About
Professional Summary
Dr Janine Donaldson is a lecturer in the School of Physiology at the University of the Witwatersrand, South Africa. Her primary research interest is the gastrointestinal tract (GIT) and the GIT accessory organs, the liver and pancreas, in both normal and diseased states. In understanding the normal physiology of the GIT, liver and pancreas as well as the progression and pathogenesis of various diseases within the GIT and its accessory organs, will enable the development of new, improved therapeutic strategies for such diseases.
Another one of her primary research interests is that of the measurement of erythrocyte osmotic fragility in various mammals and bird species. The measurement of haematological parameters, such as erythrocyte osmotic fragility, is an important clinical tool for the assessment of the overall health status of the animal. Erythrocyte osmotic fragility can be affected by various extrinsic and intrinsic factors. The effects of factors such as the consumption of a high-fat diet as well as oxidative stress on the ability of the erythrocytes to resist osmotically-induced haemolysis are currently being investigated within her research group.
Education
Academic Background-
Ph.D. University of Witwatersrand, South Africa Physiology | Completed: 2016
Publications (42)
Selected Scholarly Contributions
Animal Models of Hyperoxaluria and Their Relevance for Fundamental Research and Clinical Practice
2026
Dependency of Glucose Homeostasis on Pancreatic Enzymes with Special Reference to Amylase; Study on Healthy and Exocrine Pancreatic Insufficient Pigs
2026
Rat Model of Endogenous and Exogenous Hyperammonaemia Induced by Different Diets
2025
Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail
2025
2025
Does Chronic Pancreatitis in Growing Pigs Lead to Articular Cartilage Degradation and Alterations in Subchondral Bone?
2024
Understanding Secondary Sarcopenia Development in Young Adults Using Pig Model with Chronic Pancreatitis
2024
Longitudinal Analysis of Bone Metabolic Markers and Bone Mechanical Properties in STZ-Induced Diabetic Rats
2024
The effect of prenatal fumonisin B exposure on bone innervation in newborn Wistar rats
2024
Investigating the Influence of a Tooth Absence on Facial Bone Growth Using a Porcine Model
2024
The Regulatory Role of Pancreatic Enzymes in the Maintenance of Small Intestinal Structure and Enterocyte Turnover with Special Reference to Alpha Amylase
2024
Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders
2023
2023
Basal Intestinal Morphology, Immunolocalization of Leptin and Ghrelin and Their Receptors in Newborn Wistar Rats after Prenatal Exposure to Fumonisins
2023
Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring
2023
2023
Anti-Incretin Gut Features Induced by Feed Supplementation with Alpha-Amylase: Studies on EPI Pigs
2023
The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes
2022
Basal Blood Morphology, Serum Biochemistry, and the Liver and Muscle Structure of Weaned Wistar Rats Prenatally Exposed to Fumonisins
2022
Milk Formula Enriched with Sodium Butyrate Influences Small Intestine Contractility in Neonatal Pigs
2022
Assessing Bone Health Status and Eggshell Quality of Laying Hens at the End of a Production Cycle in Response to Inclusion of a Hybrid Rye to a Wheat–Corn Diet
2022
Alterations in Small Intestine and Liver Morphology, Immunolocalization of Leptin, Ghrelin and Nesfatin-1 as Well as Immunoexpression of Tight Junction Proteins in Intestinal Mucosa after Gastrectomy in Rat Model
2021
Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation
2021
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Prevents Bone Loss during Pregnancy—Novel Evidence from a Spiny Mouse (Acomys cahirinus) Model
2021
Modern Hybrid Rye, as an Alternative Energy Source for Broiler Chickens, Improves the Absorption Surface of the Small Intestine Depending on the Intestinal Part and Xylanase Supplementation
2021
The Effects of Prenatal Supplementation with β-Hydroxy-β-Methylbutyrate and/or Alpha-Ketoglutaric Acid on the Development and Maturation of Mink Intestines Are Dependent on the Number of Pregnancies and the Sex of the Offspring
2021
Changes in the Intestinal Histomorphometry, the Expression of Intestinal Tight Junction Proteins, and the Bone Structure and Liver of Pre-Laying Hens Following Oral Administration of Fumonisins for 21 Days
2021
Femoral µCT Analysis, Mechanical Testing and Immunolocalization of Bone Proteins in β-Hydroxy β-Methylbutyrate (HMB) Supplemented Spiny Mouse in a Model of Pregnancy and Lactation-Associated Osteoporosis
2021
Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins
2021
The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent
2021
The Effect of L-Glutamine on Basal Albumen and Yolk Indices, and Albumen Amino Acids Composition
2021
Effects of Yeast (Saccharomyces Cerevisiae) Probiotics Supplementation on Bone Quality Characteristics in Young Japanese Quail (Coturnix Japonica): The Role of Sex on the Action of the Gut-Bone Axis
2020
Structural changes in the small intestine of female turkeys receiving a probiotic preparation are dose and region dependent
2019
Quercetin administration post‐weaning attenuates high‐fructose, high‐cholesterol diet‐induced hepatic steatosis in growing, female, Sprague Dawley rat pups
2019
The effects of high-fat diets composed of different animal and vegetable fat sources on the health status and tissue lipid profiles of male Japanese quail (Coturnix coturnix japonica).
Janine Donaldson
2017
Metabolic health of guinea fowl and muscovy ducks fed a high-fat diet.
Janine Donaldson
2017
The effect of different high fat diets on erythrocyte osmotic fragility, growth performance and serum lipid concentrations in male, Japanese quail (Coturnix coturnix japonica).
Janine Donaldson
2015
Effect of dietary enrichment with canola oil on glucose tolerance, tissue glycogen Content and viscera in Coturnix cortunix japonica.
Janine Donaldson
2014
The progressive effects of a high‐fat diet on erythrocyte osmotic fragility, growth performance and serum triglyceride and cholesterol levels in Guinea fowl (Numida meleagris) and Muscovy duck (Cairina moschata).
Janine Donaldson
2014
Fat absorption and deposition in Japanese quail (Coturnix coturnix japonica) fed a high fat diet.
Janine Donaldson
2013
The effectiveness of enzymatic replacement therapy measured by turbidimetry and the lipaemic index in exocrine pancreatic insufficient young, growing pigs, fed a high-fat diet.
Janine Donaldson
2009
The effects of some over-the-counter dietary weight loss supplements on growth, hepatic glycogen stores, liver lipid profile, pancreatic protein and the gastrointestinal tract of rats.
Janine Donaldson
2007