Periannan, V. Easwaran, N.A. Khan and V. Manoharan et al., 2021. School-based exercise and life style motivation intervention (SEAL.MI) on adolescent’s cardiovascular risk factors and academic performance: Catch them young. Healthcare, Vol. 9. 10.3390/healthcare9111549.
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  28. Mohammed, Y.B., A. Alqahtani, S. Lakshmi, K. Gnanaprakash and C.T. Kumarappan, 2021. Studies on formulation development and evaluation of tolnaftate-loaded glycerosomes. Mater. Res. Innovations, 25: 233-242.
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  29. Mahmud, S., G.K. Paul, S. Biswas, S. Afrose and M.A. Mita et al., 2021. Prospective role of peptide-based antiviral therapy against the main protease of SARS-CoV-2. Front. Mol. Biosci., Vol. 8. 10.3389/fmolb.2021.628585.
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  30. Khandia, R., N. Puranik, N. Lodhi, B. Gautam and T. Alqahtani et al., 2021. Comparing heart risk scores to identify the most important risk factors for cardiovascular diseases. Eur. Rev. Med. Pharmacol. Sci., 25: 7947-7963.
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  31. Balaji, P. and K. Chidambaram, 2021. Cancer diagnosis of microscopic biopsy images using a social spider optimisation-tuned neural network. Diagnostics, Vol. 12. 10.3390/diagnostics12010011.
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  32. Alqahtani, A.M., K. Chidambaram, A. Pino-Figueroa, B. Chandrasekaran, P. Dhanaraj and K. Venkatesan, 2021. Curcumin-celecoxib: A synergistic and rationale combination chemotherapy for breast cancer. Eur. Rev. Med. Pharmacol. Sci., 25: 1916-1927.
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  33. Subramanian, P., P.S. Rajnikanth, M. Kumar and K. Chidambram, 2020. In-vitro and in-vivo evaluation of supersaturable self-nanoemulsifying drug delivery system (SNEDDS) of dutasteride. Curr. Drug Delivery, 17: 74-86.
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  34. Galvan, J.A.A., P.N. Ramalingam, S.S. Patil, M.A.S. bin Shobri, K. Chinna, M.S. Sahrir and K. Chidambaram, 2020. Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study. Heliyon, Vol. 6. 10.1016/j.heliyon.2020.e05068.
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  35. Chidambaram, K., K. Venketesan, S. Dharmalingam, R. Siddalingam, T. Ellappan and S.C. Mandal, 2020. In-vitro inhibitory effects of polyphenolic extract of ichnocarpus frutescens on carbohydrate digestive enzymes. Adv. Pharmacol. Pharm., 7: 14-21.
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  36. Andoy-Galvan, J.A., S.S. Patil, P.N. Ramalingam, M.A.S.B. Shobri, K. Chinna, M.S. Sahrir and K. Chidambaram, 2020. Self-reported competency, knowledge and practices of teachers teaching primary children with autism in government schools of West Malaysia: A cross-sectional study. F1000Research, Vol. 9. 10.12688/f1000research.24283.1.
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  37. Alqahtani, A.M., C. Kumarappan, V. Kumar, R. Srinivasan and V. Krishnaraju, 2020. Understanding the genetic aspects of resistance to antidepressants treatment. Eur. Rev. Med. Pharmacol. Sci., 24: 7784-7795.
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  38. Manickam, B., R. Sreedharan and K. Chidambaram, 2019. Drug/vehicle impacts and formulation centered stratagems for enhanced transdermal drug permeation, controlled release and safety: Unparalleled past and recent innovations-an overview. Curr. Drug Ther., 14: 192-209.
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  39. Kumarappan, C., M. Vijayakumar, E. Thilagam, M. Balamurugan and M. Thiagarajan et al., 2019. Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen. Ann. Hepatol., 10: 63-72.
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  40. Thilagam, E., K. Chidambaram and S.C. Mandal, 2018. Antidiabetic activity of senna surattensis in alloxan-induced diabetic rats. Asian J. Pharm. Clin. Res., 11: 160-163.
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  41. Siddalingam, R. and K. Chidambaram, 2016. Topical nano-delivery of 5-fluorouracil: Preparation and characterization of water-in-oil nanoemulsion. Trop. J. Pharm. Res., 15: 2311-2319.
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  42. Kumarappan, C. and S.C. Mandal, 2015. Antidiabetic effect of polyphenol enriched extract of Ichnocarpus frutescens on key carbohydrate metabolic enzymes. Int. J. Diabetes Dev. Countries, 35: 425-431.
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  43. Dharmalingam, S.R., S. Ramamurthy, K. Chidambaram and S. Nadaraju, 2014. A simple HPLC bioanalytical method for the determination of doxorubicin hydrochloride in rat plasma: Application to pharmacokinetic studies. Trop. J. Pharm. Res., 13: 409-415.
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  44. Dharmalingam, S.R., R. Madhappan, S. Ramamurthy, K. Chidambaram, M.V. Srikanth, S. Shanmugham and S.K.L. Kumar, 2014. Investigation on antidiarrhoeal activity Of Aristolochia Indica Linn. root extracts in mice. Afr. J. Trad. Complementary Altern. Med., 11: 292-294.
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  45. Thilagam, E., B. Parimaladevi, C. Kumarappan and S.C. Mandal, 2013. α-glucosidase and α-amylase inhibitory activity of Senna surattensis. J. Acupuncture Meridian Stud., 6: 24-30.
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  46. Sunil, C., S. Ignacimuthu and C. Kumarappan, 2012. Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats. J. Nat. Med., 66: 32-38.
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  47. Kumarappan, C.T. and S.C. Mandal, 2008. Polyphenolic extract of Ichnocarpus frutescens attenuates diabetic complications in streptozotocin-treated diabetic rats. Renal Fail., 30: 307-322.
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