Education
Academic Background-
Ph.D. University of Calabria, Italy Cell Biology | Completed: 2010
Editorial Services
Editorial & Publishing Roles
Editorial Board Member
Serving as Editorial Board Member for American Journal of Biochemistry and Molecular Biology.
Publications (47)
Selected Scholarly Contributions
Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells
2025
The antiport mechanism of the human LAT1 transporter: defining the molecular determinants by means of wet and dry approaches
2025
2024
OCTN1 (SLC22A4) as a Target of Heavy Metals: Its Possible Role in Microplastic Threats
2024
Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter
2023
Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications
2023
Over-Production of the Human SLC7A10 in E. coli and Functional Assay in Proteoliposomes
2023
OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions
2022
Cysteine 467 of the ASCT2 Amino Acid Transporter Is a Molecular Determinant of the Antiport Mechanism
2022
Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives
2022
2022
2022
Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
2021
Chemical Approaches for Studying the Biology and Pharmacology of Membrane Transporters: The Histidine/Large Amino Acid Transporter SLC7A5 as a Benchmark
2021
2020
2020
Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression
2020
2020
Regulatory Aspects of the Vacuolar CAT2 Arginine Transporter of S. lycopersicum: Role of Osmotic Pressure and Cations
2019
Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
2018
2016
Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter.
Mariafrancesca Scalise
2016
Glutamine transport. From energy supply to sensing and beyond.
Mariafrancesca Scalise
2016
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.
Mariafrancesca Scalise
2016
Mitochondrial carnitine/acylcarnitine transporter, a novel target of mercury toxicity.
Mariafrancesca Scalise
2015
N-linked glycosylation of human SLC1A5 (ASCT2) transporter is critical for trafficking to membrane.
Mariafrancesca Scalise
2015
Immuno-detection of OCTN1 (SLC22A4) in HeLa cells and characterization of transport function.
Mariafrancesca Scalise
2015
LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter.
Mariafrancesca Scalise
2015
Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter.
Mariafrancesca Scalise
2015
Amino acid transporters in drug discovery.
Mariafrancesca Scalise
2014
Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling.
Mariafrancesca Scalise
2014
Transport mechanism and regulatory properties of the human amino acid transporter ASCT2 (SLC1A5).
Mariafrancesca Scalise
2014
Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter. C50 and C136 are the targets for potent inhibition.
Mariafrancesca Scalise
2014
Strategies of bacterial over expression of membrane transporters relevant in human health: the successful case of the three members of OCTN subfamily.
Mariafrancesca Scalise
2013
Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris-Functional and kinetic asymmetry revealed in proteoliposomes.
Mariafrancesca Scalise
2013
OCTN cation transporters in health and disease: role as drug targets and assay development.
Mariafrancesca Scalise
2013
Cloning, large scale over-expression in E. coli and purification of the components of the human LAT 1 (SLC7A5) amino acid transporter.
Mariafrancesca Scalise
2013
Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics.
Mariafrancesca Scalise
2013
Over-expression in E. coli and purification of the human OCTN2 transport protein.
Mariafrancesca Scalise
2012
The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn`s disease.
Mariafrancesca Scalise
2012
Human OCTN2 (SLC22A5) is down-regulated in virus and nonvirus-mediated cancer.
Mariafrancesca Scalise
2012
Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: The mouse carnitine transporter OCTN3.
Mariafrancesca Scalise
2012
Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system.
Mariafrancesca Scalise
2012
IκB kinase β promotes cell survival by antagonizing p53 functions through ΔNp73α phosphorylation and stabilization.
Mariafrancesca Scalise
2011
E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1.
Mariafrancesca Scalise
2011
Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli.
Mariafrancesca Scalise
2011
Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes.
Mariafrancesca Scalise
2009