Dr. Muhammad Afzal
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Dr. Muhammad Afzal

Assistant Professor
College of Pharmacy and Pharmacology, Al-Jouf University, Skaka, Al-Jouf, Saudi Arabia

Highest Degree
Ph.D. in Pharmacology from Pacific University, Udaipur, India

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Area of Interest:

Pharmacology
100%
Behavioral Pharmacology
62%
Hepatocellular Carcinoma
90%
Cancer Cell Biology
75%
Molecular Biology
55%

Research Publications in Numbers

Books
4
Chapters
5
Articles
59
Abstracts
16

Selected Publications

  1. Imam, F., P. Kothiyal, S. Alshehri, M. Afzal and M. Iqbal et al., 2023. Hirsutidin prevents cisplatin-evoked renal toxicity by reducing oxidative stress/inflammation and restoring the endogenous enzymatic and non-enzymatic level. Biomedicines, Vol. 11. 10.3390/biomedicines11030804.
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  2. Alzarea, S.I., S. Qasim, M. Afzal, O.A. Alsaidan and H.H. Alhassan et al., 2023. Anandamide reuptake inhibitor (VDM11) as a possible candidate for COVID-19 associated depression; a combination of network pharmacology, molecular docking and in vivo experimental analysis. Processes, Vol. 11. 10.3390/pr11010143.
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  3. Afzal, M., K.S. Alharbi, S.I. Alzarea, N.M. Alyamani, I. Kazmi and E. Güven, 2023. Revealing genetic links of Type 2 diabetes that lead to the development of alzheimer's disease. Heliyon, Vol. 9. 10.1016/j.heliyon.2022.e12202.
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  4. Nautiyal, H., S.S. Imam, S. Alshehri, M.M. Ghoneim and M. Afzal et al., 2022. Polycystic ovarian syndrome: A complex disease with a genetics approach. Biomedicines, Vol. 10. 10.3390/biomedicines10030540.
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  5. Kazmi, I., F.A. Al-Abbasi, S.S. Imam, M. Afzal, M.S. Nadeem, H.N. Altayb and S. Alshehri, 2022. Formulation of piperine nanoparticles: In vitro breast cancer cell line and in vivo evaluation. Polymers, Vol. 14. 10.3390/polym14071349.
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  6. Kazmi, I., F.A. Al-Abbasi, S.S. Imam, M. Afzal, M.S. Nadeem, H.N. Altayb and S. Alshehri, 2022. Formulation and evaluation of apigenin-loaded hybrid nanoparticles. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14040783.
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  7. Kazmi, I., F.A. Al-Abbasi, M. Afzal, M.S. Nadeem, H.N. Altayb and G. Gupta, 2022. Phosphodiesterase-4 inhibitor roflumilast-mediated protective effect in sepsis-induced late-phase event of acute kidney injury: A narrative review. Pharmaceuticals, Vol. 15. 10.3390/ph15070899.
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  8. Güven, E., M. Afzal and I. Kazmi, 2022. Screening the significant hub genes by comparing tumor cells, normoxic and hypoxic glioblastoma stem-like cell lines using co-expression analysis in glioblastoma. Genes, Vol. 13. 10.3390/genes13030518.
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  9. Gilani, S.J., M.N. Bin-Jumah, F.A. Al-Abbasi, S.S. Imam and S. Alshehri et al., 2022. Antiamnesic potential of malvidin on aluminum chloride activated by the free radical scavenging property. ACS Omega, 7: 24231-24240.
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  10. Gilani, S.J., M.N. Bin-Jumah, F.A. Al-Abbasi, M.S. Nadeem and S.S. Imam et al., 2022. Rosinidin flavonoid ameliorates hyperglycemia, lipid pathways and proinflammatory cytokines in streptozotocin-induced diabetic rats. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14030547.
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  11. Gilani, S.J., M.N. Bin-Jumah, F.A. Al-Abbasi, M.S. Nadeem and S.S. Imam et al., 2022. Protective effect of fustin against ethanol-activated gastric ulcer via downregulation of biochemical parameters in rats. ACS Omega, 7: 23245-23254.
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  12. Alzarea, S.I., M. Afzal, K.S. Alharbi, A.I. Alzarea and S.K. Alenezi et al., 2022. Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats. Saudi Pharm. J., 30: 1710-1717.
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  13. Alzarea, S.I., H.H. Alhassan, A.I. Alzarea, Z.H. Al-Oanzi and M. Afzal, 2022. Antidepressant-like effects of renin inhibitor aliskiren in an inflammatory mouse model of depression. Brain Sci., Vol. 12. 10.3390/brainsci12050655.
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  14. Alharbi, K.S., M. Afzal, S.I. Alzarea, S.A. Khan, F.A. Alomar and I. Kazmi, 2022. Rosinidin protects streptozotocin-induced memory impairment-activated neurotoxicity by suppressing oxidative stress and inflammatory mediators in rats. Medicina, Vol. 58. 10.3390/medicina58080993.
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  15. Alharbi, K.S., F.A. Al-Abbasi, S.I. Alzarea, O. Afzal and A.S.A. Altamimi et al., 2022. Effects of the anthocyanin hirsutidin on gastric ulcers: Improved healing through antioxidant mechanisms. J. Nat. Prod., 85: 2406-2412.
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  16. Afzal, M., S.I. Alzarea, K.S. Alharbi, A.I. Alzarea and S.K. Alenezi et al., 2022. Rosiridin attenuates scopolamine-induced cognitive impairments in rats via inhibition of oxidative and nitrative stress leaded caspase-3/9 and TNF-α signaling pathways. Molecules, Vol. 27. 10.3390/molecules27185888.
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  17. Afzal, M., N. Sayyed, K.S. Alharbi, S.I. Alzarea and M.S. Alshammari et al., 2022. Anti-huntingtons effect of rosiridin via oxidative stress/AchE inhibition and modulation of succinate dehydrogenase, nitrite, and BDNF levels against 3-nitropropionic acid in rodents. Biomolecules, Vol. 12. 10.3390/biom12081023.
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  18. Zafar, A., N.K. Alruwaili, S.S. Imam, N.H. Alotaibi and K.S. Alharbi et al., 2021. Bioactive apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment. Saudi Pharm. J., 29: 269-279.
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  19. Zafar, A., N.K. Alruwaili, S.S. Imam, K.S. Alharbi and M. Afzal et al., 2021. Novel nanotechnology approaches for diagnosis and therapy of breast, ovarian and cervical cancer in female: A review. J. Drug Delivery Sci. Technol., Vol. 61. 10.1016/j.jddst.2020.102198.
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  20. Zafar, A., N.K. Alruwaili, D.S. Panda, S.S. Imam and K.S. Alharbi et al., 2021. Potential of natural bioactive compounds in management of diabetes: Review of preclinical and clinical evidence. Curr. Pharmacol. Rep., 7: 107-122.
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  21. Zafar, A., M. Afzal, A.M. Quazi, M. Yasir and I. Kazmi et al., 2021. Chitosan-ethyl cellulose microspheres of domperidone for nasal delivery: Preparation, in-vitro characterization, in-vivo study for pharmacokinetic evaluation and bioavailability enhancement. J. Drug Delivery Sci. Technol., Vol. 63. 10.1016/j.jddst.2021.102471.
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  22. Muzammil, A., M. Waqas, A. Umar, M. Sufyan and A. Rehman et al., 2021. Anti-aging natural compounds and their role in the regulation of metabolic pathways leading to longevity. Mini-Rev. Med. Chem., 21: 2630-2656.
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  23. Gilani, S.J., M.N. Bin-Jumah, F.A. Al-Abbasi, M.S. Nadeem, M. Afzal, N. Sayyed and I. Kazmi, 2021. Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changes. Saudi J. Biol. Sci., 28: 6963-6971.
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  24. Gilani, S.J., M.N. Bin-Jumah, F.A. Al-Abbasi, M.S. Nadeem, M. Afzal, N. Sayyed and I. Kazmi, 2021. Fustin ameliorates elevated levels of leptin, adiponectin, serum TNF-α, and intracellular oxidative free radicals in high-fat diet and streptozotocin-induced diabetic rats. ACS Omega, 6: 26098-26107.
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  25. Ameeduzzafar, M. Qumber, N.K. Alruwaili, S.N.A. Bukhari and K.S. Alharbi et al., 2021. BBD-based development of itraconazole loaded nanostructured lipid carrier for topical delivery: In vitro evaluation and antimicrobial assessment. J. Pharm. Innovation, 16: 85-98.
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  26. Afzal, M., K.S. Alharbi, S.I. Alzarea, A.M. Quazi and A. Zafar et al., 2021. Methanolic extract of Cucumis melo attenuates ethylene glycol-induced nephrolithiasis in Wistar rats. Urolithiasis, 49: 301-308.
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  27. Afzal, M., I. Kazmi, F.A. Al-Abbasi, S. Alshehri and M.M. Ghoneim et al., 2021. Current overview on therapeutic potential of vitamin D in inflammatory lung diseases. Biomedicines, Vol. 9. 10.3390/biomedicines9121843.
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  28. Afzal, M., F.A. Al-Abbasi, M.S. Nadeem, S. Alshehri and M.M. Ghoneim et al., 2021. Sodium-glucose cotransporter-2 inhibitors improve cardiovascular dysfunction in type 2 diabetic east Asians. Metabolites, Vol. 11. 10.3390/metabo11110794.
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  29. Afzal, M., Ameeduzzafar, K.S. Alharbi, N.K. Alruwaili and F.A. Al-Abassi et al., 2021. Nanomedicine in treatment of breast cancer-a challenge to conventional therapy. Semin. Cancer Biol., 69: 279-292.
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  30. Afzal, M., 2021. Recent updates on novel therapeutic targets of cardiovascular diseases. Mol. Cell. Biochem., 476: 145-155.
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  31. Shaveta, S., J. Singh, M. Afzal, R. Kaur and S.S. Imam et al., 2020. Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral efficacy: Formulation design optimization, in-vitro characterization and in-vivo biological evaluation. J. Drug Delivery Sci. Technol., Vol. 57. 10.1016/j.jddst.2020.101674.
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  32. Ameeduzzafar, N.K. Alruwaili, S.S. Imam, N.H. Alotaibi and N.A. Alhakamy et al., 2020. Formulation of chitosan polymeric vesicles of ciprofloxacin for ocular delivery: Box-behnken optimization, in vitro characterization, HET-CAM irritation, and antimicrobial assessment. AAPS PharmSciTech, Vol. 21. 10.1208/s12249-020-01699-9.
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  33. Ameeduzzafar, N. Khan, N.K. Alruwaili, S.N.A. Bukhari and B. Alsuwayt et al., 2020. Improvement of ocular efficacy of levofloxacin by bioadhesive chitosan coated PLGA nanoparticles: Box-behnken design, in-vitro characterization, antibacterial evaluation and scintigraphy study. Iran. J. Pharm. Res., 19: 292-311.
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