Prof. Dr. Kwon Kwang-il
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Prof. Dr. Kwon Kwang-il

Professor
Chungnam National University, South Korea

Highest Degree
Ph.D. in Pharmacokinetics from University of Queensland, Australia

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Area of Interest:

Pharmacology and Toxicology
100%
Cardiovascular Drug
62%
Pharmacodynamic
90%
Pharmacokinetics
75%
Drug Interaction
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Jung-woo, C., L.T. Yi, K.H. Han, L. Jaeyeon and K. Kwang-il et al., 2016. BSA and ABCB1 polymorphism affect the pharmacokinetics of sunitinib and its active metabolite in Asian mRCC patients receiving an attenuated sunitinib dosing regimen. Cancer Chemother. Pharmacol., 78: 623-632.
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  2. Noh, K., S.S. Beom, K. Kwang-il, Y. Hwi-yeol, K. Eunyoung, C.J. Tae and K. Wonku, 2015. Absolute bioavailability and metabolism of aceclofenac in rats. Arch. Pharm. Res., 38: 68-72.
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  3. Noh, K., J. Yoo-Jeong, K. Kwang-il, K. Eunyoung, C.J. Tae, Y. Hwi-yeol and K. Wonku, 2015. Quantitative determination of amisulpride in rat plasma by HPLC-MS/MS. Arch. Pharmacal Res., 38: 63-67.
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  4. Jung-woo, C., H. Jin-A, B. In-hwan, P. Sudeep and K. Kwang-il et al., 2015. Determination of influence of food intake after a single oral dose of mosapride in beagle dogs using nonlinear mixed effect modeling. J. Vet. Pharmacol. Ther., 38: 590-595.
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  5. In-Hwan, B., L. Byung-yo and K. Kwang-il, 2015. Pharmacokinetic modeling and monte carlo simulation of ondansetron following oral administration in dogs. J. Vet. Pharmacol. Ther., 38: 199-202.
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  6. Hyun-moon, B., S. Byungjeong, C. Jung-woo, Y. Hwi-yeol, Y.M. Jin and K. Kwang-il, 2015. Determination of matrine in rat plasma after oral administration of novel korean herbal medicine KIOM-MA128 and application of PK. J. Anal. Methods Chem., 10.1155/2015/431632.
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  7. Hyun-moon, B., L. Jong-Hwa, Y. Hwi-yeol and K. Kwang-il, 2015. Development of QTc prolongation model incorporating circadian rhythm using harmonic model. Xenobiotica, 45: 420-427.
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  8. Hyun-moon, B., L. Jong-Hwa, C. Jung-woo, S. Byungjeong, S. Joung-Wook, Y. Hwi-yeol and K. Kwang-il, 2015. A novel HPLC-MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics. J. Pharm. Biomed. Anal., 114: 121-126.
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  9. Yoo-Jung, J., C.J. Tae, N. Keumhan, B. In-Whan, K. Kwang-il, K. Eunyoung, Y. Young-Ran and K. Wonku, 2014. Prandial effect on the systemic exposure of amisulpride. Arch. Pharm. Res., 37: 1325-1328.
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  10. Won, S.J., H.K. Dong, J.S. Yun, S. Kim, B.Y. Choi, M.O. Jung and G.I. Kwang, 2014. A study on the predictive factor and adverse effect model of vincristine by regression model in patients with lymphoma. Korean J. Clin. Pharm., 21: 145-155.
  11. Sang-hoon, J., C. Jung-woo, S. Byung-jeong and K. Kwang-il, 2014. Bioequivalence comparison of two formulations of Fixed-Dose combination Glimepiride/Metformin (2/500 mg) tablets in healthy volunteers. Iran. J. Pharm. Res., 13: 365-371.
    PubMed  |  
  12. Lee, S.Y., J. Himchan, L. Ji-Yoon, K. Kwang-il, J.O. Soo and K.K. Sang, 2014. Inhibition of cytochrome P450 by ethambutol in human liver microsomes. Toxicol. Lett., 229: 33-40.
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  13. Kim, E., S. Beomsoo, K. Kwang-il, S.B. Joon and K. Wonku, 2014. Simultaneous determination of 7-O-succinyl macrolactin A and its active major metabolite, macrolactin A in dog plasma using high-performance liquid chromatography with UV detection. J. Sep. Sci., 37: 2833-2836.
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  14. Jung-woo, C., S. Jeong-won, M. Bimit, Y. Hwi-yeol and K. Kwang-il et al., 2014. A simple pharmacokinetic model of alendronate developed using plasma concentration and urine excretion data from healthy men. Drug Dev. Ind. Pharm., 44: 1325-1329.
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  15. Jung-woo, C., B. In-hwan, S. Jeong-won, J. Sang-hoon and K. Kwang-il et al., 2014. Development of a population pharmacokinetic model to describe olmesartan medoxomil/ hydrochlorothiazide (20/12.5 mg) FDC tablet in male healthy South Korean subjects. Int. J. Clin. Pharmacol. Ther., 52: 676-683.
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  16. In-Hwan, B., L. Byung-yo, C. Jung-woo, Y.S. Gyu, K. Wonku and K. Kwang-il, 2014. Development of a pharmacokinetic/pharmacodynamic/disease progression model in NC/Nga mice for development of novel anti-atopic dermatitis drugs. Xenobiotica, 44: 975-987.
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  17. Hwi-yeol, Y., K. Wonku, L. Buyng-yo, P. Sunkyung, Y. Young-Ran, Y.M. Jun and K. Kwang-il, 2014. Semi-Mechanistic modelling and simulation of inhibition of platelet aggregation by antiplatelet agents. Basic Clin. Pharmacol. Toxicol., 115: 352-359.
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  18. Rhee, S.J., J.W. Chae, B.J. Song, E.S. Lee and K.I. Kwon, 2013. Effect of dissolved oxygen in alcoholic beverages and drinking water on alcohol elimination in humans. Alcohol, 47: 27-30.
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  19. Lee, S.Y., J.Y. Lee, W. Kang, K.I. Kwon and S.K. Park et al., 2013. Cytochrome P450-mediated herb-drug interaction potential of Galgeun-tang. Food Chemical Toxicol., 51: 343-349.
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  20. Lee, S.Y., J.Y. Lee, W. Kang, K. Kwon, S.J. Oh, J.Y. Ma and S.K. Kim, 2013. In vitro and In vivo assessment of cytochrome P450-mediated herb-drug interaction of Ssang-hwa-tang. Food Chem., 136: 450-457.
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  21. Lee, B.Y., H.K. Yoon, I.H. Baek and K.I. Kwon, 2013. Population pharmacokinetics of multiple alcohol intake in humans. Alcohol, 47: 159-165.
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  22. Jung-woo, C., B. Hyun-moon, K. Sang-Kyum, K. Ho-il and K. Kwang-il, 2013. Quantitative determination of duloxetine and its metabolite in rat plasma by HPLC-MS/MS. Biomed. Chromatogr., 27: 953-955.
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  23. In-hwan, B., L. Byung-yo, L. Eun-sil and K. Kwang-il, 2013. Pharmacokinetics of angiotensin II receptor blockers in the dog following a single oral administration. Drug Res., 63: 357-361.
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  24. In-hwan, B., L. Byung-yo, K. Min-Soo and K. Kwang-il, 2013. Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs. Eur. J. Drug Metab. Pharmacokinet., 38: 295-299.
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  25. In-hwan, B., L. Byung-yo, K. Min-Soo and K. Kwang-il, 2013. Effect of food intake on the pharmacokinetics of sarpogrelate and its active metabolite following oral administration to beagle dogs. Xenobiotica, 43: 895-900.
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  26. In-hwan, B., K. Kwang-il and K. Min-Soo, 2013. Effect of food on the pharmacokinetics of rosuvastatin after administration of a single oral dose in dogs. Drug Res., 63: 145-149.
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  27. Hae-Jeung, L., P. Sangshin, K. Cho-il, C. Doo-won and K. Kwang-il et al., 2013. The association between disturbed eating behavior and socioeconomic Status: The online korean adolescent panel survey (OnKAPS). Open Access J., 10.1371/journal.pone.0057880.
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  28. Park, S.M., L. Joomi, S. Sook-Jun, G.P. Jong and K. Kwang-il et al., 2012. Population pharmacokinetic and pharmacodynamic modeling of transformed binary effect data of triflusal in healthy Korean male volunteers: A randomized, open-label, multiple dose, crossover study. BMC Pharmacol. Toxicol., 10.1186/2050-6511-15-75.
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  29. Mahat, B., C. Jung-woo, B. In-hwan, S. Gyu-yong, S. Jin-sook, M. Jin-yeul and K. Kwang-il, 2012. Biopharmaceutical characterization of decursin and their derivatives for drug discovery. Drug Dev. Ind. Pharm., 39: 1523-1530.
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  30. Mahat, B., C. Jung-Woo, B. In-Hwan, S. Gyu-Yong, S. Jin-Sook, C. Seong-Kwon and K. Kwang-il, 2012. Physicochemical characterization and toxicity of decursin and their derivatives from Angelica gigas. Biol. Pharm. Bull., 35: 1084-1090.
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  31. Kim, H.G., P.H. Yong, H.H. Eun, H.C. Jae and K. Kwang-il et al., 2012. The coffee diterpene kahweol inhibits metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation. Food Chem., 133: 1521-1529.
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  32. Jung-woo, C., B. In-hwan, L. Byung-yo, C. Seong-kwon and K. Kwang-il, 2012. Population PK/PD analysis of metformin using the signal transduction model. Br. J. Clin. Pharmacol., 74: 815-823.
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  33. Jung-Woo, C., K. Dong-Hyun, L. Byung-Yo, J.K. Eun and K. Kwang-il, 2012. Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. J. Chromatogr. B., 889: 44-49.
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  34. Jung-Woo, C., B. In-Hwan, A. Jung-Hwa, J.K. Eun and K. Kwang-il, 2012. Quantitative determination of amitriptyline and its metabolite in rat plasma by liquid Chromatography-tandem mass spectrometry. Bull. Korean Chem. Soc., 33: 2163-2167.
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  35. Jung-Woo, C., A. Jung-Hwa, K. Wonku, Y.M. Jin and K. Kwang-il, 2012. Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. Food Chem. Toxicol., 50: 3666-3672.
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  36. Han, E.H., G.K. Hyung, H.C. Jae, J. Yin-Jin and K. Kwang-il et al., 2012. Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation. Mol. Nutr. Food Res., 56: 797-809.
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  37. Song, J.S., C. Jung-Woo, L. Kyeong-Ryoon, H.L. Byung and K. Kwang-il et al., 2011. Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. Xenobiotica, 41: 895-902.
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  38. Noh, K., H.P. Jong, K. Minkyu, J. Mankil, J.L. Hwa, K. Kwang-il, K. Wonku and H. Hunjoo, 2011. Determination of daumone in mouse plasma by HPLC/MS-MS. Biomed. Chromatogr., 26: 152-155.
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  39. Lee, H.W., L. Min-Sun, J.S. Sook, L. Joomi and K. Kwang-il et al., 2011. A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new Enteric-coated triflusal formulations in healthy male volunteers. Expert Opin. Drug Metab. Toxicol., 7: 1471-1479.
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  40. Kim, H.G., T.H. Tran, H.H. Eun, P.H. Yong and K. Kwang-il et al., 2011. Metformin inhibits P-glycoprotein expression via the NF- κB pathway and CRE transcriptional activity through AMPK activation. Br. J. Pharmacol., 162: 1096-1108.
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  41. Jung-Woo, C., B. In-Hwan, K. Wonku and K. Kwang-il, 2011. Simultaneous determination of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in the plasma of rodents with LC-MS/MS. Arzneim.-Forsch. Drug Res., 61: 340-346.
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  42. Ji, E., K. Mi-Young, Y. Hwi-Yeol, I.K. Kyung and K. Kwang-il et al., 2011. Population pharmacokinetics of cyclosporine in korean adults undergoing living-donor kidney transplantation. Pharmacother., 31: 574-584.
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  43. Jee-Young, S., M. Byung-Jung and K. Kwang-Gil, 2011. A study on platelet aggregation inhibitory effect of fermented. Med., 55: 374-378.
  44. In-Hwan, B., K. Wonku, H.Y. Yun, S.S. Lee and K. Kwang-il, 2011. Modelling the Atypical absorption of menatetrenone and the metabolism to its Epoxide: Effect of VKORC1 polymorphism. J. Clin. Pharm. Ther., 36: 390-398.
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  45. Hwang, Y.P., J.Y. Hyo, H.C. Jae, H.H. Eun and K. Kwang-il et al., 2011. Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling. Mol. Nutr. Food Res., 55: 594-605.
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  46. Hwang, Y.P., J.H. Choi, E.H. Han, H.G. Kim and J.H. Wee et al., 2011. Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human hepg2 cells and obese mice. Nutr. Res., 31: 896-906.
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  47. Hwang, Y.P., G.K. Hyung, H.C. Jae, H.H. Eun and K. Kwang-il et al., 2011. Saponins from the roots of platycodon grandiflorum suppress ultraviolet a-induced matrix metalloproteinase-1 expression via MAPKs and NF- κ B/AP-1-dependent Signaling in HaCaT cells. Food Chem. Toxicol., 49: 3374-3382.
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  48. Won, S.J., Y.L. Byung, W.J. Jung, C.S. Seok, W.K. Kang, H.J. Chan and G.I. Kwang, 2010. Biomarkers and surrogate outcome variables for efficient drug development of lung disease drugs. J. Pharm., 54: 75-90.
  49. Song, J.S., J.R. Hyeong, S.P. Jong, S.K. Min and K. Kwang-il et al., 2010. Preclinical pharmacokinetics of PDE-310, a novel PDE4 inhibitor. Drug Metab. Pharmacokinet., 26: 192-200.
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  50. Oh, S.J., C. Jooyoung, Z. Hongmei, T.H. Tran and K. Kwang-il and K.K. Sang,et al 2010. Evaluation of antioxidant defense systems in H4IIE cells infected with a retroviral vector. Toxicol. Vitro, 24: 1105-1110.
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  51. Oh, B.K., O. Kwang-Seok, K. Kwang-il, Y.R. Shi, S.K. Young and H.L. Byung, 2010. Melanin-Concentrating Hormone-1 receptor binding activity of pheophorbides isolated from morus alba leaves. Toxicol. Vitro, 24: 919-923.
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  52. Noh, K., K. Kwang-il, C.J. Tae and K. Wonku, 2010. Quantitative determination of sparfloxacin in rat plasma by liquid Chromatography/ tandem mass spectrometry. Biomed. Chromatogr., 24: 1199-1202.
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  53. Noh, K., B. Kyoungjin, M. Bokyoung, Y.K. Eun, K. Kwang-il, C.J. Tae and K. Wonku, 2010. Enantioselective pharmacokinetics of sibutramine in rat. Arch. Pharmacal Res., 33: 267-273.
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  54. Nguyen, P.H., T.V.T. Le, H.W. Kang, J. Chae and S.K. Kim, et al., 2010. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg. Med. Chem. Lett., 20: 4128-4131.
    CrossRef  |  
  55. In-Hwan, B., L. Byung-Yo, K. Wonku and K. Kwang-il, 2010. Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: An experience with doxifluridine in beagle dogs. Eur. J. Pharm. Sci., 39: 175-180.
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  56. In-Hwan, B., L. Byung-Yo and K. Kwang-il, 2010. Oxygenated Alcohol - Sober faster !. Alcohol. -Clin. Exp. Res., 34: 1673-1674.
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  57. In-Hwan, B., L. Byung-Yo and K. Kwang-il, 2010. Influence of dissolved oxygen concentration on the pharmacokinetics of alcohol in humans. Alcohol. -Clin. Exp. Res., 34: 834-839.
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  58. In-Hwan, B., C. Jung-Woo, C. Han-Jung and K. Kwang-il, 2010. Development and validation of a robust LC-MS/MS method for the simultaneous quantification of doxifluridine and its two metabolites in beagle dog plasma. Bull. Korean Chem. Soc., 31: 2235-2241.
    Direct Link  |  
  59. Hwang, Y.P., J.Y. Hyo, H.C. Jae, K.C. Hyo and K. Kwang-il et al., 2010. 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-δ-dependent matrix metalloproteinase-9 expression. Toxicol. Lett., 198: 200-209.
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