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Charles J. Malemud

Charles J. Malemud

LiveDNA ID: 1.19973
167 Publications
0 Editorial Roles
0 Projects

Education

Academic Background
  • Ph.D. George Washington University, USA Medicine and Anatomy | Completed: 1973

Publications (167)

Selected Scholarly Contributions
Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2.
Meszaros, E.C. and C.J. Malemud,
J. Inflamm. Res., | Journal Article
10.2147/JIR.S93797
Self Charles J. Malemud
2017
Joint hypermobility syndrome and postural orthostatic tachycardia syndrome (HyPOTS).
Mandel, D., A.D. Askari, C.J. Malemud and A. Kaso,
Biomed. Res. Clin. Pract., | Journal Article
10.15761/BRCP.1000132
Self Charles J. Malemud
2017
Recent strategies for drug development in fibromyalgia syndrome.
Blumenthal, D.E. and C.J. Malemud,
Expert Rev. Neurotherapeut., | Journal Article
10.1080/14737175.2016.1207531
Self Charles J. Malemud
2016
Human parturition involves phosphorylation of progesterone receptor-A at serine-345 in myometrial cells.
Amini, P., D. Michniuk, K. Kuo, L. Yi and Y. Skomorovska-Prokvolit et al.,
Endocrinology, | Journal Article
10.1210/en.2016-1654
Self Charles J. Malemud
2016
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase and MMP9 activity.
Taylor, P.R., S. Roy, E.C. Meszaros, Y. Sun, S.J. Howell, C.J. Malemud and E. Pearlman,
J. Leukocyte Biol., | Journal Article
Self Charles J. Malemud
2016
Vaccine development for rheumatoid arthritis.
Malemud, C.J.,
Global Vaccines Immunol., | Journal Article
10.15761/GVI.1000102
Self Charles J. Malemud
2015
Blockade of recombinant human IL-6 by tocilizumab suppresses matrix metalloproteinase-9 production in the C28/I2 immortalized human chondrocyte cell line.
Meszaros, E.C., W. Dahoud, S. Mesiano and C.J. Malemud,
Integr. Mol. Med., | Journal Article
10.15761/IMM.1000158
Self Charles J. Malemud
2015
The PI3K/Akt/PTEN/mTOR pathway: A fruitful target for inducing cell death in rheumatoid arthritis?
Malemud, C.J.,
Future Med. Chem., | Journal Article
10.4155/fmc.15.55
Self Charles J. Malemud
2015
The biological basis of osteoarthritis: State of the evidence.
Malemud, C.J.,
Curr. Opin. Rheumatol., | Journal Article
10.1097/BOR.0000000000000162
Self Charles J. Malemud
2015
Clinical significance and implications of genetic and genomic studies in patients with osteoarthritis.
Muoh, O., C.J. Malemud and A.D. Askari,
Adv. Genomics Genet., | Journal Article
10.2147/AGG.S64284
Self Charles J. Malemud
2014
Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives.
Malemud, C.J. and D.E. Blumenthal,
World J. Orthopedics, | Journal Article
10.5312/wjo.v5.i4.496
Self Charles J. Malemud
2014
Deregulation of apoptosis in arthritis by altered signal transduction.
Wylie, M.A. and C.J. Malemud,
Int. J. Clin. Rheumatol., | Journal Article
Self Charles J. Malemud
2013
The biological and clinical activity of anti-malarial drugs in autoimmune disorders.
Taherian, E., A. Rao, C.J. Malemud and A.D. Askari,
Curr. Rheumatol. Rev., | Journal Article
Self Charles J. Malemud
2013
Prospects for treating osteoarthritis: Enzyme-protein interactions regulating matrix metalloproteinase activity.
Meszaros, E. and C.J. Malemud,
Therapeut. Adv. Chronic Dis., | Journal Article
10.1177/2040622312454157
Self Charles J. Malemud
2012
Inhibitors of JAK for the treatment of rheumatoid arthritis: Rationale and clinical data.
Malemud, C.J.,
Clin. Invest., | Journal Article
Self Charles J. Malemud
2012
New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders.
Wisler, B.A., J.E. Dennis and C.J. Malemud,
Curr. Signal Transduction Ther., | Journal Article
10.2174/157436211795659883
Self Charles J. Malemud
2011
Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways.
Malemud, C.J.,
Anti-Inflamm. Anti-Allergy Agents Med. Chem., | Journal Article
10.2174/1871523011107020078
Self Charles J. Malemud
2011
Molecular mechanisms in rheumatic diseases: Rationale for novel drug development-introduction.
Malemud, C.J.,
Anti-Inflamm. Anti-Allergy Agents Med. Chem., | Journal Article
10.2174/1871523011107020073
Self Charles J. Malemud
2011
Differential activation of JAK enzymes in rheumatoid arthritis and autoimmune disorders by pro-inflammatory cytokines: Potential drug targets.
Malemud, C.J.,
Int. J. Interferon Cytokine Mediator Res., | Journal Article
10.2147/IJICMR.S9470
Self Charles J. Malemud
2010
Suppression of autoimmune arthritis by small molecule inhibitors of the JAK/STAT pathway.
Malemud, C.J.,
Pharmaceuticals, | Journal Article
10.3390/ph3051446
Self Charles J. Malemud
2010
Anticytokine therapy for osteoarthritis: Evidence to date.
Malemud, C.J.,
Drugs Aging, | Journal Article
10.2165/11319950-000000000-00000
Self Charles J. Malemud
2010
Focus on pain mechanisms and pharmacotherapy in the treatment of fibromyalgia syndrome.
Malemud, C.J.,
Clin. Exp. Rheumatol., | Journal Article
Self Charles J. Malemud
2009
Recent advances in neutralizing the IL-6 pathway in arthritis.
Malemud, C.J.,
Open Access Rheumatol., | Journal Article
Self Charles J. Malemud
2009
Cardiovascular disease complications in systemic lupus erythematosus.
Torres, A., A.D. Askari and C.J. Malemud,
Biomarkers Med., | Journal Article
10.2217/bmm.09.14
Self Charles J. Malemud
2009
Targeting JAK/STAT signaling pathway in inflammatory diseases.
Malemud, C.J. and E. Pearlman,
Curr. Signal Transduction Ther., | Journal Article
10.2174/157436209789057467
Self Charles J. Malemud
2009
Targeting cytokines, chemokines and adhesion molecules in rheumatoid arthritis.
Malemud, C.J. and S.K. Reddy,
Curr. Rheumatol. Rev., | Journal Article
10.2174/157339708786263933
Self Charles J. Malemud
2008
Defining novel targets for intervention in rheumatoid arthritis: An overview.
Malemud, C.J.,
Curr. Rheumatol. Rev., | Journal Article
10.2174/157339708786263889
Self Charles J. Malemud
2008
Is there a final common pathway for arthritis?
Malemud, C.J. and M.E. Schulte,
Future Rheumatol., | Journal Article
Self Charles J. Malemud
2008
Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs.
Malemud, C.J. and A.H. Miller,
Expert Opin. Therapeut. Targets, | Journal Article
10.1517/14728222.12.2.171
Self Charles J. Malemud
2008
Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9.
Gupta, K., M. Shukla, J.B. Cowland, C.J. Malemud and T.M. Haqqi,
Arthritis Rheumatol., | Journal Article
10.1002/art.22879
Self Charles J. Malemud
2007
Gene therapy for arthritis: Defining novel gene targets.
Malemud, C.J.,
Gene Ther. Mol. Biol., | Journal Article
Self Charles J. Malemud
2007
Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways.
Malemud, C.J.,
Curr. Opin. Pharmacol., | Journal Article
10.1016/j.coph.2006.11.012
Self Charles J. Malemud
2007
Growth hormone, VEGF and FGF: Involvement in rheumatoid arthritis.
Malemud, C.J.,
Clin. Chim. Acta, | Journal Article
10.1016/j.cca.2006.06.033
Self Charles J. Malemud
2007
Body mass index and blood glucose: Correlations with serum insulin, growth hormone and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH).
Denko, C.W. and C.J. Malemud,
Rheumatol. Int., | Journal Article
10.1007/s00296-005-0588-8
Self Charles J. Malemud
2006
Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures.
Bertone, A.L., L.R. Bramlage, C.W. McIlwraith and C.J. Malemud,
Am. J. Vet. Res., | Journal Article
10.2460/ajvr.2005.66.1881
Self Charles J. Malemud
2006
Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases.
Malemud, C.J.,
Mini Rev. Med. Chem., | Journal Article
10.2174/138955706777435670
Self Charles J. Malemud
2006
Matrix metalloproteinases: Role in skeletal development and growth plate disorders.
Malemud, C.J.,
Front. Biosci., | Journal Article
10.2741/1916
Self Charles J. Malemud
2006
Matrix Metalloproteinases (MMPs) in health and disease: An overview.
Malemud, C.J.,
Front. Biosci., | Journal Article
10.2741/1915
Self Charles J. Malemud
2006
Hydrostatic pressure increases apoptosis in cartilage-constructs produced from human osteoarthritic chondrocytes.
Wenger, R., M.G. Hans, J.F. Welter, L.A. Solchaga, Y.R. Sheu and C.J. Malemud,
Front Biosci., | Journal Article
10.2741/1914
Self Charles J. Malemud
2006
Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: A review.
Ahmed, S., J. Anuntiyo, C.J. Malemud and T.M. Haqqi,
Evidence-Based Complement. Altern. Med. | Journal Article
10.1093/ecam/neh117
Self Charles J. Malemud
2005
Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases.
Denko, C.W. and C.J. Malemud,
Semin. Arthritis Rheum., | Journal Article
10.1016/j.semarthrit.2005.03.001
Self Charles J. Malemud
2005
Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndrome.
Denko, C.W. and C.J. Malemud,
Rheumatol. Int., | Journal Article
10.1007/s00296-004-0459-8
Self Charles J. Malemud
2005
The role of apoptosis in arthritis.
Malemud, C.J. and H.J. Gillespie,
Curr. Rheum. Rev., | Journal Article
10.2174/1573397054023146
Self Charles J. Malemud
2005
Protein kinases in chondrocyte signaling and osteoarthritis.
Malemud, C.J.,
Clin. Orthopaed. Related Res., | Journal Article
10.1097/01.blo.0000143802.41885.50
Self Charles J. Malemud
2004
Effects of intra-articular hyaluronic acid on ex vivo responses by third carpal bone cartilage from horses with experimentally induced synovitis.
Palmer, J.L., J. Mansour, C.J. Malemud and A.L. Bertone,
Equine Comp. Exercise Physiol., | Journal Article
10.1079/ECEP200313
Self Charles J. Malemud
2004
The serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients.
Denko, C.W. and C.J. Malemud,
Front. Biosci., | Journal Article
Self Charles J. Malemud
2004
Cytokines as therapeutic targets for osteoarthritis.
Malemud, C.J.,
BioDrugs, | Journal Article
10.2165/00063030-200418010-00003
Self Charles J. Malemud
2004
A comprehensive approach to enhancing sexual health education in the case Western reserve university school of medicine.
Kingsberg, S.A., C.J. Malemud, T. Novak, K. Cole-Kelly, M.Z. Wile, P. Spanos and T.M. Nosek,
Int. J. Impot. Res., | Journal Article
Self Charles J. Malemud
2003
Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies.
Malemud, C.J., N. Islam and T.M. Haqqi,
Cells Tissues Organs, | Journal Article
10.1159/000070573
Self Charles J. Malemud
2003
Intra-erythrocyte deposition of growth hormone in rheumatic diseases.
Denko, C.W., B. Boja and C.J. Malemud,
Rheumatol. Int., | Journal Article
10.1007%2Fs00296-002-0245-4?LI=true
Self Charles J. Malemud
2003
Epigallocatechin-3-gallate selectively inhibits interleukin-1 β-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes.
Singh, R., S. Ahmed, C.J. Malemud, V.M. Goldberg and T.M. Haqqi,
J. Orthop. Res., | Journal Article
10.1016/S0736-0266(02)00089-X
Self Charles J. Malemud
2003
Growth hormone and insulin-like growth factor-I in symptomatic and asymptomatic patients with diffuse idiopathic skeletal hyperostosis (DISH).
Denko, C.W., B. Boja and C.J. Malemud,
Front. Biosci., | Journal Article
Self Charles J. Malemud
2002
Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, p53, c-myc and bax-α and suppression of bcl-2.
Islam, N., T.M. Haqqi, K.J. Jepsen, M. Kraay, J.F. Welter, V.M. Goldberg and C.J. Malemud,
J. Cell. Biochem., | Journal Article
10.1002/jcb.10317
Self Charles J. Malemud
2002
Expression profile of protein tyrosine kinase genes in human osteoarthritis chondrocytes.
Islam, S., T. Kermode, D. Sultana, R.W. Moskowitz and H. Mukhtar et al.,
Osteoarthritis Cartilage, | Journal Article
10.1053/joca.2001.0465
Self Charles J. Malemud
2001
Tumour necrosis factor α enhances the expression of hydroxyl lyase, cytoplasmic antiproteinase-2 and a dual specificity kinase TTK in human chondrocyte-like cells.
Ah-Kim, H., X. Zhang, S. Islam, J.I. Sofi and Y. Glickberg et al.,
Cytokine, | Journal Article
10.1006/cyto.1999.0539
Self Charles J. Malemud
2000
Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells.
Islam, S., N. Islam, T. Kermode, B. Johnstone and H. Mukhtar et al.,
Biochem. Biophys. Res. Commun., | Journal Article
10.1006/bbrc.2000.2536
Self Charles J. Malemud
2000
Metabolic disturbances and synovial joint responses in osteoarthritis.
Denko, C.W. and C.J. Malemud,
Front. Biosci., | Journal Article
Self Charles J. Malemud
1999
Fundamental pathways in osteoarthritis: An overview.
Malemud, C.J.,
Front. Biosci., | Journal Article
Self Charles J. Malemud
1999
Changes in third carpal bone articular cartilage after synovectomy in normal and inflamed joints.
Palmer, J.L., A.L. Bertone, C.J. Malemud and J. Mansour,
Vet. Surg., | Journal Article
10.1111/j.1532-950X.1998.tb00134.x
Self Charles J. Malemud
1998
Effect of synovial membrane infection in vitro on equine synoviocytes and chondrocytes.
Hardy, J., A.L. Bertone and C.J. Malemud,
Am. J. Vet. Res., | Journal Article
Self Charles J. Malemud
1998
Biochemical, histochemical and immunohistochemical characterization of distal tibial osteochondrosis in horses.
Lillich, J.D., A.L. Bertone, C.J. Malemud, S.E. Weisbrode, A.J. Ruggles and S. Stevenson,
Am. J. Vet. Res., | Journal Article
Self Charles J. Malemud
1997
Biochemical and biomechanical alterations in equine articular cartilage following an experimentally-induced synovitis.
Palmer, J.L., A.L. Bertone, C.J. Malemud and J. Mansour,
Osteoarthritis Cartilage, | Journal Article
10.1016/S1063-4584(05)80321-8
Self Charles J. Malemud
1996
Forskolin stimulates aggrecan gene expression in cultured bovine chondrocytes.
Malemud, C.J., R.S. Papay and T.M. Hering,
Am. J. Therapeut., | Journal Article
Self Charles J. Malemud
1996
Site-specific proteoglycan characteristics of third carpal articular cartilage in exercised and nonexercised horses.
Palmer, J.L., A.L. Bertone, C.J. Malemud, B.G. Carter, R.S. Papay and J. Mansour,
Am. J. Vet. Res., | Journal Article
Self Charles J. Malemud
1995
Biomechanical properties of third carpal articular cartilage in exercised and nonexercised horses.
Palmer, J.L., A.L. Bertone, J. Mansour, B.G. Carter and C.J. Malemud,
J. Orthopaedic Res., | Journal Article
10.1002/jor.1100130608
Self Charles J. Malemud
1995
Phenotypic modulation of newly synthesized proteoglycans in human cartilage and chondrocytes.
Malemud, C.J., R.S. Papay, T.M. Hering, D. Holderbaum, V.M. Goldberg and T.M. Haqqi,
Osteoarthritis Cartilage, | Journal Article
10.1016/S1063-4584(05)80014-7
Self Charles J. Malemud
1995
Synthesis of aggrecan core proteins by human cartilage and chondrocytes in vitro.
Malemud, C.J. and V.M. Goldberg,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1995
Regional differences in reactive gliosis induced by substrate-bound β-amyloid.
Hoke, A., D.R. Canning, C.J. Malemud and J. Silver,
Exp. Neurol., | Journal Article
10.1006/exnr.1994.1185
Self Charles J. Malemud
1994
Biochemical and molecular characterization of stromelysin synthesized by human osteoarthritic chondrocytes stimulated with recombinant human interleukin-1.
Ganu, V.S., S.I. Hu, R. Melton, C. Winter, V.M. Goldberg, T.M. Haqqi and C.J. Malemud,
Clin. Exp. Rheumatol., | Journal Article
Self Charles J. Malemud
1994
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.
Kammer, G.M., I.U. Khan and C.J. Malemud,
J. Clin. Invest., | Journal Article
10.1172/JCI117340
Self Charles J. Malemud
1994
The effect of nonsteroidal anti-inflammatory drugs on cAMP-dependent protein kinase-mediated phosphorylation by human chondrocytes in culture.
Malemud, C.J., R.S. Papay, P. Hasler and G.M. Kammer,
Clin. Exp. Rheumatol., | Journal Article
Self Charles J. Malemud
1994
The proteoglycan synthesis repertoire of rabbit chondrocytes maintained in type II collagen gels.
Malemud, C.J., S. Stevenson, F. Mehraban, R.S. Papay, A.F. Purchio and V.M. Goldberg,
Osteoarthritis Cartilage, | Journal Article
10.1016/S1063-4584(05)80004-4
Self Charles J. Malemud
1994
A potent inhibitor of neurite outgrowth that predominates in the extracellular matrix of reactive astrocytes.
Canning, D.R., A. Hoke, C.J. Malemud and J. Silver,
Int. J. Dev. Neurosci., | Journal Article
Self Charles J. Malemud
1993
Role of astroglial extracellular matrix in the formation of rat olfactory bulb glomeruli.
Gonzalez, M.D.L., C.J. Malemud and J. Silver,
Exp. Neurol., | Journal Article
10.1006/exnr.1993.1143
Self Charles J. Malemud
1993
Human cartilage from late stage familial osteoarthritis transcribes type II collagen mRNA encoding a cysteine in position 519.
Holderbaum, D., C.J. Malemud, R.W. Moskowitz and T.M. Haqqi,
Biochem. Biophys. Res. Commun., | Journal Article
10.1006/bbrc.1993.1539
Self Charles J. Malemud
1993
Markers of osteoarthritis and cartilage research in animal models.
Malemud, C.J.,
Curr. Opin. Rheumatol., | Journal Article
Self Charles J. Malemud
1993
The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation in T lymphocytes.
Kammer, G.M., T.M. Haqqi, P. Hasler and C.J. Malemud,
Clin. Immunol. Immunopathol., | Journal Article
10.1006/clin.1993.1039
Self Charles J. Malemud
1993
Synthesis of low buoyant density proteoglycans by human chondrocytes in culture.
Malemud, C.J. and R.S. Papay,
Matrix, | Journal Article
10.1016/S0934-8832(11)80087-9
Self Charles J. Malemud
1992
A small proteoglycan isolated from human cartilage containing a nonfunctional hyaluronic acid binding region.
Thomas, E., R.S. Papay, V.M. Goldberg and C.J. Malemud,
Biochem. Int., | Journal Article
Self Charles J. Malemud
1992
Immunological analysis of proteoglycan structural changes in the early stage of experimental osteoarthritic canine cartilage lesions.
Pelletier, J.P., J. Martel-Pelletier, F. Mehraban and C.J. Malemud,
J. Orthop. Res., | Journal Article
10.1002/jor.1100100406
Self Charles J. Malemud
1992
Proteoglycan structural changes in human rheumatoid articular cartilage.
Martel-Pelletier, J., J.P. Pelletier, J.M. Cloutier, N. Rebert and C.J. Malemud,
Clin. Exp. Rheumatol., | Journal Article
Self Charles J. Malemud
1992
Suppression of proteoglycan synthesis in chondrocyte cultures derived from canine intervertebral disc.
Yoo, J.U., R.S. Papay and C.J. Malemud,
Spine, | Journal Article
Self Charles J. Malemud
1992
Directions for future research and treatment of osteoarthritis.
Malemud, C.J. and V.M. Goldberg,
Front. Biosci., | Journal Article
Self Charles J. Malemud
1991
Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates.
Ratnoff, O.D., B. Everson, P. Embury, N.P. Ziats, J.M. Anderson, M.M. Emanuelson and C.J. Malemud,
Proc. Natl. Acad. Sci., | Journal Article
Self Charles J. Malemud
1991
Enhanced sulfated-proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-β1.
Malemud, C.J., W. Killeen, T.M. Hering and A.F. Purchio,
J. Cell. Physiol., | Journal Article
10.1002/jcp.1041490119
Self Charles J. Malemud
1991
The effects of Rumalon, a glycosaminoglycan peptide complex, in a partial meniscectomy model of osteoarthritis in rabbits.
Moskowitz, R.W., J.H. Reese, R.G. Young, D. Fein-Krantz, C.J. Malemud and A.I. Caplan,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1991
Changes in proteoglycans in osteoarthritis: Biochemistry, ultrastructure and biosynthetic processing.
Malemud, C.J.,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1991
cAMP-dependent protein kinase in chondrocyte cultures: Holoenzyme activation, phosphorylation of cellular proteins, effects of NSAIDs and possible role in proteoglycan synthesis.
Malemud, C.J., R.S. Papay, P. Hasler and G.M. Kammer,
Semin Arthritis Rheum., | Journal Article
Self Charles J. Malemud
1990
Proteoglycan composition and biosynthesis by human osteochondrophytic spurs of the femoral head.
Malemud, C.J., R.S. Papay and V.M. Goldberg,
Biomaterials, | Journal Article
Self Charles J. Malemud
1990
Early-onset primary osteoarthritis and mild chondrodysplasia: Radiographic and pathologic studies with an analysis of proteoglycans.
Katzenstein, P.L., C.J. Malemud, M.N. Pathria, J.R. Carter, R.P. Sheon and R.W. Moskowitz,
Arthritis Rheum., | Journal Article
Self Charles J. Malemud
1990
Distinct cartilage proteoglycan chromatographic elution patterns in advanced human hip osteoarthritis: Correlations with histologic analysis.
Shuckett, R. and C.J. Malemud,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1990
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia.
Knowlton, R.G., P.L. Katzenstein, R.W. Moskowitz, E.J. Weaver and C.J. Malemud et al.,
N. Engl. J. Med., | Journal Article
10.1056/NEJM199002223220807
Self Charles J. Malemud
1990
Changes in osteoarthritic cartilage maintained in explant culture: Implications for understanding repair in osteoarthritis.
Malemud, C.J., R. Shuckett and V.M. Goldberg,
Scand. J. Rheumatol., | Journal Article
Self Charles J. Malemud
1989
Proteoglycans synthesized by chondrocytes of human nonarthritic and osteoarthritic cartilage.
Shuckett, R. and C.J. Malemud,
Proc. Soc. Exp. Biol. Med., | Journal Article
10.3181/00379727-190-42860
Self Charles J. Malemud
1989
Quantitation of component proteoglycans during long-term organ explant culture of human osteoarthritic hip cartilage.
Shuckett, R., V.M. Goldberg and C.J. Malemud,
J. Laboratory Clin. Med., | Journal Article
Self Charles J. Malemud
1989
Qualitative changes in human osteoarthritic hip cartilage proteoglycan synthesis during long-term explant culture.
Shuckett, R. and C.J. Malemud,
Mech. Ageing Dev., | Journal Article
10.1016/0047-6374(88)90112-1
Self Charles J. Malemud
1988
Activation of neutral metalloprotease in human osteoarthritic knee cartilage: Evidence for degradation in the core protein of sulphated proteoglycan.
Martel-Pelletier, J., J.P. Pelletier and C.J. Malemud,
Ann. Rheum. Dis., | Journal Article
10.1136/ard.47.10.801
Self Charles J. Malemud
1988
Keratan-sulphate-containing proteoglycans in human osteochondrophytic spurs of the femoral head.
Malemud, C.J., V.M. Goldberg and T.F. Kresina,
Biochem. Int., | Journal Article
Self Charles J. Malemud
1988
Eicosanoid metabolism by Leishmania donovani-infected macrophages: Mouse strain responses in prostanoid synthesis.
Reiner, N.E., L.A. Schultz and C.J. Malemud,
Am. J. Trop. Med. Hyg., | Journal Article
10.4269/ajtmh.1988.38.59
Self Charles J. Malemud
1988
Analysis of experimental immune synovitis cartilage using monoclonal antibodies reactive to rabbit proteoglycan.
Yoo, J.U., T.F. Kresina, C.J. Malemud and V.M. Goldberg,
J. Orthopaedic Res., | Journal Article
10.1002/jor.1100060310
Self Charles J. Malemud
1988
Canine osteoarthritis: Effects of endogenous neutral metalloproteoglycanases on articular cartilage proteoglycans.
Pelletier, J.P., J. Martel‐Pelletier and C.J. Malemud,
J. Orthopaedic Res., | Journal Article
10.1002/jor.1100060309
Self Charles J. Malemud
1988
The proteoglycanase from human cartilage and cultured rabbit chondrocytes and its relation to osteoarthritis.
Sapolsky, S., C. Malemud and M. Sheff,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1987
Structural characteristics of articular cartilage proteoglycan in IgG induced experimental immune synovitis.
Malemud, C.J., J.U. Yoo, V.M. Goldberg and T.F. Kresina,
Ann. Rheumatic Dis., | Journal Article
10.1136/ard.46.7.520
Self Charles J. Malemud
1987
Intact proteoglycan is a polyclonal activator of murine B-lymphocytes.
Siegel, J.N., C.J. Malemud and G.M. Kammer,
Immunol. Lett., | Journal Article
10.1016/0165-2478(87)90043-5
Self Charles J. Malemud
1987
Synthesis of a “free” form of hyaluronic acid by articular chondrocytes in monolayer culture.
Malemud, C.J., V.M. Goldberg and L.M. Miller,
Biochem. Int., | Journal Article
Self Charles J. Malemud
1987
Newly synthesized and endogenous proteoglycans in human osteoarthritic knee cartilage.
Martel-Pelletier, J., J.P. Pelletier, J.M. Cloutier and C.J. Malemud,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1987
Epitopes of proteoglycans eliciting an anti-proteoglycan response in chronic immune synovitis.
Yoo, J.U., T.F. Kresina, C.J. Malemud and V.M. Goldberg,
Proc. Natl. Acad. Sci. USA., | Journal Article
Self Charles J. Malemud
1987
Degradation of extracellular matrix in osteoarthritis: 4 fundamental questions.
Malemud, C.J., J. Martel-Pelletier and J.P. Pelletier,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1987
Proteoglycans from experimental osteoarthritic cartilage: Degradation by neutral metalloproteases.
Pelletier, J.P., J. Martel-Pelletier and C.J. Malemud,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1987
Pathological, biochemical and experimental therapeutic studies in meniscectomy models of osteoarthritis in the rabbit-its relationship to human joint pathology.
Malemud, C.J., V.M. Goldberg and R.W. Moskowitz,
Br. J. Clin. Pract., | Journal Article
Self Charles J. Malemud
1986
Suppression of prostaglandin synthesis by analogues of cyclic AMP and forskolin in chondrocyte monolayer cultures.
Malemud, C.J., T.M. Mills and R.S. Papay,
Prostaglandins, | Journal Article
10.1016/0090-6980(86)90032-8
Self Charles J. Malemud
1986
Rabbit chondrocytes maintained in serum-free medium: I. Synthesis and secretion of hydrodynamically-small proteoglycans.
Malemud, C.J. and R.S. Papay,
Exp. Cell Res., | Journal Article
10.1016/0014-4827(86)90184-9
Self Charles J. Malemud
1986
Analysis of osteoarthritic cartilage using monoclonal antibodies reactive with rabbit proteoglycan.
Kresina, T.F., C.J. Malemud and R.W. Moskowitz,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780290708
Self Charles J. Malemud
1986
Stimulation of sulfated-proteoglycan synthesis by forskolin in monolayer cultures of rabbit articular chondrocytes.
Malemud, C.J., T.M. Mills, R. Shuckett and R.S. Papay,
J. Cell. Physiol., | Journal Article
10.1002/jcp.1041290108
Self Charles J. Malemud
1986
Biosynthesis of heparan sulfate proteoglycans of developing chick breast skeletal muscle in vitro.
Noonan, D.M., D.J. Malemud and R.J. Przybylski,
Exp. Cell Res., | Journal Article
10.1016/0014-4827(86)90480-5
Self Charles J. Malemud
1986
An in vitro model of ageing of human articular cartilage sulphated-proteoglycans.
Shuckett, R. and C.J. Malemud,
Mech. Ageing Dev., | Journal Article
10.1016/0047-6374(86)90106-5
Self Charles J. Malemud
1986
Murine monoclonal antibodies recognizing rabbit proteoglycans.
Kresina, T.F. and C.J. Malemud,
Collagen Relat. Res., | Journal Article
10.1016/S0174-173X(86)80030-9
Self Charles J. Malemud
1986
Secretion of an articular cartilage proteoglycan-degrading enzyme activity by murine T lymphocytes in vitro.
Kammer, G.M., A.I. Sapolsky and C.J. Malemud,
J. Clin. Invest., | Journal Article
10.1172/JCI111985
Self Charles J. Malemud
1985
Arachidonic acid metabolism by murine peritoneal macrophages infected with Leishmania donovani: In vitro evidence for parasite-induced alterations in cyclooxygenase and lipoxygenase pathways.
Reiner, N.E. and C.J. Malemud,
J. Immunol., | Journal Article
Self Charles J. Malemud
1985
Application of new techniques to separation of proteoglycan aggregates from normal and destabilized rabbit articular cartilages.
Manicourt, D., D.S. Howell, R.W. Moskowitz, V. Goldberg, C. Malemud and J.C. Pita,
Acta Biol. Hung., | Journal Article
Self Charles J. Malemud
1984
Susceptibility of interstitial rabbit collagens to rabbit articular chondrocyte collagenase.
Kresina, T.F. and C.J. Malemud,
Collagen Relat. Res., | Journal Article
10.1016/S0174-173X(84)80012-6
Self Charles J. Malemud
1984
Arachidonic acid metabolism in murine leishmaniasis (Donovani): Ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells.
Reiner, N.E. and C.J. Malemud,
Cell. Immunol., | Journal Article
10.1016/0008-8749(84)90181-3
Self Charles J. Malemud
1984
The in vitro cell culture age and cell density of articular chondrocytes alter sulfated-proteoglycan biosynthesis.
Malemud, C.J. and R.S. Papay,
J. Cell. Physiol., | Journal Article
10.1002/jcp.1041210315
Self Charles J. Malemud
1984
Effects of polymethylmethacrylate on rabbit articular chondrocytes in monolayer culture.
Boyd, Jr. A.D., V.M. Goldberg, L.M. Miller and C.J. Malemud,
Clin. Orthop. Relat. Res., | Journal Article
Self Charles J. Malemud
1984
Characterization of newly synthesized proteoglycans from rabbit menisci in organ culture.
Webber, R.J., D.P. Norby, C.J. Malemud, V.M. Goldberg and R.W. Moskowitz,
Biochem. J., | Journal Article
10.1042/bj2210875
Self Charles J. Malemud
1984
Stimulation of cyclic AMP in chondrocyte cultures: Effects on sulfated-proteoglycan synthesis.
Malemud, C.J. and R.S. Papay,
FEBS Lett., | Journal Article
10.1016/0014-5793(84)80154-4
Self Charles J. Malemud
1984
Biosynthesis of sulfated proteoglycan in vitro by cells derived from human osteochondrophytic spurs of the femoral head.
Malemud, C.J., R.W. Moskowitz and V.M. Goldberg,
Connective Tissue Res., | Journal Article
10.3109/03008208409013694
Self Charles J. Malemud
1984
Correlation of histopathology and sulfated proteoglycans in human osteoarthritic hip cartilage.
Goldberg, V.M., D.P. Norby, B.L. Sachs, R.W. Moskowitz and C.J. Malemud,
J. Orthop. Res., | Journal Article
10.1002/jor.1100010310
Self Charles J. Malemud
1983
Arachidonic acid metabolism by rabbit synovial cells in culture: Studies of non-cyclooxygenase pathways.
Rothenberg, R.J., R.W. Moskowitz and C.J. Malemud,
Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., | Journal Article
10.1016/0005-2760(83)90015-2
Self Charles J. Malemud
1983
Phospholipase C activity in plasma membranes isolated from lapine synovial cells in monolayer culture.
Rothenberg, R.J., R.W. Moskowitz and C.J. Malemud,
Biochem. Biophys. Res. Commun., | Journal Article
10.1016/0006-291X(83)91008-2
Self Charles J. Malemud
1983
Buffer induced modification of 6-sulfated disaccharide in chondroitin lyase digestions.
Norby, D.P., V.M. Goldberg, R.W. Moskowitz and C.J. Malemud,
Anal. Biochem., | Journal Article
10.1016/0003-2697(83)90177-X
Self Charles J. Malemud
1983
Estradiol and tamoxifen stimulation of lapine articular chondrocyte prostaglandin synthesis.
Rosner, I.A., C.J. Malemud, A.I. Hassid, V.M. Goldberg, B.A. Boja and R.W. Moskowitz,
Prostaglandins, | Journal Article
10.1016/0090-6980(83)90080-1
Self Charles J. Malemud
1983
A comparison of the proteoglycans produced by rabbit articular chondrocytes in monolyayer and spinner culture and those of bovine nasal cartilage.
Keiser, H.D. and C.J. Malemud,
Connective Tissue Res., | Journal Article
10.3109/03008208309004860
Self Charles J. Malemud
1983
Intraarticular hyaluronic acid injection and synovial prostaglandins in experimental immune synovitis.
Rosner, I.A., B.A. Boja, C.J. Malemud, R.W. Moskowitz and V.M. Goldberg,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1983
'Gelatinase-like' activity from articular chondrocytes in monolayer culture.
Sapolsky, A.I., M.F. Sheff, K. Matsuta, D.S. Howell and R.W. Moskowitz et al.,
Biochim. Biophys. Acta (BBA)-Mol. Cell Res., | Journal Article
10.1016/0167-4889(83)90075-7
Self Charles J. Malemud
1983
Factors influencing metachromatic staining in paraffin-embedded sections of rabbit and human articular cartilage: A comparison of the safranin O and toluidine blue O techniques.
Getzy, L.L., C.J. Malemud, V.M. Goldberg and R.W. Moskowitz,
J. Histotechnol., | Journal Article
10.1179/his.1982.5.3.111
Self Charles J. Malemud
1982
Pathologic and metabolic responses of experimental osteoarthritis to estradiol and an estradiol antagonist.
Rosner, I.A., C.J. Malemud, V.M. Goldberg, R.S. Papay, L. Getzy and R.W. Moskowitz,
Clin. Orthop. Relat. Res., | Journal Article
Self Charles J. Malemud
1982
Biosynthesis of proteoglycan in vitro by cartilage from human osteochondrophytic spurs.
Malemud, C.J., V.M. Goldberg, R.W. Moskowitz, L.L. Getzy, R.S. Papay and D.P. Norby,
Biochem. J., | Journal Article
10.1042/bj2060329
Self Charles J. Malemud
1982
Estradiol receptors in articular chondrocytes.
Rosner, I.A., A. Manni, C.J. Malemud, B. Boja and R.W. Moskowitz,
Biochem. Biophys. Res. Commun., | Journal Article
10.1016/0006-291X(82)91266-9
Self Charles J. Malemud
1982
Tissue and organ culture studies of cartilage.
Getzy, L.L. and C.J. Malemud,
J. Histotechnol., | Journal Article
10.1179/his.1982.5.1.29
Self Charles J. Malemud
1982
Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes.
Malemud, C.J., R.W. Moskowitz and R.S. Papay,
Biochim. Biophys. Acta (BBA)-Gen. Subj., | Journal Article
10.1016/0304-4165(82)90051-4
Self Charles J. Malemud
1982
A histopathologic differentiation of tissue types in human osteoarthritic cartilage.
Sachs, B.L., V.M. Goldberg, L.L. Getzy, R.W. Moskowitz and C.J. Malemud,
J. Rheumatol., | Journal Article
Self Charles J. Malemud
1982
Response of articular chondrocytes to pituitary Fibroblst Growth Factor (FGF).
Sachs, B.L., V.M. Goldberg, R.W. Moskowitz and C.J. Malemud,
J. Cell. Physiol., | Journal Article
10.1002/jcp.1041120109
Self Charles J. Malemud
1982
Physiology of articular cartilage.
Malemud, C.J. and R.W. Moskowitz,
Clin. Rheumatic Dis., | Journal Article
Self Charles J. Malemud
1981
Neutral proteinases from articular chondrocytes in culture that degrade synthetic substrates and cartilage macromolecules.
Malemud, C.J., D.P. Norby, R.W. Moskowitz, V.M. Goldberg, A.I. Sapolsky and D.S. Howell,
Semin. Arthritis Rheumatism, | Journal Article
10.1016/0049-0172(81)90042-1
Self Charles J. Malemud
1981
Metabolic responses of cartilage in experimentally induced osteoarthritis.
Moskowitz, R.W., V.M. Goldberg and C.J. Malemud,
Ann. Rheumatic Dis., | Journal Article
10.1136/ard.40.6.584
Self Charles J. Malemud
1981
Prostaglandin biosynthesis by lapine articular chondrocytes in culture.
Malemud, C.J., R.W. Moskowitz and A. Hassid,
Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., | Journal Article
10.1016/0005-2760(81)90176-4
Self Charles J. Malemud
1981
Neutral proteinases from articular chondrocytes in culture. 2. Metal-dependent latent neutral proteoglycanase and inhibitory activity.
Sapolsky, A.I., C.J. Malemud, D.P. Norby, R.W. Moskowitz, K. Matsuta and D.S. Howell,
Biochim. Biophys. Acta (BBA)-Enzymol., | Journal Article
10.1016/0005-2744(81)90257-6
Self Charles J. Malemud
1981
Neutral proteinases from articular chondrocytes in culture. I. A latent collagenase that degrades human cartilage type II collagen.
Malemud, C.J., D.P. Norby, A.I. Sapolsky, K. Matsuta, D.S. Howell and R.W. Moskowitz,
Biochim. Biophys. Acta (BBA)-Enzymol., | Journal Article
10.1016/0005-2744(81)90336-3
Self Charles J. Malemud
1981
Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides.
Kent, L., C.J. Malemud and R.W. Moskowitz,
Prostaglandins, | Journal Article
10.1016/0090-6980(80)90073-8
Self Charles J. Malemud
1980
Metal-dependent neutral proteoglycanase activity from monolayer-cultured lapine articular chondrocytes.
Malemud, C.J., G.A. Weitzman, D.P. Norby, A.I. Sapolsky and D.S. Howell,
Transl. Res., | Journal Article
Self Charles J. Malemud
1979
Explant culture of human and rabbit articular chondrocytes.
Malemud, C.J., D.P. Norby and L. Sokoloff,
Connective Tissue Res., | Journal Article
10.3109/03008207809152628
Self Charles J. Malemud
1978
The effect of chondrocyte growth factor on membrane transport by articular chondrocytes in monolayer culture.
Malemud, C.J. and L. Sokoloff,
Connective Tissue Res., | Journal Article
10.3109/03008207809152282
Self Charles J. Malemud
1978
The effect of prostaglandins on cultured lapine articular chondrocytes.
Malemud, C.J. and L. Sokoloff,
Prostaglandins, | Journal Article
10.1016/0090-6980(77)90215-5
Self Charles J. Malemud
1977
Species differences in cell culture of mammalian articular chondrocytes.
Webber, R.J., C.J. Malemud and L. Sokoloff,
Calcified Tissue Int., | Journal Article
10.1007/BF02012767
Self Charles J. Malemud
1977
Differences in the collagen types synthesized by lapine articular chondrocytes in spinner and monolayer culture.
Norby, D.P., C.J. Malemud and L. Sokoloff,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780200211
Self Charles J. Malemud
1977
The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin.
Feinstein, G., C.J. Malemud and A. Janoff,
Biochim. Biophys. Acta (BBA)-Enzymol., | Journal Article
10.1016/0005-2744(76)90337-5
Self Charles J. Malemud
1976
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases-a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue.
Janoff, A., G. Feinstein, C.J. Malemud and J.M. Elias,
J. Clin. Invest., | Journal Article
10.1172/JCI108317
Self Charles J. Malemud
1976
Human polymorphonuclear leukocyte elastase and cathepsin G mediate the degradation of lapine articular cartilage proteoglycan.
Malemud, C.J. and A. Janoff,
Ann. N. Y. Acad. Sci., | Journal Article
10.1111/j.1749-6632.1975.tb36051.x
Self Charles J. Malemud
1975
Identification of neutral proteases in human neutrophil granules that degrade articular cartilage proteoglycan.
Malemud, C.J. and A. Janoff,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780180413
Self Charles J. Malemud
1975
Some biological characteristics of a pituitary growth factor (CGF) for cultured lapine articular chondrocytes.
Malemud, C.J. and L. Sokoloff,
J. Cell. Physiol., | Journal Article
10.1002/jcp.1040840203
Self Charles J. Malemud
1974
Preliminary experience with cell culture of human articular chondrocytes.
Srivastava, V.M.L., C.J. Malemud, A.J. Hough, J.H. Bland and L. Sokoloff,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780170209
Self Charles J. Malemud
1974
Chondroid expression by lapine articular chondrocytes in spinner culture following monolayer growth.
Srivastava, V.M.L., C.J. Malemud and L. Sokoloff,
Connective Tissue Res., | Journal Article
10.3109/03008207409152098
Self Charles J. Malemud
1974
A pituitary growth-promoting factor for articular chondrocytes in monolayer culture.
Corvol, M.T., C.J. Malemud and L. Sokoloff,
Endocrinology, | Journal Article
10.1210/endo-90-1-262
Self Charles J. Malemud
1972
Rumalon and serum-free culture of chondrocytes.
Malemud, C.J. and L. Sokoloff,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780150515
Self Charles J. Malemud
1972
Failure of Rumalon to increase sulfate incorporation by articular chondrocytes in monolayer culture.
Malemud, C.J. and L. Sokoloff,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780140616
Self Charles J. Malemud
1971
Sulfate incorporation by articular chondrocytes in monolayer culture.
Sokoloff, L., C.J. Malemud and W.T. Green,
Arthritis Rheumatol., | Journal Article
10.1002/art.1780130203
Self Charles J. Malemud
1970