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Kexin Liu

Kexin Liu

LiveDNA ID: 86.9777
45 Publications
0 Editorial Roles
0 Projects

About

Professional Summary

Dr. Kexin Liu received his B.S. degree in Clinical Medicine and M.S. degree in Pharmacology from Dalian Medical University in China and Ph.D. degree in Pharmacy in The University of Tokyo (Laboratory of Yuichi Sugiyama, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences) in Japan. The focus of his research is on the Molecular Pharmacokinetics of Transport in Liver, Intestine, Kidney as well as Transporter-Mediated DDI and MDR. Dr. Kexin Liu is a coauthor of more than 180 publications in international journals such as Hepatology, Drug Metab Dispos, J Pharmacol Exp Ther, Am J Physiol, Pharm Res, Toxical Appl Pharm, Biochem Pharmacol and 50 book chapters as well as 30 review articles. He serves as a Vice President of CSSX from 2005 and a Dean in College of Pharmacy in Dalian Medical University from 2004-2015.

Education

Academic Background
  • Ph.D. The University of Tokyo, Japan Pharmacy | Completed: 2006

Publications (45)

Selected Scholarly Contributions
Rhizoma dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Jin, Y., K. Liu, J. Peng, C. Wang, L. Kang, N. Chang and H. Sun,
Toxicol. Lett., | Journal Article
10.1016/j.toxlet.2014.10.006
Self Kexin Liu
2015
Novel dual small-molecule HIV inhibitors: Scaffolds and discovery strategies.
Song, A., H. Yu, C. Wang, X. Zhu, K. Liu and X. Ma,
Curr. Pharmaceut. Des., | Journal Article
Self Kexin Liu
2015
Potent effects of the total saponins from Dioscorea nipponica makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Yu, H., L. Zheng, L. Xu, L. Yin and Y. Lin et al.,
Phytother. Res., | Journal Article
10.1002/ptr.5243
Self Kexin Liu
2015
Alpha-lipoic acid promotes osteoblastic formation in H2O2-treated MC3T3-E1 cells and prevents bone loss in ovariectomized rats.
Fu, C., D. Xu, C.Y. Wang, Y. Jin and Q. Liu et al.,
J. Cell. Physiol., | Journal Article
10.1002/jcp.24947
Self Kexin Liu
2015
Regioselective glucuronidation of andrographolide and its major derivatives: Metabolite identification, isozyme contribution and species differences.
Tian, X., S. Liang, C. Wang, B. Wu and G. Ge et al.,
AAPS J., | Journal Article
10.1208/s12248-014-9658-8
Self Kexin Liu
2015
Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.
Lin, M., X. Zhai, G. Wang, X. Tian and D. Gao et al.,
J. Pharmacol. Sci., | Journal Article
10.1016/j.jphs.2014.12.010
Self Kexin Liu
2015
Sulfation of melatonin: Enzymatic characterization, differences of organs, species and genders and bioactivity variation.
Tian, X., X. Huo, P. Dong, B. Wu and X. Wang et al.,
Biochem. Pharmacol., | Journal Article
10.1016/j.bcp.2015.02.010
Self Kexin Liu
2015
Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1 and EL expression via the NF-κB pathway.
Wu, S., H. Xu, J. Peng, C. Wang and Y. Jin et al.,
Biochimie, | Journal Article
10.1016/j.biochi.2014.12.022
Self Kexin Liu
2015
Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.
Tao, X., X. Sun, L. Yin, X. Han and L. Xu et al.,
Free Radical Biol. Med., | Journal Article
10.1016/j.freeradbiomed.2015.03.003
Self Kexin Liu
2015
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.
Chen, T., C. Wang, Q. Liu, Q. Meng and H. Sun et al.,
Cancer Biol. Therapy, | Journal Article
10.4161/15384047.2014.987062
Self Kexin Liu
2015
Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis.
Meng, Q., X.L. Chen, C.Y. Wang, Q. Liu and H.J. Sun et al.,
Toxicol. Applied Pharmacol., | Journal Article
10.1016/j.taap.2015.01.020
Self Kexin Liu
2015
Decreased liver distribution of entecavir is related to down-regulation of Oat2/Oct1 and up-regulation of Mrp1/2/3/5 in rat liver fibrosis.
Xu, Q., C. Wang, Q. Liu, Q. Meng and H. Sun et al.,
Eur. J. Pharmaceut. Sci., | Journal Article
10.1016/j.ejps.2015.02.010
Self Kexin Liu
2015
Protective effects of alisol B 23-acetate from an edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice.
Meng, Q., X. Chen, C. Wang, Q. Liu and H. Sun et al.,
Food Funct., | Journal Article
10.1039/C5FO00082C
Self Kexin Liu
2015
Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.
Chen, X., Q. Meng, C. Wang, Q. Liu and H. Sun et al.,
Pharmaceut. Res., | Journal Article
10.1007/s11095-014-1483-3
Self Kexin Liu
2015
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu, H., L. Zheng, L. Yin, L. Xu and Y. Qi et al.,
Int. Immunopharmacol., | Journal Article
10.1016/j.intimp.2014.01.019
Self Kexin Liu
2014
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Chen, H., L. Xu, L. Yin, Y. Xu and X. Han et al.,
Proteomics, | Journal Article
10.1002/pmic.201300101
Self Kexin Liu
2014
Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.
Li, L., D. Xiang, S. Shigdar, W. Yang and Q. Li et al.,
Int. J. Nanomed., | Journal Article
10.2147/IJN.S59779
Self Kexin Liu
2014
Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury.
Yan, H., Y. Jihong, Z. Feng, X. Xiaomei and Z. Xiaohan et al.,
Crit. Care Med., | Journal Article
10.1097/CCM.0000000000000246
Self Kexin Liu
2014
Luteolin protects HUVECs from TNF-α-induced oxidative stress and inflammation via its effects on the Nox4/ROS-NF-κB and MAPK pathways.
Xia, F., C. Wang, Y. Jin, Q. Liu, Q. Meng, K. Liu and H. Sun,
J. Atheroscler. Thromb., | Journal Article
10.5551/jat.23697
Self Kexin Liu
2014
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong, D., L. Xu, X. Han, Y. Qi and Y. Xu et al.,
Molecules, | Journal Article
10.3390/molecules19067189
Self Kexin Liu
2014
Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway.
Wang, G., Z. Chen, F. Zhang, H. Jing and W. Xu et al.,
Apoptosis, | Journal Article
10.1007/s10495-014-1008-x
Self Kexin Liu
2014
iTRAQ-based proteomics for studying the effects of dioscin against nonalcoholic fatty liver disease in rats.
Xu, L., Y. Wei, D. Dong, L. Yin and Y. Qi et al.,
RSC Adv., | Journal Article
10.1039/C4RA03948C
Self Kexin Liu
2014
Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium.
Xu, L., C.Y. Wang, L. Lv, K.X. Liu, H.J. Sun and G.Z. Han,
Pharmacol. Rep., | Journal Article
10.1016/j.pharep.2014.05.013
Self Kexin Liu
2014
Preparation and characterization of curcumin thermosensitive hydrogels for intratumoral injection treatment.
Gao, M., H. Xu, C. Zhang, K. Liu and X. Bao et al.,
Drug Dev. Ind. Pharm., | Journal Article
10.3109/03639045.2013.838579
Self Kexin Liu
2014
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-Κ B and PI3K/Akt pathways.
Li, W., C. Wang, J. Peng, J. Liang and Y. Jin et al.,
Curr. Pharmaceut. Biotechnol., | Journal Article
Self Kexin Liu
2014
Bioactive metabolites of Schisanlactone E transformed by Cunninghamella blakesleana AS 3.970.
Mai, Z.P., C. Wang, Y. Wang, H.L. Zhang and B.J. Zhang et al.,
Fitoterapia, | Journal Article
10.1016/j.fitote.2014.10.016
Self Kexin Liu
2014
Methotrexate-bestatin interaction: Involvement of P-glycoprotein and organic anion transporters in rats.
Zhu, Y., Q. Meng, C. Wang, Q. Liu and X. Huo et al.,
Int. J. Pharmaceut., | Journal Article
10.1016/j.ijpharm.2014.02.020
Self Kexin Liu
2014
Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: Application to identify the function of the PEPT1 transfected cell.
Guo, X., Q. Meng, Q. Liu, C. Wang and X. Huo et al.,
Biomed. Chromatogr., | Journal Article
10.1002/bmc.3228
Self Kexin Liu
2014
MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate.
Liu, Q., C. Wang, Q. Meng, X. Huo and H. Sun et al.,
Pharmaceut. Res., | Journal Article
10.1007/s11095-013-1235-9
Self Kexin Liu
2014
The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney.
Xu, Q., C. Wang, Q. Meng, Q. Liu and P. Sun et al.,
Eur. J. Pharmaceut. Sci., | Journal Article
10.1016/j.ejps.2013.10.010
Self Kexin Liu
2014
OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human.
Sun, P., C. Wang, Q. Liu, Q. Meng and A. Zhang et al.,
Pharmacol. Rep., | Journal Article
10.1016/j.pharep.2014.02.013
Self Kexin Liu
2014
Inhibitory effect of valsartan on the intestinal absorption and renal excretion of bestatin in rats.
Huo, X., Q. Liu, C. Wang, Q. Meng and H. Sun et al.,
J. Pharmaceut. Sci., | Journal Article
10.1002/jps.23805
Self Kexin Liu
2014
Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.
Wang, L., C. Wang, J. Peng, Q. Liu and Q. Meng et al.,
Toxicol. Applied Pharmacol., | Journal Article
10.1016/j.taap.2014.03.013
Self Kexin Liu
2014
Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat.
Wang, C., C. Wang, Q. Liu, Q. Meng and J. Cang et al.,
Drug Metab. Dispos., | Journal Article
10.1124/dmd.113.055194
Self Kexin Liu
2014
PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats and in vitro in human.
Wang, L., C. Wang, Q. Liu, Q. Meng and X. Huo et al.,
Eur. J. Pharmaceut. Sci., | Journal Article
10.1016/j.ejps.2014.06.019
Self Kexin Liu
2014
Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor.
Meng, Q., X. Chen, C. Wang, Q. Liu and H. Sun et al.,
Biochem. Pharmacol., | Journal Article
10.1016/j.bcp.2014.09.009
Self Kexin Liu
2014
Pharmacokinetic interactions between herbal medicines and prescribed drugs: Focus on drug metabolic enzymes and transporters.
Meng, Q. and K. Liu,
Curr. Drug Metab., | Journal Article
Self Kexin Liu
2014
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
Ye, J., Q. Liu, C. Wang, Q. Meng and H. Sun et al.,
Pharmacol. Rep., | Journal Article
10.1016/S1734-1140(13)71026-0
Self Kexin Liu
2013
OAT1 and OAT3: Targets of drug-drug interaction between entecavir and JBP485.
Xu, Q., C. Wang, Q. Meng, Q. Liu and H. Sun et al.,
Eur. J. Pharmaceut. Sci., | Journal Article
10.1016/j.ejps.2012.12.024
Self Kexin Liu
2013
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
Zhang, A., C. Wang, Q. Liu, Q. Meng and J. Peng et al.,
Drug Metab. Dispos., | Journal Article
10.1124/dmd.112.049452
Self Kexin Liu
2013
JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.
Guo, X., Q. Meng, Q. Liu, C. Wang and H. Sun et al.,
Toxicol. Applied Pharmacol., | Journal Article
10.1016/j.taap.2013.04.029
Self Kexin Liu
2013
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.
Wang, L., Q. Meng, C. Wang, Q. Liu and J. Peng et al.,
J. Nat. Prod., | Journal Article
10.1021/np400071c
Self Kexin Liu
2013
The transporters of intestinal tract and techniques applied to evaluate interactions between drugs and transporters.
Liu, Z. and K. Liu,
Asian J. Pharmaceut. Sci., | Journal Article
10.1016/j.ajps.2013.07.020
Self Kexin Liu
2013
Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin.
Huo, X., Q. Liu, C. Wang, Q. Meng and H. Sun et al.,
Eur. J. Pharmaceut. Sci., | Journal Article
10.1016/j.ejps.2013.08.010
Self Kexin Liu
2013
Inhibitory effect of 1α,25-dihydroxyvitamin D3 on excretion of JBP485 via organic anion transporters in rats.
Miao, Q., Q. Liu, C. Wang, Q. Meng and X. Guo et al.,
Eur. J. Pharm. Sci., | Journal Article
10.1016/j.ejps.2012.11.008
Self Kexin Liu
2013