Education
Academic Background-
Ph.D. Jamia Millia Islamia University, India Biosciences | Completed: 2006
Publications (101)
Selected Scholarly Contributions
pH-mediated dual effect on α-Lactalbumin conformation in presence of ethylene glycol and PEG400: A biophysical and computational approach
2027
Correction to “Stability
and Conformational
Dynamics of Interferons: Structural Insights into the Urea- and Guanidinium
Chloride-induced Unfolding”
2026
Exploring the binding energies of new pyrazoline derivatives to DNA/BSA: antifungal, antioxidant, MD simulations and TD-DFT studies
2026
Targeting DYRK1A with rationally designed pyrazine–guanidine hybrids for Alzheimer's disease: design, synthesis, and biological evaluation
2026
Urea induced characterization & structural dynamics of the Nucleocapsid Protein using biophysical and in silico approaches
2026
Stability and Conformational
Dynamics of Interferons:
Structural Insights into the Urea- and Guanidinium Chloride-Induced
Unfolding
2026
Insights into mechanism of ionic liquids for protein stability: Future implications for neurodegeneration treatment
2026
Insight into the Interaction and Inhibition of NS3 ATPase of Dengue Virus with 3′-Azido-3′-deoxythymidine: Computational and Biophysical Approaches
2026
Deciphering the Role of Sugar Osmolytes in Free and Nano forms to Mitigate Protein Aggregation: Insights from Biophysical and Microscopic Studies
2026
Live-Cell Visualization
of DNA Double-Strand Break
Repair Dynamics via Recombinase-Coated Gold Nanoconjugates
2026
Elucidating the Antiglycation Potential of Plumbagin Against Methylglyoxal‐Induced Glycation of Bovine Liver Catalase
2026
Integrated biophysical, thermodynamic and cellular evaluation of prunetin as an α-glucosidase inhibitor: Insights from ITC, fluorescence quenching and molecular dynamics
2026
Biophysical insights into protein–co-solute interactions of alpha lactalbumin: mitigating urea effects in physiological crowded environments
2026
Integrated spectroscopic and MD simulation approach to decipher the effect of pH on the structure function of
Staphylococcus aureus
thymidine kinase
2025
pH induced structural and conformational changes in nucleocapsid protein leads to intermediate like conformation: a biophysical and computational approach
2025
Targeting tau in Alzheimer’s and beyond: Insights into pathology and therapeutic strategies
2025
Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides
2025
Biochemical Screening of Phytochemicals and Identification of Scopoletin as a Potential Inhibitor of SARS-CoV-2 Mpro, Revealing Its Biophysical Impact on Structural Stability
2025
Delineating the Mechanistic Insight of Inhibition of α-Synuclein Fibrillation by Neuro Metabolite, Myo-inositol: Implications in Synucleopathies-Related Disorders
2025
Identification of high-affinity inhibitors for epoxide hydrolase 2 from repurposed drugs in Parkinson’s disease therapeutics
2025
Computational evaluation of Jeevamrutha metabolites binding affinity to MurE enzyme of Xanthomonas oryzae pv. oryzae for bacterial disease management
2025
Targeting rice blast disease: evaluating binding affinity of trichoderma metabolite to Pyricularia oryzae GSK-1 through molecular modeling approaches
2025
Antibacterial potential of Trichoderma bioactive metabolites in managing Staphylococcus aureus infection: Integrated molecular modeling approaches
2025
Elucidating the pH-dependent conformational transitions of eryngin: Insights from molecular dynamics simulations
2024
Comprehensive Perspective Towards the Management of Proteinopathies
by Elucidating Protein Misfolding and Aggregation
2024
Understanding the Modulation of α-Synuclein Fibrillation by N-Acetyl Aspartate: A Brain Metabolite
2024
Amyloid-induced neurodegeneration: A comprehensive review through aggregomics perception of proteins in health and pathology
2024
Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects
2024
Understanding the role of potential biomarkers in attenuating multiple sclerosis progression via multiomics and network-based approach
2024
Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches
2023
Signature Garlic Phytochemical as a Potential Anti-Candidal Candidate Targeting Virulence Factors in Candida albicans
2023
Counteraction of the cetyltrimethylammonium bromide-induced protein aggregation by heparin: Potential impact on protein aggregation and neurodegenerative diseases using biophysical approaches
2023
Interaction of Thioflavin T (ThT) and 8-anilino-1-naphthalene sulfonic acid (ANS) with macromolecular crowding agents and their monomers: Biophysical analysis using in vitro and computational approaches
2023
Aggregation of irisin and its prevention by trehalose: A biophysical approach
2023
Nature's toolbox against tau aggregation: An updated review of current research
2023
Polyethylene glycol induced structural modulation of holo alpha-lactalbumin: In vitro and in vivo approach towards protein stability
2023
Laccase Engineering: Redox Potential Is Not the Only Activity-Determining Feature in the Metalloproteins
2023
Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation
2023
Therapeutic targeting of microtubule affinity‐regulating kinase 4 in cancer and neurodegenerative diseases
2023
Interaction studies of recombinant laccase with co-solutes: Using various spectroscopic, calorimetric, and in silico approaches
2023
Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
2023
Polyherbal nano formulation: A potent antibiotic resistance breaker in bovine mastitis causing MDR pathogens
2023
Recent advancement in therapeutic strategies for Alzheimer’s disease: Insights from clinical trials
2023
The Molecular Blueprint for Chronic Obstructive Pulmonary Disease (COPD): A New Paradigm for Diagnosis and Therapeutics
2023
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
2022
Parkinson’s Disease: A Current Perspectives on Parkinson’s Disease and
Key Bioactive Natural Compounds as Future Potential Drug Candidates
2022
2022
Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study
2022
Insights into the Antibacterial Activity of Prolactin-Inducible Protein against the Standard and Environmental MDR Bacterial Strains
2022
Insights into Fluctuations of Structure of Proteins: Significance of Intermediary States in Regulating Biological Functions
2022
Unraveling the Binding Mechanism of Alzheimer’s Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches
2022
Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions
2022
Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy
2022
Inhibiting Cyclin-Dependent Kinase 6 by Taurine: Implications in Anticancer Therapeutics
2022
Design and evaluation of pyrimidine derivatives as potent inhibitors of ABCG2, a breast cancer resistance protein
2022
Mechanistic Insight into the Enzymatic Inhibition of β-Amyrin against Mycobacterial Rv1636: In Silico and In Vitro Approaches
2022
Measuring Structural Changes in Cytochrome c under Crowded Conditions Using In Vitro and In Silico Approaches
2022
Identification of Thermostable Xylose Reductase fromThermothelomyces thermophilus: A Biochemical Characterization Approach to Meet Biofuel Challenges
2022
Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches
2022
Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches
2022
Heparin Accelerates the Protein Aggregation via the
Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to
Delineate the Implications on Proteinopathies
2021
Effect of Antioxidants on Heavy Metals Induced Conformational Alteration of Cytochrome C and Myoglobin
2021
Multispectroscopic and Molecular Docking Insight into
Elucidating the Interaction of Irisin with Rivastigmine Tartrate:
A Combinational Therapy Approach to Fight Alzheimer’s Disease
2021
Trehalose Restrains the Fibril Load towards α-Lactalbumin Aggregation and Halts Fibrillation in a Concentration-Dependent Manner
2021
Elucidating the Interaction of Human Ferritin with
Quercetin and Naringenin: Implication of Natural Products in Neurodegenerative
Diseases: Molecular Docking and Dynamics Simulation Insight
2021
Glossary of phytoconstituents: Can these be repurposed against SARS CoV-2? A quick in silico screening of various phytoconstituents from plant Glycyrrhiza glabra with SARS CoV-2 main protease
2021
Structural Characterization and Binding Studies of the Ectodomain G Protein of Respiratory Syncytial Virus Reveal the Crucial Role of pH with Possible Implications in Host–Pathogen Interactions
2021
Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
2021
Structural Refolding and Thermal Stability of Myoglobin in the Presence of Mixture of Crowders: Importance of Various Interactions for Protein Stabilization in Crowded Conditions
2021
Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases
2021
Impact of single amino acid substitution on the structure and function of TANK‐binding kinase‐1
2021
An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases
2021
MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease
2021
Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach
2021
Characterization of different intermediate states in myoglobin induced by polyethylene glycol: A process of spontaneous molecular self-organization foresees the energy landscape theory via in vitro and in silico approaches
2021
Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases
2021
Delineating the Aggregation-Prone Hotspot Regions (Peptides) in the Human Cu/Zn Superoxide Dismutase 1
2021
Structural Characterization of Ectodomain G Protein of Respiratory Syncytial Virus and Its Interaction with Heparan Sulfate: Multi-Spectroscopic and In Silico Studies Elucidating Host-Pathogen Interactions
2021
Discovery of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as prospective microtubule affinity regulating kinase 4 inhibitors
2020
Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations
2020
Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies
2020
Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders
2020
Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6
2020
MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy
2020
Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
2020
Effects of Ethylene Glycol on the Structure and Stability
of Myoglobin Using Spectroscopic, Interaction, and
In Silico
Approaches: Monomer Is Different from Those of Its Polymers
2020
2020
Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents
2020
Biophysical Insights into Implications of PEG-400
on the α-Crystallin Structure: Multispectroscopic and Microscopic
Approach
2020
Biophysical Elucidation of Fibrillation Inhibition
by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic
and Molecular Docking Approaches
2020
Inhibiting CDK6 Activity by Quercetin Is an Attractive
Strategy for Cancer Therapy
2020
Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders
2020
Mixture of Macromolecular Crowding Agents Has a Non-additive Effect on the Stability of Proteins
2019
Carbohydrate-Based Macromolecular Crowding-Induced Stabilization of Proteins: Towards Understanding the Significance of the Size of the Crowder
2019
Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases
2019
Ionic Liquid Green Assembly-Mediated Migration of
Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug
Delivery System
2019
Size-dependent studies of macromolecular crowding on the thermodynamic stability, structure and functional activity of proteins: in vitro and in silico approaches
2017
Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations
2017
Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies
2017
Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning
2016
Purification and structural characterization of Mce4A from Mycobacterium tuberculosis
2016