About
Professional SummaryDr. El-Sayed Abdou Zaki Khafagy is currently working as Assistant Professor in Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Egypt. He obtained his Ph.D. in Pharmaceutical Sciences from Hoshi University, Shinagawa, Tokyo, Japan in 2010. He also worked as Graduate Research Assistant at Toray Industries, Inc., New Frontiers Research Labs., Kanagawa, Japan, Senior Researcher Scientist, Visiting Scholar and Postdoctoral Researcher Fellow of The Nagai Foundation Tokyo, Kobe Gakuin University, and The University of Michigan USA. He also received number of honor and award includes JASSO Visiting Scholar Award for Research Fellowship in Japan, Fulbright Scholar Program Award for Postdoctoral Fellowship in USA, The Nagai Foundation Tokyo Research Grant Award for Young Assistant Researcher of Postdoctoral Fellowship in Japan, The Best Oral Presentation Award in 23rd Annual Meeting & Exposition of the Academy of Pharmaceutical Science and Technology, Japan, and Egyptian Government Ph.D. scholarship Award. His research area focuses on the Development of Drug Delivery Systems that enhances the Therapeutic Activity of the Incorporated Macromolecular Therapeutics (proteins and peptides), primarily through Non - parenteral routes of Administration. He follows two Parallel Approaches to achieve this Goal. First, he aims to better understand the effect of various Natural Materials and Endogenous Substances on the Mechanism(s) of Transport of Small Molecules, Macromolecules, and Polymeric Drug Delivery Systems across Epithelial Membrane. Second, he rationally Design Drug Delivery system including Polymeric carriers that can effectively exploit established Transport Mechanisms to Communicate with the different Epithelial Barriers to deliver their Therapeutic Cargo to the Diseased Tissues. He has 15 publications in journals and 13 papers in peer review conferences contributed as author/co-author. He is also supervising 1 PhD and 9 MSc thesis. He is professional member of Egyptian Society of Pharmaceutical Science (ESPS), Egyptian Syndicate of Pharmacists, Academy of Pharmaceutical Science and Technology, Japan (APSTJ), The Japan Society of Drug Delivery System (DDS), The Japanese Society for the Study of Xenobiotics (JSSX), and Fulbright Egyptian Scholar Program.
Education
Academic Background-
Ph.D. Hoshi University, Shinagawa, Tokyo, Japan Pharmaceutical Sciences | Completed: 2010
Publications (74)
Selected Scholarly Contributions
Correction: Askoura et al. Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System. Microorganisms 2021, 9, 2564
2026
RETRACTED: Cavalu et al. Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol Against Gram-Negative Bacterial Pathogens. Int. J. Mol. Sci. 2022, 23, 13088
2026
Sulforaphane Is Not Only a Food Supplement: It Diminishes the Intracellular Survival and Colonization of Salmonella enterica
2025
Correction: Hegazy et al. Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Salmonella Typhimurium Pathogenesis. Antibiotics 2022, 11, 465
2025
Correction: Khayyat et al. Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens. Microorganisms 2021, 9, 1083
2025
Correction: Khayat et al. Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis. Microorganisms 2022, 10, 2455
2025
Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension
2024
Flavonol-Glycoside and Rare Triterpenoid Derivatives Isolated from Leaves of Combretum glutinosum Perr. Ex Dc. with In Vitro Cytotoxic Activity
2023
2023
Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles
2023
Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens
2023
Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation
2023
Brain Targeting by Intranasal Drug Delivery: Effect of Different Formulations of the Biflavone “Cupressuflavone” from Juniperus sabina L. on the Motor Activity of Rats
2023
The Association of Smoking with Contact Dermatitis: A Cross-Sectional Study
2023
Ganetespib with Methotrexate Acts Synergistically to Impede NF-κB/p65 Signaling in Human Lung Cancer A549 Cells
2023
Development and Optimization of Erythromycin Loaded Transethosomes Cinnamon Oil Based Emulgel for Antimicrobial Efficiency
2023
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins
2023
Development and Characterization of Pullulan-Based Orodispersible Films of Iron
2023
Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate
2023
A Prospective Cohort Study of COVID-19: Evaluation of the Early Role of IL-1 and IL-6 Antagonists in Improving the Outcome of the Illness and Reduction in the Risk of Death
2023
Coleus aromaticus Ethanolic Leaves Extract Mediates Inhibition of NF-κB Signaling Pathway in Lung Adenocarcinoma A549 Cells
2023
In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives
2023
Development of Tea Tree Oil Based Nanoemulgel Loaded with Azithromycin for Enhancing the Antibacterial Activity
2023
Ocular Delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma
2023
Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis
2023
Ophthalmic Bimatoprost-Loaded Niosomal In Situ Gel: Preparation, Optimization, and In Vivo Pharmacodynamics Study
2023
The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens
2023
Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma
2023
Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus
2022
Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients
2022
Development and Evaluation of Clove and Cinnamon Supercritical Fluid Extracts-Loaded Emulgel for Antifungal Activity in Denture Stomatitis
2022
Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells
2022
Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin
2022
Enhancement of Vancomycin Potential against Pathogenic Bacterial Strains via Gold Nano-Formulations: A Nano-Antibiotic Approach
2022
Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity
2022
Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model
2022
Ameliorative Potential of L-Alanyl L-Glutamine Dipeptide in Colon Cancer Patients Receiving Modified FOLFOX-6 Regarding the Incidence of Diarrhea, the Treatment Response, and Patients’ Survival: A Randomized Controlled Trial
2022
Terazosin Interferes with Quorum Sensing and Type Three Secretion System and Diminishes the Bacterial Espionage to Mitigate the Salmonella Typhimurium Pathogenesis
2022
Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery
2022
Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation
2022
2022
Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin
2022
Oleuropein as a Potent Compound against Neurological Complications Linked with COVID-19: A Computational Biology Approach
2022
Cytotoxic and Apoptotic Effect of Rubus chingii Leaf Extract against Non-Small Cell Lung Carcinoma A549 Cells
2022
Amphotericin B-PEG Conjugates of ZnO Nanoparticles: Enhancement Antifungal Activity with Minimal Toxicity
2022
Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation
2022
Gold Nanoparticle-Based Resuscitation of Cefoxitin against Clinical Pathogens: A Nano-Antibiotic Strategy to Overcome Resistance
2022
RETRACTED: Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol against Gram-Negative Bacterial Pathogens
2022
Biosynthesis of Silver Nanoparticles Using Commiphora mukul Extract: Evaluation of Anti-Arthritic Activity in Adjuvant-Induced Arthritis Rat Model
2022
Formulation and Evaluation of Novel Additive-Free Spray-Dried Triamcinolone Acetonide Microspheres for Pulmonary Delivery: A Pharmacokinetic Study
2022
Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis
2022
Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis
2021
Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity
2021
Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells
2021
2021
Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma
2021
Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon
2021
Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer
2021
Secnidazole Is a Promising Imidazole Mitigator of Serratia marcescens Virulence
2021
A Novel Use of Allopurinol as A Quorum-Sensing Inhibitor in Pseudomonas aeruginosa
2021
Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System
2021
Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach
2020
Enhancing the Poor Flow and Tableting Problems of High Drug-Loading Formulation of Canagliflozin Using Continuous Green Granulation Process and Design-of-Experiment Approach
2020
In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin.
El-Sayed Abdou Zaki Khafagy
2014
One-month subchronic toxicity study of cell-penetrating peptides for insulin nasal delivery in rats.
El-Sayed Abdou Zaki Khafagy
2013
Noninvasive insulin delivery: The great potential of cell-penetrating peptides.
El-Sayed Abdou Zaki Khafagy
2013
Formulation, characterization and comparative in vitro in vivo evaluation of sustained release theophylline tablets.
El-Sayed Abdou Zaki Khafagy
2012
Oral biodrug delivery using cell-penetrating peptide.
El-Sayed Abdou Zaki Khafagy
2012
Cell-penetrating peptide-biodrug strategy for oral and nasal delivery: Review of recent findings.
El-Sayed Abdou Zaki Khafagy
2012
The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides.
El-Sayed Abdou Zaki Khafagy
2010
Structural requirements of penetratin absorption enhancement efficiency for insulin delivery.
El-Sayed Abdou Zaki Khafagy
2010
Effect of cell-penetrating peptides on the nasal absorption of insulin.
El-Sayed Abdou Zaki Khafagy
2009
Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins.
El-Sayed Abdou Zaki Khafagy
2009
Current challenges in non-invasive insulin delivery systems: A comparative review.
El-Sayed Abdou Zaki Khafagy
2007