About
Professional SummaryDr. Mario Daniel Galigniana is currently working as Professor in Department of Biological Chemistry at FCEN University of Buenos Aires and Principal Investigator of the Argentine Research Council (CONICET), Director of the Laboratory of Nuclear Receptors. He obtained his PhD in Biochemistry from University of Michigan Medical School. He is having 21 years of working experience. He is professional member American Society for Biochemistry & Molecular Biology, American Society for Microbiology, Society for Neuroscience, Evaluation Board of The University of Buenos Aires, Evaluation Board of ANPCYT, Argentina, Evaluation Board of CONICET, Argentine Society for Biochemistry and Molecular Biology, Argentine Society for Clinical Investigation, Endocrine Society, Cell Stress Society International. Dr. Mario Daniel received number of distinctions include, Elsevier Award in Appreciation of Scientific Excellence, Cherni Foundation Accesit Award, University of Buenos Aires, Young Investigator Award and Travel Awards. He is also member of editorial board. He has published 77 articles in journal and 6 chapters in book as writer/co-writer.
Education
Academic Background-
PostDoc Fellow University of Michigan, USA Pharmacology | Completed: 1999
Publications (100)
Selected Scholarly Contributions
2024
2024
The transportosome system as a model for the retrotransport of soluble proteins
2023
Roles of GR isoforms and Hsp90-binding immunophilins in the modulation of glucocorticoid biological responses.
Mario Daniel Galigniana
2023
The Scaffold Immunophilin FKBP51 Is a Phosphoprotein That Undergoes Dynamic Mitochondrial-Nuclear Shuttling
2022
Cyclophilin A is a mitochondrial factor that forms complexes with p23 – correlative evidence for an anti-apoptotic action
2021
Role of mitochondrial heat-shock proteins and immunophilins in neuro degenerative diseases.
Mario Daniel Galigniana
2021
Corticosteroid receptors as a model for the Hsp90•immunophilin-based transport machinery.
Mario Daniel Galigniana
2021
Peptidyl‐Prolyl Isomerase Activity of Immunophilins Could Be the Mere Consequence of Protein Complex Organization
2020
Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins
2020
Role of the Hsp90-immunophilin heterocomplex in cancer biology.
Mario Daniel Galigniana
2020
Rational identification of Hsp90 inhibitors as anticancer lead molecules by structure based drug designing approach.
Mario Daniel Galigniana
2020
2019
2019
2019
Reconstitution of the steroid receptor heterocomplex.
Mario Daniel Galigniana
2019
Regulation of FKBP51 and FKBP52 functions by post-translational modifications.
Mario Daniel Galigniana
2019
Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.
Mario Daniel Galigniana
2017
Editorial: Immunophilins, protein chemistry and cell biology of a promising new class of drug targets-part I.
Mario Daniel Galigniana
2016
Regulation of NF-ΚB signalling cascade by immunophilins.
Mario Daniel Galigniana
2016
Biological relevance of Hsp90‐binding immunophilins in cancer development and treatment.
Mario Daniel Galigniana
2016
Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors.
Mario Daniel Galigniana
2016
Hsp90-Binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity.
Mario Daniel Galigniana
2016
Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors.
Mario Daniel Galigniana
2015
Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of herpes simplex virus type 1.
Mario Daniel Galigniana
2015
2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead.
Mario Daniel Galigniana
2015
Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression.
Mario Daniel Galigniana
2014
Molecular docking study, synthesis and biological evaluation of Schiff bases as Hsp90 inhibitors.
Mario Daniel Galigniana
2014
Editorial: The biology of molecular chaperonesvery complex activities for quite simple proteins.
Mario Daniel Galigniana
2014
Molecular chaperone activity of TPR-domain immunophilins.
Mario Daniel Galigniana
2014
NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: A role for peptidyl-prolyl isomerase activity.
Mario Daniel Galigniana
2014
When the cell stress society international became South American: Meeting report of the IX international workshop on the molecular biology of stress responses.
Mario Daniel Galigniana
2013
Hsp90-binding immunophilins as a potential new platform for drug treatment.
Mario Daniel Galigniana
2013
Editorial: Steroid-dependent management of biological responses in the nervous system.
Mario Daniel Galigniana
2013
Molecular basis of mineralo-corticoid receptor action in the nervous system.
Mario Daniel Galigniana
2013
Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by PKA signaling pathway to control gene expression in the process of adipocyte differentiation.
Mario Daniel Galigniana
2013
System among the corticosteroids: Specificity and molecular dynamics.
Mario Daniel Galigniana
2012
The neuroregenerative mechanism mediated by the Hspp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation.
Mario Daniel Galigniana
2012
Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51.
Mario Daniel Galigniana
2012
Steroid receptor coupling becomes nuclear.
Mario Daniel Galigniana
2012
Roles for the 51-kDa and 52-kDa FK506-binding proteins in signaling and disease.
Mario Daniel Galigniana
2011
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52).
Mario Daniel Galigniana
2011
TPR-domain immunophilin FKBP51 is a novel mitochondrial factor with antiapoptotic function.
Mario Daniel Galigniana
2011
Housekeeping role of heat-shock proteins and immunophilins in the organization of cytoskeleton involves early recruitment to nascent filaments.
Mario Daniel Galigniana
2011
The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.
Mario Daniel Galigniana
2010
Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore.
Mario Daniel Galigniana
2010
Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth.
Mario Daniel Galigniana
2010
Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Mario Daniel Galigniana
2009
The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action.
Mario Daniel Galigniana
2008
Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced and bind HSP90.
Mario Daniel Galigniana
2007
Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor.
Mario Daniel Galigniana
2007
Evidence for an NL1-independent nuclear translocation of the mineralocorticoid receptor in permeabilized cells.
Mario Daniel Galigniana
2007
Differential recruitment of tetratricopeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity.
Mario Daniel Galigniana
2007
Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes.
Mario Daniel Galigniana
2006
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Mario Daniel Galigniana
2006
. Evidence for glucocorticoid receptor transport on microtubules by dynein.
Mario Daniel Galigniana
2004
Retrograde transport of the GR in neurites requires dynamic assembly of complexes with hsp90 and is linked to the CHIP component of the proteosome.
Mario Daniel Galigniana
2004
Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of novel pregnanesteroids.
Mario Daniel Galigniana
2004
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
Mario Daniel Galigniana
2004
Activation of the ligand-mineralocorticoid receptor functional unit by ancient, classical and novel ligands. Structure-activity-relationship.
Mario Daniel Galigniana
2004
Role of molecular chaperones in steroid receptor action.
Mario Daniel Galigniana
2004
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Mario Daniel Galigniana
2004
Pifithrin-α is a specific inhibitor of p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.
Mario Daniel Galigniana
2004
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex.
Mario Daniel Galigniana
2004
Visualization and mechanism of assembly of a glucocorticoid receptor-hsp70 complex primed by subsequent hsp90-dependent opening of the steroid binding cleft.
Mario Daniel Galigniana
2003
Subnuclear localization of C/EBPβ is regulated by growth hormone and dependent on MAPK.
Mario Daniel Galigniana
2003
Correlation between pregnanesteroid conformation, receptor affinity and antinatriuretic effect.
Mario Daniel Galigniana
2002
All of the protein interactions that link steroid receptor-hsp90-immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells.
Mario Daniel Galigniana
2002
Impairment of mineralocorticoid receptor-dependent biological response by oxidative stress and ageing. Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of EF-2 in kidney cells.
Mario Daniel Galigniana
2002
Differences in nuclear retention characteristics of agonist-activated glucocorticoid receptor may determine specific biological responses.
Mario Daniel Galigniana
2002
Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxido-progesterone.
Mario Daniel Galigniana
2002
Binding of hsp-90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain.
Mario Daniel Galigniana
2002
The decrease in uroporphyrinogen activity induced by ethanol predisposes the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage.
Mario Daniel Galigniana
2002
Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus.
Mario Daniel Galigniana
2001
Stoichiometry, abundance and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.
Mario Daniel Galigniana
2001
Chronic morphine treatment alters pituitary-adrenal negative feedback sensitivity and downregulates glucocorticoid receptors in the rat brain.
Mario Daniel Galigniana
2001
Functional regulation of corticosteroid receptors by phosphorylation and redox potential.
Mario Daniel Galigniana
2000
Oxidative stress induced by L-buthionine-(S, R)-sulfoximine, a selective inhibitor of glutathione metabolism, abrogates mouse kidney mineralocorticoid receptor function.
Mario Daniel Galigniana
2000
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.
Mario Daniel Galigniana
2000
Mechanism of action of the potent sodium-retaining steroid 11, 19-oxidoprogesterone.
Mario Daniel Galigniana
2000
Inhibition of glucocorticoid receptor by nitric oxide.
Mario Daniel Galigniana
1999
The glucocorticoid properties of the synthetic steroid pregna-1,4-diene-11β-ol-3,20-dione (ΔHOP) are not entirely correlated with the steroid binding to the glucocorticoid receptor.
Mario Daniel Galigniana
1999
Inhibition of glucocorticoid receptor nucleocytoplasmic shuttling by okadaic acid requires intact cytoskeleton.
Mario Daniel Galigniana
1999
Comparative inhibition by hard and soft metal ions of steroid-binding capacity of renal mineralocorticoid receptor cross-linked to the 90-kDa heat-shock protein heterocomplex.
Mario Daniel Galigniana
1999
Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery.
Mario Daniel Galigniana
1999
Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90 and cytoplasmic dynein.
Mario Daniel Galigniana
1999
A model for the cytoplasmic trafficking of signalling proteins involving the hsp90-binding immunophilins and p50cdc37.
Mario Daniel Galigniana
1999
The role of DnaJ-like proteins in the glucocorticoid receptor-hsp90 heterocomplex assembly by the reconstituted hsp90-p60-hsp70 foldosome complex.
Mario Daniel Galigniana
1998
Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives.
Mario Daniel Galigniana
1998
Native rat kidney mineralocorticoid receptor is a phosphoprotein whose transformation to a DNA-binding form is induced by phosphatases.
Mario Daniel Galigniana
1998
Tautomycin inhibits phosphatase-dependent transformation of the rat kidney mineralocorticoid receptor.
Mario Daniel Galigniana
1998
Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton.
Mario Daniel Galigniana
1998
Protein phosphatase 5 is a major component of glucocorticoid receptor-hsp90 complexes with properties of an FK506-binding immunophilins.
Mario Daniel Galigniana
1997
Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.
Mario Daniel Galigniana
1997
21-OH-6,19-oxido-progesterone: A novel synthetic steroid with specific anti-glucocorticoid properties.
Mario Daniel Galigniana
1997
Stability study on renal type I mineralocorticoid receptor.
Mario Daniel Galigniana
1996
Features of the shuttle pair 11β-hydroxy-progesterone/11-ketoprogesterone.
Mario Daniel Galigniana
1996
Sodium-retaining activity of some natural and synthetic 21-deoxysteroids.
Mario Daniel Galigniana
1995
11,19-oxidoprogesterone: A potent sodium retaining steroid binding to an alternative site in rat kidney type I receptor.
Mario Daniel Galigniana
1994
Ligand properties of 11,19-oxidoprogesterone: A preliminary report.
Mario Daniel Galigniana
1993