Muhammad Shahid
Associate Professor
CECOS University of IT and Emerging Sciences
LiveDNA ID:
92.33805
About
Professional Summary
Dr. Shahid's research is in preclinical pharmacology, ethnopharmacology, and pain medicine, with a central focus on neuropathic pain. His work follows a consistent arc: establishing rodent models of neuropathy, characterizing the persistent pain states that develop, and testing how candidate compounds reverse them. His models include chronic constriction injury of the sciatic nerve, cisplatin-induced peripheral neuropathy, and streptozotocin-induced diabetic neuropathy. In these, mechanical and thermal sensitivity are tracked over time with allodynia and hyperalgesia paradigms. His candidate compounds come from both natural and synthetic sources. Standardized Bacopa monnieri extract alleviated allodynia and hyperalgesia after nerve injury and protected against opioid- and cisplatin-related organ toxicity. The flavonoid 6-methoxyflavone reduced neuropathic nociception across chronic constriction injury, cisplatin, and diabetic models. The antioxidant tiopronin attenuated the expression of neuropathic allodynia and hyperalgesia. A major translational strand is his work on topical gabapentin. Preclinical studies in chronic constriction injury and cisplatin-induced neuropathy showed that a gabapentin gel relieves neuropathic pain locally. These findings supported a formulation later used clinically for patients who cannot tolerate the adverse effects of oral gabapentin. Through collaborative work, his research extends to neuroprotection and Alzheimer's-related models, toxicology, and the ethnopharmacology of medicinal plants in pain, inflammation, pyrexia, and chemotherapy-induced vomiting.
Research interests: Preclinical pharmacology; ethnopharmacology; pain medicine; neuropathic pain; neuroprotection; natural products.
Employment
Professional Appointments
Associate Professor
CECOS University of IT and Emerging Sciences
Education
Academic Background-
Ph.D. University of Peshawar, Pakistan Pharmacology and Toxicology | Mar 2014 — Jul 2019
Publications (92)
Selected Scholarly Contributions
Phytochemical Profiling and Evaluation of the Anti-inflammatory and Antinociceptive Effects of Lilium polyphyllum Bulb Using In Silico, In Vitro and In Vivo Models
2026
Bukiniczia cabulica (Boiss.) Lincz. ameliorate diabetes-induced neuropathy: analgesic, anti-diabetic and anti-neuropathic using enzyme inhibitory, molecular docking and in-vivo studies
2026
RETRACTED: Khan et al. Norfloxacin Loaded Lipid Polymer Hybrid Nanoparticles for Oral Administration: Fabrication, Characterization, In Silico Modelling and Toxicity Evaluation. Pharmaceutics 2021, 13, 1632
2025
Galegine, a Bioprivileged Alkaloid from Tithonia tubaeformis: Antipyretic Activity Insights
2025
Novel efficacy of pregnane and flavonoid glycosides from
Desmidorchis flava
in in vivo nociceptive and inflammatory paradigms and their target prediction by cheminformatics approach
2025
Evaluation of the Ameliorative Potential of 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione against Scopolamine-Induced Alzheimer’s Disease
2024
6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression
2024
Quantitative-HPLC-DAD polyphenols analysis, anxiolytic and cognition enhancing potentials of Sorbaria tomentosa Lindl. Rehder
2023
Flavonoids containing Vitex negundo extract displayed calcium channels blocking property underlying its anti-diarrheal and anti-spasmodic activities
2022
Muricazine, a new hydrazine derivative from Ranunculus muricatus L. with antioxidant, lipoxygenase and urease inhibitory activities
2022
Antidiarrheal and antispasmodic activities of Trillium govanianum rhizomes extract: involvement of calcium channel blockade
2022
Cassia artemisiodes attenuates nociceptive and diabetes-induced neuropathic pain modalities apropos antioxidant and anti-inflammatory mechanisms
2022
Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway
2022
Comparative in-vitro anti-inflammatory, anticholinesterase and antidiabetic evaluation: computational and kinetic assessment of succinimides cyano-acetate derivatives
2022
Phytotherapeutic Approach in the Management of Cisplatin Induced Vomiting; Neurochemical Considerations in Pigeon Vomit Model
2022
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors
2022
EFFECT OF THE FLAVONOID 6-AMINOFLAVONE IN ASPIRIN-INDUCED GASTRIC ULCER IN SPRAGUE-DAWELY RATS: A HISTOMORPHOLOGICAL STUDY
2022
Bioavailability and hepatoprotection enhancement of berberine and its nanoparticles prepared by liquid antisolvent method
2021
Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation
2021
Neuroprotective Studies on Polygonum hydropiper L. Essential Oils Using Transgenic Animal Models
2021
Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction
2021
Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia
2021
Isolation, Characterization and Neuroprotective Activity of Folecitin: An In Vivo Study
2021
Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches
2021
Isolation of tyrosine derived phenolics and their possible beneficial role in anti-inflammatory and antioxidant potential of Tithonia tubaeformis
2021
Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and assessment of acute and sub-acute toxicity
2021
A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats
2021
The antioxidant N-(2-mercaptopropionyl)-glycine (tiopronin) attenuates expression of neuropathic allodynia and hyperalgesia
2021
Muriolide, a novel antioxidant lactone from Ranunculus muricatus.
Muhammad Shahid
2021
6-Methoxyflavanone abates cisplatin-induced neuropathic pain apropos anti-inflammatory mechanisms: A behavioral and molecular simulation study
2020
Clarithromycin loaded lipid polymer hybrid nanoparticles: Fabrication, in vitro and in vivo evaluation
Muhammad Shahid
2020
2020
Efficacy assessment of salicylidene salicylhydrazide in chemotherapy associated peripheral neuropathy
2020
Cholinesterase's Enzymes Inhibition and Michaelis-Menten Kinetics Studies on Ethnomedicinally Important Plant Chenopodium botrys
Muhammad Shahid
2020
The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity
Muhammad Shahid
2020
2020
Engineering of naproxen loaded polymer hybrid enteric microspheres for modified release tablets: Development, characterization, in silico modelling and in vivo evaluation.
Muhammad Shahid
2020
Enhancement of bioavailability and hepatoprotection by silibinin through conversion to nanoparticles prepared by liquid antisolvent method.
Muhammad Shahid
2020
Clarithromycin loaded lipid polymer hybrid nanoparticles: Fabrication, in vitro and in vivo evaluation.
Muhammad Shahid
2020
Comparative cholinesterase, α-glucosidase inhibitory, antioxidant, molecular docking, and kinetic studies on potent succinimide derivatives.
Muhammad Shahid
2020
Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders
2019
Attenuation of cisplatin associated testicular toxicity by 6-hydroxyflavone
Muhammad Shahid
2019
Effect of 6-hydroxyflavone on cisplatin-induced histopathological and biochemical changes in liver of Sprague-Dawely rats
Muhammad Shahid
2019
Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy
2019
Domperidone nanocrystals with boosted oral bioavailability: Fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction.
Muhammad Shahid
2019
Pistacia integerrima gall extract mediated green synthesis of gold nanoparticles and their biological activities.
Muhammad Shahid
2019
Green synthesis and biological activities of gold nanoparticles functionalized with Salix alba.
Muhammad Shahid
2019
Synthesis of pyrrolidine-2,5-dione based anti-inflammatory drug: In vitro COX-2, 5-LOX inhibition and in vivo anti-inflammatory studies.
Muhammad Shahid
2019
Gummy gold and silver nanoparticles of apricot (Prunus armeniaca) confer high stability and biological activity.
Muhammad Shahid
2019
Prunus armeniaca and Prunus domestica Gums: Exploring their Synergistic Binding Potential in Tablets
Muhammad Shahid
2018
Frequency of gastrointestinal parasites among children in clinical practices Peshawar, KPK, Pakistan
Muhammad Shahid
2018
Suppression of Cisplatin-Induced Vomiting by Cannabis sativa in Pigeons: Neurochemical Evidences
2018
Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit
2018
Multifunctional theranostic applications of biocompatible green-synthesized colloidal nanoparticles
2018
HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana
2018
Novel hydroquinone derivatives alleviate algesia, inflammation and pyrexia in the absence of gastric ulcerogenicity.
Muhammad Shahid
2018
Dexibuprofen nanocrystals with improved therapeutic performance: Fabrication, characterization, in silico modeling, and in vivo evaluation.
Muhammad Shahid
2018
A new glycosidic antioxidant from Ranunculus muricatus L. (Ranunculaceae) exhibited lipoxygenasae and xanthine oxidase inhibition properties
2017
Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.
2017
GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.
2017
Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model
2017
Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach
2017
A Novel Pregabalin Functionalized Salicylaldehyde Derivative Afforded Prospective Pain, Inflammation, and Pyrexia Alleviating Propensities
2017
A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.
2017
2017
Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation
2017
A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats
2017
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Muhammad Shahid
2017
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia.
Muhammad Shahid
2017
Olanzapine induced biochemical and histopathological changes after its chronic administration in rats
2016
Development of fixed dose combination tablets of aripiprazole plus divalproex sodium and their simultaneous determination using HPLC-UV
2016
Pharmacological screening of Monotheca buxifolia (Falc.) A. DC. for antinociceptive, anti-inflammatory and antipyretic activities
2016
Pharmaceutical evaluation and toxicological quantification of heavy metals and adulterated allopathic contents in raw and finished dosage form of antihypertensive herbal products
Muhammad Shahid
2016
Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms
2016
Hepatoprotective effect of Monotheca buxifolia fruit against antitubercular drugs-induced hepatotoxicity in rats
2016
Beneficial Effects of Trillium govanianum Rhizomes in Pain and Inflammation
2016
6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain
2016
Beneficial effects of Bacopa monnieri extract on opioid induced toxicity
2016
Green synthesis and biological activities of gold nanoparticles functionalized with Citrus reticulata, Citrus aurantium, Citrus sinensis and Citrus grandis
Muhammad Shahid
2015
GC/MS analysis, free radical scavenging, anticancer and β-glucuronidase inhibitory activities of Trillium govanianum rhizome
2015
Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii
2015
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin
2015
Pharmacological basis for the use of Hypericum oblongifolium as a medicinal plant in the management of pain, inflammation and pyrexia
2015
Synthesis of pyrrolidine -2,5-dione based anti-inflammatory drug: In vitro COX-2, 5-LOX inhibition and in vivo anti-inflammatory studies
Muhammad Shahid
2015
Neuroprotective effect of Bacopa monnieri against morphine-induced histopathological changes in the cerebellum of rats
Muhammad Shahid
2015
Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates
2014
Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study
2014
Attenuation of Cisplatin-Induced Emetogenesis by Standardized Bacopa monnieri Extracts in the Pigeon: Behavioral and Neurochemical Correlations
2014
Protective effect of Bacopa monniera methanol extract against carbon tetrachloride induced hepatotoxicity and nephrotoxicity
Muhammad Shahid
2014
Comparative histopathology of acetaminophen induced hepatotoxicity in animal models of mice and rats
Muhammad Shahid
2014
Essential oil composition of Mentha piperita L. and its antimicrobial effects against common human pathogenic bacterial and fungal strains
Muhammad Shahid
2013
Biochemical and antimicrobial properties of Citrus peel waste
Muhammad Shahid
2013