About
Professional SummaryDr. AKHIGBE Roland Eghoghosoa is a physician and Physiologist with keen interest in Reproductive Medicine (Andrology), Endocrinology and Metabolism and Toxicology. He has worked on the role of oxidative stress in the pathogenesis of various oathological conditions. He has published over 50 papers in peer-reviewed journals with 43 in Scopus, and 35 indexed in Pubmed, with over 914 citations.
Education
Academic Background-
Ph.D. Ladoke Akintola University of Technology, Nigeria Clinical Medicine | Completed: 2020
Publications (38)
Selected Scholarly Contributions
2026
CoQ10 mitigates BPA-induced cardiotoxicity by maintaining cellular antioxidant levels and Na+/K+-ATPase and Ca2+-ATPase activities
2026
Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies
2025
The consequences of climate change and male reproductive health: A review of the possible impact and mechanisms
2025
Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
2025
Curcumin ameliorates dichlorvos-induced cardiac injury by suppressing oxidative stress and downregulating pro-inflammatory cytokines in male Wistar rats
2025
Cardioprotective effect of metformin/donepezil combination in HFD/STZ-induced diabetic male Wistar rats involves acetylcholinesterase inhibition and modulation of Bax/Bcl-2/caspase 3 pathway
2025
Neurotoxic effects of acyclovir: impacts on oxidative stress, inflammation, and neurotransmitter dynamics in male Wistar rats
2025
2025
Impact of electromagnetic radiation on human reproduction health: Causes, consequences, and potential therapeutic approaches
2025
Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models
2024
Acetate attenuates lead-induced dysregulation of testicular steroidogenesis and spermatogenesis by targeting oxidative stress, inflammatory cytokines, and apoptosis
2024
SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis
2024
Proton Pump Dysfunction and Upregulation of Caspase‐3 Activity via Oxidative‐Sensitive Signaling Mediate Rohypnol‐Induced Testicular Toxicity
2023
Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats
2023
Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase/uric acid/caspase 3-mediated apoptotic signaling in male Wistar rats
2023
Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage
2022
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis
2022
Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury
2022
2022
Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury
2022
Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study
2022
Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury
2022
Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats
2022
Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats
2021
2021
The impact of reactive oxygen species in the development of cardiometabolic disorders: a review
2021
HAART and anti‐Koch’s impair sexual competence, sperm quality and offspring quality when used singly and in combination in male Wistar rats
2021
Apoptotic inducement of neuronal cells by codeine: possible role of disrupted redox state and caspase 3 signaling
2021
Co-administration of HAART and antikoch triggers cardiometabolic dysfunction through an oxidative stress-mediated pathway
2021
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content
2021
Moringa oleifera seed oil partially abrogates 2,3-dichlorovinyl dimethyl phosphate (Dichlorvos)-induced cardiac injury in rats: Evidence for the role of oxidative stress.
Roland Eghoghosoa Akhigbe
2021
Staging of the estrous cycle and induction of estrus in experimental rodents: an update
2020
The physiology of male reproduction: Impact of drugs and their abuse on male fertility
2020
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis.
Roland Eghoghosoa Akhigbe
2020
Possible links between COVID-19 and male fertility.
Roland Eghoghosoa Akhigbe
2020
Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis.
Roland Eghoghosoa Akhigbe
2020
Assessment of sexual behaviour and fertility indices in male rabbits following chronic codeine use.
Roland Eghoghosoa Akhigbe
2019