Dr. Shajrul Amin
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Dr. Shajrul Amin

Professor
Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India

Highest Degree
Ph.D. in Biochemistry from University of Kashmir, Srinagar, India

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Proteins Characterization
90%
Genetic Epidemiology
75%
Enzymes Purification
55%

Research Publications in Numbers

Books
2
Chapters
5
Articles
75
Abstracts
0

Selected Publications

  1. Wani, H.A., S. Majid, A.A. Bhat, S. Amin and R. Farooq et al., 2019. Impact of catechol-O-methyltransferase gene variants on methylation status of P16 and MGMT genes and their downregulation in colorectal cancer. Eur. J. Cancer Prevent., 28: 68-75.
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  2. Rasool, S.U.A., S. Ashraf, M. Nabi, F. Rashid, S.R. Masoodi, K.M. Fazili and S. Amin, 2019. Insulin gene VNTR class III allele is a risk factor for insulin resistance in Kashmiri women with polycystic ovary syndrome. Meta Gene, Vol. 21. 10.1016/j.mgene.2019.100597.
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  3. Rasool, S.U.A., S. Ashraf, M. Nabi, F. Rashid, K.M. Fazili and S. Amin, 2019. Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome. Diabet. Metab. Syndrome: Clin. Res. Rev., 13: 2098-2105.
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  4. Manzoor, S., M.A. Ganie, S. Amin, Z.A. Shah and I.A. Bhat et al., 2019. Oral contraceptive use increases risk of inflammatory and coagulatory disorders in women with polycystic ovarian syndrome: An observational study. Scient. Rep., Vol. 9. 10.1038/s41598-019-46644-4.
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  5. Kawa, I.A., A. Masood, S. Amin, M.F. Mustafa and F. Rashid, 2019. Clinical Perspectives of Posttranslational Modifications. In: Protein Modificomics, Dar, T.A. and L.R. Singh (Eds.)., Academic Press, Elsevier, USA., pp: 37-68.
  6. Jeelani, H., M.A. Ganie, S. Amin, Q. Fatima and I.A. Kawa et al., 2019. Effect of Paraoxonase1 (PON1) gene polymorphisms on PON1 activity, HDL, LDL and MDA levels in women with polycystic ovary syndrome (PCOS): A case-control study. Meta Gene, Vol. 20. 10.1016/j.mgene.2019.100552.
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  7. Fatima, Q., S. Amin, I.A. Kawa, H. Jeelani, S. Manzoor, S.M. Rizvi and F. Rashid, 2019. Evaluation of antioxidant defense markers in relation to hormonal and insulin parameters in women with Polycystic Ovary Syndrome (PCOS): A case-control study. Diabet. Metab. Syndrome: Clin. Res. Rev., 13: 1957-1961.
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  8. Dar, K.B., A.H. Bhat, S. Amin, S. Anjum and B.A. Reshi et al., 2019. Exploring proteomic drug targets, therapeutic strategies and protein-protein interactions in cancer: Mechanistic view. Curr. Drug Targets, 18: 430-448.
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  9. Dar, K.B., A.H. Bhat, S. Amin, B.A. Reshi, M.A. Zargar, A. Masood and S.A. Ganie, 2019. Elucidating critical proteinopathic mechanisms and potential drug targets in neurodegeneration. Cell. Mol. Neurobiol., 40: 313-345.
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  10. Ashraf, S., M. Nabi, F. Rashid and S. Amin, 2019. Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: A review. Egypt. J. Med. Hum. Genet., Vol. 20. 10.1186/s43042-019-0031-4.
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  11. Yousuf, S.D., M.A. Ganie, S. Jeelani, S. Mudassar and Z.A. Shah et al., 2018. Effect of six-month use of oral contraceptive pills on plasminogen activator inhibitor-1 & factor VIII among women with polycystic ovary syndrome: An observational pilot study. Indian J. Med. Res., 148: S151-S155.
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  12. Rather, M.A., Z.S. Bhat, A.M. Lone, M. Maqbool, S. Amin, B.A. Bhat and Z. Ahmad, 2018. In vitro antimycobacterial activity of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione: A new chemical entity against Mycobacterium tuberculosis. Int. J. Antimicrob. Agents, 52: 265-268.
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  13. Nabi, M., A. Bhat, S.U.A. Rasool, S. Ashraf, R. Maqbool, S.A. Ganie and S. Amin, 2018. Physico-chemical characterization and anti-microbial activity of serine protease inhibitors purified from the seeds of Sophora japonica. Pak. J. Biol. Sci., 21: 432-440.
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  14. Maqbool, R., S. Amin, S. Majeed, A. Bhat and M. Nabi, 2018. XRCC1 Arg194Trp polymorphism is no risk factor for skin cancer development in Kashmiri population. Egypt. J. Med. Hum. Genet., 19: 91-95.
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  15. Jabeen, S., S.A. Bhat, S. Majid, N.A. Naikoo, R. Farooq, S. Ishaq and S. Amin, 2018. Scenario of hypothyroidism and its recent advances in the diagnosis and management-A review. Int. J. Recent Scient. Res., 9: 25288-25299.
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  16. Farooq, R., S. Majid, S.A. Bhat, S. Amin, M.H. Bhat, H.A. Wani and P.A. Shah, 2018. Association of adiponectin gene polymorphism with type 2 diabetes and metabolic syndrome. Transl. Metab. Syndrome Res., 1: 39-47.
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  17. Dar, K.B., A.H. Bhat, S. Amin, S. Anjum and B.A. Reshi et al., 2018. Exploring proteomic drug targets, therapeutic strategies and protein-protein interactions in cancer: Mechanistic view. Curr. Drug Targets, Vol. 18. 10.2174/1568009618666180803104631.
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  18. Dar, K.B., A.H. Bhat, S. Amin, R. Hamid and S. Anees et al., 2018. Modern computational strategies for designing drugs to curb human diseases: A prospect. Curr. Top. Med. Chem., 18: 2702-2719.
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  19. Yousuf, S.D., M.A. Ganie, M.A. Zargar, S.U. Amin, G.A. Bhat, A. Masood and F. Rashid, 2017. The Lys469glu/K469E polymorphism of the inflammatory gene intercellular adhesion molecule-1 lacks any apparent role in the polycystic ovary syndrome in Kashmiri women: A case control study. Asian Pac. J. Cancer Prev., 18: 2925-2930.
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  20. Sakina, S., F. Rashid, M. Rizvi, S. Abeer, S. Ashraf, S. Manzoor and S. Amin, 2017. Comparative analysis of clinical, biochemical and hormonal profile of obese versus lean Kashmiri PCOS patients-A pilot study. Int. J. Adv. Sci. Eng. Technol., 5: 55-60.
  21. Rather, M.A., F. Rasool, Z.S. Bhat, H.U. Dar and M. Maqbool et al., 2017. Design and synthesis of indolopyridone hybrids as new antituberculosis agents. Microb. Pathogenesis, 113: 330-334.
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  22. Rather, M., A.M. Lone, B. Teli, Z.S. Bhat and P. Singh et al., 2017. Synthesis, biological evaluation and structure-activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents. Med. Chem. Commun., 8: 2133-2141.
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  23. Manzoor, S., A.M. Gania, S.D. Yusuf, S. Amin, R. Habib and F. Rashid, 2017. Metabolic derangements and possible CVD risk in PCOS women owing to use of OCP’s as a treatment mode-Pros and Cons. J. Endocrinol. Diabetes Obes., Vol. 5. .
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  24. Jeelani, H., M.A. Ganie, S. Amin, I.A. Kawa, Q. Fatima, Z. Drabu and F. Rashid, 2017. Polycystic ovary syndrome (PCOS) and related diseases. Precision Med., 2: 23-29.
  25. Farooq, R., S. Amin, R. Malik, H.A. Wani, M.H. Bhat and S. Majid, 2017. Type 2 diabetes and metabolic syndrome-adipokine levels and effect of drugs. Gynecol. Endocrinol., 33: 75-78.
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  26. Dar, K.B., A.H. Bhat, S. Amin, M.A. Zargar and A. Masood, 2017. Evaluation of antibacterial, antifungal and phytochemical screening of Solanum nigrum. Biochem. Anal. Biochem., Vol. 6. 10.4172/2161-1009.1000309.
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  27. Dar, K.B., A.H. Bhat, S. Amin, A. Masood, M.A. Zargar and S.A. Ganie, 2017. Herbal compounds as potential anticancer therapeutics. Ann. Pharmacol. Pharm., Vol. 2. .
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  28. Rather, M.A., S. Mansoor, Z.S. Bhat and S. Amin, 2016. Evaluation of antimicrobialand antioxidant activities of Swertia petiolata. Adv. Biomed. Pharm., 3: 293-300.
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  29. Rather, M.A., S. Amin, M. Maqbool, Z.S. Bhat, P.N. Gupta and Z. Ahmad, 2016. Preparation and in vitro characterization of albumin nanoparticles encapsulating an anti-tuberculosis drug-levofloxacin. Adv. Sci. Eng. Med., 8: 912-917.
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  30. Rather, M.A. and S. Amin, 2016. A comprehensive review on the phytochemical and pharmacological aspects of Podophyllum hexandrum: A high value medicinal plant. Adv. Biomed. Pharm., 3: 216-226.
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  31. Dar, K.B., A.H. Bhat, S. Amin, S. Anees, A. Masood, M.I. Zargar and S.A. Ganie, 2016. Efficacy of aqueous and methanolic extracts of rheum spiciformis against pathogenic bacterial and fungal strains. J. Clin. Diagn. Res., 10: 18-22.
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  32. Dar, K.B., A.H. Bhat, S. Amin, A. Masood, M.A. Zargar and S.A. Ganie, 2016. Inflammation: A multidimensional insight with advanced focus on natural anti-inflammatory therapeutic compounds. Curr. Med. Chem., 23: 3775-3800.
  33. Rakashanda, S., A.K. Qazi, R. Majeed, S.M. Andrabi, A. Hamid, P.R. Sharma and S. Amin, 2015. Plant-derived protease inhibitors LC-pi (Lavatera cashmeriana) inhibit human lung cancer cell proliferation in vitro. Nutr. Cancer, 67: 156-166.
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  34. Makhdoomi, M.A., I.A. Shah, G.A. Bhat, S. Amin, M.M. Lone, F. Islami and N.A. Dar, 2015. Association between GSTM1 and GSTT1 polymorphisms and esophageal squamous cell carcinoma: Results from a case-control study in Kashmir, India. Tumor Biol., 36: 2613-2619.
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  35. Ashaq, I., A. Shajrul, M. Akbar ahnd F. Rashid, 2015. Protein Misfolding Diseases: In Perspective of Gain and Loss of Function. In: Proteostasis and Chaperone Surveillance, Singh, L.R., T.A. Dar and P. Ahmad (Eds.). Springer, New Delhi, ISBN: 978-81-322-2466-2, pp: 105-118.
  36. Ganie, S.A., T.A. Dar, R. Hamid, O. Zargar and S.U. Abeer et al., 2014. In Vitro Antioxidant and Cytotoxic Activities of Arnebia benthamii (Wall ex. G. Don): A Critically Endangered Medicinal Plant of Kashmir Valley. Oxid. Med. Cell. Longevity, 10.1155/2014/792574.
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  37. Ganie, S.A., T.A. Dar, B. Zargar, R. Hamid and O. Zargar et al., 2014. Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract. J. Environ. Pathol. Toxicol. Oncol., 33: 131-143.
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  38. Farrukh, M.R., A. UlNissar, A. Quadri, R.A. Rather and L. Sharma et al., 2014. Oxidative stress mediated Ca2+ release manifests endoplasmicreticulum stress leading to unfolded protein response in UV-Birradiated human skin cells. J. Dermatol. Sci., 75: 24-35.
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  39. Farooq, R., S. Amin, H. Bashir, B.A. Ganaie and S. Majid, 2014. TCF4 may act as a tumour suppressor gene in colorectal carcinogenesis. World J. Pharm. Res., 3: 431-443.
  40. Wani, H.A., A.A. Bhat, A.A. Mattoo, H. Khan and S. Amin et al., 2013. Distribution of P16 Promoter Hypermethylation in Male/Female Colorectal Cancer Patients of Kashmir Valley. Int. J. Eng. Sci. Inventions, 2: 11-17.
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  41. Rakhashanda, S. and S. Amin, 2013. Proteases as targets in anticancer therapy using their inhibitors. J. Life Sci., 5: 133-138.
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  42. Rakashanda, S., S. Mubashir, Y. Qurishi, A. Hamid, A. Masood and S. Amin, 2013. Trypsin inhibitors from Lavatera cashmeriana Camb. seeds: Isolation, characterization and in-vitro cytoxicity activity. Int. J. Pharm. Sci. Invent., 2: 55-65.
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  43. Rakashanda, S., A.K. Qazi, R. Majeed, S. Rafiq and I.M. Dar et al., 2013. Antiproliferative activity of Lavatera cashmeriana-protease inhibitors towards human cancer cells. Asian Pac. J. Cancer Prev., 14: 3975-3978.
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  44. Nisa, H., A.N. Kamili, S.A. Bandh, B.A. Lone and J.A. Parray, 2013. Phytochemical screening, antimicrobial and antioxidant efficacy of different extracts of Rumex dentatus L.-a locally used medicinal herb of Kashmir Himalaya. Asian Pac. J. Trop. Dis., 3: 434-440.
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  45. Humeera, N., A.N. Kamili, S.A. Bandh, B.A. Lone and N. Gousia, 2013. Antimicrobial and antioxidant activities of alcoholic extracts of Rumex dentatus L. Microb. Pathogenesis, 57: 17-20.
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  46. Farooq, R., S. Amin, H. Wani, A. Bhat and H. Bashir et al., 2013. CPG Methylation in Exon 1 of TCF4 Gene as an Early Biomarker of Gastric Cancer. Int. J. Pharm. Sci. Rev. Res., 20: 93-97.
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  47. Farooq, R., A.A. Bhat, H.A. Wani, H. Bashir, N.A. Naikoo and S. Amin, 2013. Role of hematological parameters in diagnosis and prognosis of gastric carcinoma in Kashmir, India. Int. Res. J. Pharm., 4: 134-137.
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  48. Wani, H.A., M.A. Beigh, S. Amin, A.A. Bhat and S. Bhat et al., 2012. Methylation profile of promoter region of p16 gene in colorectal cancer patients of Kashmir valley. J. Biol. Regul. Homeostatic Agents, 27: 297-307.
  49. Rakashanda, S., M. Ishaq, A. Masood and S. Amin, 2012. Antibacterial activity of a trypsin-chymotrypsin-elastase inhibitor isolated from Lavatera cashmeriana camb. seeds. J. Anim. Plant Sci., 22: 983-986.
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  50. Rakashanda, S., F. Rana, S. Rafiq, A. Masood and S. Amin, 2012. Role of proteases in cancer: A review. Biotechnol. Mol. Biol. Rev., 7: 90-101.
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  51. Gulzar, S. and S. Amin, 2012. Kinetic studies on β-galactosidase isolated from apricots (Prunus armeniaca kaisa). Am. J. Plant Sci., 3: 636-645.
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  52. Ganie, S.A., S. Amin, R. Hamid, A. Hamid and R. Majeed et al., 2012. Podophyllum Hexandrum Aqueous Extract As A Potential Free Radical Scavenger. Redox Rep., 17: 54-62.
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  53. Farrukh, R., M.A. Zargar, A. Akhtar, S.A. Tasduq and S. Surjeet et al., 2012. Antibacterial and Antifungal Activity of Thymus serpyllum. Bot. Res. Int., 5: 36-39.
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  54. Amin, S. and F. Rana, 2012. Medicinal Properties of Thymus serphyllum: Thymus serphyllum a Potential Therapeutic Agent. LAP LAMBERT Academic Publishing, Germany, ISBN-13: 978-3-8473-4318-9, Pages: 112.
  55. Handoo, I., S. Gulzar, S. Amin and P. Sultan, 2011. Effect of sulfite on phosphoenol pyruvate carboxylase of maize (Zea Mays). Adv. Environ. Biol., 5: 612-616.
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  56. Ganie, S. and S. Amin, 2011. Antioxidant and Anticancer Activity of Podophyllum hexandrum. LAP Lambert Academic Publishing, Germany, ISBN-13: 978-3-8473-1963-4, Pages: 148.
  57. Akbar, M., B. Minu, A. Shajrul and S. Rakashanda, 2011. Ultrastructural Changes in Malva sylvestris Leaves in Response to Aqueous Sulfur Dioxide. J. Phytol., 3: 28-30.
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  58. Gani, S., S. Amin and A. Masood, 2010. Changes associated with pesticide overload in Pisum sativum. Adv. Plant Sci., 23: 131-134.
  59. Amin, S. and A. Masood, 2010. Changes in C4 Photosynthesis in Response to Sulfur Dioxide Exposure: Biochemical and Metabolic Changes. LAP Lambert Academic Publishing, Germany, ISBN-13: 978-3-8383-4840-7, Pages: 196.
  60. Balkhi, M., S. Amin and A. Masood, 2009. Effect of Aqueous Sulphur Dioxide on the Biochemical and Antioxidant Properties of Malva sylvestris. Asian J. Environ. Sci., 3: 139-145.
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  61. Amin, S., M. Farooq, R.K. Hans and A. Masood, 2009. Changes in the kinetic properties of Zea mays NADP-malic enzyme in response to sulphur dioxide exposure. Int. J. Plant Sci., 4: 415-419.
  62. Geelani, R., M. Bashir, S. Amin, A. Zargar and A. Masood, 2007. Effect of aqueous sulfur dioxide on ultra structure of Spinacea oleracea leaves. Asian J. Biotechnol. Microbiol. Environ. Sci., 9: 95-98.
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  63. Geelani, R., M. Bashir, S. Amin and A. Masood, 2007. Role of molybdenum In the biological function of sulfite oxidase. J. Ind. Pollut. Control, 23: 297-304.
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  64. Amin, S., R.K. Hans, M. Farooq and A. Masood, 2007. Inhibition of Zea mays phosphoenolpyruvate carboxylase by sulfur dioxide. Toxicol. Int., 14: 103-109.
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  65. Amin, S., R.K. Hans, M. Farooq and A. Masood, 2007. Effects of sulfur dioxide fumigation on the biochemical characteristics of Zea mays. Pollut. Res., 26: 567-572.
  66. Masood, A., A. Seema, S. Amin and M. Farooq, 2001. Effect of Sulfur Dioxide on Spinach Foliar Glycolipids. Pollutant Res., 20: 299-301.
  67. Masood, A., A. Seema, S. Amin and M. Farooq, 1999. Biochemical effects of aqueous sulfur dioxide in Spinach leaf discs. Asian J. Microbiol. Biotechnol. Environ. Sci. Pap., 1: 101-106.
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  68. Ganai, B.A., A. Masood, S. Amin, I. Javaid and H. Rabia, 1996. Effect of gaseous air pollutants on enzyme activities. J. Oriental Sci., 2: 83-86.