Education
Academic Background-
Ph.D. Institute of Experimental Morphology and Anthropology with Museum, Bulgaria Biomedical Sciences | Completed: 2003
Publications (80)
Selected Scholarly Contributions
Development of Experimental in vitro Models to Elucidate Molecular Mechanisms Underlying Pathology and its Prevention
2026
Investigation of materials for the development of new molecular and cellular antiviral and antimalignancy vaccines and immunization methods: a pilot study
2025
Free radicals, male reproductivity diseases and male infertility: Review.
Iskra Ventseslavova Sainova
2019
Comparison of protein composition from sperm probe with other biological materials by combining of several methods for assay. A pilot study.
Iskra Ventseslavova Sainova
2019
Sperm mitochondrial biology during spermatogenesis and fertilization.
Iskra Ventseslavova Sainova
2018
Development of methods for identification of protein composition in mammalian sperm fluid and comparison with other biological materials. A pilot study.
Iskra Ventseslavova Sainova
2018
Sperm mitochondria-associated male infertility: Sperm quality defects and mitochondria (mtDNA) anomalies: Review.
Iskra Ventseslavova Sainova
2017
Application of low-dose laser irradiation and 3D-observation methods for detection and assay of features for cell differentiation directions: A pilot study.
Iskra Ventseslavova Sainova
2017
Development of techniques for identification of protein composition in mammalian sperm fluid by comparison with other biological probes from mammals, by combining different assay methods. A pilot study.
Iskra Ventseslavova Sainova
2017
Morphological studies on the spermatogenesis and graffi myeloid tumor cell dissemination (Methastases) in the testes of tumor-bearing hamsters.
Iskra Ventseslavova Sainova
2017
Role of IL-18 in inflammation.
Iskra Ventseslavova Sainova
2017
Development of strategies for prevention of neoplastic processes on cellular and organism levels in vitro and in vivo. A pilot study.
Iskra Ventseslavova Sainova
2017
Histopathological changes in the testis of hamsters with experimentally induced myeloid tumor of Graffi
Iskra Ventseslavova Sainova
2016
A pilot study on the relationship of the cytoskeleton components with normal cellular functions and injuries in malignant and neuro-degenerative multi-factor disorders, using biological systems with rat, mouse and human origin.
Iskra Ventseslavova Sainova
2016
Development of strategies for appropriate laboratory incubation of adult stem/progenitor cells and explants from different tissues.
Iskra Ventseslavova Sainova
2016
Development of novel observation and evaluation methods for understanding the role of cytoskeleton components in the cell life processes. A pilot study.
Iskra Ventseslavova Sainova
2016
Investigation on the relationship of cytoskeleton components with normal cell functions and injuries in neuro-degenerative disorders, using in vitro-, in vivo- and ex vivo-biological systems with mouse, rat and human origin.
Iskra Ventseslavova Sainova
2016
Cytoskeleton molecules and inter-molecular interactions, underlining the cell differentiation direction in various types of biological systems with mouse, rat and human origin.
Iskra Ventseslavova Sainova
2016
Investigation on the role of the cytoskeleton components and interactions with their participation for the cell differentiation direction in several types of biological systems with mouse and human origin.
Iskra Ventseslavova Sainova
2016
Immature spermatogenic cells in semen fluids of infertile men.
Iskra Ventseslavova Sainova
2016
A pilot study of methods about detection of inter-molecular interactions as individual units of intra-cellular structures, intra- and extra-cellular cascade regulatory pathways.
Iskra Ventseslavova Sainova
2016
Round immature spermatogenic cells in semen fluids of infertile men with diagnose “migrating testis”. Two casuistic cases in adults.
Iskra Ventseslavova Sainova
2015
Activation of mechanisms, mediated by Dcn1-HACE1-, JAK-STAT- and NF-κB-cascade regulatory pathways in in vitro- and in vivo-experimental models.
Iskra Ventseslavova Sainova
2015
Testing the influence of growth factors, extra-cellular matrix components, plant extracts and organic detergents, on the osteoblast and osteoclast in vitro-differentiation direction of human and mouse cell progenitors from different sources.
Iskra Ventseslavova Sainova
2015
Directions of in vitro-differentiation of adult stem/progenitor cells, depending of the respective sources and incubation conditions.
Iskra Ventseslavova Sainova
2015
Investigation of the molecular and intra-molecular mechanisms, determining the cell differentiation direction in appropriate incubation conditions, on cellular and organism levels.
Iskra Ventseslavova Sainova
2015
Development of methods for detection of intra- and extra-cellular intra-molecular interactions, underlining the direction of cell differentiation. A pilot study.
Iskra Ventseslavova Sainova
2015
Experimental models for investigation of antioxidant and immunomodulatory effects in vitro of Aronia melanocarpa extract.
Iskra Ventseslavova Sainova
2015
Experimental models of cell in vitro-differentiation by different laboratory incubation times in the presence of Aronia melanocarpa fruit extract.
Iskra Ventseslavova Sainova
2015
Development of methods for activation of genes from Cul-Nedd-, STAT- and NK-κB-mediated cascade regulatory pathways.
Iskra Ventseslavova Sainova
2015
Experimental models for investigation on the influence of Aronia melanocarpa fruit extract on the cell differentiation and antioxidant capacity in vitro.
Iskra Ventseslavova Sainova
2014
Antioxidant effects of Aronia melanocarpa extract after doxorubicin treatment in vitro and in vivo.
Iskra Ventseslavova Sainova
2014
Antioxidant effect of Aronia melanocarpa extract after doxorubicin treatment.
Iskra Ventseslavova Sainova
2014
Development of methods for safe in vitro-differentiation of different progenitor types in osteoblasts/osteoblast-like and osteoclast/osteoclast-like cells with human and mouse origin.
Iskra Ventseslavova Sainova
2014
Experimental in vitro-models from rodent and human for balanced activity between oncogenes and tumor-suppressor genes.
Iskra Ventseslavova Sainova
2014
Development of novel engineering and bio-informatics methods for protein identification.
Iskra Ventseslavova Sainova
2014
In vitro-cultivation of human oral mucosa epithelial cells and tissue explants as a modern method for applications in therapy of limbal stem cell deficiency: A pilot study.
Iskra Ventseslavova Sainova
2014
Transmission electron microscope study on the beneficial role of Aronia melanocarpa fruit extract on Dox-induced cardiotoxicity in mice.
Iskra Ventseslavova Sainova
2014
Achievement of balanced activity between oncogenes, tumor-suppressor genes and their protein products in experimental models from human, rat and mouse.
Iskra Ventseslavova Sainova
2014
Insights into mechanisms of doxorubicin toxicity.
Iskra Ventseslavova Sainova
2014
Experimental in vitro-rodent and human normal and malignant cell models.
Iskra Ventseslavova Sainova
2014
Experimental human and rodent models for balanced activity of oncogenes and tumor-suppressor genes and their protein products.
Iskra Ventseslavova Sainova
2014
Development of novel in vitro-cultivation techniques for derivation of corneal epithelial explants.
Iskra Ventseslavova Sainova
2013
Experimental rodent and human models for balanced activity of oncogenes and tumor-suppressor genes and their protein products.
Iskra Ventseslavova Sainova
2013
Differentiation of stem and progenitor cells from bone marrow in activated dendritic cells and lymphocytes with anti-malignant properties.
Iskra Ventseslavova Sainova
2013
Development of improved methods for protein separation and identification.
Iskra Ventseslavova Sainova
2013
Immune mechanisms in bronchial asthma.
Iskra Ventseslavova Sainova
2013
Experimental rodent and human in vitro-models for balanced activity of oncogenes and tumor-suppressor genes.
Iskra Ventseslavova Sainova
2012
Experimental human and animal models for balanced activity of oncogenes and tumor- suppressor genes and their protein products.
Iskra Ventseslavova Sainova
2012
Experimental in vitro-mouse and human stem cell models for balanced activity of oncogenes and tumor-suppressor genes.
Iskra Ventseslavova Sainova
2012
Experimental human and rodent models for balanced activity of oncogenes and tumor-suppressor genes in vitro and in vivo.
Iskra Ventseslavova Sainova
2012
Experimental in vitro-human and animal models for balanced activity of oncogenes and tumor-suppressor genes and their protein products.
Iskra Ventseslavova Sainova
2012
Experimental in vitro-stem cell models for balanced activity of oncogenes and tumor-suppressor genes from mouse and human.
Iskra Ventseslavova Sainova
2012
Differentiation of stem and progenitor cells in activated immune cells with anti-malignant properties.
Iskra Ventseslavova Sainova
2012
Experimental in vitro rodent and human normal and malignant cell models for balanced activity of oncogenes and tumor-suppressor genes.
Iskra Ventseslavova Sainova
2011
Achievement of balanced oncogenes and tumor-suppressor genes activity in normal and malignant cells in vitro and in vivo.
Iskra Ventseslavova Sainova
2011
In vitro- and in vivo-experimental models for balanced activity of oncogenes and tumor-suppressor genes in normal and malignant cells.
Iskra Ventseslavova Sainova
2011
Experimental model for safe in vitro- and in vivo-influence of internal and external factors of cell differentiation.
Iskra Ventseslavova Sainova
2011
Experimental in vitro-model for safe gene transfer in stem and progenitor cells by recombinant gene constructs.
Iskra Ventseslavova Sainova
2010
Experimental model for safe gene transfer by recombinant gene constructs.
Iskra Ventseslavova Sainova
2010
Malignant stem cell-targeted treatment in therapeutic strategies against cancer and leukemia.
Iskra Ventseslavova Sainova
2009
Leucocyte cytochemistry and hematometric indices in chronic heroin addicts.
Iskra Ventseslavova Sainova
2008
In vitro-differentiation of embryonic mammalian cells as a material base for gene-engineering manipulations.
Iskra Ventseslavova Sainova
2007
Changes in blood viscosity and erythrocyte indices in chronic heroin abusers.
Iskra Ventseslavova Sainova
2007
Evaluation of berberine as a DNA-specific fluorescent dye and DNA-intercalating antitumor alkaloid.
Iskra Ventseslavova Sainova
2006
Whole blood viscosity and erythrocyte hematometric indices in chronic heroin addicts.
Iskra Ventseslavova Sainova
2006
Evaluation of berberine as a DNA-specific fluorescent dye, antitumor-, antioxidant- and immunomodulatory drug.
Iskra Ventseslavova Sainova
2005
Investigation of the morphology of cell clones, derived from the mammalian EBTr cell line and their susceptibility to the vaccine avian poxvirus strains FK and Dessau.
Iskra Ventseslavova Sainova
2005
Something more about zinc.
Iskra Ventseslavova Sainova
2002
Polygene diseases and disorders.
Iskra Ventseslavova Sainova
2001
Propagation of avian pox virus vaccine strains in a mammalian EBTr cell line: A pilot study.
Iskra Ventseslavova Sainova
2001
Cytotoxicity induced by herbicides glyphosate and alachlor in vitro.
Iskra Ventseslavova Sainova
2001
Propagation of avian poxvirus vaccine strains in duck embryo cell line DEC 99.
Iskra Ventseslavova Sainova
2001
Propagation of avian virus strains in the permanent duck embryo cell line DEC 99.
Iskra Ventseslavova Sainova
2001
Cytotoxicity induced by 3-ethyl-2-oxa- 1,4,2 oxazaphosphorinane and α-ethyl-α-N-(hydroxyethylamino) methylphosphonic acid in vitro.
Iskra Ventseslavova Sainova
2001
Propagation of avian pox virus vaccine strains in duck embryo cell cultures.
Iskra Ventseslavova Sainova
2000
Cytotoxic effect of isoquinoline alkaloids on tumor cell lines.
Iskra Ventseslavova Sainova
2000
Interferometric microscope for investigation of biological objects.
Iskra Ventseslavova Sainova
2000
Low level of sex chromosomal mosaicism in patients with schizophrenia.
Iskra Ventseslavova Sainova
1999
Frequency and type of structural chromosomal aberrations in patients with schizophrenia.
Iskra Ventseslavova Sainova
1999