About
Professional SummaryDr. Haiyun Xu is currently working as Professor at Department of Anatomy and Mental Health Center, Shantou University Medical College. She obtained her PhD in Department of Anatomy from Peking Union Medical College, China in 1996. She is also working as Executive Director at University of Manitoba and member of Academic Committee of the Shantou University Medical College. Dr. Haiyun received honor includes, Laura E. Chapman Award, Saskatchewan Psychiatry Research Foundation, W.G. Dewhurst Award, Canadian College of Neuro Psychopharmacology, Molstad Trust Intramural Research Award, U of S, W.G. Dewhurst Award, CCNP, and Post Award Winner, Seroquel ISS Investigators Meeting. She is also member of editorial board in number of journals. She is also serving as reviewer of many journals. She also invited to deliver lecturers in several Institutes. She has published (47) articles in journals, (2) chapters in book, (43) presentations in conferences, and reviewer of (3) articles contributed as author/co-author.
Education
Academic Background-
Ph.D. Peking Union Medical College, China Neurobiology | Completed: 1996
Publications (84)
Selected Scholarly Contributions
Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells
2024
Review of: "Insomnia Prevalence and Mental Health Correlates Among 18,646 Users of an Internet-Based Cognitive-Behavioral Therapy Website: Archival Real-World Data from the United States, 2017-2019"
2024
Hypercoagulable state in patients with schizophrenia: different effects of acute and chronic antipsychotic medications
2023
Application of a Digital Mental Health Clinic in Secondary Schools: Functionality and Effectiveness Evaluation (Preprint)
2023
Regulatory T cells mediate insomnia-related psychotic symptoms and cognitive impairment in chronic schizophrenia patients
2023
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment
2023
Application of a Digital Mental Health Clinic in Secondary Schools: Functionality and Effectiveness Evaluation
2023
Artesunate reverses clozapine-induced lipid metabolism disorder in BRL-3A cells by effecting AMPK pathway.
Haiyun Xu
2023
The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia
2022
Neuron-glia Integrity: Functional Assessment, Molecular Underpinnings, and Implication for Higher Brain Functions
2020
Maternal separation with early weaning impairs neuron-glia integrity: non-invasive evaluation and substructure demonstration
2020
The long-term effects of adolescent social defeat stress on oligodendrocyte lineage cells and neuroinflammatory mediators in mice.
Haiyun Xu
2020
COVID-19 infection outbreak increases anxiety level of general public in China: Involved mechanisms and influencing factors.
Haiyun Xu
2020
Neuroinflammation and anti-inflammation treatment in psychiatric disorders.
Haiyun Xu
2019
Atypical antipsychotics-induced metabolic syndrome and nonalcoholic fatty liver disease: A critical review.
Haiyun Xu
2019
Advances in the study of neurobiological mechanisms underlying the increased risk for anxiety and depression in the adults with experience of early-life maternal separation.
Haiyun Xu
2019
Chemical exchange saturation transfer and its application in human brain imaging.
Haiyun Xu
2018
Involvement of family environmental, behavioral and social functional factors in children with attention-deficit/hyperactivity disorder.
Haiyun Xu
2018
Adenosine promotes the recovery of mice from the cuprizone-induced behavioral and morphological changes while effecting on microglia and inflammatory cytokines in the brain.
Haiyun Xu
2018
Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients.
Haiyun Xu
2018
N‐acetylcysteine attenuates the cuprizone‐induced behavioral changes and oligodendrocyte loss in male C57BL/7 mice via its anti‐inflammation actions.
Haiyun Xu
2018
The research progress on the heterogeneity of bipolar disorder and major depressive disorder.
Haiyun Xu
2017
Chronic administration of haloperidol and working memory: Roles of caudate putamen dopamine receptors.
Haiyun Xu
2017
Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides.
Haiyun Xu
2017
The comorbidity of bipolar disorder, diabetes mellitus, and autoimmune hypothyroidism in an adult woman with Turner’s syndrome: A case report.
Haiyun Xu
2017
Attention-deficit hyperactivity disorder in elementary school students in Shantou, China: Prevalence, subtypes and influencing factors.
Haiyun Xu
2017
The neuroinflammation mechanisms of schizophrenia.
Haiyun Xu
2016
Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders.
Haiyun Xu
2016
Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model.
Haiyun Xu
2016
The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats.
Haiyun Xu
2016
Differential neurometabolite alterations in brains of medication‐free individuals with bipolar disorder and those with unipolar depression: A two‐dimensional proton magnetic resonance spectroscopy study.
Haiyun Xu
2016
Neuroinflammation in schizophrenia focused on the pharmacological and therapeutic evidence.
Haiyun Xu
2015
Differential imbalances of brain glutamate/GABA in patients with bipolar disorder and unipolar depression.
Haiyun Xu
2015
Quetiapine mitigates the ethanol-induced oxidative stress in brain tissue, but not in the liver, of the rat.
Haiyun Xu
2015
Quetiapine mitigates the neuroinflammation and oligodendrocyte loss in the brain of C57BL/6 mouse following cuprizone exposure for one week.
Haiyun Xu
2015
The cuprizone-induced changes in 1H-MRS metabolites and oxidative parameters in C57BL/6 mouse brain: Effects of quetiapine.
Haiyun Xu
2015
Evolution of blood-brain barrier damage associated with changes in brain metabolites following acute ischemia.
Haiyun Xu
2015
Double encephalitis with herpes simplex virus type II and cytomegalovirus in an elder Chinese: A case report.
Haiyun Xu
2015
Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus.
Haiyun Xu
2015
Changes in proinflammatory cytokines and white matter in chronically stressed rats.
Haiyun Xu
2015
The progress in the application of rTMS for the treatment of schizo-phrenia.
Haiyun Xu
2014
Olanzapine ameliorates neuropathological changes and increases IGF-1 expression in frontal cortex of C57BL/6 mice exposed to cuprizone.
Haiyun Xu
2014
Concurrent changes in 1H-MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: Possible implications for schizophrenia.
Haiyun Xu
2014
Fluoxetine improves behavioral performance by suppressing the production of soluble β-Amyloid in APP/PS1 mice.
Haiyun Xu
2014
Brain metabolite changes in subcortical regions after exposure to cuprizone for 6 weeks: Potential implications for schizophrenia.
Haiyun Xu
2014
The progresses in psychiatric research and prospects for their translation.
Haiyun Xu
2013
Locomotor activity and anxiety status, but not spatial working memory are affected in mice after brief exposure to cuprizone.
Haiyun Xu
2013
Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2.
Haiyun Xu
2013
Interleukin-1β inhibits the differentiation of hippocampal neural precursor cells into serotonergic neurons.
Haiyun Xu
2013
2012
A multi-scale Bayesian hypothesis testing approach for the analysis of prepulse inhibition test.
Haiyun Xu
2012
Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination.
Haiyun Xu
2012
Haloperidol-induced spatial memory deficits are accompanied with the upregulation of D1 and D2 receptors in the caudate putamen of C57BL/6 mouse.
Haiyun Xu
2012
Weighted kernel density estimation of the prepulse inhibition test.
Haiyun Xu
2011
Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice.
Haiyun Xu
2010
Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain.
Haiyun Xu
2010
Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia.
Haiyun Xu
2009
Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.
Haiyun Xu
2009
Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
Haiyun Xu
2009
Quetiapine alleviates the cuprizone-induced demyelination and promotes the remyelination following withdrawal of cuprizone.
Haiyun Xu
2008
Demonstration of an anti-oxidative stress mechanism of quetiapine: Implications for the treatment of Alzheimer's disease.
Haiyun Xu
2008
Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes.
Haiyun Xu
2008
In vitro and in vivo evidence for neuroprotective effects of antipsychotic drugs: Implications for the pathophysiology and treatment of schizophrenia.
Haiyun Xu
2007
Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occulusion in mice.
Haiyun Xu
2007
Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice.
Haiyun Xu
2007
Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment.
Haiyun Xu
2007
The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats.
Haiyun Xu
2006
Haloperidol and atypical antipsychotics share a same action of decreasing p75NTR mRNA levels in PC12 cells.
Haiyun Xu
2006
Quetiapine and venlafaxine share common actions on the hippocampal formation in rats exposed to chronic restraint stress.
Haiyun Xu
2006
Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress.
Haiyun Xu
2005
Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in hippocampal formations of stressed rats.
Haiyun Xu
2005
Atypical antipsychotics protect PC12 cells against amyloid-induced apoptosis by inhibiting oxidative stress.
Haiyun Xu
2005
Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats.
Haiyun Xu
2005
Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by neurotoxic regimen of dl-amphetamine in rats.
Haiyun Xu
2005
Post-stress changes in BDNF and Bcl-2 immuno-reactivities in hippocampal neurons: Effect of chronic administration of olanzapine.
Haiyun Xu
2004
The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine.
Haiyun Xu
2004
Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine.
Haiyun Xu
2004
Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats.
Haiyun Xu
2004
The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+ -induced apoptosis.
Haiyun Xu
2003
Dose-related effects of chronic antidepressants on the neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus.
Haiyun Xu
2003
Quetiapine attenuates the immobiliza-tion stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus.
Haiyun Xu
2002
Heroin-induced neuronal activation in rat brain: Assessed by functional MRI.
Haiyun Xu
2000
1999
Neurochemical organization of the macaque retina: Effect of TTX on levels and gene expression of cytochrome oxidase and nitric oxide synthase and on the immnoreactivity of Na+K+ ATPase and NMDA receptor subunit I.
Haiyun Xu
1998