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Mohamed Mohamed Sayed-Ahmed

Mohamed Mohamed Sayed-Ahmed

LiveDNA ID: 20.6255
ACSE
56 Publications
0 Editorial Roles
0 Projects

Education

Academic Background
  • Ph.D. Duke University Medical Center, USA Pharmacology and Experimental Oncology | Completed: 1995

Publications (56)

Selected Scholarly Contributions
Endothelin System Blockade Extenuates Sepsis‐Induced Acute Heart and Kidney Injuries via Modulating ET‐1/Klotho/p38‐MAPK
Alaa Al‐kadi, Aliaa F. Anter, Remon Roshdy Rofaeil, Mohamed M. Sayed‐Ahmed, Sara Mohamed Naguib Abdel Hafez, Al‐Shaimaa F. Ahmed
Clinical and Experimental Pharmacology and Physiology | Journal Article
10.1111/1440-1681.70042
Crossref
2025
Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model
Somow S. Kamel, Naiyra A. Abdel Baky, Riham M. Karkeet, Abdel‐Moneim M. Osman, Mohamed M. Sayed‐Ahmed, Mariam A. Fouad
Clinical and Experimental Pharmacology and Physiology | Journal Article
10.1111/1440-1681.13598
Crossref
2022
Potential role of oxidative stress on the prescription of rehabilitation interventions in spinal cord injury.
Lam, T., Z. Chen, M.M. Sayed-Ahmed, A. Krassioukov and A.A. Al-Yahya,
Spinal Cord, | Journal Article
10.1038/sc.2013.71
Self Mohamed Mohamed Sayed-Ahmed
2013
Novel 4(3H)-quinazolinone analogs: Synthesis and anticonvulsant activity.
El-Azab, A.S., S.G. Abdel-Hamide, M.M. Sayed-Ahmed, G.S. Hassan and T.M. El-Hadiyah et al.,
Med. Chem. Res., | Journal Article
10.1007/s00044-012-0280-y
Self Mohamed Mohamed Sayed-Ahmed
2013
Increased expression of biological markers as potential therapeutic targets in Saudi women with triple-negative breast cancer.
Sayed-Ahmed, M.M., M.M. Hafez, A.A. Al-Shabanah, S.S. Al-Rejaie and A.M. Aleisa et al.,
Tumori, | Journal Article
10.1177/030089161309900418
Self Mohamed Mohamed Sayed-Ahmed
2012
MicroRNAs and metastasis-related gene expression in egyptian breast cancer patients.
Hafez, M.M., Z.K. Hassan, A.R. Zekri, A.A. Gaber, S.S. Al-Rejaie, M.M. Sayed-Ahmed and O.A. Al-Shabanah,
Asian Pac. J. Cancer Prev., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2012
Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues.
El-Subbagh, H.I., G.S. Hassan, A.S. El-Azab, A.A. Abdel-Aziz and A.A. Kadi et al.,
Eur. J. Med. Chem., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2011
Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression.
Alhaider, A.A., H.M. Korashy, M.M. Sayed-Ahmed, M. Mobark, H. Kfoury and M.A. Mansour,
Chemico-Biol. Interact., | Journal Article
10.1016/j.cbi.2011.03.014
Self Mohamed Mohamed Sayed-Ahmed
2011
L-carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues.
Sayed-Ahmed, M.M.,
J. Nephrol., | Journal Article
10.5301/JN.2011.6447
Self Mohamed Mohamed Sayed-Ahmed
2011
Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats.
Nagi, M.N., O.A. Al-Shabanah, M.M. Hafez and M.M. Sayed-Ahmed,
J. Biochem. Mol. Toxicol., | Journal Article
10.1002/jbt.20369
Self Mohamed Mohamed Sayed-Ahmed
2011
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study.
El-Azab, A.S., M.A. Al-Omar, A.A. Abdel-Aziz, N.I. Abdel-Aziz and M.A. El-Sayed et al.,
Eur. J. Med. Chem., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2010
Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation.
Al-Shabanah, O.A., M.M. Hafez, M.M. Al-Harbi, Z.K. Hassan, S.S. Al-Rejaie, Y.A. Asiri and M.M. Sayed-Ahmed,
Oxid. Med. Cell. Longev., | Journal Article
10.4161/oxim.3.6.14416
Self Mohamed Mohamed Sayed-Ahmed
2010
Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi Syndrome rat model.
Sayed-Ahmed, M.M., A.Q. Darweesh and A.J. Fatani,
Oxidative Med. Cell. Longevity, | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2010
Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling.
Sayed-Ahmed, M.M., A.M. Aleisa, S.S. Al-Rejaie, A.A. Al-Yahya, O.A. Al-Shabanah, M.M. Hafez and M.N. Nagi,
Oxidative Med. Cell. Longevity, | Journal Article
10.4161/oxim.3.4.12714
Self Mohamed Mohamed Sayed-Ahmed
2010
Role of carnitine in cancer chemotherapy-induced multiple organ toxicity.
Sayed-Ahmed, M.M.,
Saudi Pharm. J., | Journal Article
10.1016/j.jsps.2010.07.008
Self Mohamed Mohamed Sayed-Ahmed
2010
Progression of cyclophosphamide-induced acute renal metabolic damage in carnitine-depleted rat model.
Sayed-Ahmed, M.M.,
Clin. Exp. Nephrol., | Journal Article
10.1007/s10157-010-0321-0
Self Mohamed Mohamed Sayed-Ahmed
2010
Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat.
Abdel Baky, N.A., Z.F. Zaidi, A.J. Fatani, M.M. Sayed-Ahmed and H. Yaqub,
Brain Res. Bull., | Journal Article
10.1016/j.brainresbull.2010.07.004
Self Mohamed Mohamed Sayed-Ahmed
2010
Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver.
Nagi, M.N., H.A. Almakki, M.M. Sayed-Ahmed and A.M. Al-Bekairi,
Food Chem. Toxicol., | Journal Article
10.1016/j.fct.2010.05.072
Self Mohamed Mohamed Sayed-Ahmed
2010
Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model.
Sayed-Ahmed, M.M., O.A. Al-Shabanah, M.M. Hafez, A.M. Aleisa and S.S. Al-Rejaie,
Eur. J. Pharmacol., | Journal Article
10.1016/j.ejphar.2010.05.002
Self Mohamed Mohamed Sayed-Ahmed
2010
Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats.
Fatani, A.G., A.Q. Darweesh, L. Rizwan, A.M. Aleisa, O.A. Al-Shabanah and M.M. Sayed-Ahmed,
Chemotherapy, | Journal Article
10.1159/000298822
Self Mohamed Mohamed Sayed-Ahmed
2010
Increased urinary losses of carnitine and decreased intramitochondrial coenzyme a in gentamicin-induced acute renal failure in rats.
Al-Shabanah, O.A., A.M. Aleisa, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, A.G. Fatani and M.M. Sayed-Ahmed,
Nephrol. Dial. Trans., | Journal Article
10.1093/ndt/gfp457
Self Mohamed Mohamed Sayed-Ahmed
2010
Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats.
Al-Rejaie, S.S., A.M. Aleisa, A.A. Al-Yahya, S.A. Bakheet and A. Alsheikh et al.,
World J. Gastroenterol., | Journal Article
10.3748/wjg.15.1373
Self Mohamed Mohamed Sayed-Ahmed
2009
Reversal of doxorubicin resistance by adenovirus-mediated transfer of cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells.
Kamel, M.W., S.A. Salama, S. Saleh, A.M.M.Osman, M.S. Ahmed and A. Al-Hendy,
Cancer Therapy, | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2007
Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues.
Aleisa, A.M., A.A. Al-Majed, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, O.A. Al-Shabanah and M.M. Sayed-Ahmed,
Clin. Exp. Pharmacol. Physiol., | Journal Article
10.1111/j.1440-1681.2007.04714.x
Self Mohamed Mohamed Sayed-Ahmed
2007
Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats.
Sayed-Ahmed, M.M. and M.N. Nagi,
Clin. Exp. Pharmacol. Physiol., | Journal Article
10.1111/j.1440-1681.2007.04560.x
Self Mohamed Mohamed Sayed-Ahmed
2007
Multidrug resistance to cancer chemotherapy: Genes involved and blockers.
Sayed-Ahmed, M.M.,
Saudi Pharm. J., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2007
Increased serum and cardiac acyl-carnitine/free carnitine ratio during development of doxorubicin-induced cardiotoxicity.
Sayed-Ahmed, M.M.,
Saudi Pharm. J., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2007
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
Al-Majed, A.A., M.M. Sayed-Ahmed, F.A. Al-Omar, A.A. Al-Yahya, A.M. Aleisa and O.A. Al-Shabanah,
Clin. Exp. Pharmacol. Physiol., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2006
Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model.
Al-Majed, A.A., M.M. Sayed-Ahmed, A.A. Al-Yahya, A.M. Aleisa, S.S. Al-Rejaie and O.A. Al-Shabanah,
Pharmacol. Res., | Journal Article
10.1016/j.phrs.2005.12.005
Self Mohamed Mohamed Sayed-Ahmed
2006
Contribution of nitric oxide and epidermal growth factor receptor in antimetastatic potenial of paclitaxel in human liver cancer cells (Heb G2).
Sayed-Ahmed, M.M. and A.M. Mohamed,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2005
Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat.
El-Demerdash, E., A.S. Awad, R.M. Taha, A.M. El-Hady and M.M. Sayed-Ahmed,
Pharmacol. Res., | Journal Article
10.1016/j.phrs.2004.10.002
Self Mohamed Mohamed Sayed-Ahmed
2005
Acetyl-L-carnitine modulates bleomycin-induced oxidative stress and energy depletion in lung tissues.
Sayed-Ahmed, M.M., H.H. Mansour, O.A. Gharib and H.F.Hafez,
J. Egypt. Nat. Canc. Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2004
Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model.
Sayed-Ahmed, M.M., M. Eissa, S. Kenawy, N. Mostafa, M. Calvani and A.M. Osman,
Chemotherapy, | Journal Article
10.1159/000080689
Self Mohamed Mohamed Sayed-Ahmed
2004
Protective role of carnitine esters against Alcohol-induced gastric lesions in rats.
Arafa, H.M.M. and M.M. Sayed-Ahmed,
Pharmacol. Res., | Journal Article
10.1016/S1043-6618(03)00154-3
Self Mohamed Mohamed Sayed-Ahmed
2003
New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity.
El-Demerdash, E., A.A. Ali, M.M. Sayed-Ahmed and A.M. Osman,
Cancer Chemother. Pharmacol., | Journal Article
10.1007%2Fs00280-003-0676-y
Self Mohamed Mohamed Sayed-Ahmed
2003
Contribution of nitric oxide in doxorubicin-related cytotoxicity in murine tumour model.
Sayed-Ahmed, M.M., S.A. Shouman and L.A. Ramadan,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2002
L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits.
Sayed-Ahmed, M.M., M.M. Khattab, M.Z. Gad and N. Mostafa,
Pharmacol. Res., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2001
Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy.
Sayed-Ahmed, M.M., M.M. Khattab, M.Z. Gad and A.M. Osman,
Pharmacol. Toxicol., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2001
Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals.
Ramadan, L.A., S.A. Shouman, M.M. Sayed-Ahmed and O.H. El-Habit,
Pharmacol. Res., | Journal Article
10.1006/phrs.2000.0763
Self Mohamed Mohamed Sayed-Ahmed
2001
Propionyl-l-carnitine as protector against adriamycin-induced cardiomyopathy.
Sayed-Ahmed, M.M., T.M. Salman, H.E. Gaballah, S.A. Abou El-Naga, R. Nicolai and M. Calvani,
Pharmacol. Res., | Journal Article
10.1006/phrs.2000.0786
Self Mohamed Mohamed Sayed-Ahmed
2001
Effect of cremophor-El on cisplatin induced organs toxicity in normal rats.
Ramadan, L.A., O. El-Habit, H. Arafa and M.M. Sayed-Ahmed,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2001
Plasma endothelin (ET-1) as a marker for doxorubicin-induced cardiotoxicity in egyptian patients.
Osman, A.M., H. Gaballa, N.H. Mohamed, N.M. Ali., M.S. Ahmed and H.M. Arafa,
J. Egypt Soc. Toxicol., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2000
Modulation by verapamil of doxorubicin induced expression of multidrug resistance gene (mdr-1/P-glycoprotein) in murine tumour cells.
Osman, A.M., M.A. Mohamed, A.A. Abdel-Wahab and M.S. Ahmed,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2000
Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid β-oxidation in isolated heart mitochondria.
Sayed-Ahmed, M.M., S.A. Shouman, B.M. Rezk, M.H. Khalifa, A.M. Osman and M.M. El-Merzabani,
Pharmacol. Res., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2000
Protection by L-carnitine against the inhibition of gene expression of heart fatty acid binding protein by chronic administration of doxorubicin.
Sayed-Ahmed, M.M., A.M. Kishk, S. Soloma and S. Abdel-Aleem,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2000
Effects of trichloroactate, water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice.
Salman, T.M. and M.M. Sayed-Ahmed,
Sci. J. Az. Med. Fac. (Girls), | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
2000
The protective effect of methimazole against cisplatin-induced chromosomal abberrations.
Hanafy, M., S.M.M. Ahmed and A.M. Osman,
Sci. J. Az. Med. Fac.(Girls), | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1999
Reversal of doxorubicin-induced cardiac metabolic damage by l-carnitine.
Sayed-Ahmed, M.M., S. Sharawy, S.A. Shouman and A.M. Osman,
Pharmacol. Res., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1999
Potenial promise of using L-carnitine and Coenzyme Q10 as protective agents against Cisplatin-induced nephrotoxicity.
Sayed-Ahmed, M.M., M. Khattab, A. Khalifa, M. El-Khabany and A.M. Osman,
J. Egypt. National Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1999
Verapamil enhancement of the cytotoxic and cell cycle perturbation of doxorubicin in Ehrlich ascites carcinoma cells in vivo.
Abidli, N., M.M. Sayed-Ahmed, S.M. El-Gerzawy, M.M. El-Didi, C. Benlatreche, M.M. El-Merzabani and A.M. Osman,
J. Egypt. National Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1999
Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes.
Abdel-Aleem, S., M.M. El-Merzabani, M. Sayed-Ahmed, D.A. Taylor and J.E. Lowe,
J. Mol. Cell. Cardiol., | Journal Article
10.1006/jmcc.1996.0323
Self Mohamed Mohamed Sayed-Ahmed
1997
Regulation of fatty acid oxidation by acetyl-CoA generated from glucose utilization in isolated myocytes.
Abdel-Aleem, S., M.A. Nada, M. Sayed-Ahmed, S.C. Hendrickson, J. St Louis, H.P. Walthall and J.E. Lowe,
J. Mol. Cell. Cardiol., | Journal Article
10.1006/jmcc.1996.0077
Self Mohamed Mohamed Sayed-Ahmed
1996
Stimulation of non-oxidative glucose utilization by L-carnitine in isolated myocytes.
Abdel-Aleem, S., M. Sayed-Ahmed, M.A. Nada, S.C. Hendrickson, J. St Louis and J.E. Lowe,
J. Mol. Cell. Cardiol., | Journal Article
10.1006/jmcc.1995.0234
Self Mohamed Mohamed Sayed-Ahmed
1995
Reduced induction of carbohydrate utilization by inhibition of fatty acid oxidation in myocytes from diabetic animals.
Abdel-Aleem, S., S. Sharwi, M. Badr, M. Sayed-Ahmed, M.P. Anstadt and J.E. Lowe,
Horm. Metab. Res., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1994
Potentiation of the chemotherapeutic effect of methotrexate by hyperthermia in experimental animal tumour model.
Shouman, S.A., M.M. Sayed-Ahmed and M.M. El-Merzabani,
J. Egypt. Nat. Cancer Inst., | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1994
Hyperthermic potentiation of cisplatin cytotoxicity on solid Ehrlich carcinoma.
Osman, A.M., M.M. Ahmed, M.T. Khyyal and M.M. El-Merzabani,
Tumori, | Journal Article
Self Mohamed Mohamed Sayed-Ahmed
1993