Dr. Graeme Bradley
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Dr. Graeme Bradley

Professor
University of Fort Hare, South Africa

Highest Degree
Ph.D. in Biochemistry from University Of Port Elizabeth, South Africa

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Area of Interest:

Biomedical Sciences
100%
Biocatalysis
62%
Chemometrics
90%
Biotechnological Applications
75%
Biotic Stress
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sagbo, I.J., M. van de Venter, T. Koekemoer and G. Bradley, 2018. In vitro antidiabetic activity and mechanism of action of Brachylaena elliptica (Thunb.) DC. Evid.-Based Complement. Altern. Med., Vol. 2018. 10.1155/2018/4170372.
    CrossRef  |  
  2. Akinrinde, S.A., A.J. Afolayan and G. Bradley, 2018. Phytochemical composition and antioxidant activities of Dianthus thunbergii Hooper and Hypoxis argentea Harv Ex Baker: Plants used for the management of diabetes mellitus in Eastern Cape, South Africa. Pharmacogn. Magaz., 14: 195-202.
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  3. Akinrinde, A., T. Koekemoer, M. van de Venter and G. Bradley, 2018. In vitro investigation of the potential anti-diabetic activity of the corm extract of Hypoxis argentea Harv. Ex Baker. Acta Pharm., 68: 389-407.
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  4. Sagbo, I.J., A.J. Afolayan and G. Bradley, 2017. Antioxidant, antibacterial and phytochemical properties of two medicinal plants against the wound infecting bacteria. Asian Pac. J. Trop. Biomed., 7: 817-825.
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  5. Odeyemi, S., A.J. Afolayan and G. Bradley, 2017. Phytochemical analysis and anti-oxidant activities of Albuca bracteata Jacq. and Albuca setosa Jacq bulb extracts used for the management of diabetes in the Eastern Cape, South Africa. Asian Pac. J. Trop. Biomed., 7: 577-584.
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  6. Njom, H.A., J. Mebalo, T.G. Terefe, R.N. Ndip and G. Bradley, 2017. Phenolics and their potential as biochemical markers for rust resistance in South Africa. Afr. J. Soil Sci., 5: 426-434.
  7. Katiyatiya, C.L.F., G. Bradley and V. Muchenje, 2017. Thermotolerance, health profile and cellular expression of HSP90AB1 in Nguni and Boran cows raised on natural pastures under tropical conditions. J. Thermal Biol., 69: 85-94.
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  8. Stempa, T., V. Muchenje, A.M. Abrahams and G. Bradley, 2016. Sex and breed affect plasma glucose, lactate, cortisol, meat quality but not muscle glycolytic potential of Dorper and Merino lambs. Anim. Prod. Sci., 58: 958-964.
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  9. Chulayo, A., G. Bradley and V. Muchenje, 2016. Effects of transport distance, lairage time and stunning efficiency on cortisol, glucose, HSPA1A and how they relate with meat quality in cattle. Meat Sci., 117: 89-96.
    CrossRef  |  
  10. Pfunde, C.N., C.S. Mutengwa and G. Bradley, 2015. Genetic variation of selected quality protein maize inbred lines. Afr. J. Agric Res., 10: 4087-4093.
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  11. Odeyemi, S., A. Afolayan and G. Bradley, 2015. In vitro anti-inflammatory and free radical scavenging activities of crude saponins extracted from Albuca bracteata jacq. bulb. Afr. J. Traditional Complementary Altern. Med., 12: 34-40.
    Direct Link  |  
  12. Omoruyi, B.E., A.J. Afolayan and G. Bradley, 2014. The inhibitory effect of Mesembryanthemum edule (L.) bolus essential oil on some pathogenic fungal isolates. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-168.
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  13. Omoruyi, B.E., A.J. Afolayan and G. Bradley, 2014. Chemical composition profiling and antifungal activity of the essential oil and plant extracts of Mesembryanthemum edule (L.) bolus leaves. Afr. J. Tradit. Complement. Altern. Med., 11: 19-30.
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  14. Ibraheem, O., C.E.J. Botha, G. Bradley, G. Dealtry and S. Roux, 2014. Rice sucrose transporter1 (OsSUT1) up‐regulation in xylem parenchyma is caused by aphid feeding on rice leaf blade vascular bundles. Plant Biol., 16: 783-791.
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  15. Oyedemi, S., T. Koekemoer, G. Bradley, M. van de Venter and A. Afolayan, 2013. In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (Gilg). Int. J. Diabetes Dev. Countries, 33: 120-127.
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  16. Oyedemi, S.O., T. Koekemoer, G. Bradley, M. van de Venter and A.J. Afolayan, 2012. In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (GILG). Planta Med., Vol. 78. 10.1055/s-0032-1320805.
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  17. Oyedemi, S.O., G. Bradley and A.J. Afolayan, 2012. In vitro and in vivo antioxidant properties of aqueous extract from Strychnos henningsii Gilg stem bark. Free Radic. Biol. Med., 53: S113-S113.
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  18. Oyedemi, S., G. Bradley and A. Afolayan, 2012. Antidiabetic activities of aqueous stem bark extract of Strychnoshenningsii Gilg in streptozotocin-nicotinamide type 2 diabetic rats. Iran. J. Pharm. Res., 11: 221-228.
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  19. Omoruyig, B.E., G. Bradley and A.J. Afolayan, 2012. Antioxidant and phytochemical properties of Carpobrotus edulis (L.) bolus leaf used for the management of common infections in HIV/AIDS patients in Eastern Cape Province. BMC Complementary Altern. Med., Vol. 12. 10.1186/1472-6882-12-215.
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  20. Omoruyi, B.E., G. Bradley and A.J. Afolayan, 2012. Ethnomedicinal survey of medicinal plants used for the management of HIV/AIDS infection among local communities of Nkonkobe Municipality, Eastern Cape, South Africa. J. Med. Plants Res., 6: 3603-3608.
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  21. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Protective effect of Tulbaghia violacea Harv. on aortic pathology, tissue antioxidant enzymes and liver damage in diet-induced atherosclerotic rats. Int. J. Mol. Sci., 13: 12747-12760.
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  22. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Protective effect of T. violacea rhizome extract against hypercholesterolemia-induced oxidative stress in Wistar rats. Molecules, 17: 6033-6045.
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  23. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Effect of methanolic extract of Tulbaghia violacea rhizomes on antioxidant enzymes and lipid profile in normal rats. Afr. J. Pharm. Pharmacol., 6: 1026-1030.
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  24. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Chemical composition, antioxidant activity and toxicity evaluation of essential oil of Tulbaghia violacea harv. J. Med. Plants Res., 6: 2340-2347.
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  25. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Antioxidant activity of acetone and ethanolic leaves extracts of Hippobromus pauciflorus (Lf) Radlk. Afr. J. Biotechnol., 11: 1206-1213.
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  26. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Anti-hyperlipidemic and biochemical effect of extract of Tulbaghia violacea rhizomes on high cholesterol diet fed rats. Afr. J. Biotechnol., 11: 13498-13505.
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  27. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2012. Acute and sub-chronic toxicity studies of methanolic extract of Tulbaghia violacea rhizomes in Wistar rats. Afr. J. Biotechnol., 11: 14934-14940.
    Direct Link  |  
  28. Adeyemi, S.A., F.B. Lewu, P.O. Adebola, G. Bradley and A.I. Okoh, 2012. Protein content variation in cowpea genotypes (Vigna unguiculata L. Walp.) grown in the Eastern Cape province of South Africa as affected by mineralised goat manure. Afr. J. Agric. Res., 7: 4943-4947.
    Direct Link  |  
  29. Oyedemi, S.O., G. Bradley and A.J. Afolayan, 2011. Beneficial effect of aqueous stem bark extracts of Strychnos henningsii Gilg in Streptozotocin-nicotinamide induced type 2 diabetic wistar rats. Int. J. Pharmacol., 7: 773-781.
    Direct Link  |  
  30. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2011. Ethnobotanical information on plants used for the management of cardiovascular diseases in Nkonkobe Municipality, South Africa. J. Med. Plants Res., 5: 4256-4260.
    Direct Link  |  
  31. Olorunnisola, O.S., G. Bradley and A.J. Afolayan, 2011. Antioxidant properties and cytotoxicity evaluation of methanolic extract of dried and fresh rhizomes of Tulbaghia violacea. Afr. J. Pharm. Pharmacol., 5: 2490-2497.
    Direct Link  |  
  32. Jimoh, M.A., C.E.J. Botha, O. Edwards and G. Bradley, 2011. Population growth rate and relative virulence of the two South African biotypes of Russian wheat aphid, Diuraphis noxia and bird cherry‐oat aphid, Rhopalosiphum padi, on resistant and non‐resistant barley. Entomol. Exp. Applic., 138: 12-20.
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  33. Ibraheem, O., R.M. Hove, M.A. Jimoh, C.E.J. Botha and G. Bradley, 2011. Understanding aphid-plant co-habitation. Fort Hare Papers, 17: 5-32.
  34. Ibraheem, O., G. Dealtry, S. Roux and G. Bradley, 2011. The effect of drought and salinity on the expressional levels of sucrose transporters in rice (‘Oryza sativa’ Nipponbare) cultivar plants. Plant Omics, 4: 68-74.
    Direct Link  |  
  35. Ibraheem, O., C.E.J. Botha and G. Bradley, 2011. The role of the rice sucrose transporter SUT1 in retrieval during cereal stress response and phloem feeding. S. Afr. J. Bot., 77: 532-533.
  36. Oyedemi, S.O., G. Bradley and A.J. Afolayan, 2010. Toxicological effects of the aqueous stem bark extract of Strychnos henningsii Gilg in Wistar rats. J. Nat. Pharm., 1: 33-39.
    Direct Link  |  
  37. Oyedemi, S.O., G. Bradley and A.J. Afolayan, 2010. In-vitro and -vivo antioxidant activities of aqueous extract of Strychnos henningsii Gilg. Afr. J. Pharm. Pharmacol., 4: 70-78.
    Direct Link  |  
  38. Ibraheem, O., C.E.J. Botha and G. Bradley, 2010. In silico analysis of cis-acting regulatory elements in 5' regulatory regions of sucrose transporter gene families in rice (Oryza sativa Japonica) and Arabidopsis thaliana. Comput. Biol. Chem., 34: 268-283.
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  39. Saheed, S.A., I. Cierlik, K.A. Larsson, G. Delp, G. Bradley, L.M. Jonsson and C.E. Botha, 2009. Stronger induction of callose deposition in barley by Russian wheat aphid than bird cherry‐oat aphid is not associated with differences in callose synthase or β‐1,3‐glucanase transcript abundance. Physiol. Plant., 135: 150-161.
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  40. Oyedemi, S.O., G. Bradley and A.J. Afolayan, 2009. Ethnobotanical survey of medicinal plants used for the management of diabetes mellitus in the Nkonkobe municipality of South Africa. J. Med. Plant Res., 3: 1040-1044.
    Direct Link  |  
  41. Oyedemi, S.O., G. Pirochenva, L.V. Mabinya, G. Bradley and A.J. Afolayan, 2008. Compositions and comparisons of antimicrobial potencies of some essential oils and antibiotics against selected bacteria. Afr. J. Biotechnol., 7: 4140-4146.
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  42. Ibraheem, O. and G. Bradley, 2008. Sucrose assimilation and the role of sucrose transporters in plant wound response. Afr. J. Biotechnol., 7: 4850-4855.
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  43. Daniel, S., G. Bradley, V.M. Longshaw, C. Soti, P. Csermely and G.L. Blatch, 2008. Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock and its proposed nuclear localization signal is involved in Hsp90 binding. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1783: 1003-1014.
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  44. Saheed, S.A., K.A. Larsson, G. Delp, C.E.J. Botha, L.M.V. Jonsson and G. Bradley, 2007. Wound callose synthesis in response to Russian wheat aphid and bird cherry-oat aphid feeding on barley cv Clipper. S. Afr. J. Bot., 73: 310-310.
    CrossRef  |  
  45. Louw, C., A. Gordon, N. Johnston, C. Mollatt, G. Bradley and C.G. Whiteley, 2007. Arginine deiminases: therapeutic tools in the etiology and pathogenesis of Alzheimer's disease. J. Enzyme Inhib. Med. Chem., 22: 121-126.
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  46. Daniel, S., C. Soti, P. Csermely, G. Bradley and G.L. Blatch, 2007. Hop: An Hsp70/90 Co-Chaperone that Functions within and Beyond Hsp70-Hsp90 Protein Folding Pathways. In: The Networking of Chaperones by Co-chaperones, Blatch, G.L. (Ed.). Springer, New York, ISBN: 978-0-387-49308-4, pp: 26-37.
  47. Daniel, S., G. Bradley and G.L. Blatch, 2005. Mapping of functional residues in the Hsp70/Hsp90 organizing protein, mSTI1: G1-013P. FEBS J., 272: 351-351.
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  48. Boshoff, A., W.S. Nicoll, F. Hennessy, M.H. Ludewig and S. Daniel et al., 2004. Molecular chaperones in biology, medicine and protein biotechnology. S. Afr. J. Sci., 100: 665-677.
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  49. Rafudeen, S., G. Gxaba, G. Makgoke, G. Bradley and G. Pironcheva et al., 2003. A role for plant natriuretic peptide immuno‐analogues in NaCl‐and drought‐stress responses. Physiol. Plant., 119: 554-562.
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  50. Maryani, M.M., M.V. Morse, G. Bradley, H.R. Irving, D.M. Cahill and C.A. Gehring, 2003. In situ localization associates biologically active plant natriuretic peptide immuno‐analogues with conductive tissue and stomata. J. Exp. Bot., 54: 1553-1564.
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  51. Wiid, I., R. Grundlingh, W. Bourn, G. Bradley, A. Harington, E.G. Hoal-van Helden and P. van Helden, 2002. O6-alkylguanine-DNA alkyltransferase DNA repair in mycobacteria: Pathogenic and non-pathogenic species differ. Tuberculosis, 82: 45-53.
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  52. Maryani, M.M., G. Bradley, D.M. Cahill and C.A. Gehring, 2001. Natriuretic peptides and immunoreactants modify osmoticum-dependent volume changes in Solanum tuberosum L. mesophyll cell protoplasts. Plant Sci., 161: 443-452.
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  53. Bradley, G., R.J. Naude, K. Muramoto, F. Yamauchi and W. Oelofsen, 1996. Ostrich (Struthio camelus) carboxypeptidase B: Purification, kinetic properties and characterization of the pancreatic enzyme. Int. J. Biochem. Cell Biol., 28: 521-529.
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  54. Bradley, G., R.J. Naude, K. Muramoto, F. Yamauchi and W. Oelofsen, 1994. Ostrich (Struthio camelus) carboxypeptidase A: Purification, kinetic properties and characterization of the pancreatic enzyme. Int. J. Biochem., 26: 555-564.
    PubMed  |  
  55. Bradley, G., D. Litthauer and W. Oelofsen, 1992. Partial characterisation of human and porcine adipose acidic protease activity. Comp. Biochem. Physiol. B, 102: 25-30.
    PubMed  |  
  56. Bradley, G., R.J. Naude and W. Oelofsen, 1985. The isolation and characterization of serum albumin from the ostrich (Struthio camelus). Comp. Biochem. Physiol. B, 82: 829-835.
    PubMed  |