Dr. Rajesh Ramasamy
My Social Links

Dr. Rajesh Ramasamy

Associate Professor
Faculty of Medicine and Health Science, Universiti Putra Malaysia, Malaysia

Highest Degree
Ph.D. in Immunology from Imperial College London, UK

Share this Profile

Area of Interest:

Biomedical Sciences
100%
Microbiology
62%
Parasite Immunology
90%
Pathology
75%
Virology
55%

Research Publications in Numbers

Books
1
Chapters
2
Articles
102
Abstracts
3

Selected Publications

  1. Sandrasaigaran, P., S.J.R. Algraittee, A.R. Ahmad, S. and R. Ramasamy, 2018. Characterisation and immunosuppressive activity of human cartilage-derived mesenchymal stem cells. Cytotechnology, 70: 1037-1050.
    CrossRef  |  Direct Link  |  
  2. Subramani, B., S. Subbannagounder, C. Ramanathanpullai, S. Palanivel and R. Ramasamy, 2017. Impaired redox environment modulates cardiogenic and ion-channel gene expression in cardiac-resident and non-resident mesenchymal stem cells. Exp. Biol. Med., 242: 645-656.
    CrossRef  |  Direct Link  |  
  3. Mutalib, M.A., A. Rahmat, F. Ali, F. Othman and R. Ramasamy, 2017. Nutritional compositions and antiproliferative activities of different solvent fractions from ethanol extract of Cyphomandra betacea (Tamarillo) fruit. Malays. J. Med. Sci., 24: 19-32.
    CrossRef  |  Direct Link  |  
  4. Lau, S.X., Y.Y. Leong, W.H. Ng, A.W.P. Ng and I.S. Ismail et al., 2017. Human mesenchymal stem cells promote CD34+ hematopoietic stem cell proliferation with preserved red blood cell differentiation capacity. Cell Biol. Int., 41: 697-704.
    CrossRef  |  Direct Link  |  
  5. Fauzi, F.M., C.M. John, A. Karunanidhi, H.Y. Mussa, R. Ramasamy, A. Adam and A. Bender, 2017. Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes. J. Ethnopharmacol., 197: 61-72.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Vellasamy, S., S. Vidyadaran, E. George and R. Ramasamy, 2016. Basic fibroblast growth factor enhances the expansion and secretory profile of human placenta-derived mesenchymal stem cells. Malays. J. Med. Health Sci., 12: 49-59.
    Direct Link  |  
  7. Vellasamy, S., C.K. Tong, N.A. Azhar, R. Kodiappan, S.C. Chan, A. Veerakumarasivam and R. Ramasamy, 2016. Human mesenchymal stromal cells modulate T-cell immune response via transcriptomic regulation. Cytotherapy, 18: 1270-1283.
    CrossRef  |  Direct Link  |  
  8. Subramani, B., S. Subbannagounder, S. Palanivel, C. Ramanathanpullai and S. Sivalingam et al., 2016. Generation and characterization of human cardiac resident and non-resident mesenchymal stem cell. Cytotechnology, 68: 2061-2073.
    CrossRef  |  Direct Link  |  
  9. Shariat, A., S.B.M. Tamrin, M. Arumugam, M. Danaee and R. Ramasamy, 2016. The need for evidence-based exercise prescription for office workers. Malays. J. Public Health Med., 16: 52-55.
    Direct Link  |  
  10. Shariat, A., S.B.M. Tamrin, M. Arumugam, M. Danaee and R. Ramasamy, 2016. Prevalence rate of musculoskeletal discomforts based on severity level among office workers. Acta Medica Bulgarica, 43: 54-63.
    CrossRef  |  Direct Link  |  
  11. Shariat, A., S.B.M. Tamrin, M. Arumugam, M. Danaee and R. Ramasamy, 2016. Office exercise training to reduce and prevent the occurrence of musculoskeletal disorders among office workers: A hypothesis. Malays. J. Med. Sci., 23: 54-58.
    CrossRef  |  Direct Link  |  
  12. Shariat, A., S.B.M. Tamrin, M. Arumugam, M. Danaee and R. Ramasamy, 2016. Musculoskeletal disorders and their relationship with physical activities among office workers: A review. Malays. J. Public Health Med., 16: 62-74.
    Direct Link  |  
  13. Shariat, A., S.B.M. Tamrin, M. Arumugam and R. Ramasamy, 2016. The Bahasa Melayu version of Cornell Musculoskeletal Discomfort Questionnaire (CMDQ): Reliability and validity study in Malaysia. Work, 54: 171-178.
    CrossRef  |  Direct Link  |  
  14. Shariat, A., S.B. Tamrin, M. Arumugam, M. Danaee and R. Ramasamy, 2016. Comparative reliability of different instruments used to measure the severity of musculoskeletal disorders in office workers. Work, 54: 753-758.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Shariat, A., M. Arumugam, R. Ramasamy and M. Danaee, 2016. Package of office exercise training as a new idea for office workers. Iran. J. Public Health, 45: 544-545.
    PubMed  |  Direct Link  |  
  16. Ridzuan, N., C.M. John, P. Sandrasaigaran, M. Maqbool, L.C. Liew, J. Lim and R. Ramasamy, 2016. Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus. World J. Diabetes, 7: 271-278.
    PubMed  |  
  17. Ridzuan, N., A. Al Abbar, W.K. Yip, M. Maqbool and R. Ramasamy, 2016. Characterization and expression of senescence marker in prolonged passages of rat bone marrow-derived mesenchymal stem cells. Stem Cells Int., Vol. 2016. 10.1155/2016/8487264.
    CrossRef  |  Direct Link  |  
  18. Pei-Shen, A., R. Ramasamy, N.H. Hussin, C. Soon-Keng, S. Heng-Fong and M. Abdullah, 2016. Differential expression patterns of leukaemia associated genes in leukaemia cell lines compared to healthy controls. Malays. J. Med. Health Sci., 12: 33-45.
    Direct Link  |  
  19. Mutalib, M.A., F. Ali, F. Othman, R. Ramasamy and A. Rahmat, 2016. Phenolics profile and anti-proliferative activity of Cyphomandra betacea fruit in breast and liver cancer cells. SpringerPlus, Vol. 5. 10.1186/s40064-016-3777-x.
    CrossRef  |  
  20. Mojani, M.S., A. Rahmat, R. Ramasamy, V.H. Sarmadi, P. Sandrasaigaran, S. Vellasamy and S.M.A. Hejazi, 2016. Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats. Malays. J. Nutr., 22: 421-432.
    Direct Link  |  
  21. Abdul Aziz, S.H., C.M. John, N.I.S.M. Yusof, M. Nordin, R. Ramasamy, A. Adam and F.M. Fauzi, 2016. Animal model of gestational diabetes mellitus with pathophysiological resemblance to the human condition induced by multiple factors (nutritional, pharmacological and stress) in rats. BioMed Res. Int., Vol. 2016. 10.1155/2016/9704607.
    CrossRef  |  Direct Link  |  
  22. Sandrasaigaran, R., S. Vidyadaran and R. Ramasamy, 2015. Human umbilical cord tissue serves as an ideal reservoir of mesenchymal stem cells as compare to the full term umbilical cord blood. Regener. Res., 4: 5-12.
    Direct Link  |  
  23. Mun-Fun, H., N. Ferdaos, S.N. Hamzah, N. Ridzuan and N.A. Hisham et al., 2015. Rat full term amniotic fluid harbors highly potent stem cells. Res. Vet. Sci., 102: 89-99.
    CrossRef  |  Direct Link  |  
  24. Borojerdi, M.H., M. Maqbool, Z. Yusoff, S. Vidyadaran, L.K. Hwa, E. George and R. Ramasamy, 2015. The efficiency of cell sorting and harvesting methods for in vitro expansion of human umbilical cord blood derived CD34+ hematopoietic stem cells. Malays. J. Med. Health Sci., 11: 21-28.
    Direct Link  |  
  25. Appukutty, M., K. Ramasamy, S. Rajan, S. Vellasamy, R. Ramasamy and A.K. Radhakrishnan, 2015. Effect of orally administered soy milk fermented with Lactobacillus plantarum LAB12 and physical exercise on murine immune responses. Beneficial Microbes, 6: 491-496.
    CrossRef  |  Direct Link  |  
  26. Mojani, M.S., V.H. Sarmadi, S. Vellasamy, P. Sandrasaigaran, A. Rahmat, L.S. Peng and R. Ramasamy, 2014. Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats. Cell. Immunol., 289: 145-149.
    CrossRef  |  Direct Link  |  
  27. Mojani, M.S., A. Ghasemzadeh, A. Rahmat, S.P. Loh and R. Ramasamy, 2014. Assessment of bioactive compounds, nutritional composition and antioxidant activity of Malaysian young ginger (Zingiber officinale Roscoe). Int. Food Res. J., 21: 1931-1935.
    Direct Link  |  
  28. Jose, S., S.W. Tan, Y.Y. Ooi, R. Ramasamy and S. Vidyadaran, 2014. Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-α levels. J. Neuroinflamm., Vol. 11. 10.1186/s12974-014-0149-8.
    CrossRef  |  Direct Link  |  
  29. Yan, S.W., R. Ramasamy, N.B.M. Alitheen and A. Rahmat, 2013. A comparative assessment of nutritional composition, total phenolic, total flavonoid, antioxidant capacity and antioxidant vitamins of two types of Malaysian underutilized fruits (Averrhoa bilimbi and Averrhoa carambola). Int. J. Food Propert., 16: 1231-1244.
    CrossRef  |  Direct Link  |  
  30. Vellasamy, S., P. Sandrasaigaran, S. Vidyadaran, M. Abdullah, E. George and R. Ramasamy, 2013. Mesenchymal stem cells of human placenta and umbilical cord suppress T-cell proliferation at G0 phase of cell cycle. Cell Biol. Int., 37: 250-256.
    CrossRef  |  Direct Link  |  
  31. Shalini, V., V. Sharmili, G. Elizabeth, A. Mahenderan and R. Rajesh, 2013. Immunosuppressive activity of human umbilical cord and placenta derived mesenchymal stem cells on lymphocytes' proliferation. Regener. Res., 2: 41-49.
    Direct Link  |  
  32. Ramasamy, R., 2013. Diabetes: A silent killer. Malays. J. Med. Health Sci., 9: 1-2.
    Direct Link  |  
  33. Rahmat, Z.A., S. Jose, R. Ramasamy and S. Vidyadaran, 2013. Reciprocal interactions of mouse bone marrow-derived mesenchymal stem cells and BV2 microglia after lipopolysaccharide stimulation. Stem Cell Res. Ther., Vol. 4. 10.1186/scrt160.
    CrossRef  |  Direct Link  |  
  34. Ooi, Y.Y., Z. Rahmat, S. Jose, R. Ramasamy and S. Vidyadaran, 2013. Immunophenotype and differentiation capacity of bone marrow-derived mesenchymal stem cells from CBA/Ca, ICR and Balb/c mice. World J. Stem Cells, 5: 34-42.
    PubMed  |  
  35. Mojani, M.S., V.H. Sarmadi, A. Rahmat and R. Ramasamy, 2013. Effect of palm tocotrienols versus alpha-tocopherol on lymphocyte's proliferation in streptozotocin-induced diabetic rats. Res. Immunol.: Int. J., Vol. 2013. 10.5171/2013.189211.
    CrossRef  |  ISI  |  
  36. Hashem Boroojerdi, M., N. Daneshvar, P. Ghoraishizadeh, R. Ramasamy, Z. Seman and S. Noor, 2013. Range determination of antigen expression in myeloid, erythroid and lymphoid cell lineages among patients with myelodysplastic syndrome. Iran. J. Blood Cancer, 6: 19-26.
    Direct Link  |  
  37. Boroojerdi, M.H., N. Daneshvar, P. Ghoraishizadeh, S.M. Noor, Z. Seman and R. Ramasamy, 2013. Descriptive analysis of antigen expression pattern in refractory anemia, refractory anemia with ringed sideroblasts and refractory anemia with excess blast cases using flow cytometry. J. Med. Biomed. Sci., 4: 49-56.
  38. Vellasamy, S., P. Sandrasaigaran, S. Vidyadaran, E. George and R. Ramasamy, 2012. Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue. World J. Stem Cells, 4: 53-61.
    Direct Link  |  
  39. Shalini, V., S. Pratheep, A.M.H. Muhammad, V. Sharmili, G. Elizabeth and R. Rajesh, 2012. Generation and characterisation of human mesenchymal stem cells derived from umbilical cord and placenta. Regener. Res., 1: 48-56.
    Direct Link  |  
  40. Ramasamy, R., C.K. Tong, W.K. Yip, S. Vellasamy, B.C. Tan and H.F. Seow, 2012. Basic fibroblast growth factor modulates cell cycle of human umbilical cord-derived mesenchymal stem cells. Cell Proliferation, 45: 132-139.
    CrossRef  |  Direct Link  |  
  41. Ngai, S.C., R. Ramasamy and S. Abdullah, 2012. Production of lentivirus carrying green fluorescent protein with different promoters for in vitro gene transfer. Pertanika J. Sci. Technol., 20: 269-281.
    Direct Link  |  
  42. Mojani, M.S., A. Rahmat, R. Ramasamy and S.M.A. Hejazi, 2012. Palm tocotrienols and α-tocopherol attenuate inflammatory biomarkers in streptozotocin-induced diabetic rats. Curr. Top. Nutraceutical Res., 10: 117-122.
    Direct Link  |  
  43. John, C.M., R. Ramasamy, G. Al Naqeeb, A.H.D. Al-Nuaimi and A. Adam, 2012. Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses. Curr. Med. Chem., 19: 5181-5186.
    CrossRef  |  Direct Link  |  
  44. Fonseka, M., R. Ramasamy, B.C. Tan and H.F. Seow, 2012. Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) inhibit the proliferation of K562 (human erythromyeloblastoid leukaemic cell line). Cell Biol. Int., 36: 793-801.
    CrossRef  |  Direct Link  |  
  45. Broojerdi, M.H., R. Ramasamy, S.M. Noor and Z.B. Seman, 2012. Qualitative flow cytometric analysis of Malaysian Myelodysplastic Syndromes (MDS) patients. Med. J. Malaysia, 67: 77-80.
    Direct Link  |  
  46. Appukutty, M., A.K. Radhakrishnan, K. Ramasamy, R. Ramasamy and A.B.A. Majeed et al., 2012. Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice. BMC Res. Notes, Vol. 5. 10.1186/1756-0500-5-649.
    CrossRef  |  Direct Link  |  
  47. Abdullah, M., P.S. Chai, M.Y. Chong, E.R.M. Tohit, R. Ramasamy, C.P. Pei and S. Vidyadaran, 2012. Gender effect on in vitro lymphocyte subset levels of healthy individuals. Cell. Immunol., 272: 214-219.
    CrossRef  |  Direct Link  |  
  48. Yan, S.W., R. Ramasamy, B.M.A. Noorjahan and R. Asmah, 2011. Cytotoxic effect of carambola ethanolic extract on hormone-dependent human breast cancer cell line (MCF-7). Malays. J. Microsc., 7: 116-120.
  49. Tong, C.K., S. Vellasamy, B.C. Tan, M. Abdullah, S. Vidyadaran, H.F. Seow and R. Ramasamy, 2011. Generation of mesenchymal stem cell from human umbilical cord tissue using a combination enzymatic and mechanical disassociation method. Cell Biol. Int., 35: 221-226.
    CrossRef  |  Direct Link  |  
  50. Tan, S.W., R. Ramasamy, M. Abdullah and S. Vidyadaran, 2011. Inhibitory effects of palm α-, γ- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cell. Immunol., 271: 205-209.
    CrossRef  |  Direct Link  |  
  51. Nordin, N., M.I. Lai, A. Veerakumarasivam, R. Ramasamy, S. Abdullah, W.Y. Wendy-Yeo and R. Rosli, 2011. Induced pluripotent stem cells: History, properties and potential applications. Med. J. Malaysia, 66: 4-9.
    Direct Link  |  
  52. Maqbool, M., S. Vidyadaran, E. George and R. Ramasamy, 2011. Optimisation of laboratory procedures for isolating human peripheral blood derived neutrophils. Med. J. Malaysia, 66: 296-299.
    PubMed  |  Direct Link  |  
  53. Maqbool, M., S. Vidyadaran, E. George and R. Ramasamy, 2011. Human mesenchymal stem cells protect neutrophils from serum‐deprived cell death. Cell Biol. Int., 35: 1247-1251.
    CrossRef  |  Direct Link  |  
  54. Lai, M.I., W.Y. Wendy-Yeo, R. Ramasamy, N. Nordin, R. Rosli, A. Veerakumarasivam and S. Abdullah, 2011. Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. J. Assisted Reprod. Genet., 28: 291-301.
    CrossRef  |  Direct Link  |  
  55. John, C.M., P. Sandrasaigaran, C.K. Tong, A. Adam and R. Ramasamy, 2011. Immunomodulatory activity of polyphenols derived from Cassia auriculata flowers in aged rats. Cell. Immunol., 271: 474-479.
    CrossRef  |  Direct Link  |  
  56. Hameed, A.T., R. Ibrahim, A.J. Karim, A. Zuki, T. Azmi and R. Ramasamy, 2011. Neurobiological observations of bone mesenchymal stem cells in vitro and in vivo of injured sciatic nerve in rabbit. J. Anim. Vet. Adv., 10: 686-691.
    CrossRef  |  Direct Link  |  
  57. George, E., M.I. Lai, L.K. Teh, R. Ramasamy and E.H. Goh et al., 2011. Screening for intermediate and severe forms of thalassaemia in discarded red blood cells: Optimization and feasibility. Med. J. Malaysia, 66: 429-434.
    PubMed  |  Direct Link  |  
  58. Badiei, A., H.F. Seow, R. Ramasamy and S. Vidyadaran, 2011. In vitro effects of lipopolysaccharide and active fragment of beta amyloid on the morphology and ultrastructure of microglia. J. Adv. Biomed. Pathobiol. Res., 1: 8-14.
  59. Al-Timmemi, H.A., R. Ibrahim, K.A.M. Al-Jashamy, M.Z. Abu Bakar @ Zakaria, T.A.T. Ibrahim and R. Ramasamy, 2011. Identification of adipogenesis and osteogenesis pathways of differentiated bone marrow stem cells in vitro in rabbits. Ann. Microsc., 11: 24-29.
    Direct Link  |  
  60. Subramaiam, H., A. Badiei, R. Ramasamy, M. Abdullah and S. Vidyadaran, 2010. Establishing a culture system that supports in vitro expansion of adult microglia. Malays. J. Med. Health Sci., 6: 25-30.
    Direct Link  |  
  61. Sarmadi, V.H., C.K. Tong, S. Vidyadaran, M. Abdullah, H.F. Seow and R. Ramasamy, 2010. Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest. Med. J. Malaysia, 65: 209-214.
    PubMed  |  Direct Link  |  
  62. Ramasamy, R., M. Maqbool, A.L. Mohamed and R.M. Noah, 2010. Elevated neutrophil respiratory burst activity in essential hypertensive patients. Cell. Immunol., 263: 230-234.
    CrossRef  |  Direct Link  |  
  63. Ramasamy, R., K. Krishna, M. Maqbool, S. Vellasamy, V.H. Sarmadi, M. Abdullah and S. Vidyadaran, 2010. The effect of human mesenchymal stem cell on neutrophil oxidative burst. Malays. J. Med. Health Sci., 6: 11-17.
    Direct Link  |  
  64. Ooi, Y.Y., R. Ramasamy, Z. Rahmat, H. Subramaiam and S.W. Tan et al., 2010. Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide. Int. Immunopharmacol., 10: 1532-1540.
    CrossRef  |  Direct Link  |  
  65. Maha, A., L. Rampal, M.Z. Azhar, M.S. Sherina and V. Sharmili et al., 2010. Attitude towards sex: Study of secondary schoolchildren in Selangor State. Malays. J. Med. Health Sci., 6: 33-61.
    Direct Link  |  
  66. Abdullah, S., W.Y. Wendy-Yeo, H. Hosseinkhani, M. Hosseinkhani and E. Masrawa et al., 2010. Gene transfer into the lung by nanoparticle dextran-spermine/plasmid DNA complexes. BioMed Res. Int., Vol. 2010. 10.1155/2010/284840.
    CrossRef  |  Direct Link  |  
  67. Vidyadaran, S., Y.Y. Ooi, H. Subramaiam, A. Badiei, M. Abdullah, R. Ramasamy and H.F. Seow, 2009. Effects of macrophage colony-stimulating factor on microglial responses to lipopolysaccharide and beta amyloid. Cell. Immunol., 259: 105-110.
    CrossRef  |  Direct Link  |  
  68. Sharmili, V., A. Maha, L. Rampal, M.T.E. Rahayu and K. Mirnalini et al., 2009. Execution and challenges of using focus group discussions as a research tool for secondary school students. Malays. J. Med. Health Sci., 5: 39-48.
    Direct Link  |  
  69. Tong, C.K., V. Sarmadi, S. Vidyadaran, S.Y. Latifah, H.F. Seow and R. Ramasamy, 2008. Human bone marrow-derived mesenchymal stem cells suppress T cell proliferation by inducing cell cycle arrest. Malays. J. Med. Health Sci., 4: 41-50.
    Direct Link  |  
  70. Ramasamy, R., C.K. Tong, H.F. Seow, S. Vidyadaran and F. Dazzi, 2008. The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function. Cell. Immunol., 251: 131-136.
    CrossRef  |  Direct Link  |  
  71. Ramasamy, R., H. Fazekasova, E.W.F. Lam, I. Soeiro, G. Lombardi and F. Dazzi, 2007. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation, 83: 71-76.
    CrossRef  |  Direct Link  |  
  72. Ramasamy, R., E.W. Lam, I. Soeiro, V. Tisato, D. Bonnet and F. Dazzi, 2007. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth. Leukemia, 21: 304-310.
    CrossRef  |  Direct Link  |  
  73. Dazzi, F., R. Ramasamy, S. Glennie, S.P. Jones and I. Roberts, 2006. The role of mesenchymal stem cells in haemopoiesis. Blood Rev., 20: 161-171.
    CrossRef  |  Direct Link  |