Education
Academic Background-
Ph.D. Tunghai University, Taiwan Life Science | Completed: 2008
Publications (83)
Selected Scholarly Contributions
Propofol in Perioperative Management of Head and Neck Cancer: A Narrative Review of Molecular Mechanisms and Clinical Implications
2026
Regulation of endoplasmic reticulum stress and ferroptosis by rutin in a rat model of periodontitis
2026
Characterization of the oral microbiota in zygomatic versus dental implants: Implications for full-mouth rehabilitation
2026
Anti-inflammatory and polarization-modulating effects of Houttuynia cordata in LPS-stimulated RAW264.7 macrophages
2026
Molecular Mechanisms in Oral Squamous Cell Carcinoma: Integrative Roles of Cancer-Associated Fibroblasts, Immune Microenvironment, and Precision Therapeutic Opportunities
2026
The COVIDTW3 Study: Impact of Variants of Concern and Vaccination on Mortality in Intubated Patients with COVID-19-Related Respiratory Failure from 2021 to 2023
2026
Natural Products in Endometrial Cancer: Molecular Mechanisms, Preclinical Evidence, and Clinical Perspectives
2026
Natural Products in Clear Cell Renal Cell Carcinoma: Rewiring the VHL-HIF Axis, Metabolic Plasticity, and Tumor–Immune Interactions
2026
Editorial for the Special Issue “The Role of Bioactives in Inflammation, 2nd Edition”
2026
Reprogramming Mitochondrial Adaptation: LONP1 at the Crossroads of Proteostasis, Metabolism, and Disease
2026
EpCAM Signaling in Oral Cancer Stem Cells: Implications for Metastasis, Tumorigenicity, and Therapeutic Strategies
2025
The Role of Methyl Canthin-6-one-2-carboxylate in Targeting the NLRP3 Inflammasome in Rheumatoid Arthritis Treatment
2025
2025
Herbal Medicine in Breast Cancer Therapy: Mechanisms, Evidence, and Future Perspectives
2025
2025
Reconstruction of the mandibular condyle using liquid nitrogen–treated autograft in a case of fibrous dysplasia
2025
Comparisons of efficacy and safety of immunotherapies for Alzheimer’s disease treatment: A network meta-analysis of randomised controlled trials
2025
Colostrum-Derived Exosomal Lactoferrin Promotes Skin Fibroblast Regeneration by Suppressing Inflammatory Responses
2025
Therapeutic Targeting of Apoptosis, Autophagic Cell Death, Necroptosis, Pyroptosis, and Ferroptosis Pathways in Oral Squamous Cell Carcinoma: Molecular Mechanisms and Potential Strategies
2025
Plant Extracts and Natural Compounds for the Treatment of Urinary Tract Infections in Women: Mechanisms, Efficacy, and Therapeutic Potential
2025
Immune Evasion in Head and Neck Squamous Cell Carcinoma: Roles of Cancer-Associated Fibroblasts, Immune Checkpoints, and TP53 Mutations in the Tumor Microenvironment
2025
Herba Houttuyniae Induces Cell Apoptosis through Caspases, Endoplasmic Reticulum Stress, and Mitochondrial Membrane Potential
2025
Editorial for the Special Issue “Early Molecular Diagnosis and Comprehensive Treatment of Tumors”
2025
2025
2024
Tazarotene-induced Gene 1 Induces Melanoma Cell Death by Triggering Endoplasmic Reticulum Stress Response
2024
2024
The Interplay between von Hippel–Lindau Tumor Suppressor Gene, Lon Protease, ROS Accumulation, and Inflammation in Clear Cell Renal Cell Carcinoma
2024
2024
Molecular Biological Mechanisms of Action of Chrysophanol in Hepatic Stellate Cells Activated by Hepatic B Virus X Based on Network Pharmacology
2024
The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways
2023
Pinostrobin and Tectochrysin Conquer Multidrug-Resistant Cancer Cells via Inhibiting P-Glycoprotein ATPase
2023
The COVIDTW study: Clinical predictors of COVID-19 mortality and a novel AI prognostic model using chest X-ray
2023
2023
Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells
2022
Combined Acupoints for the Treatment of Patients with Obesity: An Association Rule Analysis
2022
Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells
2022
Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation
2022
Pharmacological Interventions for Excessive Daytime Sleepiness in Adults with Narcolepsy: A Systematic Review and Network Meta-Analysis
2022
An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease
2021
Loss of Function of von Hippel‐Lindau Trigger Lipocalin 2‐Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells
2021
Poor Work Efficiency is Associated with Poor Exercise Capacity and Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
2021
An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis
2021
The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice
2021
Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines
2021
2021
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
2021
Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells
2021
Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice
2021
Tournefortia sarmentosa Inhibits the Hydrogen Peroxide-Induced Death of H9c2 Cardiomyocytes
2021
Poria cocos Regulates Cell Migration and Actin Filament Aggregation in B35 and C6 Cells by Modulating the RhoA, CDC42, and Rho Signaling Pathways
2021
Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis
2021
2021
Combination of Acupoints in Treating Patients with Chronic Obstructive Pulmonary Disease: An Apriori Algorithm‐Based Association Rule Analysis
2020
Role of Chrysophanol in Epithelial‐Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt‐3‐Dependent Pathway
2020
An Apriori Algorithm‐Based Association Rule Analysis to Identify Herb Combinations for Treating Uremic Pruritus Using Chinese Herbal Bath Therapy
2020
Chrysophanol Prevents Lipopolysaccharide‐Induced Hepatic Stellate Cell Activation by Upregulating Apoptosis, Oxidative Stress, and the Unfolded Protein Response
2020
Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
2020
Oridonin Attenuates Lipopolysaccharide‐Induced ROS Accumulation and Inflammation in HK‐2 Cells
2020
Age, Period and Cohort Analysis of Rates of Emergency Department Visits Due to Pneumonia in Taiwan, 1998–2012
2020
Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury
2020
A Meta-Analysis of Comparing Intermittent Epidural Boluses and Continuous Epidural Infusion for Labor Analgesia
2020
2020
Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells
2020
Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux.
Chan-Yen Kuo
2019
Apoptotic effects of hsian‐tsao (Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK and caspase‐3 pathways.
Chan-Yen Kuo
2019
UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection.
Chan-Yen Kuo
2017
VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling.
Chan-Yen Kuo
2017
Role of CAPE on cardiomyocyte protection via connexin 43 regulation under hypoxia.
Chan-Yen Kuo
2016
Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia.
Chan-Yen Kuo
2015
Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells.
Chan-Yen Kuo
2014
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents.
Chan-Yen Kuo
2013
Propofol inhibits superoxide production, elastase release and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
Chan-Yen Kuo
2013
Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.
Chan-Yen Kuo
2013
Caffeic acid phenethyl ester inhibits proliferation and migration and induces apoptosis in platelet-derived growth factor-BB-stimulated human coronary smooth muscle cells.
Chan-Yen Kuo
2012
A prototype tissue engineered blood vessel using amniotic membrane as scaffold.
Chan-Yen Kuo
2012
Apoptosis induced by hepatitis B virus X protein in a CCL13-HBx stable cell line.
Chan-Yen Kuo
2012
Interaction abolishment between mutant caveolin-1Δ62-100 and ABCA1 reduces HDL-mediated cellular cholesterol efflux.
Chan-Yen Kuo
2011
ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells.
Chan-Yen Kuo
2009
Caffeic acid phenethyl ester inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using a local delivery system.
Chan-Yen Kuo
2009
Effects of hepatitis B virus X protein (HBx) on cell-growth inhibition in a CCL13-HBx stable cell line.
Chan-Yen Kuo
2008
HBx inhibits the growth of CCL13-HBX-stable cells via the GSK-3β/β-catenin cascade.
Chan-Yen Kuo
2008
Functional characterization of hepatitis B virus X protein based on the inhibition of tumorigenesis in nude mice injected with CCL13-HBx cells.
Chan-Yen Kuo
2008