Dr. Bhahwal Ali Shah
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Dr. Bhahwal Ali Shah

Researcher
CSIR-Indian Institute of Integrative Medicine, India

Highest Degree
Ph.D. in Chemistry from Guru Nanak Dev University, India

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Area of Interest:

Chemistry
100%
Natural Products
62%
Medicinal Chemistry
90%
Chemical Polymerization
75%
Chemical Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sultan, S., V. Gupta and B.A. Shah, 2017. Photoredox‐catalyzed isatin reactions: Access to dibenzo‐1,7‐naphthyridine carboxylate and tryptanthrin. ChemPhotoChem, 1: 120-124.
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  2. Magotra, A., M. Kumar, M. Kushwaha, P. Awasthi and C. Raina et al., 2017. Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigates (GA-L7): An endophytic fungus from Grewia asiatica L. AMB Expr., Vol. 7. 10.1186/s13568-017-0343-z.
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  3. Koul, M., A. Kumar, R. Deshidi, V. Sharma and R.D. Singh et al., 2017. Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells. BMC Cell Biol., Vol. 18. 10.1186/s12860-017-0141-0.
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  4. Gupta, S., A.U. Ahsan, A. Wani, V. Khajuria and L.A. Nazir et al., 2017. The amino analogue of β-boswellic acid efficiently attenuates the release of pro-inflammatory mediators than its parent compound through the suppression of NF-κB/IκBα signalling axis. Cytokine. 10.1016/j.cyto.2017.12.004.
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  5. Dhamale, O.P., R. Lawrence, E.M. Wiegmann, B.A. Shah and K. Al-Mafraji et al., 2017. Arylsulfatase K is the lysosomal 2-sulfoglucuronate sulfatase. ACS Chem. Biol., 12: 367-373.
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  6. Deshidi, R., S. Devari, M. Kushwaha, A.P. Gupta and R. Sharma et al., 2017. Isolation and quantification of alternariols from endophytic fungus, Alternaria alternata: LC‐ESI‐MS/MS analysis. ChemistrySelect, 2: 364-368.
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  7. Ahmad, M., M.A. Aga, J.A. Bhat, B. Kumar and A. Rouf et al., 2017. Exploring derivatives of quinazoline alkaloid l-vasicine as cap groups in the design and biological mechanistic evaluation of novel antitumor histone deacetylase inhibitors. J. Med. Chem., 60: 3484-3497.
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  8. Sultan, S., M. Kumar, S. Devari, D. Mukherjee and B.A. Shah, 2016. Copper-manganese spinel oxide catalyzed synthesis of amides and azobenzenes via aminyl radical cations. ChemCatChem, 8: 703-707.
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  9. Sharma, S., S. Sultan, S. Devari and B.A. Shah, 2016. Radical-radical cross coupling reactions of photo-excited fluorenones. Org. Biomol. Chem., 14: 9645-9649.
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  10. Sharma, S., S. Gupta, V. Khajuria, A. Bhagat, Z. Ahmed and B.A. Shah, 2016. Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6. Bioorg. Med. Chem. Lett., 26: 695-698.
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  11. Pathania, A.S., S.K. Guru, S. Kumar, A. Kumar and M. Ahmad et al., 2016. Interplay between cell cycle and autophagy induced by boswellic acid analog. Scient. Rep., Vol. 6. 10.1038/srep33146.
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  12. Pandey, A., M. Rizvi, B.A. Shah and S. Bani, 2016. Anti-arthritogenic effect of Saponin-1 by alteration of Th1/Th2 cytokine paradigm in arthritic mice. Cytokine, 79: 103-113.
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  13. Kumar, A., A. Qayum, P.R. Sharma, S.K. Singh and B.A. Shah, 2016. Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents. Bioorg. Med. Chem. Lett., 26: 76-81.
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  14. Goswami, A., B.A. Shah, N. Batra, A. Kumar and S.K. Guru et al., 2016. Multiple pharmacological properties of a novel parthenin analog P16 as evident by its cytostatic and antiangiogenic potential against pancreatic adenocarcinoma PANC-1 cells. Anti-Cancer Agents Med. Chem., 16: 771-780.
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  15. Devari, S., M.A. Rizvi and B.A. Shah, 2016. Visible light mediated chemo-selective oxidation of benzylic alcohols. Tetrahedron Lett., 57: 3294-3297.
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  16. Devari, S. and B.A. Shah, 2016. Visible light-promoted C–H functionalization of ethers and electron-deficient arenes. Chem. Commun., 52: 1490-1493.
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  17. Deshidi, R., S. Devari, M. Rizvi and B.A. Shah, 2016. Regio‐selective phosphation and phosphonation of 9‐fluorenones. ChemistrySelect, 1: 6040-6043.
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  18. Rizvi, M.A., M. Zaki, M. Afzal, M. Mane and M. Kumar et al., 2015. Nuclear blebbing of biologically active organoselenium compound towards human cervical cancer cell (HeLa): In vitro DNA/HSA binding, cleavage and cell imaging studies. Eur. J. Med. Chem., 90: 876-888.
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  19. Qazi, A.K., A. Hussain, S. Khan, M.A. Aga and A. Behl et al., 2015. Quinazoline based small molecule exerts potent tumor suppressive properties by inhibiting PI3K/akt/FoxO3a signalling in experimental colon cancer. Cancer Lett., 2015: 1428-1432.
  20. Kumar, M., S. Devari, A. Kumar, S. Sultan, Q.N. Ahmed, M. Rizvi and B.A. Shah, 2015. Copper (II)‑triflate‑catalyzed oxidative amidation of terminal alkynes: A general approach to α‑ketoamides. Asian J. Org. Chem., 4: 438-441.
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  21. Kumar, M., A. Kumar, M.A. Rizvi and B.A. Shah, 2015. Acetaldehyde in asymmetric organocatalytic transformations. RSC Adv., 5: 55926-55937.
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  22. Kumar, A., M. Kumar, S. Sharma, S. Guru, S. Bhushan and B.A. Shah, 2015. Design, synthesis and bio-evaluation of cryptophycins based tubulin inhibitors. Eur. J. Med. Chem., 93: 55-63.
  23. Kumar, A. and B.A. Shah, 2015. Synthesis of biaryls via benzylic C-C bond cleavage of styrenes and benzyl alcohols. Org. Lett., 17: 5232-5235.
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  24. Guru, S.K., A.S. Pathania, S. Kumar, D. Ramesh and M. Kumar et al., 2015. Secalonic acid-D represses HIF1α/VEGF-mediated angiogenesis by regulating the Akt/mTOR/p70S6K signaling cascade. Cancer Res., 75: 2886-2896.
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  25. Devari, S., A. Kumar and B.A. Shah, 2015. C-H functionalization of terminal alkynes towards stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones. Chem. Commun., 51: 5013-5016.
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  26. Deshidi, R., S. Devari and B.A. Shah, 2015. Metal free access to quinolines via C-C bond cleavage of styrenes. Org. Chem. Front., 2: 515-519.
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  27. Deshidi, R., S. Devari and B.A. Shah, 2015. Iodine‐promoted oxidative amidation of terminal alkenes–synthesis of α‐ketoamides, benzothiazoles and quinazolines. Eur. J. Org. Chem., 2015: 1428-1432.
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  28. Deshidi, R., M.A. Rizvi and B.A. Shah, 2015. Highly efficient dehydrogenative cross-coupling of aldehydes with amines and alcohols. RSC Adv., 5: 90521-90524.
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  29. Sharma, S., M. Ahmad, J.A. Bhat, A. Kumar and M. Kumar et al., 2014. Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death. Bioorg. Med. Chem. Lett., 24: 4729-4734.
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  30. Rizvi, M.A., S. Guru, T. Naqvi, M. Kumar and N. Khumbhar et al., 2014. An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides. Bioorg. Med. Chem. Lett., 24: 3440-3446.
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  31. Rasool, S., V. Rasool, T. Naqvi, B.A. Ganai and B.A. Shah, 2014. Genetic unraveling of colorectal cancer. Tumor Biol., 35: 5067-5082.
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  32. Kumar, M., A. Kumar, M. Rizvi, M. Mane, K. Vanka, S.C. Taneja and B.A. Shah, 2014. Synthesis of α,β‐unsaturated δ‐lactones by vinyl acetate mediated asymmetric cross‐aldol reaction of acetaldehyde: Mechanistic insights. Eur. J. Org. Chem., 2014: 5247-5255.
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  33. Kumar, B., M.A. Aga, A. Rouf, B.A. Shah and S.C. Taneja, 2014. Tetrahydropyranyl ether (THPE) formation in hydroxyl group protection and conversion to other useful functionalities. RSC Adv., 4: 21121-21130.
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  34. Kumar, B., M.A. Aga, A. Rouf, B.A. Shah and S.C. Taneja, 2014. Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam. RSC Adv., 4: 17206-17209.
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  35. Gupta, P., A. Rouf, B.A. Shah, N. Mahajan, A. Chaubey and S.C. Taneja, 2014. Arthrobacter sp. lipase catalyzed kinetic resolution of BINOL: The effect of substrate immobilization. J. Mol. Catal. B: Enzyme, 101: 35-39.
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  36. Devari, S., S. Jaglan, M. Kumar, R. Deshidi and S. Guru et al., 2014. Capsaicin production by Alternaria alternate, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis. Phytochemistry, 98: 183-189.
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  37. Devari, S., M. Kumar, R. Deshidi, M. Rizvi and B.A. Shah, 2014. A general metal-free approach for the stereoselective synthesis of C-glycals from unactivated alkynes. Beilstein J. Org. Chem., 10: 2649-2653.
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  38. Deshidi, R., M. Kumar, S. Devari and B.A. Shah, 2014. A general metal free approach to α-ketoamides via oxidative amidation-diketonization of terminal alkynes. Chem. Commun., 50: 9533-9535.
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  39. Chib, R., M. Kumar, M. Rizvi, S. Sharma and A. Pandey et al., 2014. Anti-inflammatory terpenoids from Boswellia ovalifoliolata. RSC Adv., 4: 8632-8637.
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  40. Aga, M.A., B. Kumar, A. Rouf, B.A. Shah and S.C. Taneja, 2014. Vasicine as tridentate ligand for enantioselective addition of diethylzinc to aldehydes. Tetrahedron Lett., 55: 2639-2641.
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  41. Qurishi, Y., A. Hamid, P.R. Sharma, Z.A. Wani and D.M. Mondhe et al., 2013. NFκB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression. Anticancer Agents Med. Chem., 13: 777-790.
  42. Qadri, M., S. Johri, B.A. Shah, A. Khajuria and T. Sidiq et al., 2013. Identification and bioactive potential of endophytic fungi isolated from selected plants of the Western Himalayas. SpringerPlus, Vol. 2. 10.1186/2193-1801-2-8.
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  43. Pathania, A.S., A. Joshi, S. Kumar, S.K. Guru and S. Bhushan et al., 2013. Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. Apoptosis, 18: 1561-1573.
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  44. Mehra, R., A. Nargotra, B.A. Shah, S.C. Taneja, R.A. Vishwakarma and S. Koul, 2013. Pro-apoptotic properties of parthenin analogs: A quantitative structure-activity relationship study. Med. Chem. Res., 22: 2303-2311.
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  45. Kumar, M., M. Qadri, P.R. Sharma, A. Kumar and S.S. Andotra et al., 2013. Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara. J. Nat. Prod., 76: 194-199.
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  46. Gupta, P., A. Rouf, B.A. Shah, D. Mukherjee and S.C. Taneja, 2013. Efficient preparation of biologically important 1,2-amino alcohols. Synthetic Commun., 43: 505-519.
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  47. Devari, S., R. Deshidi, M. Kumar, A. Kumar and S. Sharma et al., 2013. Osmium (VI) catalyzed chemoselective oxidation of allylic and benzylic alcohols. Tetrahedron Lett., 54: 6407-6410.
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  48. Chib, R., B.A. Shah, S.S. Andotra, V. Bharadwaj, R.K. Gupta, S.C. Taneja and R.K. Khajuria, 2013. Quantification of sesquiterpene lactones in Parthenium hyterophorous by normal-phase HPLC. J. Chromatographic Sci., 51: 950-953.
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  49. Aga, M.A., B. Kumar, A. Rouf, B.A. Shah, S.S. Andotra and S.C. Taneja, 2013. Natural (−)‐vasicine as a novel source of optically pure 1‐benzylpyrrolidin‐3‐ol. Helvetica Chimica Acta, 96: 969-977.
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  50. Qurishi, Y., A. Hamid, P.R. Sharma, Z.A. Wani and D.M. Mondhe et al., 2012. PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models. Future Oncol., 8: 867-881.
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  51. Kumar, A., B.A. Shah, S. Singh, A. Hamid and S.K. Singh et al., 2012. Acyl derivatives of bowswellic acids as inhibitors of NF-kappa β and STATs. Bioorg. Med. Chem. Lett., 22: 431-435.
  52. Khan, S., R. Kaur, B.A. Shah, F. Malik and A. Kumar et al., 2012. A novel cyano derivative of 11‐Keto‐β‐boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp‐90 cascade, mitochondrial integrity and other cell survival signaling events in HL‐60 cells. Mol. Carcinogenesis, 51: 679-695.
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  53. Kant, R., V.K. Gupta, K. Kapoor, R. Chib, B.A. Shah and S.C. Taneja, 2012. 1,2,3,4,5,6-Hexa-O-acetyl-scyllo-inositol. Acta Crystallogr. Sect. E: Struct. Rep. Online, 68: o2594-o2594.
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  54. Raja, A.F., F. Ali, I.A. Khan, A.S. Shawl, D.S. Arora, B.A. Shah and S.C. Taneja, 2011. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata. BMC Microbiol., Vol. 11. 10.1186/1471-2180-11-54.
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  55. Kumar, M., B.A. Shah and S.C. Taneja, 2011. Tandem catalysis by lipase in a vinyl acetate‐mediated cross‐aldol reaction. Adv. Synthesis Catalysis, 353: 1207-1212.
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  56. Kumar, B., M.A. Aga, A. Rouf, B.A. Shah and S.C. Taneja, 2011. 2,3-Unsaturated allyl glycosides as glycosyl donors for selective α-glycosylation. J. Org. Chem., 76: 3506-3510.
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  57. Kumar, A., F. Malik, S. Bhushan, B.A. Shah and S.C. Taneja et al., 2011. A novel parthenin analog exhibits anti-cancer activity: Activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells. Chem.-Biol. Interact., 193: 204-215.
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  58. Khan, S., R. Chib, B.A. Shah, Z.A. Wani and N. Dhar et al., 2011. A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death. Eur. J. Pharmacol., 660: 241-248.
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  59. Kaur, R., S. Khan, R. Chib, T. Kaur and P.R. Sharma et al., 2011. A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Eur. J. Med. Chem., 46: 1356-1366.
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  60. Kapoor, K., V.K. Gupta, Rajnikant, R. Chib, B.A. Shah and S.C. Taneja, 2011. Crystal structure of methyl-2-cyano-3,11-dioxurs-1,12-dien-24-oate. X-ray Struct. Anal. Online, 27: 43-44.
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  61. Kapoor, K., V.K. Gupta, B.A. Shah, S.S. Andotra and S.C. Taneja, 2011. Crystal structure Of 3, 8-dibromo-3-(Bromomethyl)-3, 3a,4,5,6,6a-hexahydro-6a-hydroxy-6,9a-dimethylazuleno [4, 5-b] furan-2, 9-dione-sesquiterpene lactone. X-Ray Struct. Anal. Online, 27: 67-68.
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  62. Chib, R., B.A. Shah, N. Anand, A. Pandey and K. Kapoor et al., 2011. Psilostachyn, acetylated pseudoguainolides and their analogues: Preparation and evaluation of their anti-inflammatory potential. Bioorg. Med. Chem. Lett., 21: 4847-4851.
  63. Chashoo, G., S.K. Singh, P.R. Sharma, D.M. Mondhe and A. Hamid et al., 2011. A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition. Chem.-Biol. Interact., 189: 60-71.
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  64. Chashoo, G., S.K. Singh, D.M. Mondhe, P.R. Sharma and S.S. Andotra et al., 2011. Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative. Eur. J. Pharmacol., 668: 390-400.
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  65. Anand, N., B.A. Shah, M. Kapoor, R. Parshad and R.L. Sharma et al., 2011. Entrapment and kinetic resolution of stabilized axial and equatorial conformers of spiro-β-lactams. J. Org. Chem., 76: 5999-6006.
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  66. Shah, B.A. and S.C. Taneja, 2010. Structural Modifications of Parthenin; A Sesquiterpene Lactone of Immense Biological Potential. In: Compendium of Bioactive Natural Products, Taneja, S.C., V.K. Gupta and B.D. Gupta (Eds.). Vol. 7, Studium Press, USA., pp: 45-76.
  67. Shah, B.A. and S.C. Taneja, 2010. Biological Prospective of Pinitol and its Structurally Modified Products. In: Compendium of Bioactive Natural Products, Taneja, S.C., V.K. Gupta and B.D. Gupta (Eds.). Vol. 7, Studium Press, USA., pp: 247-266.
  68. Shah, B.A., R. Kaur, P. Gupta, A. Kumar and V.K. Sethi et al., 2009. Structure-activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads. Bioorg. Med. Chem. Lett., 19: 4394-4398.
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  69. Shah, B.A., R. Chib, P. Gupta, V.K. Sethi and S. Koul et al., 2009. Saponins as novel TNF -α inhibitors: Isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus. Org. Biomol. Chem., 7: 3230-3235.
  70. Shah, B.A., G.N. Qazi and S.C. Taneja, 2009. Boswellic acids: A group of medicinally important compounds. Nat. Prod. Rep., 26: 72-89.
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  71. Bhat, K.A., B.A. Shah, K.K. Gupta, A. Pandey, S. Bani and S.C. Taneja, 2009. Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils. Bioorg. Med. Chem. Lett., 19: 1939-1943.
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  72. Gupta, P., S.C. Taneja, B.A. Shah, D. Mukherjee, R. Parshad, S.S. Chimni and G.N. Qazi, 2008. An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols. Tetrahedron: Asymmetry, 19: 1898-1903.
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  73. Shah, B.A., S.C. Taneja, V.K. Sethi, P. Gupta, S.S. Andotra, S.S. Chimni and G.N. Qazi, 2007. The formation of novel 1,3-dioxolanes: Atypical Baylis-Hillman reaction of a sesquiterpene lactone parthenin. Tetrahedron Lett., 48: 955-960.
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  74. Mukherjee, D., B.A. Shah, P. Gupta and S.C. Taneja, 2007. Tandem acetalation-acetylation of sugars and related derivatives with enolacetates under solvent-free conditions. J. Org. Chem., 72: 8965-8968.
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  75. Gupta, P., V.K. Sethi, S.C. Taneja, B.A. Shah and S.S. Andotra et al., 2007. Odoriferous cyclic ethers via co‐halogenation reaction: Facile preparation of nerol oxide, florol®, florol® methyl ether and pityol® methyl ether. Helvetica Chimica Acta, 90: 196-204.
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  76. Gupta, P., S.C. Taneja, B.A. Shah, V.K. Sethi and G.N. Qazi, 2007. Lipase-catalyzed separation of geometrical isomers: Geraniol-nerol. Chem. Lett., 36: 1110-1111.
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  77. Gupta, P., B.A. Shah, R. Parshad, G.N. Qazi and S.C. Taneja, 2007. A facile approach towards enantiomerically pure masked β-amino alcohols. Green Chem., 9: 1120-1125.
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