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Hajime Higuchi

Hajime Higuchi

LiveDNA ID: 81.22513
72 Publications
0 Editorial Roles
0 Projects

Education

Academic Background
  • PostDoc Fellow Mayo Clinic Graduate School, USA Medicine | Completed: 2002

Publications (72)

Selected Scholarly Contributions
Endoscopic snare papillectomy for a solitary Peutz-Jeghers-type polyp in the duodenum with ingrowth into the common bile duct: Case report.
Suzuki, K., H. Higuchi, S. Shimizu, M. Nakano, H. Serizawa and S. Morinaga,
World J. Gastroenterol., | Journal Article
10.3748/wjg.v21.i26.8215
Self Hajime Higuchi
2015
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer.
Mayanagi, S., M. Kitago, T. Sakurai, T. Matsuda and T. Fujita et al.,
Cancer Sci., | Journal Article
10.1111/cas.12621
Self Hajime Higuchi
2015
Ampullary adenoma treated by endoscopic double-snare retracting papillectomy.
Soma, H., N. Miyata, S. Hozawa, H. Higuchi and Y. Yamagishi et al.,
Gut Liver, | Journal Article
10.5009/gnl14206
Self Hajime Higuchi
2015
Endoscopic ultrasound-guided drainage for a mediastinal pancreatic pseudocyst.
Sugimoto, S., Y. Yamagishi, H. Higuchi and T. Kanai,
Internal Med., | Journal Article
10.2169/internalmedicine.53.3503
Self Hajime Higuchi
2014
TGF-β1 in tumor microenvironments induces immunosuppression in the tumors and sentinel lymph nodes and promotes tumor progression.
Nakamura, S., T. Yaguchi, N. Kawamura, A. Kobayashi and T. Sakurai et al.,
J. Immunother., | Journal Article
10.1097/CJI.0000000000000011
Self Hajime Higuchi
2014
CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion.
Nakamura, Y., T. Kanai, K. Saeki, M. Takabe and J. Irie et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.00318.2012
Self Hajime Higuchi
2013
Activated hepatic stellate cells mediate the differentiation of macrophages.
Chang, J., T. Hisamatsu, K. Shimamura, K. Yoneno and M. Adachi et al.,
Hepatol. Res., | Journal Article
10.1111/j.1872-034X.2012.01111.x
Self Hajime Higuchi
2013
Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells.
Kabashima-Niibe, A., H. Higuchi, H. Takaishi, Y. Masugi and Y. Matsuzaki et al.,
Cancer Sci., | Journal Article
10.1111/cas.12059
Self Hajime Higuchi
2013
Biliary findings assist in predicting enlargement of intraductal papillary mucinous neoplasms of the pancreas.
Matsuzaki, J., H. Suzuki, S. Okuda, A. Tanimoto and K. Asakura et al.,
Clin. Gastroenterol. Hepatol., | Journal Article
10.1016/j.cgh.2012.11.027
Self Hajime Higuchi
2013
Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature.
Funakoshi, S., A. Hashiguchi, K. Teramoto, N. Miyata and S. Kurita et al.,
Oncol. Lett., | Journal Article
10.3892/ol.2012.1008
Self Hajime Higuchi
2013
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells.
Akagi, H., H. Higuchi, H. Sumimoto, T. Igarashi and A. Kabashima et al.,
Gastric Cancer, | Journal Article
10.1007/s10120-012-0153-6
Self Hajime Higuchi
2013
5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis.
Miyoshi, J., T. Yajima, K. Shimamura, K. Matsuoka and S. Okamoto et al.,
Anticancer Res., | Journal Article
Self Hajime Higuchi
2012
Chemoresistance is associated with cancer stem cell-like properties and epithelial-to-mesenchymal transition in pancreatic cancer cells.
Izumiya, M., A. Kabashima, H. Higuchi, T. Igarashi and G. Sakai et al.,
Anticancer Res., | Journal Article
Self Hajime Higuchi
2012
Colon neoplastic cells do not originate from bone marrow-derived cells after sex-mismatched bone marrow transplantation.
Sakai, G., T. Yajima, H. Takaishi, T. Mori and H. Higuchi et al.,
Anticancer Res., | Journal Article
Self Hajime Higuchi
2012
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway.
Ichikawa, R., T. Takayama, K. Yoneno, N. Kamada and M.T. Kitazume et al.,
Immunology, | Journal Article
10.1111/j.1365-2567.2012.03554.x
Self Hajime Higuchi
2012
Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty.
Miyata, N., T. Azuma, S. Hozawa, H. Higuchi and A. Yokoyama et al.,
Pancreas, | Journal Article
10.1097/MPA.0b013e31823b66d3
Self Hajime Higuchi
2012
Gemcitabine as first-line chemotherapy in elderly patients with unresectable pancreatic carcinoma.
Yamagishi, Y., H. Higuchi, M. Izumiya, G. Sakai and H. Iizuka et al.,
J. Gastroenterol., | Journal Article
10.1007/s00535-010-0258-9
Self Hajime Higuchi
2010
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL‐R2/DR5 and caspase-8.
Kurita, S., H. Higuchi, Y. Saito, N. Nakamoto and H. Takaishi et al.,
Cancer Sci., | Journal Article
10.1111/j.1349-7006.2010.01565.x
Self Hajime Higuchi
2010
Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion.
Kabashima, A., H. Higuchi, H. Takaishi, Y. Matsuzaki and S. Suzuki et al.,
Int. J. Cancer, | Journal Article
10.1002/ijc.24349
Self Hajime Higuchi
2009
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease.
Takaishi, H., T. Matsuki, A. Nakazawa, T. Takada and S. Kado et al.,
Int. J. Med. Microbiol., | Journal Article
10.1016/j.ijmm.2007.07.016
Self Hajime Higuchi
2008
Microscopic colitis with granuloma which responded to steroid therapy.
Iwai, H., T. Hisamatsu, H. Iizuka, T. Oyama and H. Higuchi et al.,
Internal Med., | Journal Article
10.2169/internalmedicine.46.0160
Self Hajime Higuchi
2007
Cyclooxygenase-2 inhibitor and interferon-β synergistically induce apoptosis in human hepatoma cells in vitro and in vivo.
Nakamoto, N., H. Higuchi, H. Kanamori, S. Kurita and S. Tada et al.,
Int. J. Oncol., | Journal Article
10.3892/ijo.29.3.625
Self Hajime Higuchi
2006
Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes.
Adachi, M., H. Higuchi, S. Miura, T. Azuma and S. Inokuchi et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.00415.2003
Self Hajime Higuchi
2004
Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
Taniai, M., A. Grambihler, H. Higuchi, N. Werneburg and S.F. Bronk et al.,
Cancer Res., | Journal Article
10.1158/0008-5472.CAN-03-2770
Self Hajime Higuchi
2004
Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.
Higuchi, H., A. Grambihler, A. Canbay, S.F. Bronk and G.J. Gores,
J. Biol. Chem., | Journal Article
10.1074/jbc.M309476200
Self Hajime Higuchi
2004
Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors.
Higuchi, H. and G.J. Gores,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.00491.2002
Self Hajime Higuchi
2003
Mechanisms of liver injury: An overview.
Higuchi, H. and G.J. Gores,
Curr. Mol. Med., | Journal Article
10.2174/1566524033479528
Self Hajime Higuchi
2003
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.
Feldstein, A.E., A. Canbay, M.E. Guicciardi, H. Higuchi, S.F. Bronk and G.J. Gores,
J. Hepatol., | Journal Article
10.1016/S0168-8278(03)00460-4
Self Hajime Higuchi
2003
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.
Canbay, A., A.E. Feldstein, H. Higuchi, N. Werneburg, A. Grambihler, S.F. Bronk and G.J. Gores,
Hepatology, | Journal Article
10.1053/jhep.2003.50472
Self Hajime Higuchi
2003
Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression.
Janssen, H.L., H. Higuchi, A. Abdulkarim and G.J. Gores,
J. Hepatol., | Journal Article
10.1016/S0168-8278(03)00265-4
Self Hajime Higuchi
2003
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.
Canbay, A., M.E. Guicciardi, H. Higuchi, A. Feldstein and S.F. Bronk et al.,
J. Clin. Invest., | Journal Article
10.1172/JCI200317740
Self Hajime Higuchi
2003
cFLIP-L inhibits p38 MAPK activation: An additional anti-apoptotic mechanism in bile acid-mediated apoptosis.
Grambihler, A., H. Higuchi, S.F. Bronk and G.J. Gores,
J. Biol. Chem., | Journal Article
10.1074/jbc.M303229200
Self Hajime Higuchi
2003
Apoptotic body engulfment by a human stellate cell line is profibrogenic.
Canbay, A., P. Taimr, N. Torok, H. Higuchi, S. Friedman and G.J. Gores,
Lab. Invest., | Journal Article
10.1097/01.LAB.0000069036.63405.5C
Self Hajime Higuchi
2003
The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury.
Natori, S., H. Higuchi, P. Contreras and G.J. Gores,
Liver Transplant., | Journal Article
10.1053/jlts.2003.50019
Self Hajime Higuchi
2003
Bile acids activate EGF receptor via a TGF-α-dependent mechanism in human cholangiocyte cell lines.
Werneburg, N.W., J.H. Yoon, H. Higuchi and G.J. Gores,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.00536.2002
Self Hajime Higuchi
2003
Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.
Taimr, P., H. Higuchi, E. Kocova, R.A. Rippe, S. Friedman and G.J. Gores,
Hepatology, | Journal Article
10.1053/jhep.2003.50002
Self Hajime Higuchi
2003
Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis.
Higuchi, H., J.H. Yoon, A. Grambihler, N. Werneburg, S.F. Bronk and G.J. Gores,
J. Biol. Chem., | Journal Article
10.1074/jbc.M209387200
Self Hajime Higuchi
2003
Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.
Yoon, J.H., N.W. Werneburg, H. Higuchi, A.E. Canbay and S.H. Kaufmann et al.,
Cancer Res., | Journal Article
Self Hajime Higuchi
2002
Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis.
Canbay, A., H. Higuchi, S.F. Bronk, M. Taniai, T.J. Sebo and G.J. Gores,
Gastroenterology, | Journal Article
10.1053/gast.2002.35953
Self Hajime Higuchi
2002
p16INK4a promoter mutations are frequent in Primary Sclerosing Cholangitis (PSC) and PSC-associated cholangiocarcinoma.
Taniai, M., H. Higuchi, L.J. Burgart and G.J. Gores,
Gastroenterology, | Journal Article
10.1053/gast.2002.36021
Self Hajime Higuchi
2002
Cholestasis increases tumor necrosis factor-related apoptotis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity.
Higuchi, H., S.F. Bronk, M. Taniai, A. Canbay and G.J. Gores,
J. Pharmacol. Exp. Therapeut., | Journal Article
10.1124/jpet.102.040030
Self Hajime Higuchi
2002
Transmural pressure induces IL-6 secretion by intestinal epithelial cells.
Kishikawa, H., S. Miura, H. Yoshida, M. Hirokawa and H. Nakamizo et al.,
Clin. Exp. Immunol., | Journal Article
10.1046/j.1365-2249.2002.01895.x
Self Hajime Higuchi
2002
Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
Yoon, J.H., H. Higuchi, N.W. Werneburg, S.H. Kaufmann and G.J. Gores,
Gastroenterology, | Journal Article
10.1053/gast.2002.32410
Self Hajime Higuchi
2002
Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9.
Torok, N.J., H. Higuchi, S. Bronk and G.J. Gores,
Cancer Res., | Journal Article
Self Hajime Higuchi
2002
Nuclear factor-κB and TNF-α mediate gastric ulceration induced by phorbol myristate acetate.
Takeuchi, T., S. Miura, L. Wang, K. Uehara and M. Mizumori et al.,
Dig Dis. Sci., | Journal Article
10.1023/A:1019633114854
Self Hajime Higuchi
2002
Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.
Higuchi, H., H. Miyoshi, S.F. Bronk, H. Zhang, N. Dean and G.J. Gores,
J. Pharmacol. Exp. Therapeut., | Journal Article
Self Hajime Higuchi
2001
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.
Higuchi, H., S.F. Bronk, Y. Takikawa, N. Werneburg, R. Takimoto, W. El-Deiry and G.J. Gores,
J. Biol. Chem., | Journal Article
10.1074/jbc.M105300200
Self Hajime Higuchi
2001
Loading of mechanical pressure activates mitogen-activated protein kinase and early immediate gene in intestinal epithelial cells.
Hirokawa, M., S. Miura, H. Kishikawa, H. Yoshida and H. Nakamizo et al.,
Dig. Dis. Sci., | Journal Article
10.1023/A:1010607819842
Self Hajime Higuchi
2001
The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes.
Higuchi, H., M. Adachi, S. Miura, G.J. Gores and H. Ishii,
Hepatology, | Journal Article
10.1053/jhep.2001.26380
Self Hajime Higuchi
2001
Chronic ethanol consumption exacerbates microcirculatory damage in rat mesentery after reperfusion.
Han, J.Y., S. Miura, Y. Akiba, H. Higuchi and S. Kato et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.2001.280.5.g939
Self Hajime Higuchi
2001
Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: Implications for gene therapy.
Higuchi, H., S.F. Bronk, A. Bateman, K. Harrington, R.G. Vile and G.J. Gores,
Cancer Res., | Journal Article
Self Hajime Higuchi
2000
Assay of antioxidant and antiinflammatory activity of nitric oxide in vivo.
Higuchi, H., D.N. Granger, H. Saito and I. Kurose,
Methods Enzymol., | Journal Article
10.1016/S0076-6879(99)01106-4
Self Hajime Higuchi
1999
Altered migration of gut-derived T lymphocytes after activation with concanavalin A.
Hokari, R., S. Miura, H. Fujimori, S. Koseki and Y. Tsuzuki et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.1999.277.4.g763
Self Hajime Higuchi
1999
Increased expression of inducible nitric oxide synthase and peroxynitrite in Helicobacter pylori gastric ulcer.
Sakaguchi, A.A., S. Miura, T. Takeuchi, R. Hokari and M. Mizumori et al.,
Free Radic. Biol. Med., | Journal Article
10.1016/S0891-5849(99)00124-0
Self Hajime Higuchi
1999
Induction of endothelin-1 synthesis by IL-2 and its modulation of rat intestinal epithelial cell growth.
Shigematsu, T., S. Miura, M. Hirokawa, R. Hokari and H. Higuchi et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.1998.275.3.G556
Self Hajime Higuchi
1998
Nitric oxide modulates T-lymphocyte migration in Peyer's patches and villous submucosa of rat small intestine.
Hokari, R., S. Miura, H. Fujimori, Y. Tsuzuki and T. Shigematsu et al.,
Gastroenterology, | Journal Article
10.1016/S0016-5085(98)70141-6
Self Hajime Higuchi
1998
Endothelins promote egg albumin-induced intestinal anaphylaxis in rats.
Shigematsu, T., S. Miura, M. Hirokawa, R. Hokari and H. Higuchi et al.,
Gastroenterology, | Journal Article
10.1016/S0016-5085(98)70201-X
Self Hajime Higuchi
1998
Oxidative stress and mitochondrial damage precedes gastric mucosal cell death induced by ethanol administration.
Hirokawa, M., S. Miura, H. Yoshida, I. Kurose and T. Shigematsu et al.,
Alcoh. Clin. Exp. Res., | Journal Article
Self Hajime Higuchi
1998
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
Kimura, H., R. Hokari, S. Miura, T. Shigematsu and M. Hirokawa et al.,
Gut, | Journal Article
10.1136/gut.42.2.180
Self Hajime Higuchi
1998
Pressure stimulates proliferation and DNA synthesis in rat intestinal epithelial cells.
Hirokawa, M., S. Miura, T. Shigematsu, H. Yoshida and R. Hokari et al.,
Life Sci., | Journal Article
10.1016/S0024-3205(97)00531-6
Self Hajime Higuchi
1997
Enhanced lymphocyte interaction in postcapillary venules of Peyer's patches during fat absorption in rats.
Tsuzuki, Y., S. Miura, I. Kurose, M. Suematsu and H. Higuchi et al.,
Gastroenterology, | Journal Article
10.1053/gast.1997.v112.pm9041243
Self Hajime Higuchi
1997
Active oxidants mediate IFN-alpha-induced microvascular alterations in rat mesentery.
Higuchi, H., I. Kurose, D. Fukumura, H.J. Yan and H. Saito et al.,
J. Immunol., | Journal Article
Self Hajime Higuchi
1997
Vasoactive intestinal peptide modulates T lymphocyte migration in Peyer's patches of rat small intestine.
Miura, S., H. Serizawa, Y. Tsuzuki, I. Kurose and M. Suematsu et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.1997.272.1.G92
Self Hajime Higuchi
1997
Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease.
Kimura, H., S. Miura, T. Shigematsu, N. Ohkubo and Y. Tsuzuki et al.,
Digestive Dis. Sci., | Journal Article
10.1023/A:1018849405922
Self Hajime Higuchi
1997
Ethanol-induced apoptosis and oxidative stress in hepatocytes.
Higuchi, H., I. Kurose, S. Kato, S. Miura and H. Ishii,
Alcoh.: Clin. Exp. Res., | Journal Article
10.1111/j.1530-0277.1996.tb01804.x
Self Hajime Higuchi
1996
IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage.
Fukumura, D., S. Miura, I. Kurose, H. Higuchi and H. Suzuki et al.,
Dig. Dis. Sci., | Journal Article
10.1007/BF02100147
Self Hajime Higuchi
1996
Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.
Saito, H., I. Kurose, H. Ebinuma, D. Fukumura and H. Higuchi et al.,
Int. Immunol., | Journal Article
10.1093/intimm/8.7.1165
Self Hajime Higuchi
1996
Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo.
Fukumura, D., Y. Yonei, I. Kurose, H. Saito and T. Ohishi et al.,
Hepatology, | Journal Article
10.1002/hep.510240124
Self Hajime Higuchi
1996
Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine.
Miura, S., D. Fukumura, I. Kurose, H. Higuchi and H. Kimura et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.1996.271.3.g461
Self Hajime Higuchi
1996
Endotoxin stimulates lymphocyte-endothelial interactions in rat intestinal Peyer's patches and villus mucosa.
Miura, S., Y. Tsuzuki, I. Kurose, M. Suematsu and T. Shigematsu et al.,
Am. J. Physiol.-Gastrointest. Liver Physiol., | Journal Article
10.1152/ajpgi.1996.271.2.g282
Self Hajime Higuchi
1996
Effect of chronic ethanol feeding on nitric oxide synthesis by rat Kupffer cells.
Kimura, H., S. Miura, H. Higuchi, I. Kurose and Y. Tsuzuki et al.,
Alcoholism: Clin. Exp. Res., | Journal Article
10.1111/j.1530-0277.1996.tb01734.x
Self Hajime Higuchi
1996
α4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats.
Tsuzuki, Y., S. Miura, M. Suematsu, I. Kurose and T. Shigematsu et al.,
Int. Immunol., | Journal Article
10.1093/intimm/8.3.287
Self Hajime Higuchi
1996