Prof. Dr. Jing Xian Yang
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Prof. Dr. Jing Xian Yang

Director, Proffesor
Liaoning University of Traditional Chinese Medicine, China

Highest Degree
Ph.D. in Medical Biology from Dalian Medical University, China

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Area of Interest:

Pharmacology and Toxicology
100%
Biological Chemistry
62%
Neuropharmacology
90%
Brain Research
75%
Clinical Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yu-hui, Y., L. Shao-heng, G. Zhong, Z. Sa-feng and Y. Jing-xian et al., 2016. Neurotrophin-3 promotes proliferation and cholinergic neuronal differentiation of bone marrow- derived neural stem cells via notch signaling pathway. Life Sci., 166: 131-138.
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  2. Yan, Y.H., S.H. Li, H.Y. Li, Y. Lin and J.X. Yang, 2016. Osthole protects bone marrow-derived neural stem cells from oxidative damage through PI3K/Akt-1 pathway. Neurochem. Res., 42: 398-405.
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  3. Song, J., N. Li, Y. Xia, Z. Gao and S.F. Zou et al., 2016. Arctigenin treatment protects against brain damage through an anti-inflammatory and anti-apoptotic mechanism after needle insertion. Front. Pharmacol., Vol. 7. 10.3389/fphar.2016.00182.
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  4. Song, J., N. Li, Y. Xia, Z. Gao and S.F. Zou et al., 2016. Arctigenin confers neuroprotection against mechanical trauma injury in human neuroblastoma SH-SY5Y cells by regulating miRNA-16 and miRNA-199a expression to alleviate inflammation. J. Mol. Neurosci., 60: 115-129.
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  5. Li, S., Y. Yan, Y. Jiao, Z. Gao and Y. Xia et al., 2016. Neuroprotective effect of osthole on neuron synapses in an Alzheimer’s disease cell model via upregulation of MicroRNA-9. J. Mol. Neurosci., 60: 71-81.
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  6. Li, H., K. Tingguo, Q. Bin, K. Liang, J. Yanan, C. Yang, Z. Jianghua and Y. Jingxian, 2016. Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D-galactose/AlCl3 inducing rats model of Alzheimer’s disease. J. Ethnopharmacol., 17: 162-169.
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  7. Jiao, Y., K. Liang, Y. Ying-Jia, L. Shao-Heng, T. Zhen-Yu and Y. Jingxian, 2016. Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer’s disease. Neuropharmacol., 108: 332-344.
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  8. Ying-Jia, Y., T. Zheng-Yu, L. Kong, J. Ya-Nan, L. Shao-Heng, Y. Yu-Hui and Y. Jing-Xian, 2015. Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer’s disease model. Toxicol. Appl. Pharmacol., 289: 474-481.
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  9. Yang, X., K. Liang, Y. Ying-Jia, J. Yanan, J. Song, T. Zhen-Yu and Y. Jing-xian, 2015. Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury. J. Neuroinflammation, 10.1186/s12974-015-0373-x.
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  10. Yang, J.X., Z. Nan, W.W. Han, G. Peng, Y. Qing-Ping and P.W. Qing, 2015. CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats. J. Biol. Chem., 290: 1994-2006.
    CrossRef  |  PubMed  |  
  11. Ya-Nan, J., Y. Ying-Jia, K. Liang and Y. Jing-Xian, 2015. Protective effect of osthole on SH-SY5Y cells transfected with APP595/596 gene. Chin. J. Pathophysiol., 31: 2053-2058.
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  12. Liang, K., Y. Hu, Y. Ya-Nan, J. Ying-Jia, L. Shao-Heng and Y. Jing-Xian, 2015. The coumarin derivative osthole stimulates adult neural stem cells, promotes neurogenesis in the hippocampus and ameliorates cognitive impairment in APP/PS1 transgenic mice. Biol. Pharm. Bull., 38: 1290-1301.
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  13. Zhang, N., Q. Wen, L. Ren, W. Liang and Y. Xia et al., 2013. Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells. Int. J. Mol. Sci., 14: 18657-18669.
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  14. Hu, Y., Q. Wen, W. Liang, T. Kang and L. Ren et al., 2013. Osthole reverses beta-amyloid peptide cytotoxicity on neural cells by enhancing cyclic AMP response element-binding protein phosphorylation. Biol. Pharmaceut. Bull., 36: 1950-1958.
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  15. Zhang, N., K. Tingguo, X. Yang, W. Qingping and Y. Jingxian et al., 2012. Effects of Salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. Eur. J. Pharmacol., 697: 32-39.
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  16. Yang, J.X., Y. Yaping, G.M. Cun, K. Tingguo and Z. Nan et al., 2012. Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis. Acta Neuropathol., 124: 491-503.
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  17. Lin, G., L.X. Zhi, Z. Xu, G. Hui and Y. Jing-xian et al., 2011. Epoxyaurapten inhibition of smooth muscle contraction and phosphorylation of myosin light chain by myosin light chain kinase. J. Med. Plants Res., 5: 3412-3420.
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  18. De-Qiang, D., X. Zheng, Y. Guang, Z. Jian-Feng, Q. Ying-Kun, Y. Jing-Xian and K. Ting-Guo, 2011. Prediagnostic methods for the hemolysis of herbal medicine injection. J. Ethnopharmacol., 128: 445-450.
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  19. Jing-Xian, Y., S. Xiang-guo, X. Zhi-li, Y. Yu-hui, L. Li and H. Guo-zhu, 2010. Study on antithrombotic mechanism of veratriene in ussuri. Chin. Med. Guide, 32: 177-178.
  20. Yang, J.X., L.J. Zhi, C.F. Denise, G.M. Cun and Y. Shou et al., 2009. Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis. J. Clin. Invest., 119: 3678-3691.
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  21. Jing-Xian,Y., R. Abdolmohamad and Z. Guang-Xian, 2009. Cellular remyelinating therapy in multiple sclerosis. J. Neurol. Sci., 276: 1-5.
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  22. Yang, J., K. Bridges, K.Y. Chen and A.Y.C. Liu, 2008. Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. PloS One, Vol. 3. 10.1371/journal.pone.0002864.
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  23. Jing-Xian, Y., B. Krsten, C. Kuang-Yu and Y.C.L. Alice, 2008. Neural differentiation and the attenuated heat shock response. Brain Res., 1203: 39-50.
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  24. Jing-Xian, Y., 2006. The implementation of quality education and the necessary quality of teachers. China Educ. Res. Innov., 3: 104-104.
  25. Yang, J.X., S.Y. Li, G.Z. Han, Y. Lin and J. Zhang, 2005. The special feature of calponin on myosins phosphorylated by MLCK and PKA respectively. J. Nanjing Med. Univ., 19: 111-115.
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  26. Jing-xian, Y and L. Yuan, 2005. The action of PKA on smooth muscle myosin phosphorylation. Life Sci., 77: 2669-2675.
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  27. Jing-Xian, Y., F. Xiao-Hua, Z. Ying, T. Ze-Yao and L. Yuan, 2004. The influence of trace amount of calponin on the smooth muscle myosins in different states. Biochem. Biophys. Res. Commun., 318: 904-910.
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  28. Jing-Xian, Y., F. Xiao-Hua and Z. Ying, 2004. Influence of trace amount of calponin on smooth muscle myosin in different states. Acta Biochim. Biophys. Sin, 36: 529-536.
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  29. Yang, J.X., X.M. Wang, Z.Y. Tang, H. Chen, H. Xu and Y. Lin, 2003. The characterization of Ca2+-calmodulin independent phosphorylation of myosin light chains by a fragment from myosin light chain kinase. Acta Bioch. Bioph. Sin, 35: 793-800.
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  30. Jing-Xian, Y., X.M. Wang, Z.Y. Tang and L. Yuan, 2003. The characterization of myosin light chain phosphorylation by the constitutively active fragment of MLCK. Chin. Med. Sci. J., 18: 206-212.