Dr. Deniz  Ekinci
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Dr. Deniz Ekinci

Assistant Professor
Ondokuz Mayis University, Turkiye


Highest Degree
Ph.D. in Biochemistry from Ataturk University, Erzurum, Turkiye

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Area of Interest:

Chemistry
100%
Biochemistry
62%
Organic Chemistry
90%
Gene Expression Analysis
75%
Bioorganic Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Turkoglu, E.A., M. Senturk, C.T. Supuran and D. Ekinci, 2017. Carbonic anhydrase inhibitory properties of some uracil derivatives. J. Enzyme Inhib. Med. Chem., 32: 74-77.
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  2. Soydan, E., A. Guler, S. Biyik, M. Senturk, C.T. Supuran and D. Ekinci, 2017. Carbonic anhydrase from Apis mellifera: Purification and inhibition by pesticides. J. Enzyme Inhib. Med. Chem., 32: 47-50.
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  3. Guler, A., A.V. Garipoglu, H. Onder, S. Biyik, H. Kocaokutgen and D. Ekinci, 2017. Comparing biochemical properties of pure and adulterated honeys produced by feeding honeybees (Apis mellifera L.) colonies with different levels of ındustrial commercial sugars. Univ. Vet. Fak. Derg., 23: 259-268.
  4. Yaseen, R., D. Ekinci, A. Hameed, S. Ovais and P. Rathore et al., 2016. Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors. Bioorganic Med. Chem. Lett., 26: 1337-1341.
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  5. Onder, H., A. Guler, S. Biyik, v Ekinci, A.V. Garipoglu and H. Kocaokutgen, 2016. Origin estimation of honey samples by using constant and discriminative function coefficients of pure honey and honey produced by colonies feeding with different sugars. Kafkas Univ. Vet. Fak. Derg., 22: 21-28.
  6. Durdagi, S., N. Korkmaz, S. Isik, D. Vullo and D. Astley et al., 2016. Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds. J. Enzyme Inhib. Med. Chem., 31: 1214-1220.
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  7. Arslan, T., G. Celik, H. Celik, M. Senturk, N. Yayli and D. Ekinci, 2016. Synthesis and biological evaluation of novel bischalcone derivatives as carbonic anhydrase ınhibitors. Arch. Pharm., 349: 741-748.
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  8. Korkmaz, N., O.A. Obaidi, M. Senturk, D. Astley, D. Ekinci and C.T. Supuran, 2015. Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors. J. Enzyme Inhibition Med. Chem., 30: 75-80.
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  9. Isik, S., D. Vullo, S. Durdagi, D. Ekinci and M. Senturk et al., 2015. Interaction of carbonic anhydrase isozymes I, II and IX with some pyridine and phenol hydrazinecarbothioamide derivatives. Bioorganic Med. Chem. Lett., 25: 5636-5641.
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  10. Guney, M., H. Cavdar, M. Senturk and D. Ekinci, 2015. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorganic Med. Chem. Lett., 25: 3261-3263.
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  11. Fidan, I., R.E. Salmas, M. Arslan, M. Senturk and S. Durdagi et al., 2015. Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives. Bioorganic Med. Chem., 23: 7353-7358.
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  12. Arslan, M., M. Senturk, I. Fidan, O. Talaz, D. Ekinci, S. Cosgun and C.T. Supuran, 2015. Synthesis of 3,4-dihydroxypyrrolidine-2,5-dione and 3,5-dihydroxybenzoic acid derivatives and evaluation of the carbonic anhydrase I and II inhibition. J. Enzyme Inhib. Med. Chem., 6: 896-900.
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  13. Abdel-Aziz, A.A.M., A.S. El-Azab, D. Ekinci, M. Senturk and C.T. Supuran, 2015. Investigation of arenesulfonyl-2-imidazolidinones as potent carbonic anhydrase inhibitors. J. Enzyme Inhibition Med. Chem., 30: 81-84.
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  14. Mercan, L., D. Ekinci and C.T. Supuran, 2014. Characterization of carbonic anhydrase from Turkish native “gerze” chicken and influences of metal ions on enzyme activity. J. Enzyme Inhib. Med. Chem., 29: 773-776.
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  15. Guler, A., H. Kocaokutgen, A.V. Garipoglu, H. Onder, D. Ekinci and S. Biyik, 2014. Detection of adulterated honey produced by honeybee (Apis mellifera L.) colonies fed with different levels of commercial industrial sugar (C3 and C4 plants) syrups by the carbon isotope ratio analysis. Food Chem., 155: 155-160.
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  16. Atasever, A., M. Arslan, N. Sirkecioglu, A. Bayir, D. Ekinci and M. Senturk, 2014. Influence of different dietary lipids on the activity of metabolic enzymes in brown trout (Salmo trutta). Turk. J. Fish. Aquatic Sci., 14: 31-36.
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  17. Ozdemir, Z.O., M. Senturk and D. Ekinci, 2013. Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules. J. Enzyme Inhibit. Med. Chem., 28: 316-319.
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  18. Mercan, L., A. Okumus, M. Senturk and D. Ekinci, 2013. In vitro enzymatic response of Turkish native chicken Gerze to heavy metal exposure. J. Enzyme Inhibit. Med. Chem., 28: 52-57.
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  19. Talaz, O., H. Cavdar, S. Durdagi, H. Azak and D. Ekinci, 2012. Synthesis of 1,4-bis(indolin-1-ylmethyl) benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II. Bioorg. Med. Chem., 21: 1477-1482.
    CrossRef  |  PubMed  |  
  20. Senturk, M., D. Ekinci, S. Goksu and C.T. Supuran, 2012. Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II and VI. J. Enzyme Inhibit. Med. Chem., 27: 365-369.
    CrossRef  |  PubMed  |  
  21. Koz, O., D. Ekinci, M. Senturk, A. Perrone and S. Piacente et al., 2012. Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes. J. Enzyme Inhib. Med. Chem., 28: 412-417.
    CrossRef  |  PubMed  |  
  22. Ekinci, D., N.I. Kurbanoglu, E. Salamci, M. Senturk and C.T. Supuran, 2012. Carbonic anhydrase inhibitors: Inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds. J. Enzyme Inhibit. Med. Chem., 27: 845-848.
    CrossRef  |  Direct Link  |  
  23. Ekinci, D., M. Cankaya, M. Senturk and T.A. Coban, 2012. Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: In vitro approach. J. Enzyme Inhib. Med.Chem., 28: 824-828.
    CrossRef  |  PubMed  |  
  24. Ekinci, D., M. Al-Rashida, G. Abbas, M. Senturk and C.T. Supuran, 2012. Chromone containing sulfonamides as potent carbonic anhydrase inhibitors. J. Enzyme Inhibit. Med. Chem., 27: 744-747.
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  25. Ekinci, D., L. Karagoz, D. Ekinci, M. Senturk and C.T. Supuran, 2012. Carbonic anhydrase inhibitors: In vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids. J. Enzyme Inhib. Med. Chem., 28: 283-288.
    CrossRef  |  PubMed  |  
  26. Ekinci, D., H. Cavdar, S. Durdagi, O. Talaz, M. Senturk and C.T. Supuran, 2012. Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI. Eur. J. Med. Chem., 49: 68-73.
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  27. Demirdag, R., V. Comaklı, M. Senturk, D. Ekinci, O.I. Kufrevioglu and C.T. Supuran, 2012. Purification and characterization of carbonic anhydrase from sheep kidney and influences of sulfonamides on enzyme activity. Bioorg. Med. Chem., 21: 1522-1525.
    CrossRef  |  PubMed  |  
  28. Demirdag, R., E. Yerlikaya, E. Aksakal, O.I. Kufrevioglu and D. Ekinci, 2012. Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes. Environ. Toxicol. Pharmacol., 34: 218-222.
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  29. Cavdar, H., O. Talaz and D. Ekinci, 2012. Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects. Bioorg. Med. Chem. Lett., 22: 7499-7503.
    CrossRef  |  PubMed  |  
  30. Cavdar, H., D. Ekinci, O. Talaz, N. Saracoglu, M. Senturk and C.T. Supuran, 2012. α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters. J. Enzyme Inhibit. Med. Chem., 27: 148-154.
    CrossRef  |  PubMed  |  
  31. Balaydin, H.T., S. Durdagi, D. Ekinci, M. Senturk, S. Goksu and A. Menzek, 2012. Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds. J. Enzyme Inhibit. Med. Chem., 27: 467-475.
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  32. Balaydin, H.T., H. Soyut, D. Ekinci, S. Goksu, S. Beydemir, A. Menzek and E. Sahin, 2012. Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products. J. Enzyme Inhibition Med. Chem., 27: 43-50.
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  33. Alp, C., A. Maresca, N. A. Alp, M.S. Gultekin, D. Ekinci, A. Scozzafava and C.T. Supuran, 2012. Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II. J. Enzyme Inhib. Med.Chem., 28: 294-298.
    CrossRef  |  PubMed  |  
  34. Ekinci, D., İ. Fidan, S. Durdagi, S. Kaban and C.T. Supuran, 2012. Kinetic and in silico analyses of thiazolidin-based inhibitors of α-carbonic anhydrase isoenzymes. J. Enzyme Inhib. Med. Chem., 28: 370-374.
    PubMed  |  Direct Link  |  
  35. Siktar, E., D. Ekinci, E. Siktar, S. Beydemir, I. Gulcin and M. Gunay, 2011. Protective role of L-carnitine supplementation against exhaustive exercise-induced oxidative stress in rats. Eur. J. Pharmacol., 668: 407-413.
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  36. Senturk, M., D. Ekinci, H.A. Alici and S. Beydemir, 2011. Paraoxonase-1, an organophosphate detoxifier and cardioprotective enzyme, is inhibited by anesthetics: An in vitro and in vivo insight. Biochem. Physiol., 101: 206-211.
    CrossRef  |  
  37. Erdogan, O., S.B. Ceyhun, D. Ekinci and E. Aksakal, 2011. Impact of deltamethrin exposure on mRNA expression levels of metallothionein A, B and cytochrome P450 1A in rainbow trout muscles. Gene, 484: 13-17.
    Direct Link  |  
  38. Ekinci, D., S.B. Ceyhun, M. Senturk, D. Erdem, O.I. Kufrevioglu, and C.T. Supuran, 2011. Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg. Med. Chem., 19: 744-748.
    CrossRef  |  
  39. Ekinci, D., S.B. Ceyhun, E. Aksakal and O. Erdogan, 2011. IGF and GH mRNA levels are suppressed upon exposure to micromolar concentrations of cobalt and zinc in rainbow trout white muscle. Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 153: 336-341.
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  40. Ekinci, D., M. Senturk and O.I. Kufrevioglu, 2011. Salicylic acid derivatives: Synthesis, features and usage as therapeutic tools. Expert Opin. Therapeut. Patents, 21: 1831-1841.
    CrossRef  |  PubMed  |  
  41. Ekinci, D. and M. Senturk, 2011. Assesment of metal inhibition of antioxidant enzyme glutathione reductase from rainbow trout liver. J. Enzyme Inhibit. Med. Chem., 28: 11-15.
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  42. Durdagi, S., M. Senturk, D. Ekinci, H.T. Balaydin and S. Goksu et al., 2011. Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site. Bioorg. Med. Chem., 19: 1381-1389.
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  43. Ceyhun, S.B., M. Senturk, E. Yerlikaya, O. Erdogan, O.I. Kufrevioglu and D. Ekinci, 2011. Purification and characterization of carbonic anhydrase from the teleost fish Dicentrarchus labrax (European Seabass) liver and toxicological effects of metals on enzyme activity. Environ. Toxicol. Pharmacol., 32: 69-74.
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  44. Ceyhun, S.B., E. Aksakal, D. Ekinci, O. Erdogan and S. Beydemir, 2011. Influence of cobalt and zinc exposure on mRNA expression profiles of metallothionein and cytocrome P450 in rainbow trout. Biol. Trace Element Res., 144: 781-789.
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  45. Cakmak, R., S. Durdagi, D. Ekinci, M. Senturk and G. Topal, 2011. Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorg. Med. Chem. Lett., 21: 5398-5402.
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  46. Aksakal, E., D. Ekinci, O. Erdogan, S. Beydemir, Z. Alim and S.B. Ceyhun, 2011. Increasing stocking density causes inhibition of metabolic-antioxidant enzymes and elevates mRNA levels of heat shock protein 70 in rainbow trout. Livestock Sci., 141: 69-75.
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  47. Ekinci, D., M. Senturk, S. Beydemir, O.I. Kufrevioglu and C.T. Supuran, 2010. An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides. Chem. Biol. Drug Des., 76: 552-558.
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  48. Ekinci, D., M. Senturk, 2010. Interactions of Fungicides and Pesticides with Specific Enzymes. In: Fungicides, Carisse, O. (Ed.). IN-TECH, Rijeka, Croatia, ISBN: 978-953-307-266-1, pp: 383-404.
  49. Ekinci, D., H. Cavdar, O. Talaz, M. Senturk and C.T. Supuran, 2010. NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II. Bioorg. Med. Chem., 18: 3559-3563.
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  50. Ekinci, D. and S. Beydemir, 2010. Risk assessment of pesticides and fungicides for acid-base regulation and salt transport in rainbow trout tissues. Pesticide Biochem. Physiol., 97: 66-70.
    CrossRef  |  
  51. Ekinci, D. and S. Beydemir, 2010. Purification of PON1 from human serum and assessment of enzyme kinetics against metal toxicity. Biol. Trace. Elem. Res., 135: 112-120.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Ceyhun, S.B., M. Senterk, D. Ekinci, O. Erdogan, A. Ciltas and E.M. Kocaman, 2010. Deltamethrin attenuates antioxidant defense system and induces the expression of heat shock protein 70 in rainbow trout. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 152: 215-223.
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  53. Alp, C., D. Ekinci, M.S. Gultekin, M. Senturk, E. Sahin, O.I. Kufrevioglu, 2010. A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg. Med. Chem., 18: 4468-4474.
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  54. Aksakal, E., S.B. Ceyhun, O. Erdogan and D. Ekinci, 2010. Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 152: 451-455.
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  55. Senturk, M., O. Talaz, D. Ekinci, H. Cavdar and O.I. Kufrevioglu, 2009. In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorganic Med., Chem. Lett., 19: 3661-3663.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Ekinci, D. and S. Beydemir, 2009. Evaluation of the impacts of antibiotic drugs on PON 1; a major bioscavenger against cardiovascular diseases. Eur. J. Pharmacol., 617: 84-89.
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  57. Ekinci, D. and S. Beydemir, 2009. Effect of some analgesics on paraoxonase-1 purified from human serum. J. Enzyme Inhib. Med. Chem., 24: 1034-1039.
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  58. Coban, T.A., S. Beydemir, I. Gucin, D. Ekinci, A. Innocenti, D. Vullo and C.T. Supuran, 2009. Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV. Bioorg. Med. Chem., 17: 5791-5795.
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  59. Gulcin, I., S. Beydemir, T.A. Coban and D. Ekinci, 2008. The Inhibitory effect of dantrolene sodium and propofol on 6-phosphogluconate dehydrogenase from rat erythrocyte. Fresenius Environ. Bull., 17: 1283-1287.
    Direct Link  |  
  60. Coban, T.A., S. Beydemir, I. Gulcin and D. Ekinci, 2008. The effect of ethanol on erythrocyte carbonic anhydrase isoenzymes activity: An in vivo and in vitro study. J. Enzyme Inhibit. Med. Chem., 23: 266-270.
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  61. Ciftci, M., S. Beydemir and D. Ekinci, 2008. Effects of some drugs on enzyme activity of glucose 6- phosphate dehydrogenase from chicken erythrocytes in vitro. Asian J. Chem., 20: 2189-2196.
  62. Alici, H.A., D. Ekinci and S. Beydemir, 2008. Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo. Clin. Biochem., 41: 1384-1390.
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  63. Ekinci, D., S. Beydemir and Z. Alim, 2007. Some drugs inhibit in vitro hydratase and esterase activities of human carbonic anhydrase-I and II. Pharmacol. Rep., 59: 580-587.
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  64. Ekinci, D., S. Beydemir and O.I. Kufrevioglu, 2007. In vitro inhibitory effects of some heavy metals on human erytrocyte carbonic anhydrases. J. Enzyme Inhibit. Med. Chem., 22: 745-750.
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  65. Coban, T.A., S. Beydemir, I. Gulcin and D. Ekinci, 2007. Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol. Pharm. Bull., 30: 2257-2261.
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  66. Cankaya, M., A.M. Hernandez, M. Ciftci, S. Beydemir and H. Ozdemir et al., 2007. An analysis of expression patterns of genes encoding proteins with catalytic activities. BMC Genomics, Vol., 8. 10.1186/1471-2164-8-232.
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  67. Ekinci, D., S. Beydemir, O.I. Kufrevioglu, M. Ciftci and M. Cankaya et al., 2006. Gene expression analysis of carbonic anhydrase isoenzyme genes in mouse genome by in situ hybridization. FEBS J., 273: 250-251.