Dr. Daniel Udofia Owu
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Dr. Daniel Udofia Owu

Professor
University of Calabar, Nigeria

Highest Degree
Ph.D. in Cardiovascular Physiology from University of Calabar, Calabar, Nigeria

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Area of Interest:

Biomedical Sciences
100%
Cardiac Metabolism
62%
Cardiovasccular
90%
Blood Biochemical Factors
75%
Gastric Ulcers
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
62
Abstracts
1

Selected Publications

  1. Ujong, G.O., J.A. Beshel, I.A. Okon and D.U. Owu, 2022. Anti-inflammatory potentials of ethanolic leaf extract of Gongronema latifolium in streptozotocin induced diabetic rats. World J. Bio. Pharm. Health Sci., 11: 77-84.
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  2. Ujong, G.O., J.A. Beshel, E. Nkanu, O.P. Ubana and O.E. Ofem, 2022. Ethanolic extract of Gongronema latifolium improves learning and memory in Swiss albino mice. J. Drug Delivery Ther., 12: 45-50.
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  3. Okon, I.A., J.A. Beshel, V.U. Nna and D.U. Owu, 2022. Gongronema latifolium leaf extract protects against dexamethasone‐induced myocardial cell injury via cardiac oxido‐inflammatory molecules modulation. J. Food Biochem., 10.1111/jfbc.14378.
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  4. Okon, I.A., J.A. Bes, I.S. Udoakag, J.P. Udia and D.U. Owu, 2022. L-arginine oral supplementation reverses hematological and electrolytes imbalances in adrenaline-induced myocardial injury in rats. J. Med. Sci., 22: 90-98.
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  5. Nwokocha, C., J. Palacios, V.E. Ojukwu, V.U. Nna and D.U. Owu et al., 2022. Oxidant-induced disruption of vascular K+ channel function: Implications for diabetic vasculopathy. Arch. Physiol. Biochem., 10.1080/13813455.2022.2090578.
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  6. Basse, I.O., I.A. Oko, J.A. Bes, E.B. Umo and D.U. Owu, 2022. Aqueous leaves extract of Telfairia occidentalis (Fluted Pumpkin) protects against gastric ulcer and inhibits intestinal motility in wistar rats. J. Appl. Sci., 22: 92-99.
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  7. Ben, E.E., A.E. Asuquo and D.U. Owu 2021. Possible Amelioration of Oxidative Stress Damage Via Cyclo-Oxygenase Pathway by Aqueous Extract of Terminalia Catappa Leaves in Alloxan Induced Diabetic Rats. GSC Biol. and Pharm. Sci. 16: 038-048.
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  8. Beshel, J.A., F.N. Beshel, J.N. Nwangwa, I.O. Asuquo and C.I. Ejim et al. 2020. Cardioprotective Role of Theobroma Cacao against Isoproterenol-Induced Acute Myocardial Injury. CHAMC 10.2174/1871525718999200917114954.
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  9. Okon, I.A., U.F. Ufot, U.G. Onoyeraye, E.O. Nwachukwu and D.U. Owu, 2019. Effect of Gongronema latifolium on lipid profile, oral glucose tolerance test and some hematological parameters in fructose-induced hyperglycemia in Wistar rats. Pharm. Biomed. Res., 5: 25-31.
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  10. Nkanu, E.E., D.U. Owu and E.E. Osim, 2019. Extra virgin olive oil and palm oil diets reduce blood pressure via Katp/Bkca ion channels in rats. J. Applied Sci., 19: 537-543.
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  11. Justin Atiang Beshel, Javier Palacios, Favour Nyoh Beshel, Clement Oshie Nku, Daniel U. Owu, Magdalene Nwokocha, Jorge Bórquez, Mario J. Simirgiotis, Chukwuemeka R. Nwokocha 2019. Blood Pressure-Reducing Activity of Gongronema latifolium Benth. (Apocynaeceae) and the Identification of its Main Phytochemicals by Uhplc Q-Orbitrap Mass Spectrometry. J. Basic. Clin. Physiol. Pharmacol. 10.1515/jbcpp-2018-0178.
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  12. Ben, E.E., A.E. Asuquo and D.U. Owu 2019. The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats. AJRIMPS 6: 1-11.
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  13. Ben, E.E., A.E. Asuquo and D.U. Owu 2019. Serum Levels of Some Inflammatory Markers in Alloxan- Induced Diabetic Rats Treated with Aqueous Leaf Extract of Terminalia catappa and Exogenous Insulin. AJRIMPS 6: 1-9.
    CrossRef  |  Direct Link  |  
  14. Nkanu, E.E., D.U. Owu and E.E. Osim, 2018. Altered potassium ion channel function as a possible mechanism of increased blood pressure in rats fed thermally oxidized palm oil diets. J. Dietary Suppl., 15: 431-444.
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  15. Aribo, E.O., E.J. Ani, E.E. Osim and D.U. Owu, 2018. The effect of long term consumption of thermoxidised palm oil diet on some reproductive parameters in male Wistar rats. World J. Pharmaceut. Res., 7: 68-81.
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  16. Ani, E.J., D.U. Owu, E.E. Osim and A.U. Ime, 2018. Chronic consumption of Thermoxidized Palm Oil diet (TPO) adversely affects haemostatic status and histology of some organs in rabbit. Saudi J. Med. Pharmaceut. Sci., 4: 191-198.
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  17. Nna, V.U., U.Z. Usman, E.O. Ofutet and D.U. Owu, 2017. Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride-induced oxidative stress in the uterus and ovaries of female Wistar rats. Food Chem. Toxicol., 102: 143-155.
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  18. Udia, P.M., L.P. Takem, U.F. Ufot, A.B. Antai and D.U. Owu, 2016. Insulin and alpha amylase levels in alloxan-induced diabetic rats and the effect of Rothmannia hispida (K. Schum) Fagerl leaf extract. J. Phytopharmacol., 5: 1-5.
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  19. Owu, D.U., C.R. Nwokocha, D.E. Ikpi and E.I. Ogar, 2016. Effect of vitamin C supplementation on platelet aggregation and serum electrolytes levels in streptozotocin-induced diabetes mellitus in rats. Niger. J. Physiol. Sci., 31: 55-61.
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  20. Udia, P.M., D.U. Owu, O.J. Ogbonna and L.P. Takem, 2015. Possible mechanism of antispasmodic action of Garcinia kola seed extract on isolated Guinea pig ileum. Br. J. Med. Med. Res., 6: 688-698.
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  21. Oka, V.O., A.L. Udefa, V.U. Nna and D.U. Owu, 2015. Sildenafil citrate and tramadol administered separately and in combination affects basal metabolic rate, triiodothyronine (T3) and cortisol levels in albino wistar rats. Trends Med. Res., 10: 51-62.
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  22. Ebong, P.E. and D.U. Owu, 2015. Medicinal Plants in the Prevention and Treatment of Hypertension. In: Phytomedicine: The Panacea for Healthcare Delivery in Nigeria, Ebong, P.E. (Ed.). University of Calabar Press, Calabar, Nigeria, pp: 134-143.
  23. Ani, E.J., V.U. Nna, D.U. Owu and E.E. Osim, 2015. Effect of chronic consumption of two forms of palm oil diet on serum electrolytes, creatinine and urea in rabbits. J. Applied Pharma. Sci., 5: 115-119.
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  24. Ani, E.J., O.E. Ofem, D.U. Owu and E.E. Osim, 2015. Distortions in sensitivity of carotid baroreceptor reflexes in rabbits following consumption of two forms of palm oil diets. Br. J. Med. Med. Res., 8: 245-255.
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  25. Nwokocha, C.R., N. Younger-Coleman, M. Nwokocha, D.U. Owu and M. Iwuala, 2014. Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet. Pharmacogn. Res., 6: 240-245.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Nwokocha, C., N. Younger-Coleman, M. Nwokocha, D. Owu and M. Iwuala, 2014. A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration. Pharmacogn. Res., 6: 306-311.
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  27. Owu, D.U., N.N. Orie, C.R. Nwokocha, M. Muzyamba, L.H. Clapp and E.E. Osim, 2013. Attenuated vascular responsiveness to K+ channel openers in diabetes mellitus: The differential role of reactive oxygen species. Gen. Physiol. Biophys., 32: 527-534.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Owu, D.U., N.N. Orie, C.R. Nwokocha, L.H. Clapp and E.E. Osim, 2013. Comparative effect of type 1 and type 2 diabetes mellitus on vascular responses of rat thoracic aorta to potassium ion channel openers. Br. J. Med. Med. Res., 3: 748-759.
    CrossRef  |  Direct Link  |  
  29. Okon, U.A., A.O. Obembe, T.H. Olubobokun and D.U. Owu, 2013. Anti-gastric ulcerative activity of Ocimum gratissimum in streptozotocin-induced diabetic rats. J. Scient. Res. Rep., 2: 408-422.
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  30. Nwokocha, C.R., N. Younger-Coleman, M. Nwokocha, D.U. Owu, H. Asemota, M. Iwuala and A. Lay-Ekuakille, 2013. Analysis of time of measurement and modes of administration of some medicinal plants additives on mercury accumulation in the liver. Int. J. Meas. Technol. Instrum. Eng., 3: 60-70.
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  31. Owu, D.U., C.R. Nwokocha, A.O. Obembe, A.D. Essien, D.E. Ikpi and E.E. Osim, 2012. Effect of Gongronema latifolium ethanol leaf extract on gastric acid secretion and cytoprotection in streptozotocin-induced diabetic rats. West Indian Med. J., 61: 853-860.
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  32. Owu, D.U., A.O. Obembe, C.R. Nwokocha, I.E. Edoho and E.E. Osim, 2012. Gastric ulceration in diabetes mellitus: Protective role of vitamin C. ISRN Gastroenterol. 10.5402/2012/362805.
    CrossRef  |  
  33. Nwokocha, C.R., M.I. Nwokocha, I. Aneto, J. Obi and D.C. Udekweleze et al., 2012. Comparative analysis on the effect of Lycopersicon esculentum (tomato) in reducing cadmium, mercury and lead accumulation in liver. Food Chem. Toxicol., 50: 2070-2073.
    CrossRef  |  Direct Link  |  
  34. Nwokocha, C.R., M.I. Nwokocha, D.U. Owu, J. Obi and B. Olatunde et al., 2012. Comparative analysis on the effect of palm oil (Elaeis guineensis) in reducing cadmium and lead accumulation in liver of Wistar rats. Pharmacogn. Res., 4: 214-218.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Nwokocha, C.R., D.U. Owu, M.I. Nwokocha, C.S. Ufearo and M.O.E. Iwuala, 2012. Comparative study on the efficacy of Allium sativum (garlic) in reducing some heavy metal accumulation in liver of Wistar rats. Food Chem. Toxicol., 50: 222-226.
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  36. Nwokocha, C.R., D.U. Owu, M.I. Nwokocha, C.S. Ufearo and M.O. Iwuala, 2012. Comparative study on the hepatoprotection to heavy metals of Zingiber officinale. Pharmacogn. Res., 4: 208-213.
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  37. Nwokocha, C.R., D.U. Owu, M. McLaren, J. Murray and R. Delgoda et al., 2012. Possible mechanisms of action of the aqueous extract of Artocarpus altilis (breadfruit) leaves in producing hypotension in normotensive Sprague-Dawley rats. Pharmaceut. Biol., 50: 1096-1102.
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  38. Nwokocha, C.R., D.U. Owu, K. Kinlocke, J. Murray, R. Delgoda, K. Thaxter, G. McCalla and L. Young, 2012. Possible mechanism of action of the hypotensive effect of Peperomia pellucida and interactions between human cytochrome P450 enzymes. Med. Arom. Plants, Vol. 1. 10.4172/2167-0412.1000105.
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  39. Nwokocha, C.R., D.U. Owu, I.O. Ajayi, A.B. Ebeigbe and M.I. Nwokocha, 2012. Experimental malaria: The in vitro and in vivo blood pressure paradox. Cardiovasc. J. Afr., 23: 98-102.
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  40. Nwokocha, C.R., D.U. Owu, A. Gordon, K. Thaxter, G. McCalla, R.I. Ozolua and L. Young, 2012. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats. Pharmaceut. Biol., 50: 1436-1441.
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  41. Nwokocha, C.R., C.S. Ufearo, D.U. Owu, N.C. Idemudo and L.C. Ojukwu, 2012. In vivo distribution of lead in male and female rats after intraperitoneal and oral administration. Toxicol. Ind. Health, 28: 131-135.
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  42. Nwokocha, C.R., R.I. Ozolua, D.U. Owu, M.I. Nwokocha and A.C. Ugwu, 2011. Antihypertensive properties of Allium sativum (garlic) on normotensive and two kidney one clip hypertensive rats. Niger J. Physiol. Sci., 26: 213-218.
    PubMed  |  
  43. Nwokocha, C.R., M.I. Nwokocha, D.U. Owu, E. Edidjana, N. Nwogbo, U. Ekpo and C.S. Ufearo, 2011. Estimation of absorbed cadmium in tissues of male and female Albino rats through different routes of administration. Niger. J. Physiol. Sci., 26: 97-101.
    Direct Link  |  
  44. Nwokocha, C.R., I.O. Ajayi, D.U. Owu and A.B. Ebeigbe, 2011. Specificity of vascular reactivity and altered response in experimental malaria. West Indian Med. J., 60: 330-335.
    PubMed  |  Direct Link  |  
  45. Nwokocha, C.R., D.U. Owu, C.S. Ufearo and M.O.E. Iwuala, 2011. Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats. J. Ethnopharmacol., 135: 488-491.
    CrossRef  |  Direct Link  |  
  46. Obembe, A.O., D.U. Owu, O.O. Okwari, A.B. Antai and E.E. Osim, 2010. Intestinal fluid and glucose transport in Wistar rats following chronic consumption of fresh or oxidised palm oil diet. ISRN Gastroenterol., Vol. 2011. 10.5402/2011/972838.
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  47. Obembe, A.O., A.B. Antai, D.U. Owu, O.O. Okwari, M.U. Eteng and E.E. Osim, 2010. Bile secretion and palm oil diets in Wistar rats. Nutr. Food Sci., 40: 388-394.
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  48. Udia, P.M., V.B. Braide and D.U. Owu, 2009. Antispasmodic and spasmolytic effects of methanolic extract from seeds of Garcinia kola on isolated rat small intestine. Niger. J. Physiol. Sci., 24: 111-116.
    CrossRef  |  Direct Link  |  
  49. Owu, D.U., E.E. Ben, A.B. Antai, E.A. Ekpe and P.M. Udia, 2008. Stimulation of gastric acid secretion and intestinal motility by Vernonia amygdalina extract. Fitoterapia, 79: 97-100.
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  50. Obembe, A.O., O.O. Okwari, D.U. Owu, A.B. Antai and E.E. Osim, 2008. Intestinal motility and transit following chronic ingestion of different forms of palm oil diets. Nig. J. Physiol. Sci., 23: 95-99.
    Direct Link  |  
  51. Antai, A.B., D.U. Owu and O.E. Ofem, 2008. Effect of aqueous extract of Rothmannia hispida on gastric acid secretion and gastric mucosa protection (Cytoprotection). Mary Slessor J. Med., 8: 32-36.
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  52. Owu, D.U., A.B. Antai, K.H. Udofia, A.O. Obembe, K.O. Obasi and M.U. Eteng, 2006. Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats. J. Biosci., 31: 575-579.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Eteng, M.U., H.A. Ibekwe, T.E. Amatey, B.J. Bassey, F.U. Uboh and D.U. Owu, 2006. Effect of vitamin C on Serum lipids and electrolyte profile of Albino Wistar Rats. Niger. J. Physiol. Sci., 21: 15-19.
    PubMed  |  Direct Link  |  
  54. Owu, D.U., U.B. Udoete, N. Azah and E.U. Eyong, 2005. Effect of Bonny light crude oil on some haematological parameters of guinea pigs. Biokemistri, 17: 165-170.
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  55. Okwari, O.O., A.B. Antai, D.U. Owu, E.J. Peters and E.E. Osim, 2005. Lung function status of workers exposed to wood dust in timber markets in Calabar, Nigeria. Afr. J. Med. Med. Sci., 34: 141-145.
    PubMed  |  
  56. Eteng, M.U., R.R. Ettarh and D.U. Owu, 2003. Effect of theobromine exposure on haematological parameters in rats. Niger. J. Physiol. Sci., 18: 4-6.
    Direct Link  |  
  57. Eno, A.E., O.I. Owo, E.H. Itam, R.R. Ettarh, C.C. Mfem and D.U. Owu, 1999. Contraction of the isolated guinea pig ileum induced by the crude extract from Eleophorbia drupifera leaves. Global J. Pure Applied Sci., 5: 45-52.
  58. Eno, A.E., E.H. Itam, D.U. Owu, T. Ettrarh and R.S. Konya, 1999. Haemolytic activity of the crude extract from Elaeophorbia drupifera leaves. Biosci. Res. Commun., 11: 89-96.
  59. Ebong, P.E., D.U. Owu and E.U. Isong, 1999. Influence of palm oil (Elaesis guineensis) on health. Plant Food Human Nutr., 53: 209-222.
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  60. Owu, D.U., E.E. Osim and P.E. Ebong, 1998. Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets. Acta Tropica, 69: 65-73.
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  61. Owu, D.U., E.E. Osim and N.N. Orie, 1997. Altered responses of isolated aortic smooth muscle following chronic ingestion of palm oil diets in rats. Afr. J. Med. Med. Sci., 26: 83-86.
    PubMed  |  
  62. Osim, E.E., D.U. Owu and K.M. Etta, 1996. Arterial pressure and lipid profile in rats following chronic ingestion of palm oil diets. Afr. J. Med. Med. Sci., 25: 335-340.
    PubMed  |  
  63. Osim, E.E., D.U. Owu, E.U. Isong and I.B. Umoh, 1994. Influence of chronic consumption of thermoxidized and fresh palm oil diets on basal metabolic rate, body weight and morphology of tissues in rats. Discovery Innov., 6: 389-396.
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  64. Osim, E.E., D.U. Owu, E. Isong and I.B. Umoh, 1992. Influence of chronic consumption of thermally oxidized palm oil diet on platelet aggregation in rats. Discov. Innov. 4: 83-87.