Education
Academic Background-
Ph.D. University of Valladolid, Spain Chemistry | Completed: 1980
Publications (98)
Selected Scholarly Contributions
Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses.
Miguel Quintanilla
2016
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Miguel Quintanilla
2016
Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.
Miguel Quintanilla
2016
Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation.
Miguel Quintanilla
2016
Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.
Miguel Quintanilla
2015
New experimental models of skin homeostasis and diseases.
Miguel Quintanilla
2015
Enhanced tumorigenicity by mitochondrial DNA mild mutations.
Miguel Quintanilla
2015
New insights into the role of podoplanin in the epithelial-mesenchymal transition.
Miguel Quintanilla
2015
Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.
Miguel Quintanilla
2015
Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.
Miguel Quintanilla
2015
Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells.
Miguel Quintanilla
2014
Podoplanin is a substrate of presenilin-1/γ-secretase.
Miguel Quintanilla
2014
Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability.
Miguel Quintanilla
2014
Evaluation of mitochondrial function and metabolic reprogramming during tumor progression in a cell model of skin carcinogenesis.
Miguel Quintanilla
2013
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Miguel Quintanilla
2013
Polymorphisms in HIF-1α affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx.
Miguel Quintanilla
2013
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.
Miguel Quintanilla
2011
The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.
Miguel Quintanilla
2011
Using living cells to transport therapeutic genes for cancer treatment.
Miguel Quintanilla
2011
Podoplanin associates with CD44 to promote directional cell migration.
Miguel Quintanilla
2010
The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras.
Miguel Quintanilla
2010
Rac1 modulates TGF-β1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes.
Miguel Quintanilla
2010
Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinoma.
Miguel Quintanilla
2010
2010
Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter.
Miguel Quintanilla
2009
The emerging role of TGF-β superfamily coreceptors in cancer.
Miguel Quintanilla
2009
Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis.
Miguel Quintanilla
2009
S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology.
Miguel Quintanilla
2008
Murine endoglin-specific single-chain Fv fragments for the analysis of vascular targeting strategies in mice.
Miguel Quintanilla
2008
Functional blockade of Smad4 leads to a decrease in β-catenin levels and signaling activity in human pancreatic carcinoma cells.
Miguel Quintanilla
2008
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Miguel Quintanilla
2008
Targeting sodium/iodide symporter gene expression for estrogen-regulated imaging and therapy in breast cancer.
Miguel Quintanilla
2008
2008
2008
Uveal vs. cutaneous melanoma. Origins and causes of the differences.
Miguel Quintanilla
2008
Intratumoral lymphatic vessels and VEGF-C expression are predictive factors of lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma.
Miguel Quintanilla
2007
SPECT/CT imaging of oncolytic adenovirus propagation in tumours in vivo using the Na/I symporter as a reporter gene.
Miguel Quintanilla
2007
A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.
Miguel Quintanilla
2007
A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.
Miguel Quintanilla
2007
Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.
Miguel Quintanilla
2006
Molecular biology of malignant melanoma and other cutaneous tumors.
Miguel Quintanilla
2006
Caspase-1 as a radio-and chemo-sensitiser in vitro and in vivo.
Miguel Quintanilla
2006
Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: Association of a specific T (14; 15) with malignant progression.
Miguel Quintanilla
2005
Characterization of murine S-endoglin isoform and its effects on tumor development.
Miguel Quintanilla
2005
Characterization of human PA2. 26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas.
Miguel Quintanilla
2005
Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral cavity.
Miguel Quintanilla
2004
PA2. 26 antigen (T1α/podoplanin): A small mucin-like transmembrane glycoprotein associated with cell migration and cancer.
Miguel Quintanilla
2003
Murine models of skin carcinogenesis.
Miguel Quintanilla
2003
TGF-β signaling and epidermal carcinogenesis.
Miguel Quintanilla
2003
Expression of the TGF-β coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.
Miguel Quintanilla
2003
Transforming growth factor β-1 induces Snail transcription factor in epithelial cell lines mechanisms for epithelial mesenchymal transitions.
Miguel Quintanilla
2003
Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes.
Miguel Quintanilla
2002
TGF-β1 and Smad4 overexpression induces a less invasive phenotype in highly invasive spindle carcinoma cells.
Miguel Quintanilla
2002
Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling.
Miguel Quintanilla
2001
Ectopic expression of PA2. 26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression.
Miguel Quintanilla
2000
Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas.
Miguel Quintanilla
2000
Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-β1 in transformed keratinocytes.
Miguel Quintanilla
2000
Genistein and curcumin block TGF-β1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes.
Miguel Quintanilla
2000
Signaling during mouse skin tumor progression.
Miguel Quintanilla
2000
Adenovirus lacking the 19 K-and 55 K-E1B genes exerts a marked cytotoxic effect in human malignant cells.
Miguel Quintanilla
1999
In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.
Miguel Quintanilla
1999
Identification of PA2. 26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes.
Miguel Quintanilla
1999
Urokinase expression and binding activity associated with the transforming growth factor b1-induced migratory and invasive phenotype of mouse epidermal keratinocytes.
Miguel Quintanilla
1999
In vivo tumor suppressor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene.
Miguel Quintanilla
1998
Transforming growth factor β1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton.
Miguel Quintanilla
1998
Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.
Miguel Quintanilla
1998
Antitumoral effect of E1B defective adenoviruses in human malignant cells.
Miguel Quintanilla
1998
Induction of PA2. 26, a cell‐surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis.
Miguel Quintanilla
1997
In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene.
Miguel Quintanilla
1997
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Miguel Quintanilla
1996
Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene.
Miguel Quintanilla
1996
The expression pattern of the cell adhesion molecules E-, P-cadherin and α6β4 integrin is altered in premalignant skin tumors of p53 deficient mice.
Miguel Quintanilla
1996
Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E‐cadherin expression and correlated with reduced levels of Ha‐ras oncogene products.
Miguel Quintanilla
1996
Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.
Miguel Quintanilla
1995
Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours.
Miguel Quintanilla
1995
E-cadherin expression in basal cell carcinoma.
Miguel Quintanilla
1994
Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.
Miguel Quintanilla
1993
Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture.
Miguel Quintanilla
1993
Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes.
Miguel Quintanilla
1993
Expression of α6β4 integrin increases during malignant conversion of mouse epidermal keratinocytes: Association of β4 subunit to the cytokeratin fraction.
Miguel Quintanilla
1992
Expression of syndecan in transformed mouse keratinocytes.
Miguel Quintanilla
1992
Mouse skin carcinomas but not papillomas aberrantly express the simple epithelial type II keratin 8.
Miguel Quintanilla
1992
1992
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
Miguel Quintanilla
1992
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Miguel Quintanilla
1991
A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis.
Miguel Quintanilla
1991
Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia.
Miguel Quintanilla
1989
Immunological relationships between Artemia RNA polymerases and between RNA polymerases II from different eukaryotic organisms.
Miguel Quintanilla
1987
v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis.
Miguel Quintanilla
1986
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis.
Miguel Quintanilla
1986
The role of ras gene mutations in initiation of chemical carcinogenesis.
Miguel Quintanilla
1986
An approach to the molecular mechanisms of cancer induction.
Miguel Quintanilla
1986
Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum.
Miguel Quintanilla
1985
Purification and subunit structure of RNA polymerase II from different stages of Artemia development.
Miguel Quintanilla
1984
Post‐transcriptional regulation of endoribonuclease VI expression during Artemia development.
Miguel Quintanilla
1983
Purification and characterization of a novel UpN-specific endoribonuclease VI from Artemia larvae.
Miguel Quintanilla
1982
Dinucleoside triphosphatase from rat liver.
Miguel Quintanilla
1977
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
Miguel Quintanilla
1976