Dr. Muhammad  Ali
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Dr. Muhammad Ali

Assistant Professor
Comsats Institute of Information Technology, Pakistan


Highest Degree
PostDoc Fellow in Organic Synthesis from University of Bristol, UK

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Biography

Dr. Muhammad Ali is currently working as Assistant Professor at Department of Chemistry, COMSATS Institute of Information Technology, University Road, Abbottabad, Pakistan. He has obtained his PhD in Synthetic Organic Chemistry/Medicinal Chemistry from HEJ Research Institute of Chemistry, University of Karachi, and Post Doctorate in Development of New Methodologies in Organic Synthesis from School of Chemistry, University of Bristol, UK. Previously he was appointed as Assistant Professor at NUST Center of Virology & Immunology, NUST, Islamabad, and Postdoctoral Research Associate at HEJ Research Institute of Chemistry, University of Karachi, and Junior Research Fellow and Research Associate at HEJ Research Institute of Chemistry. His main area of research interest focus on Organoboron Chemistry with special reference to Lithiation-Borylation Chemistry, Transition Metal Chemistry and Asymmetric Synthesis/Catalysis with particular interest to discover new Chemical reactions for drug discovery and methodology development, together with, General Synthetic Organic Chemistry with particular emphasis on the development and synthesis of pharmaceutically important motifs. Dr. Ali received honors includes PCST Research Productivity Award, NRPU-HEC Research Grant Award worth 14.86 Million Rs (PI) and NRPU-HEC Research Grant Award worth 14.86 Million Rs (PI) and IRSIP Fellowship, Uppsala University, Sweden. He has 51 publications in journals as author/co-author. He has completed 3 research grants. He is life member of Chemical Society of Pakistan, Affiliate Member of IUPAC.

Area of Interest:

Chemistry
100%
Organoboron Chemistry
62%
Lithiation-Borylation Chemistry
90%
Transition Metal Chemistry
75%
Drug Discovery
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Taha, M., N.H. Ismail, S. Imran, M. Ali, W. Jamil, N. Uddin and S.M. Kashif, 2016. Identification of bisindolylmethane-hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT and in silico SAR intimations. RSC Adv., 6: 3276-3289.
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  2. Taha, M., N.H. Ismail, S. Imran, A. Wadood and M. Ali et al., 2016. Novel thiosemicarbazide-oxadiazole hybrids as unprecedented inhibitors of yeast α-glucosidase and in silico binding analysis. RSC Adv., 6: 33733-33742.
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  3. Rashid, U., F. Rahim, M. Taha, M. Arshad, H. Ullah, T. Mahmood and M. Ali, 2016. Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies. Bioorg. Chem., 66: 111-116.
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  4. Rahim, F., M. Ali, S. Ullah, U. Rashid and H. Ullah et al., 2016. Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies. Chin. Chem. Lett., 27: 693-697.
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  5. Zawawi, N.K.N.A., M. Taha, N. Ahmat, A. Wadood and N.H. Ismail et al., 2015. Novel 2,5-disubtituted-1,3,4-oxadiazoles with benzimidazole backbone: A new class of β-glucuronidase inhibitors and in silico studies. Bioorg. Med. Chem., 23: 3119-3125.
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  6. Taha, M., N.H. Ismail, S. Imran, M. Selvaraj and H. Rashwan et al., 2015. Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors. Bioorg. Chem., 61: 36-44.
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  7. Taha, M., N.H. Ismail, S. Imran, M. Selvaraj and A. Rahim et al., 2015. Synthesis of novel benzohydrazone-oxadiazole hybrids as β-glucuronidase inhibitors and molecular modeling studies. Bioorganic Med. Chem., 23: 7394-7404.
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  8. Taha, M., N.H. Ismail, S. Imran, A. Wadood, F. Rahim, M. Ali and A.U. Rehman, 2015. Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions. Med. Chem. Commun., 6: 1826-1836.
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  9. Taha, M., N.H. Ismail, K. Javaid, S. Imran and A. Wadood et al., 2015. Evaluation of 2-indolcarbohydrazones as potent α-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions. Bioorg. Chem., 63: 24-35.
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  10. Jamil, W., S. Solangi, M. Ali, K.M. Khan, M. Taha and M.Y. Khuhawar, 2015. Syntheses, characterization, in vitro antiglycation and DPPH radical scavenging activities of isatin salicylhydrazidehydrazone and its Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal complexes. Arabian J. Chem., (In Press). 10.1016/j.arabjc.2015.02.015.
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  11. Taha, M., N.H. Ismail, W. Jamil, H. Rashwan and S.M. Kashif et al., 2014. Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities. Eur. J. Med. Chem., 84: 731-738.
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  12. Taha, M., N.H. Ismail, M. Ali, K.M. Khan, W. Jamil, S.M. Kashif and M. Asraf, 2014. Synthesis of indole-2-hydrazones in search of potential leishmanicidal agents. Med. Chem. Res., 23: 5282-5293.
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  13. Khan, M., M. Yousaf, A. Wadood, M. Junaid and M. Ashraf et al., 2014. Discovery of novel oxindole derivatives as potent α-glucosidase inhibitors. Bioorg. Med. Chem., 22: 3441-3448.
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  14. Khan, K.M., A. Karim, S. Saied, N. Ambreen and X. Rustamova et al., 2014. Evaluation of the thiazole Schiff bases as β-glucuronidase inhibitors and their in silico studies. Mol. Diversity, 18: 295-306.
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  15. Khan, F.A., T. Mahmood, M. Ali, A. Saeed and A. Maalik, 2014. Pharmacological importance of an ethnobotanical plant: Capsicum annuum L. Nat. Prod. Res., 28: 1267-1274.
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  16. Khan, K.M., N. Ambreen, F. Naz, N.A. Rao, M. Ali, M. Arshad and S. Perveen, 2013. Free radical scavenging potential anilinoacridines and acridinylhydrazides. J. Chem. Soc. Pak., 35: 202-205.
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  17. Khan, K.M., M. Rani, N. Ambreen, M. Ali, S. Hussain, S. Perveen and M.I. Choudhary, 2013. 2, 5-Disubstituted-1,3,4-oxadiazoles: Thymidine phosphorylase inhibitors. Med. Chem. Res., 22: 6022-6028.
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  18. Khan, K.M., M. Khan, M. Ali, M.I. Qadir, S. Perveen, A. Karim and M.I. Choudhary, 2013. Superoxide respiratory burst inhibitory activity of Bis-schiff bases of isatins. J. Chem. Soc. Pak., 35: 987-993.
  19. Khan, K.M., A. Karim, M. Ali, A. Ahmad and A. Amyn, 2013. Antibacterial activities of some arylidene barbiturate derivatives. J. Chem. Soc. Pak., 35: 891-894.
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  20. Wahab, A., A. Sultana, K.M. Khan, A. Irshad, N. Ambreen, M. Ali and M. Bilal, 2012. Chemical investigation of Xanthium strumarium Linn and biological activity of its different fractions. J. Pharm. Res., 5: 1984-1987.
  21. Imran, M., Y. Waheed, S. Manzoor, M. Bilal, W. Ashraf, M. Ali and M. Ashraf, 2012. Interaction of Hepatitis C virus proteins with pattern recognition receptors. Virol. J., Vol. 9. 10.1186/1743-422X-9-126.
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  22. Khan, K.M., M. Khan, M. Ali, M. Taha and A. Hameed et al., 2011. Synthesis and DPPH radical scavenging activity of 5-Arylidene-N, NDimethylbarbiturates. Med. Chem., 7: 231-236.
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  23. Khan, K.M., M. Ali, M. Khan, M. Taha and S. Perveen, 2011. NH4Cl mediated new protocol for the synthesis of 5-arylidene barbiturates. Lett. Org. Chem., 8: 28-32.
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  24. Khan, K.M., M. Ali, A. Wadood, M. Khan and M.A. Lodhi et al., 2011. Molecular modeling-based antioxidant arylidene barbiturates as urease inhibitors. J. Mol. Graphics Model., 30: 153-156.
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  25. Zareef, M., R. Iqbal, J.H. Zaidi, M. Arfan, M. Ali and K.M. Khan, 2010. A new method of reducing 2-mercapto-substituted 1,3,4-oxadizoles: Synthesis of acylhydrazine derivatives. Lett. Org. Chem., 7: 411-414.
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  26. Perveen, S., N. Fatima, K.M. Khan, A. Khan, M. Ali and M.I. Choudhary, 2010. Synthesis of carbamate derivatives of biological interest. J. Chem. Soc. Pak., 32: 338-343.
  27. Naz, S., J.H. Zaidi, T. Mehmood, S. Wali, M. Ali, M. Taha and K.M. Khan, 2010. Synthesis of imides and amides from diacetyl-L-tartaric acid anhydride. Lett. Org. Chem., 7: 319-322.
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  28. Khan, K.M., M. Taha, F. Rahim, M. Ali, W. Jamil, S. Perveen and M.I. Choudhary, 2010. An improved method for the synthesis of disulfides by periodic acid and sodium hydrogen sulfite in water. Lett. Org. Chem., 7: 415-419.
  29. Khan, K.M., A. Wadood, M. Ali, Z. Ul-Haq and M.A. Lodhi et al., 2010. Identification of potent urease inhibitors via ligand-and structure-based virtual screening and in vitro assays. J. Mol. Graphics Model., 28: 792-798.
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  30. Hasan, A., A. Sadiq, A. Abbas, E. Mughal, K.M. Khan and M. Ali, 2010. Isolation and synthesis of flavonols and comparison of their antioxidant activity. Nat. Prod. Res. Part A, 24: 995-1003.
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  31. Khan, K.M., S. Saeed, M. Ali, M. Gohar and J. Zahid et al., 2009. Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents. Bioorg. Med. Chem., 17: 2447-2451.
    PubMed  |  
  32. Khan, K.M., N.A. Rao, M. Ali, S. Perveen, M.I. Choudhary and W. Voelter, 2009. Facile, economical and direct synthesis of 9-anilinoacridines. Nat. Prod. Res. Part A, 23: 5-9.
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  33. Khan, K.M., M. Taha, M. Ali and S. Perveen, 2009. A mild and alternative approach towards symmetrical disulfides using H3IO5/NaHSO3 combination. Lett. Org. Chem., 6: 319-320.
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  34. Khan, K.M., M. Khan, M. Ali, M. Taha, S. Rasheed, S. Perveen and M.I. Choudhary, 2009. Synthesis of bis-Schiff bases of isatins and their antiglycation activity. Bioorg. Med. Chem., 17: 7795-7801.
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  35. Khan, K.M., M. Ali, T.A. Farooqui, M. Khan, M. Taha and S. Perveen, 2009. An improved method for the synthesis of 5-arylidene barbiturates using BiCl3. J. Chem. Soc. Pak., 31: 823-828.
  36. Khan, K.M., Zia-Ullah, S. Perveen, S. Hayat, M. Ali and W. Voelter, 2008. A convenient iodination method for alcohols using cesium iodide/methanesulfonic acid and its comparison using cesium iodide/p-toluenesulfonic acid or cesium iodide/aluminium chloride. Nat. Prod. Res. Part A, 22: 1264-1269.
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  37. Khan, K.M., M. Ali, M. Taha, S. Perveen, M.I. Choudhary and W. Voelter, 2008. An expedient and selective approach towards disulfides using sodium bromate/sodium hydrogen sulfite reagent. Lett. Org. Chem., 5: 432-434.
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  38. Khan, K.M., M. Ali, A. Ajaz, S. Perveen and M.I. Choudhary, 2008. Synthesis of 5-arylidene barbiturates: A novel class of DPPH radical scavengers. Lett. Drug Des. Discov., 5: 286-291.
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  39. Cheruku, P., A. Paptchikhine, M. Ali, J.M. Neudorfl and P.G. Andersson, 2008. Development of new thiazole-based iridium catalysts and their applications in the asymmetric hydrogenation of trisubstituted olefins. Org. Biomol. Chem., 6: 366-373.
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  40. Siddiqui, R., N. Sultana, K.M. Khan, N. Akbar, M. Ali and S. Arayne, 2007. Effects of skeletal modifications of ciprofloxacin on antibacterial, antifungal and cytotoxic activities. J. Chin. Clin. Med., 21: 188-195.
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  41. Khan, K.M., Z. Ullah, M.A. Lodhi, M. Ali, M.I. Choudhary, Atta-ur-Rahman and Zaheer-ul-Haq, 2006. Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors. Mol. Divers., 10: 223-231.
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  42. Khan, K.M., S.A. Shahzad, M. Rani, M. Ali, S. Perveen, A. Anwar and W. Voelter, 2006. Synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones under microwave irradiation. Lett. Org. Chem., 3: 286-288.
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