Dr. Khaled Nabih Zaki Rashed
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Dr. Khaled Nabih Zaki Rashed

Lecturer
National Research Center, Egypt

Highest Degree
Ph.D. in Organic Chemistry from El-Menoufia University, Egypt

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Biography

A researcher in Pharmacognosy department in National Research Centre and I got my Ph. D. degree in science, organic chemistry department, faculty of science, menoufia university 2010. My scientific research interests are extraction and isolation of bio-active chemical constituents of medicinal plants as flavonoids, alkaloids, terpenoids, other phenolic and aromatic compounds by different chromatographic methods: paper chromatography (PC), column chromatography (CC), and thin layer chromatography (TLC). Chemical structural elucidation of natural products by techniques of spectroscopic analysis as UV, IR, 1D (1H-NMR, 13C-NMR), and MS, 2D-NMR (H, H-COSY, HSQC, HMBC). I had published more than 70 articles in international journals.

I had attended three local conferences and participated in nine international conferences. I had a supervision of two M. Sc. students.

I had a followship to Germany Universities (November 2006), and a certificate for the Scientific Excellence from NRC (2012), (2013), (2014), (2015).

I am a member of Association of Agriculture Technology in Southeast Asia (AATSEA) and an editor in more than 50 international journals and a reviewer in more than 10 international journals.

I am a member of eight international projects (Brazil, Turkey, France, Portugal, Croatia, South Africa, also I had many international cooperations with Dr. Monica Butnariu (Romania), Dr. Marina Sokovic (Serbia), Prof. Dr. Isabel Ferreira (Portugal), Prof. Dr. Robert Domitrović (Croatia), Prof. Dr. Chistiane Feitosa (Brazil), Dr. Francesca Pintus (Italy), Dr. Lucy Ono (Brazil), Dr. Wilson Cunha (Brazil), Dr. Maryna van de Venter (South Africa), Dr. Karin Seron (France), Dr. Aytaç Guder Turkey and Dr. Samy Selim (Faculty of Science, Suez Canal University, Ismailia, Egypt).

Area of Interest:

Pharmacology and Toxicology
100%
Natural Product
62%
Phytochemistry
90%
Medicinal Plants
75%
Pharmacognosy
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
104
Abstracts
5

Selected Publications

  1. Do Nascimento Cavalcante, A., C.M. Feitosa, F.P. da Silva Santos, A.P.R. de Sousa, Jr. and R.D.S.S. de Souza et al., 2019. Elaboration and characterization of the inclusion complex between β-cyclodextrin and the anticholinesterase 2-oleyl-1, 3-dipalmitoyl-glycerol extracted from the seeds of Platonia insignis MART. J. Mol. Struct., 1177: 286-301.
    CrossRef  |  Direct Link  |  
  2. Tundis, R., K. Rashed, A. Said, F. Menichini and M.R. Loizzo, 2014. In vitro cancer cell growth inhibition and antioxidant activity of Bomabax ceiba (Bombacaeae) flower extracts. Nat. Prod. Commun., 9: 691-694.
  3. Said, A., M. Abo-El-Fotouh, A.R. Alshabrawy, J. Psotova, U. Hawas, A. Omar and K. Rashed, 2014. Evaluation of anti-oxidant, cytotoxic and cytoprotective activities of Alhagi maurorum extracts and phytochemical profile. Indian J. Drugs, 2: 65-72.
  4. Rashed, K.N.Z., 2014. Medicinal plants as a Safe target for treatment of cancer. Nat. Prod. Chem. Res. Vol. 2. .
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  5. Rashed, K.N. and M. Butnariu, 2014. Isolation and antimicrobial and antioxidant evaluation of bio-active compounds from Eriobotrya japonica stems. Adv. Pharmaceut. Bull., 4: 75-81.
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  6. Rashed, K., X.J. Zhang, M.T. Luo and Y.T. Zheng, 2014. Evaluation of Antia€ HIVa€ 1 activity of Cordia myxa L. and phytochemical profile. Banata€TMs J. Biotechnol., 9: 51-56.
  7. Rashed, K., X.J. Zhang, M.T. Luo and Y.T. Zheng, 2014. Evaluation of Anti-HIV-1 activity of Cordia myxa L. and phytochemical profile. Banat's J. Biotechnol., 9: 51-56.
  8. Rashed, K., M.E. Sahuc, G. Deloison, N. Calland, P. Brodin, Y. Rouille and K. Seron, 2014. Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro. J. Funct. Foods, 11: 185-191.
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  9. Rashed, K., I. Potocnjak, J. Giacometti, M. Skoda and R. Domitrovic, 2014. Terminalia bellerica aerial parts ethyl acetate extract exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. J. Funct. Foods, 8: 319-330.
    CrossRef  |  Direct Link  |  
  10. Rashed, K., C.C.S. Ana, M.P.F. Paulo and M.F. Chistiane, 2014. Phytoconstituents and evaluation of acetylcholinesterase inhibition by methanol extract of Liqidambar styraciflua (L.) aerial parts. J. Applied Pharm., 6: 143-152.
  11. Rashed, K., C.C.S. Ana, M.F.C. Katrica and M.F. Chistiane, 2014. Evaluation of acetylcholinesterase Inhibition by Bauhinia alba aerial parts methanol extract and bioactive constituents. Pharmanest, 5: 1791-1800.
  12. Rashed, K., C. Noacmie, D. Gaspard, R. Yves and S. Karin, 2014. In-vitro antiviral activity of Pistacia chinensis flavonoids against Heptatitis C Virus (HCV). J. Applied Pharm., 6: 865-875.
  13. Rashed, K., A. Ciric, J. Glamoclija, R.C. Calhelha, I.C. Ferreira and M. Sokovic, 2014. Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components. Ind. Crops Prod., 59: 189-196.
    CrossRef  |  Direct Link  |  
  14. Rashed, K., A. Ciric, J. Glamoclija and M. Sokovic, 2014. Antibacterial and antifungal activities of methanol extract and phenolic compounds from Diospyros virginiana L. Ind. Crops Prod., 59: 210-215.
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  15. Rashed, K., 2014. Medicinal plants with antioxidant potential: A review. Hygeia J. Drugs Med., 6: 106-110.
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  16. Rashed, K., 2014. Antioxidant potential of Cedrela odorata stems extracts and Bio-active phytoconstituents. Hygeia J. Drugs Med., 6: 25-30.
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  17. Rashed, K. and P. Min-Hsiung, 2014. Antiinflammatory activity of Diospyros kaki peels and bioactive constituents. Pharma Res. J., 10: 7-15.
  18. Rashed, K. and O. Lucy, 2014. Evaluation of cytotoxicicity, Anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Diospyros kaki fruits and phytoconstituents. Pharma Res. J., 10: 22-31.
  19. Rashed, K. and M. Butnariu, 2014. Antimicrobial and antioxidant activities of Bauhinia racemosa Lam. and chemical content. Iran. J. Pharm. Res., 13: 1073-1080.
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  20. Loizzo, M.R., K. Rashed, A. Said, M. Bonesi, F. Menichini and R. Tundis, 2014. Antiproliferative and antioxidant properties of Alhagi maurorum Boiss (Leguminosae) aerial parts. Ind. Crops Prod., 53: 289-295.
    CrossRef  |  Direct Link  |  
  21. Esfahani, B.N., F. Hozoorbakhsh, K. Rashed, S.A. Havaei, K. Heidari and S. Moghim, 2014. Effect of Lagerstroemia tomentosa and Diospyros virginiana methanolic extracts on different drug-resistant strains of Mycobacterium tuberculosis. Res. Pharm. Sci., 9: 193-198.
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  22. Ayoob, F.A., H.M. Awad, S.M. El-Kousy, K. Rashed and N.H. Al-Sayed, 2014. Phytochemical and biological investigations of Terminalia bellerica Roxb. leaves. J. Pharm. Res., 8: 500-510.
  23. Aswar, U., M. Gurav, G. More, K. Rashed and M. Aswar, 2014. Effect of aqueous extract of Solanum xanthocarpum Schrad. And Wendl. on postmenopausal syndrome in ovariectomized rats. J. Integrat. Med., 12: 439-446.
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  24. Rashed, K.N.Z., 2013. Medicinal plants as a potential source for treatment of diabetes mellitus. World J. Pharm. Sci., 1: 1-2.
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  25. Rashed, K.N.Z., 2013. Comparison of antioxidant potential of Dimocarpus longan Lour. Extracts and the main phytoconstituents. Int. J. Sci. Invent. Today, 2: 487-491.
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  26. Rashed, K.N., M.G. da Cruz, G.P.G. Vieira, L.G. Magalhaes and W.R. Cunha, 2013. Evaluation of schistosomicidal and leishmanicidal activities from Carica papaya (Linn.) stem and phytochemical composition. Top. J. Herbal Med., 2: 239-243.
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  27. Rashed, K.N., C.W. Chang, L.Y. Wu and W.H. Peng, 2013. Hepatoprotective activity of Diospyros lotus fruits on acute liver injury induced by carbon tetrachloride and phytochemical analysis. Topcls. J. Herb. Med., 2: 75-83.
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  28. Rashed, K.N., A. Ciric, J. Glamoclija, R.C. Calhelha, I.C. Ferreira and M. Sokovic, 2013. Antimicrobial activity, growth inhibition of human tumour cell lines and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. Aerial parts. BioMed Res. Int., 10.1155/2013/659183.
    CrossRef  |  
  29. Rashed, K.N., 2013. Comparison of antioxidant activity of Terminalia bellerica Roxb. peels extracts and bio-active constituents. Top. J. Herbal Med., 2: 261-265.
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  30. Rashed, K.N. and G. Fouche, 2013. Chemical constituents, phytochemical analysis and in vitro anticancer activity of Hedera helix L. Top. J. Herbal Med., 2: 223-227.
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  31. Rashed, K., X.J. Zhang, M.T. Luo and Y.T. Zheng, 2013. Inhibition of Human Immunodeficiency Virus (HIV-1) by Terminalia muelleri extracts and bioactive constituents. Pharmanest, 4: 1069-1080.
  32. Rashed, K., X.J. Zhang, M.T. Luo and Y.T. Zheng, 2013. Evaluation of inhibition of Lagerstroemia tomentosa stems extracts for HIV-1 and phytochemical constituents. Int. J. Innov. Pharm. Sci. Res., 1: 22-30.
  33. Rashed, K., X.J. Zhang, M.T. Luo and Y.T. Zheng, 2013. Evaluation of Anti-HIV-1 activity from Cestrum nocturnum L. aerial parts and phytochemical analysis. Rev. Prog., 1: 1-6.
  34. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Phytochemical screening of the polar extracts of Carica papaya Linn. and the evaluation of their anti-HIV-1 activity. J. Applied Ind. Sci., 1: 49-53.
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  35. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Phytochemical content and Anti-HIV-1 activity of Sapindus Saponaria (L). J. For. Prod. Ind., 2: 22-26.
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  36. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Inhibition of Human Immunodeficiency Virus (HIV-1) by Hedera helix L. Extracts and phytoconstituents. Int. J. Mol. Biol. Biochem., 1: 1-7.
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  37. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Anti-HIV-1 potential of Bauhinia racemosa Lam. (Caesalpiniaceae) and phytochemical profile. Top. J. Herbal Med., 2: 95-102.
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  38. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Anti-HIV-1 activity of Dimocarpus longan Lour. extracts and the main chemical content. Global J. Microbiol. Biochem., 1: 1-7.
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  39. Rashed, K., M.T. Luo, L.T. Zhang and Y.T. Zheng, 2013. Dodonaea viscose (L.) extracts as anti Human Immunodeficiency Virus type-1 (HIV-1) agents and phytoconstituents. Peak J. Med. Plant Res., 1: 19-25.
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  40. Rashed, K., K. Trevor and M. van de Venter, 2013. In-vitro gastroprotective effect and bioactive compounds from Terminalia bellerica Roxb. seeds. Pharma Res. J., 10: 41-53.
  41. Rashed, K., G.D.C. Michele, M.S. Julia, R.C. Wilson and G.M. Lizandra, 2013. Evaluation of schitosomicidal and leishmanicidal activities from Alnus rugosa (L.) and phytochemical composition. Int. J. Innov. Pharm. Sci. Res., 1: 192-199.
  42. Rashed, K., G.D.C. Michele, M.S. Julia, G.M. Lizandra and R.C. Wilson, 2013. Evaluation of schitosomicidal and leishmanicidal activities from Lagerstroemia tomentosa stems and phytochemical content. Mintage J. Pharm. Med. Sci., 2: 3-5.
  43. Rashed, K., G.D.C. Michele, M.S. Julia, G.M. Lizandra and R.C. Wilson, 2013. Evaluation of schitosomicidal and leishmanicidal activities from Dodonaea viscose L. and phytochemical profile. Int. J. Invent. Pharm. Sci., 1: 462-466.
  44. Rashed, K., C.W. Chang, L.Y. Wu and W.H. Peng, 2013. Hepatoprotective effect of Cestrum parqui L. aerial parts and phytochemical profile. World J. Pharm. Sci., 1: 39-46.
  45. Rashed, K., C.W. Chang, L.Y. Wu and W.H. Peng, 2013. Hepatoprotective effect from Cedrela odorata and phytochemical profile. J. Pharm. Cosmetic Sci., 1: 45-52.
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  46. Rashed, K., C.F.C. Randy and B.N. Tzi, 2013. Bio-active phytoconstituents from non-polar extracts of Diospyros lotus stems and demonstration of antifungal activity in the extracts. World J. Pharm. Sci., 1: 99-108.
  47. Rashed, K., C.C.S. Ana, M.M.N. Jose and M.F. Chistiane, 2013. Evaluation of acetylcholinesterase inhibition by Alnus rugosa L. stems methanol extract and phytochemical content. Int. J. Biomed. Adv. Res., 4: 606-609.
  48. Rashed, K., A. Said and M. Ahmed, 2013. Antiviral activity of Ailanthus excelsa (Roxb.) against Herpes Simplex virus type 1 (HSV-1) in-vitro and phytochemical analysis. J. Pharm. Res. Opin., 3: 15-17.
  49. Rashed, K., A. Said and C. Ho-kim, 2013. Effect of Ailanthus altissima (Mill.) swingle and Ailanthus excelsa (Roxb) stem bark extracts on streptozotocin induced diabetes. Rev. Prog., 1 : 1-5.
  50. Rashed, K., 2013. Investigation of antioxidant activity from Cestrum nocturnum L. stems and phytochemical content. Rev. Prog., 1: 1-6.
    Direct Link  |  
  51. Rashed, K., 2013. Evaluation of antioxidant activity of Sapindus saponaria L. leaves and phytochemical profile. J. Applied Chem., 1: 1-4.
  52. Rashed, K., 2013. Antioxidant activity of different extracts of Vitex agnus-castus (L.) and phytochemical profile. Res. Pharm., 3: 1-5.
  53. Rashed, K., 2013. Antioxidant activity of Schinopsis balansae Engl. leaves and phytochemical content. J. Applied Chem., 1 : 91-94.
  54. Rashed, K., 2013. Antioxidant activity of Hedera helix L. extracts and the main phytoconstituents. Int. J. Allied Med. Sci. Clin. Res., 1: 62-64.
  55. Rashed, K., 2013. Antioxidant activity from Diospyros Ebenum stems extracts and phytochemical profile. J. Applied Ind. Sci., 1: 70-72.
  56. Rashed, K. and O. Lucy, 2013. Phytochemical, cytotoxic anti- HSV-1 (Herpes Simplex Virus type-1) and anti-bacterial studies of Terminalia laxiflora Engl. and Diels. Hygeia J. Drugs Med., 5: 76-86.
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  57. Rashed, K. and O. Lucy, 2013. Evaluation of cytotoxicicity, Anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Pistacia lentiscus L. and phytoconstituents. Int. J. Invent. Pharm. Sci., 1 : 526-531.
  58. Rashed, K. and O. Lucy, 2013. Evaluation of cytotoxicicity, Anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents. Int. Curr. Pharm. J., 3: 211-218.
  59. Rashed, K. and J. Postova, 2013. Phytochemical analysis, free radical scavenging, cytotoxic and cytoprotective activities of Terminalia muelleri L. extracts. J. Pharm. Cosmetic Sci., 1: 61-68.
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  60. Rashed, K. and J. Postova, 2013. Bioactivities of non polar extracts of Diospyros ebenum stems and active principles isolation. Top. J. Herbal Med., 2: 174-181.
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  61. Rashed, K. and F. Gerda, 2013. Anticancer activity of Dimocarpus longan Lour. Leaf extracts in vitro and phytochemical profile. Greener J. Med. Plant Res., 1: 1-5.
  62. Rashed, K. and F. Gerda, 2013. Anticancer activity of Carica papaya extracts in-vito and phytochemical analysis. Greener J. Pharm. Pharmacol., 1: 1-5.
  63. Rashed, K., A. Said and H. Tokuda, 2013. Lipid content from Ailanthus altissima Mill. Swingle and Ailanthus excelsa Roxb. with antitumor activity against Epstein-Barr virus early antigen activation. Med. Chem. Drug Discovery, 4: 47-54.
  64. Seo, Y.M., B.H. Lee, K. Rashed and A. Said, 2012. Antioxidant and cyclooxygenase (COX) inhibitory activities of Ailanthus altissima (Mill.) Swingle leaves. IUFS J. Biol., 71: 77-84.
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  65. Said, A., K. Rashed, H. Tokuda and A. Huefner, 2012. Antitumor activity of Ailanthus excelsa (Roxb) stem bark fractions and canthin-6-one. IUFS J. Biol., 71: 1-6.
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  66. Rashed, K., X. Zhang, M. Luo and Y. Zheng, 2012. Anti-HIV-1 activity of phenolic compounds isolated from Diospyros lotus fruits. Phytopharmacology, 3: 199-207.
  67. Rashed, K., K. Slowing, A. Said and M. Cueto, 2012. Analgesic, antipyretic and antiulcer activities of Ailanthus altissima (Mill.) swingle. Phytopharmacology, 3: 341-350.
    Direct Link  |  
  68. Rashed, K. and M. Butnariu, 2012. Antimicrobial and antioxidant activities of Lagerstroemia tomentosa. Nat. Sci., 10: 189-192.
    Direct Link  |  
  69. Said, A., R. Tundis, U.W. Hawas, S.M. El-Kousy and K. Rashed et al., 2010. In vitro antioxidant and antiproliferative activities of flavonoids from Ailanthus excels (Roxb.) (Simaroubaceae) leaves. Z Naturforsch. C., 65: 180-186.
    PubMed  |  Direct Link  |  
  70. Melanchauski, L.S., A.P.G.S. Broto, T.M. Moraes, A.L.M. Nasser and A. Said et al., 2010. Gastroprotective and antisecretory effects of Ailanthus excelsa (Roxb). J. Nat. Med., 64: 109-113.
    CrossRef  |  Direct Link  |  
  71. Said, A., W.H. Usama, S. El-Shenawy, M.N. Salwa and K. Rashed, 2009. Biologically active flavonoids from Ailanthus excelsa leaves. IUFS J. Biol., 68: 25-38.
  72. Said, A., U.W. Hawas, S.M. Nofal, K. Rashed and A. Huefner, 2009. Pharmaco-chemical studies on the aqueous methanolic extract of Diospyros lotus leaves. Res. J. Phytochem., 3: 1-12.
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  73. Loizzo, M.R., A. Said, R. Tundis, U.W. Hawas and K. Rashed et al., 2009. Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds. Plant Foods Hum. Nutr., 64: 264-270.
    PubMed  |  Direct Link  |  
  74. Galli, G.V., M. Dell'Agli, S. Parapini, N. Basilico and D. Taramelli et al., 2008. Anti-plasmodial activity of Ailanthus excelsa. Fitoterapia, 79: 112-116.
    CrossRef  |  PubMed  |  
  75. Cabrera, W., S. Genta, A. Said, A. Farag and K. Rashed et al., 2008. Hypoglycemic activity of ailanthus excelsa leaves in normal and streptozotocin-induced diabetic rats. Phytother. Res., 22: 303-307.
    PubMed  |  Direct Link  |  
  76. Baycu, G., A. Said, A. Farag and K. Rashed, 2008. Protein patterns and chemical constituents of ailanthus altissima (Miller) swingle and Ailanthus excelsa Roxb. IUFS J. Biol., 67: 81-88.
  77. Loizzo, M.R., A. Said, R. Tundis, K. Rashed, G.A. Statti, A. Hufner and F. Menichini, 2007. Inhibition of Angiotensin Converting Enzyme (ACE) by flavonoids isolated from Ailanthus excels (Roxb) (Simaroubaceae). Phytother. Res., 21: 32-36.
    PubMed  |  Direct Link  |  
  78. Tzakou, O., A. Said, A. Farag and K. Rashed, 2006. Volatile constituents of Ailanthus excelsa Roxb. Flavour Fragance J., 21: 899-901.
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  79. Said, A., J. Psotova, M. Shehata and K. Rashed, 2006. Free radical scavening, cytotoxic and cytoprotective activities of Ailanthus species. J. Gene. Eng. Biotechnol., 4: 89-105.
  80. Rashed, K., A. Said, G. Baycu, L. Dogan and A. Huefner et al., 2006. Cytotoxic activity of Ailanthus excels (Roxb.) leaves extracts on Myelogenous leukemia (K562) cell lines in vitro. J. Arab Soc. Med. Res., 1: 82-91.
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  81. Lampronti, I., K. Rashed, R. Gambari and A. Said, 2005. Antiproliferative activity of Ailanthus excelsa (Roxb.). J. Biotechnol. Mol. Biol., 17: 175-181.