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Chandrahas Koumar Ratnacaram

Chandrahas Koumar Ratnacaram

LiveDNA ID: 91.34409
14 Publications
0 Editorial Roles
0 Projects

About

Professional Summary

I received my Ph.D. from Department of Zoology (Biochemistry and Molecular biology Lab), BHU, Varanasi in 2004 where I explored the mechanisms of differential gene regulation by Androgen Receptor promoter during aging in the mouse brain cortex under Prof. M.K. Thakur. Having gained experience in Molecular Neurobiology, I joined as a postdoc under Prof. V. Ravindranath at NBRC, Manesar where I studied the role of Estrogens as neuroprotectors for Parkinson’s and Alzheimer’s disease.

Thereafter, I joined as a postdoc under Prof. Pierre Chambon/Prof. Daniel Metzger at IGBMC, Strasbourg, France to work on the role of nuclear receptors in Prostate Cancer and to develop and validate mouse models that mimic the kinetics of human prostate cancer progression. Subsequently, I moved to A*STAR IMCB, as a research fellow to investigate the role of Cdks in Meiosis and epigenetic modifiers in Head and Neck and Gastric cancer and had profiled patient tumors for pre-clinical testing of chemotherapeutic agents using PDX. Thereafter I joined as an Associate Professor at YRC in 2018 to continue working on Epigenetics and Cancer Biology.

Education

Academic Background
  • Ph.D. Banaras Hindu University, India Biochemistry and Molecular Biology | Completed: 2004
  • M.Sc. Pondicherry Central Unversty, India Life Sciences | Completed: 1996
  • B.Sc. Pondicherry Central Unversty, India Zoology, Botany, Chemistry | Completed: 1994

Publications (14)

Selected Scholarly Contributions
Splicing: A New Dimension in Decoding the Complex Traits for Cervical Cancer
Varsha Sai B, Ashwini Prabhu, Ratnacaram Chandrahas Koumar
Current Cancer Drug Targets | Journal Article
Crossref
2026
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Asrarunissa Kalmatte, Punchappady Devasya Rekha, Chandrahas Koumar Ratnacaram
Molecular Biology Reports | Journal Article
Crossref
2023
Repertoires of MicroRNA-30 family as gate-keepers in lung cancer.
Kanthaje, S., N. Baikunje, I. Kandal and C.K. Ratnacaram,
Front. Biosci. (Schol Ed), | Journal Article
Self Chandrahas Koumar Ratnacaram
2021
CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.
Palmer, N., S.Z.A. Talib, C.K. Ratnacaram, D. Low and X. Bisteau et al.,
J. Cell Biol., | Journal Article
Self Chandrahas Koumar Ratnacaram
2019
CDK2 catalytic activity is essential for meiotic cell division in vivo.
Chauhan, S., M.K. Diril, J.H.S. Lee, X. Bisteau and V. Manoharan et al.,
Biochem. J., | Journal Article
Self Chandrahas Koumar Ratnacaram
2016
Antisense oligonucleotideu2013mediated MDM4 exon 6 skipping impairs tumor growth.
Dewaele, M., T. Tabaglio, K. Willekens, M. Bezzi and S.X. Teo et al.,
J. Clin. Invest., | Journal Article
Self Chandrahas Koumar Ratnacaram
2015
Cyclin-dependent kinase 1 (CDK1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.
Diril, M.K., C.K. Ratnacaram, V.C. Padmakumar, T. Du and M. Wasser et al.,
Proc. Nat. Acad. Sci., | Journal Article
Self Chandrahas Koumar Ratnacaram
2012
Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection.
Saeed, U., S. Karunakaran, D.P. Meka, R.C. Koumar and S. Ramakrishnan et al.,
Neurotoxic. Res., | Journal Article
Self Chandrahas Koumar Ratnacaram
2009
Temporally controlled ablation of pten in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.
Ratnacaram, C.K., M. Teletin, M. Jiang, X. Meng, P. Chambon and D. Metzger,
Proc. Nat. Acad. Sci., | Journal Article
Self Chandrahas Koumar Ratnacaram
2008
17u03b2-estradiol modulates age-dependent binding of 40 kDa nuclear protein to androgen receptor promoter in mouse cerebral cortex.
Thakur, M.K. and R.C. Kumar,
Biogerontology, | Journal Article
Self Chandrahas Koumar Ratnacaram
2007
Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain.
Karunakaran, S., U. Saeed, S. Ramakrishnan, R.C. Koumar and V. Ravindranath,
Brain Res., | Journal Article
Self Chandrahas Koumar Ratnacaram
2007
Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain.
Kumar, R.C. and M.K. Thakur,
Neurobiol. Aging, | Journal Article
Self Chandrahas Koumar Ratnacaram
2004
Sex steroids reduce DNAsei accessibility of androgen receptor promoter in adult male mice brain.
Kumar, R.C. and M.K. Thakur,
Mol. Brain Res., | Journal Article
Self Chandrahas Koumar Ratnacaram
2004
Age- and sex-related expression of norbin in the brain cortex of mice.
Mani, S.T., R.C. Kumar and M.K. Thakur,
Neurosci. Lett., | Journal Article
Self Chandrahas Koumar Ratnacaram
2001