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Wei-Jia Kong

Wei-Jia Kong

LiveDNA ID: 86.24126
26 Publications
0 Editorial Roles
0 Projects

Education

Academic Background
  • Ph.D. Chinese Academy of Medical Sciences, China Virology | Completed: 2011

Publications (26)

Selected Scholarly Contributions
Gastrodin protects against ethanol-induced liver injury and apoptosis in hepg2 cells and animal models of alcoholic liver disease.
Zhang, Y., C. Wang, B. Yu, J.D. Jiang and W.J. Kong,
Biol. Pharm. Bull., | Journal Article
Self Wei-Jia Kong
2018
Structure-activity relationship of berberine derivatives for their glucose-lowering activities.
Ren, G., Y.X. Wang, Y.H. Li, D.Q. Song, W.J. Kong and J.D. Jiang,
Int. J. Clin. Exp. Med., | Journal Article
Self Wei-Jia Kong
2017
Prevention and treatment of cancer targeting chronic inflammation: Research progress, potential agents, clinical studies and mechanisms.
Zhang, Y., W. Kong and J. Jiang,
Sci. China Life Sci., | Journal Article
Self Wei-Jia Kong
2017
Gastrodin ameliorates oxidative stress and proinflammatory response in nonalcoholic fatty liver disease through the AMPK/Nrf2 pathway.
Qu, L.L., B. Yu, Z. Li, W.X. Jiang, J.D. Jiang and W.J. Kong,
Phytother. Res., | Journal Article
10.1002/ptr.5541
Self Wei-Jia Kong
2016
Berberine Analogue Y53 has Improved Antioxidant and Anti-Inflammatory Activities in Diabetic C57BL/6J Mice with Liver Steatosis
Zheng Li, Zeng-Yan Zuo, Dan-Qing Song, Ying-Hong Li, Jian-Dong Jiang, Wei-Jia Kong
Int. J. Pharmacol., | Journal Article
10.3923/ijp.2016.11.18
Self Wei-Jia Kong
2016
Learning from berberine: Treating chronic diseases through multiple targets.
Yao, J., W.J. Kong and J.D. Jiang,
Sci. China Life Sci., | Journal Article
10.1007/s11427-013-4568-z
Self Wei-Jia Kong
2015
Pharmacological effects of statins related to gap junction modulation.
Qu, L., J. Jiang and W. Kong,
Pharmacol. Pharm., | Journal Article
Self Wei-Jia Kong
2014
Berberine up-regulates hepatic low-density lipoprotein receptor through ras-independent but AMP-activated protein kinase-dependent Raf-1 activation.
Li, Z., J.D. Jiang and W.J. Kong,
Biol. Pharmaceut. Bull., | Journal Article
10.1248/bpb.b14-00412
Self Wei-Jia Kong
2014
Tetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein function.
Shan, Y.Q., Y.P. Zhu, J. Pang, Y.X. Wang, D.Q. Song, W.J. Kong and J.D. Jiang,
Biol. Pharm. Bull., | Journal Article
10.1248/bpb.b13-00272
Self Wei-Jia Kong
2013
Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux.
Shan, Y.Q., G. Ren, Y.X. Wang, J. Pang and Z.Y. Zhao et al.,
Metabolism, | Journal Article
10.1016/j.metabol.2012.09.009
Self Wei-Jia Kong
2013
Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation.
Wang, Y.X., W.J. Kong, Y.H. Li, S. Tang and Z. Li et al.,
Bioorg. Med. Chem., | Journal Article
10.1016/j.bmc.2012.09.029
Self Wei-Jia Kong
2012
Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine.
Li, Y.H., Y. Li, P. Yang, W.J. Kong and X.F. You et al.,
Bioorg. Med. Chem., | Journal Article
10.1016/j.bmc.2010.06.106
Self Wei-Jia Kong
2010
Silencing MR-1 attenuates inflammatory damage in mice heart induced by angII.
Dai, W., J. Jiang, W. Kong and Y. Wang,
Biochem. Biophy. Res. Commun., | Journal Article
10.1016/j.bbrc.2009.12.130
Self Wei-Jia Kong
2010
Protein kinase D activation stimulates the transcription of the insulin receptor gene.
Zhang, H., W.J. Kong, Y.Q. Shan, D.Q. Song and Y. Li et al.,
Mol. Cell. Endocrinol., | Journal Article
10.1016/j.mce.2010.07.022
Self Wei-Jia Kong
2010
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Zhang, H., J. Wei, R. Xue, J.D. Wu and W. Zhao et al.,
Metabolism, | Journal Article
10.1016/j.metabol.2009.07.029
Self Wei-Jia Kong
2010
Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice.
Dai, W., W. He, G. Shang, J. Jiang, Y. Wang and W. Kong,
AJP: Heart Circulatory Physiol., | Journal Article
10.1152/ajpheart.00582.2009
Self Wei-Jia Kong
2010
Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.
Kong, W.J., H. Zhang, D.Q. Song, R. Xue and W. Zhao et al.,
Metabolism, | Journal Article
10.1016/j.metabol.2008.08.013
Self Wei-Jia Kong
2009
Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships and cholesterol-lowering efficacy.
Li, Y.H., P. Yang, W.J. Kong, Y.X. Wang and C.Q. Hu et al.,
J. Med. Chem., | Journal Article
10.1021/jm801157z
Self Wei-Jia Kong
2009
Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor.
Wang, Y.X., Y.P. Wang, H. Zhang, W.J. Kong and Y.H. Li et al.,
Bioorg. Med. Chem. Lett., | Journal Article
10.1016/j.bmcl.2009.09.059
Self Wei-Jia Kong
2009
Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis.
Zhao, W., R. Xue, Z.X. Zhou, W.J. Kong and J.D. Jiang,
Biomed. Pharm., | Journal Article
Self Wei-Jia Kong
2008
Synthesis and structure–activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators.
Yang, P., D.Q. Song, Y.H. Li, W.J. Kong and Y.X. Wang et al.,
Bioorg. Med. Chem. Lett., | Journal Article
10.1016/j.bmcl.2008.07.005
Self Wei-Jia Kong
2008
Combination of simvastatin with berberine improves the lipid-lowering efficacy.
Kong, W.J., J. Wei, Z.Y. Zuo, Y.M. Wang and D.Q. Song et al.,
Metab.-Clin. Exp., | Journal Article
10.1016/j.metabol.2008.01.037
Self Wei-Jia Kong
2008
Human low-density lipoprotein receptor gene and its regulation.
Kong, W. J., J. Liu and J.D. Jiang,
J. Mol. Med., | Journal Article
Self Wei-Jia Kong
2006
In vivo activities of cytokine oncostatin M in the regulation of plasma lipid levels.
Kong, W., P. Abidi, F.B. Kraemer, J.D. Jiang and J. Liu,
J. Lipid Res., | Journal Article
Self Wei-Jia Kong
2005
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
Kong, W., J. Wei, P. Abidi, M. Lin and S. Inaba et al.,
Nat. Med., | Journal Article
10.1038/nm1135
Self Wei-Jia Kong
2004
Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases.
Kong, W.J. and J.D. Jiang,
Chin. Pharmacol. Bull., | Journal Article
Self Wei-Jia Kong
2003