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Ahmad Hamad Alhowail

Ahmad Hamad Alhowail

LiveDNA ID: 966.30951
55 Publications
0 Editorial Roles
0 Projects

Education

Academic Background
  • Ph.D. Auburn University, USA Drug Discovery and Development | Completed: 2017
  • M.Sc. Auburn University, USA Pharmaceutical Sciences, Pharmacology | Completed: 2014

Publications (55)

Selected Scholarly Contributions
Short-term effects of alcohol detoxification on cardiovascular, hematological, and oxidative stress biomarkers: A prospective cohort study
Ashraf Mahmoud Emara, Anoud Maseer Ateeq Alshammari, Ahmad H. Alhowail, Rehab Mohamed Elgharabawy
PLOS One | Journal Article
Crossref
2026
Reprogramming lysosomal–purinergic crosstalk governs the synergistic attenuation of NLRP3 inflammasome activation by cyclodextrin–P2X7 blockade in diabetic rats
Elsayed A. Elmorsy, Manal Mohamed Hatem, Hamad Alsaykhan, Abdulaziz A. Alsalloom, Mostafa M. Khodeir, Mohammed Alorini, Rabab S. Hamad, Alshaimaa A. Farrag, Mohamed A.M. Ali, Norah Suliman Alsoqih, Omar Almansour, Mariam S. Alharbi, Ahmad H. Alhowail, Hesham Saad Ata, Basem H. Elesawy, Ahmed Sameh, Sameh Saber
European Journal of Pharmacology | Journal Article
Crossref
2026
Engineered exosomal delivery of semaglutide activates SIRT1–FOXO3a–miR-124 signaling and protects against cortical neuroinflammation
Elsayed A. Elmorsy, Sameh Saber, Ahmed Y. Kira, Manal Mohamed Hatem, Mohammed Alorini, Suzan Awad AbdelGhany Morsy, Hamad Alsaykhan, Abdulaziz A. Alsalloom, Nahla B. Mohamed, Norah Suliman Alsoqih, Rabab S. Hamad, Youssef El-Sayed, Nagwa Mahmoud Ramadan, Mostafa M. Khodeir, Ahmad H. Alhowail, Enas A. Mohamed, Amira Karam Khalifa
Journal of Drug Delivery Science and Technology | Journal Article
Crossref
2026
Tirzepatide Ameliorates Renal Dysfunction, Dyslipidemia, and Thyroid Hormone Dysregulation in Diabetic Rats
Amal M. AlRashidi, Ahmad H. Alhowail
International Journal of Pharmacology | Journal Article
Crossref
2026
Sacubitril/Valsartan Fails to Ameliorate Cisplatin-Induced Cognitive Impairment
Abdullah Alshammari, Maha Aldubayan, Ahmad Alwashmi, Ahmad Alhowail
Drug Design, Development and Therapy | Journal Article
Crossref
2026
Effects of Sumatriptan, Baclofen and Gabapentin on Acute and Chronic Neuropathic Pain in a Rat Model of Sciatic Nerve Ligation
Bader Ahmad Algohane, Hussein Mohammad Ali, Ahmad Hamad Alhowail, Mohammed Fulayyih Alharbi, Hossam Abdelkader Elsisi
International Journal of Pharmacology | Journal Article
Crossref
2025
Comparison of Bumetanide, Levetiracetam and Sodium Valproate Effects on Convulsions and Motor Coordination in Experimental Models
Mohammed Fulayyih Alharbi, Hussein Mohammad Ali, Ahmad Hamad Alhowail, Bader Ahmad Algohane, Hossam Abdelkader Elsisi
International Journal of Pharmacology | Journal Article
Crossref
2025
Safety and efficacy of tocilizumab in COVID-19: A systematic evaluation of adverse effects and therapeutic outcomes
Othman AlOmeir, Ahmad H. Alhowail, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq, Rafiulla Gilkaramenthi, Abida Khan, Mohd Imran, Tafadzwa Dzinamarira
Journal of Infection and Public Health | Journal Article
Crossref
2025
Effect of Tirzepatide on Cisplatin and Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity
Ahmad Hamad Alhowail, Maha Abdulrahman Aldubayan, Tahani H. Ibrahim, Khalid Saad Alharbi, Saleh Yasser Almogbel, Ammar Hamad Alhowail, Hanan Mubarak Almutairi, Salma Abdulrahman Alolayan, Malak Salah Alharbi, Amal Mubarak Alrashidi, Syed Imam Rabbani
International Journal of Pharmacology | Journal Article
Crossref
2025
Comparative Analysis of Pioglitazone and Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation, and Oxidative Stress in Diabetic Rats
Ahmad Alhowail, Mohammed Aldawsari, Maha Aldubayan
Drug Design, Development and Therapy | Journal Article
Crossref
2025
Assessing the Influence of Intermittent Alcohol Access on Acrylamide-Induced Neuronal Toxicity in an Experimental Rat Model
Abdulaziz Arif A. Alshammari, Awyed Batah Almutairi, Minhajul Arfeen, Abdullah Saleh Alkhamiss, Maha A. Aldubayan, Ahmad H. Alhowail, Vasudevan Mani
Brain Sciences | Journal Article
Crossref
2024
Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross‐Sectional Analysis
Saud D. AlOtaibi, Hossam A. Elsisi, Mohammed J. AlShammary, Saud A. AlQader, Hejab A. AlHarbi, Bayan R. AlOlaiyan, Ahmad O. Alanazi, Firas S. AlMendeel, Yazeed N. AlHarbi, Ibrahim AlKhalaf, Ahmad H. Alhowail, Abdelhamid Mohamed Elwy, Ashraf M. Emara
Journal of Toxicology | Journal Article
Crossref
2024
Impact of Metformin on Hypothyroidism Induced by Cyclophosphamide in Rats
Ahmad Hamad Alhowail, Maha Abdulrahman Aldubayan
International Journal of Pharmacology | Journal Article
Crossref
2024
Postprandial Antioxidative Response to Ingestion of Formulated Date- and Fruit-Based Nutritional Bars by Healthy Individuals
Manahel A. Alolyan, Hani A. Alfheeaid, Ahmad H. Alhowail, Majed M. Alamri, Modhi S. Alghasham, Nada A. Alzunaidy, Hassan Barakat
Nutrients | Journal Article
Crossref
2024
Pioglitazone Mitigates the Toxic Effect of Doxorubicin-Induced Nephrotoxicity
Ahmad Hamad Alhowail, Maha Abdulrahman Aldubayan, Sattam Khulaif Alenezi, Deem Ibrahim Alyahya, Hanoof Sami Alhumaidi, Lolwah Hamad Alqarawi, Sahab Waleed Alshebel, Hamzah Abdullah Aljabr, Nafea Ayed Alsubaihi, Sulaiman Mohammed Alsultan, Abdulaziz Abdulrrahman Alomary, Yousef Mohammed Alhamda, Mona Fahad Albassam
International Journal of Pharmacology | Journal Article
Crossref
2024
Synergistic Effects of Metformin and Fluorouracil on Cognitive Disability via Inducing Neuroinflammation in Rat Models
Ahmad Hamad Alhowail
International Journal of Pharmacology | Journal Article
Crossref
2024
The Ameliorative Effect of Pioglitazone against Neuroinflammation Caused by Doxorubicin in Rats
May M. Alsaud, Ahmad H. Alhowail, Maha A. Aldubayan, Ibtesam S. Almami
Molecules | Journal Article
Crossref
2023
Protective Effect of Galantamine against Doxorubicin-Induced Neurotoxicity
Rawan S. Alsikhan, Maha A. Aldubayan, Ibtesam S. Almami, Ahmad H. Alhowail
Brain Sciences | Journal Article
Crossref
2023
Comparison of Pioglitazone and Galantamine in Preventing Doxorubicin-Induced Glutamate Receptors mRNA Overexpression
Ahmad Hamad Alhowail, Maha Abdulrahman Aldubayan, Ibtesam Sayedalameen Almami
International Journal of Pharmacology | Journal Article
Crossref
2023
Effect of Various Intermittent Fasting Protocols on Hyperglycemia-Induced Cognitive Dysfunction in Rats
Hani Alfheeaid, Ahmad Alhowail, Faiyaz Ahmed, Abdel Zaki, Areej Alkhaldy
Brain Sciences | Journal Article
Crossref
2023
Development of Diphenyl carbonate-Crosslinked Cyclodextrin Based Nanosponges for Oral Delivery of Baricitinib: Formulation, Characterization and Pharmacokinetic Studies
Mohammed F Aldawsari, Ahmad H Alhowail, Md Khalid Anwer, Mohammed Muqtader Ahmed
International Journal of Nanomedicine | Journal Article
Crossref
2023
Pioglitazone and Metformin on Improving Cognitive Dysfunction Caused by Diabetes Mellitus: A Comparative Study
Ahmad Alhowail, Abdullah Alomran, Naif Alqefari, Maha Aldubayan, Sattam Alenezi
International Journal of Pharmacology | Journal Article
Crossref
2023
Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase
Mohamed S. Abdel-Bakky, Anas S. A. Aldakhili, Hussein M. Ali, Ali Y. Babiker, Ahmad H. Alhowail, Salman A. A. Mohammed
Pharmaceuticals | Journal Article
Crossref
2023
Comparative Analysis of the Cardiotoxic Effects Induced by Various Chemotherapeutic Agents
Ahmad Alhowail, Maha Aldubayan
International Journal of Pharmacology | Journal Article
Crossref
2023
The Impact of Metformin on the Development of Hypothyroidism and Cardiotoxicity Induced by Cyclophosphamide, Methotrexate, and Fluorouracil in Rats
Ahmad H. Alhowail, Maha A. Aldubayan
Pharmaceuticals | Journal Article
Crossref
2023
Phenyl-2-aminoethyl selenide ameliorates hippocampal long-term potentiation and cognitive deficits following doxorubicin treatment
Ahmad H. Alhowail, Matthew Eggert, Jenna Bloemer, Priyanka D. Pinky, Lauren Woodie, Subhrajit Bhattacharya, Dwipayan Bhattacharya, Manal A. Buabeid, Bruce Smith, Muralikrishnan Dhanasekaran, Gary Piazza, Miranda N. Reed, Martha Escobar, Robert D. Arnold, Vishnu Suppiramaniam
PLOS ONE | Journal Article
Crossref
2023
Natural and Synthetic Agents Targeting Reactive Carbonyl Species against Metabolic Syndrome
Tapan Behl, Amit Gupta, Sridevi Chigurupati, Sukhbir Singh, Aayush Sehgal, Vishnu Nayak Badavath, Ahmad Alhowail, Vasudevan Mani, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau
Molecules | Journal Article
Crossref
2022
Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature
Ahmad Alhowail, Rawan Alsikhan, May Alsaud, Maha Aldubayan, Syed Imam Rabbani
Drug Design, Development and Therapy | Journal Article
Crossref
2022
Mechanisms Underlying Cognitive Impairment Induced by Prenatal Alcohol Exposure
Ahmad Alhowail
Brain Sciences | Journal Article
Crossref
2022
Phytochemical Analysis, Pharmacological and Safety Evaluations of Halophytic Plant, Salsola cyclophylla
Hamdoon A. Mohammed, Mohsen S. Al-Omar, Salman A. A. Mohammed, Ahmad H. Alhowail, Hussein M. Eldeeb, Mohammed S. M. Sajid, Essam M. Abd-Elmoniem, Osama A. Alghulayqeh, Yasser I. Kandil, Riaz A. Khan
Molecules | Journal Article
Crossref
2021
Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice
Vasudevan Mani, Minhajul Arfeen, Hussein M. Ali, Abdel-Moneim Hafez Abdel-Moneim, Maha Aldubayan, Ahmad Alhowail
Brain Sciences | Journal Article
Crossref
2021
Bacterial endosymbiont inhabiting Leucaena leucocephala leaves and their antioxidant and antidiabetic potential
Sridevi Chigurupati, Shantini Vijayabalan, Kesavanarayanan Krishnan Selvarajan, Ahmad Alhowail, Fatema Kauser
Journal of Complementary and Integrative Medicine | Journal Article
Crossref
2021
Factors Affecting the Incidence, Progression, and Severity of COVID‐19 in Type 1 Diabetes Mellitus
Amira S. Ahmed, Wejdan S. Alotaibi, Maha A. Aldubayan, Ahmad H. Alhowail, Amal H. Al-Najjar, Sridevi Chigurupati, Rehab M. Elgharabawy
BioMed Research International | Journal Article
Crossref
2021
Pharmacological and pharmacognostical valuation of Canna indica leaves extract by quantifying safety profile and neuroprotective potential.
Chigurupati, S., N.A.R. Alharbi, A.K. Sharma, A. Alhowail and V.R. Vardharajula et al.,
Saudi J. Bio. Sci., | Journal Article
Self Ahmad Hamad Alhowail
2021
Loss of RAR-α and RXR-α and enhanced caspase-3-dependent apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent.
Abdel-Bakky, M.S., G.K. Helal, E.S.M. El-Sayed, E. Amin and A. Alqasoumi et al.,
Korean J. Physiol. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2021
The effect of depression on treatment adherence among a sample of Saudi patients diagnosed with acne vulgaris.
Alghofaili, A., S. Alolayan, A. Alhowail, M.A. Mobark, S. Alderaibi and Y. Almogbel,
Clin., Cosmet. Invest. Dermatol., | Journal Article
Self Ahmad Hamad Alhowail
2021
Linking COVID-19 and parkinson`s disease: targeting the role of vitamin-d.
Behl, T., S. Kumar, A. Sehgal, S. Singh and N. Sharma et al.,
Biochem. Biophys. Res. Commun., | Journal Article
Self Ahmad Hamad Alhowail
2021
Antimicrobial Exploration Between Counterpart Endosymbiont and Host Plant (Tamarindus indica Linn.)
Sridevi Chigurupati, Shantini Vijayabalan, Kesavanarayanan K. Selvarajan, Maha Aldubayan, Ahmad Alhowail, Vasudevan Mani, Suprava Das
Current Pharmaceutical Biotechnology | Journal Article
Crossref
2020
Effect of Metformin on Doxorubicin-Induced Memory Dysfunction
Ibrahim Alharbi, Hindi Alharbi, Yasser Almogbel, Abdullah Alalwan, Ahmad Alhowail
Brain Sciences | Journal Article
Crossref
2020
Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats
Shatha G. Felemban, Maha A. Aldubayan, Ahmad H. Alhowail, Ibtesam S. Almami
Oxidative Medicine and Cellular Longevity | Journal Article
Crossref
2020
Phytochemical composition, antioxidant and antidiabetic potential of methanolic extract from Corchorus olitorius linn. grown in Saudi Arabia.
Chigurupati, S., H.S. Aladhadh, A. Alhowail, K.K. Selvarajan and S. Bhatia,
Medic. Plants Int. J. Phytomedicines Related Ind., | Journal Article
Self Ahmad Hamad Alhowail
2020
Ameliorative effect of Terminalia chebula on hematological complications induced by doxorubicin.
M, A., A. Alhowail, M. Aldubayan and R. SI,
Biomed. Pharmacol. J., | Journal Article
Self Ahmad Hamad Alhowail
2020
Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury.
Abdel-Bakky, M.S., G.K. Helal, E.M. El-Sayed, A.H. Alhowail and A.M. Mansour et al.,
Naunyn-Schmiedeberg`s Arch. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2020
Silver citrate nanoparticles inhibit PMA-induced TNFα expression via deactivation of NF-κB activity in human cancer cell-lines, MCF-7.
Abdellatif, A.A., Z. Rasheed, A.H. Alhowail, A. Alqasoumi and M. Alsharidah et al.,
Int. J. Nanomed., | Journal Article
Self Ahmad Hamad Alhowail
2020
Mahanimbine-induced neuroprotection via cholinergic system and attenuated amyloidogenesis as well as neuroinflammation in lipopolysaccharides-induced mice.
Azahan, N.S.M., V. Mani, K. Ramasamy, S.M. Lim and R.M.J. James et al.,
Pharmacogn. Mag., | Journal Article
Self Ahmad Hamad Alhowail
2020
Anthocyanins rich pomegranate cream as a topical formulation with anti-aging activity.
Abdellatif, A.A.H., S.H. Alawadh, A. Bouazzaoui, A.H. Alhowail and H.A. Mohammed,
J. Dermatolog. Treat., | Journal Article
Self Ahmad Hamad Alhowail
2020
Effect of acute chemotherapy on glucose levels in rats.
Alhowail, A.H., G.S. Alfawzan, M.A. Aldubayan and L.S. Alsalamah,
Int. J. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2020
Effects of metformin on the survival rate of CMF (cyclophosphamide, methotrexate and 5-fluorouracil)-treated rats.
Alhowail, A., M. Aldubayan, A. Alqasomi, I. Alharbi and H. Alharbi,
Int. J. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2020
Effect of warfarin treatment on memory function in mice.
Alhowail, A.H., S.I. Rabbani, I.F. Alharbi, H.S. Alharbi and R.S. Alharbi,
Int. J. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2020
Ciprofloxacin produces memory deficits in male mice.
Alhowail, A.H.,
Int. J. Pharmacol., | Journal Article
Self Ahmad Hamad Alhowail
2020
Formulation of Ethyl Cellulose Microparticles Incorporated Pheophytin A Isolated from Suaeda vermiculata for Antioxidant and Cytotoxic Activities
Hamdoon A. Mohammed, Mohsen S. Al-Omar, Mahmoud Zaki El-Readi, Ahmad H. Alhowail, Maha A. Aldubayan, Ahmed A. H. Abdellatif
Molecules | Journal Article
Crossref
2019
Metformin administration increases the survival rate of doxorubicin-treated mice.
Alhowail, A. and Y. Almogbel,
Die Pharm., | Journal Article
Self Ahmad Hamad Alhowail
2019
Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation.
Alhowail, A.H., J. Bloemer, M. Majrashi, P.D. Pinky and S. Bhattacharya et al.,
Toxicol. Mech. Methods, | Journal Article
Self Ahmad Hamad Alhowail
2019
Altered AMPA receptor expression plays an important role in inducing bidirectional synaptic plasticity during contextual fear memory reconsolidation.
Bhattacharya, S., W. Kimble, M. Buabeid, D. Bhattacharya and J. Bloemer et al.,
Neurobiol. Learning Memory, | Journal Article
Self Ahmad Hamad Alhowail
2017
Peripherally restricted viral challenge elevates extracellular glutamate and enhances synaptic transmission in the hippocampus.
Hunsberger, H.C., D. Wang, T.J. Petrisko, A. Alhowail and S.E. Setti et al.,
J. Neurochem., | Journal Article
Self Ahmad Hamad Alhowail
2016