Education
Academic Background-
Ph.D. University of Valencia, Spain Pharmacy | Completed: 2006
Publications (86)
Selected Scholarly Contributions
Integrated Roles of The Thioredoxin-related Protein of 14 kDa, TRP14, in Sulfur Amino Acid Metabolism, Protein Posttranslational Modifications and Signaling
2026
Experimental Workflows for the Accurate Identification of Mitochondrial Redox Events
2026
DIVERGENT ROLES OF NOX1 AND NOX2 IN ACUTE PANCREATITIS AND DOWNREGULATION OF NOX2 IN OBESITY
2026
Obesity suppresses neutrophil-dependent itaconate signaling promoting ferroptosis in acute pancreatitis
2026
2025
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation
2024
Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation
2023
p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3
2022
Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis
2019
Surgical versus nonsurgical treatment of infected pancreatic necrosis: More arguments to change the paradigm.
2013
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups.
2013
Special issue on Oxidative stress and redox signaling in the gastrointestinal tract and related organs.
2013
p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species.
2013
Amniotic fluid oxidative and nitrosative stress biomarkers correlate with fetal chronic hypoxia in diabetic pregnancies.
2013
Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice.
2013
Mitochondrial dysfunction in cholestatic liver diseases.
2012
Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol.
2012
Redox signaling and histone acetylation in acute pancreatitis.
2012
Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions.
2011
Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis.
2010
Role of redox signaling, protein phosphatases and histone acetylation in the inflammatory cascade in acute pancreatitis: Therapeutic implications.
2010
Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age.
2010
Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats.
2010
Targeting mitochondria: A new promising approach for the treatment of liver diseases.
2010
Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis.
2010
Measurement of mitochondrial membrane potential and proton leak.
2010
Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants.
2009
Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: A key role for protein phosphatases.
2009
Pentoxifylline prevents loss of PP2A phosphatase activity and recruitment of histone acetyltransferases to proinflammatory genes in acute pancreatitis.
2009
Antenatal steroids and antioxidant enzyme activity in preterm infants: Influence of gender and timing.
2009
Preterm resuscitation with low oxygen causes less oxidative stress, inflammation and chronic lung disease.
2009
Mitochondrial involvement in non-alcoholic steatohepatitis.
2008
Modulation of longevity-associated genes by estrogens or phytoestrogens.
2008
Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance.
2008
The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFRamplification.
2008
Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38.
2008
Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury.
2008
Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis.
2008
Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?
2008
2007
Vitamins C and E prevent AZT-induced leukopenia and loss of cellularity in bone marrow. Studies in mice.
2007
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.
2007
Inspired supplemental oxygen reduces markers of oxidative stress during elective colon surgery.
2007
Obstructive sleep apnea: arterial oxygen desaturation coincides with increases in systemic oxidative stress markers measured with continuous monitoring.
2007
Glutathione is recruited into the nucleus in early phases of cell proliferation.
2007
Age-related increase in xanthine oxidase activity in human plasma and rat tissues.
2007
Multiple intrahepatic pseudocysts in acute pancreatitis.
2007
Mitochondrial oxidant signalling in Alzheimer's disease.
2007
Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide.
2007
Oxidative stress in marathon runners: Interest of antioxidant supplementation.
2006
Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFκB.
2006
Interaction between cytokines and oxidative stress in acute pancreatitis.
2006
Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens.
2006
Co-administration of pentoxifylline and thiopental causes death by acute pulmonary oedema in rats.
2006
Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration.
2006
Does oxygen concentration used for resuscitation influence outcome of asphyxiated newly born infants treated with hypothermia?
2006
Decreasing xanthine Oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats.
2005
Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis. Relevance for diagnosis of autoimmune pancreatitis.
2005
17β-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFκB cascade.
2005
Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds.
2005
Room-air resuscitation causes less damage to heart and kidney than 100% oxygen.
2005
AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E.
2004
Glutathione regulates telomerase activity in 3T3 fibroblasts.
2004
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.
2004
Mitochondrial theory of aging: Importance to explain why females live longer than males.
2003
Pancreatic function after severe acute biliary pancreatitis: The role of necrosectomy.
2003
Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen.
2003
Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males.
2003
Allopurinol and markers of muscle damage among participants in the Tour de france.
2003
The role of mitochondrial oxidative stress in aging.
2003
Cysteine may be an essential amino acid in the premature infant from a functional point of view.
2002
Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly born infants.
2002
Ginkgo biloba extract EGB 761 protects against mitochondrial aging in the brain and in the liver.
2002
Mitochondrial damage in aging and apoptosis.
2002
Role of cytokines and oxidative stress in the pathophysiology of - 5 -acute pancreatitis: Therapeutical implications.
2002
Xanthine oxidase is involved in free radical production in type 1 diabetes. Protection by allopurinol.
2002
Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism.
2002
Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress.
2001
Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants.
2001
Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates.
2001
Hepatic γ-cystathionase deficiency in patients with AIDS.
2001
Mitochondria, oxidative stress and aging.
2000
Free radicals in exhaustive physical exercise: Mechanism of production, and protection by antioxidants.
2000
Mechanism of free radical production in exhaustive exercise in humans and rats; Role of xanthine oxidase and protection by allopurinol.
2000
Pentoxifylline ameliorates cerulein-induced pancreatitis in rats: Role of glutathione and nitric oxide.
2000
Mitochondrial oxidative stress plays a key role in aging and apoptosis.
2000