Dr. Weien Yuan
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Dr. Weien Yuan

Associate Professor
Shanghai Jiao Tong University, China

Highest Degree
M.D. in Pharmacy and Nanomedicine from Shanghai Jiao Tong University, China

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Area of Interest:

Pharmacology and Toxicology
100%
Nanomedicine
62%
Drug Design
90%
Pharmacy
75%
Neuroscience
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhao, H., F. Wu, Y. Cai, Y. Chen, L. Wei, Z. Liu and W. Yuan, 2013. Local antitumor effects of intratumoral delivery of rlL-2 loaded sustained-release dextran/PLGA-PLA core/shell microspheres. Int. J. Pharm., 450: 235-240.
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  2. Xu, D., F. Wu, Y. Chen, L. Wei and W. Yuan, 2013. pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein. Int. J. Nanomed., 8: 3405-3414.
    CrossRef  |  PubMed  |  
  3. Wu, N., L. Song, X. Yang, W. Yuan and Z. Liu, 2013. NMDA receptor regulation of levodopa-induced behavior and changes in striatal G protein-coupled receptor kinase 6 and β-arrestin-1 expression in parkinsonian rats. Clin. Int. Aging, 8: 347-352.
    CrossRef  |  PubMed  |  
  4. Wu, F., Z. Zhou, J. Su, L. Wei, W. Yuan and T. Jin, 2013. Development of dextran nanoparticles for stabilizing delicate proteins. Nanoscale Res. Lett., 8: 197-197.
    CrossRef  |  PubMed  |  
  5. Wei, L., F. Wu, D. Shi, C. Hu and X. Li et al., 2013. Spontaneous intercalation of long-chain alkyl ammonium into edge-selectively oxidized graphite to efficiently produce high-quality graphene. Sci. Rep., Vol. 3. 10.1038/srep02636.
    CrossRef  |  Direct Link  |  
  6. Ma, L., L. Wei, F. Wu, Z. Hu, Z. Liu and W. Yuan, 2013. Advances with microRNAs in Parkinson's disease research. Drug Des. Dev. Ther., 7: 1103-1113.
    CrossRef  |  PubMed  |  
  7. Ma, A., C. Wang, Y. Chen and W. Yuan, 2013. P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy. Drug Des. Dev. Ther., 7: 1447-1454.
    CrossRef  |  PubMed  |  
  8. Liang, D., X. Fu, M. Liao, W. Yuan and J. Su, 2013. Development of dextran microparticles loaded with IL-1Ra of high-encapsulation efficiency and high-bioactivity by a novel method without exposing IL-1Ra to water-oil interfaces. Powder Technol., 235: 299-302.
    CrossRef  |  Direct Link  |  
  9. Hong, X., L. Wei, F. Wu, Z. Wu, L. Chen, Z. Liu and W. Yuan, 2013. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des. Dev. Ther., 7: 945-952.
    CrossRef  |  PubMed  |  
  10. Ge, X., Q. Zhang, Y. Cai, S. Duan and S. Chen et al., 2013. PEG-PCL-DEX polymersome-protamine vector as an efficient gene delivery system via PEG-guided self-assembly. Nanomedicine. 10.2217/nnm.13.83.
    CrossRef  |  PubMed  |  
  11. Chen, S., X. Ge, Y. Chen, N. Lv, Z. Liu and W. Yuan, 2013. Advances with RNA interference in Alzheimer's disease research. Drug Des. Dev. Ther., 7: 117-125.
    CrossRef  |  PubMed  |  
  12. Cai, Y.P., Y.G. Chen, X. Hong, Z. Liu and W. Yuan, 2013. Porous microsphere and its applications. Int. J. Nanomed., 8: 1111-1120.
  13. Cai, Y., L. Wei, L. Ma, X. Huang, A. Tao, Z. Liu and W. Yuan, 2013. Long acting preparations of exenatide. Drug Des. Dev. Ther., 7: 963-970.
    CrossRef  |  PubMed  |  
  14. Yuan, W., Z. Hu, J. Su, F. Wu, Z. Liu and T. Jin, 2012. Preparation and characterization of recombinant human growth hormone-Zn2+-dextran nanoparticles using aqueous phas-aqueous phase emulsion. Nanomedicine, 8: 424-427.
    CrossRef  |  PubMed  |  
  15. Yuan, W. and Z. Liu, 2012. Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres. Int. J. Nanomed., 7: 257-270.
    CrossRef  |  PubMed  |  
  16. Yang, X., Y. Chen, X. Hong, N. Wu, L. Song, W. Yuan and Z. Liu, 2012. Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats. Drug Des. Dev. Ther., 6 : 341-347.
    CrossRef  |  PubMed  |  
  17. Yang, X., R. Zheng, Y. Cai, W. Yuan, M. Liao and Z. Liu, 2012. Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats. Int. J. Nanomed., 7: 2077-2086.
    CrossRef  |  PubMed  |  
  18. Yang, S., Y. Feng, L. Zhang, N. Chen, W. Yuan and T. Jin, 2012. A scalable fabrication process of polymer microneedles. Int. J. Nanomed., 7: 1415-1422.
    CrossRef  |  PubMed  |  
  19. Xu, D., Z. Hu, J. Su, F. Wu and W. Yuan, 2012. Micro and nanotechnology for intracellular delivery therapy protein. Nano-Micro Lett., 4: 118-123.
    CrossRef  |  
  20. Xiang, S., J. Su, H. Tong, F. Yang and W. Tong et al., 2012. Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy. Biomaterials, 33: 6520-6532.
    CrossRef  |  PubMed  |  
  21. Sun, W., Y. Chen and W. Yuan, 2012. Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors. Int. J. Nanomed., 8: 1499-1506.
    CrossRef  |  PubMed  |  
  22. Rong, X., S. Yang, H. Miao, T. Guo and Z. Wang et al., 2012. Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCs. Invest. Ophthalmol. Vis. Sci., 53: 6025-6034.
    CrossRef  |  PubMed  |  
  23. Ma, L., X. Hong, Z. Liu and W. Yuan, 2012. Stabilisation and encapsulation of protein into biodegradable microspheres with zinc ion and protein in polyethylene glycol solution formed nanoparticles by freeze-drying. Micro Nano Lett., 7: 215-218.
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  24. Liu, G., X. Hong, M. Jiang and W. Yuan, 2012. Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method. Int. J. Nanomed., 7: 4559-4569.
    CrossRef  |  
  25. Liu, G., X. Hong, M. Jiang and W. Yuan, 2012. Preparation of bioactive interferon α-loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion. Int. J. Nanomed., 7: 4841-4848.
    CrossRef  |  PubMed  |  
  26. Hu, Z., M. Liao, Y. Chen, Y. Cai and L. Meng et al., 2012. A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone. Int. J. Nanomed., 7: 5719-5924.
    CrossRef  |  PubMed  |  
  27. Duan, S., X. Ge, N. Lu, F. Wu, W. Yuan and T. Jin, 2012. Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system. Int. J. Nanomed., 7: 3813-3822.
  28. Duan, S., W. Yuan, F. Wu and T. Jin, 2012. Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA. Angew. Chem. Int. Edn., 51: 7938-7941.
    CrossRef  |  Direct Link  |  
  29. Yuan, W. and Z. Liu, 2011. Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. Int. J. Nanomed., 6: 3139-3149.
    CrossRef  |  
  30. Wu, F., W. Yuan, J. Su, J. Ren and T. Jin, 2011. Preparation and characterisation of PLGA microspheres for sustained release of recombinant human granulocyte colony-stimulating factor. Micro Nano Lett., 6: 181-185.
    CrossRef  |  Direct Link  |  
  31. Rong, X., X. Mo, T. Ren, S. Yang and W. Yuan et al., 2011. Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. Eur. J. Pharm. Sci., 43: 334-342.
    CrossRef  |  PubMed  |  
  32. Ren, T., X. Yang, N. Wu, Y. Cai, Z. Liu and W. Yuan, 2011. Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats. Neurosci. Lett., 502: 117-122.
    CrossRef  |  PubMed  |  
  33. Ren, T., W. Yuan, H. Zhao and T. Jin, 2011. Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles. Micro Nano Lett., 6: 70-74.
    CrossRef  |  
  34. Hu, Z., Y. Liu, W. Yuan, F. Wu, J. Su and T. Jin, 2011. Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf. B, 86: 206-211.
    CrossRef  |  Direct Link  |  
  35. Zhang, Y., F. Wu, W. Yuan and T. Jin, 2010. Polymersomes of asymmetric bilayer membrane formed by phase-guided assembly. J. Control Release, 147: 413-419.
    CrossRef  |  PubMed  |  
  36. Yuan, W., Y. Zhang, F. Wu, H. Li and Y. Cai et al., 2010. Preparation of protein-loaded sustained-release microspheres via solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E) emulsification. Colloids Surf. B., 79: 326-333.
    CrossRef  |  PubMed  |  
  37. Yuan, W., T. Ren, F. Wu, H. Zhao and T. Jin, 2010. A novel preparation method for microspheres by glycerol modified solid-in-oil-in-water multi-emulsion. Polym. Adv. Technol., 21: 371-376.
    CrossRef  |  Direct Link  |  
  38. Yang, X., W. Yuan, T. Ren, L. Song, N. Wu and Z. Liu, 2010. Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats. NeuroReport, 21: 837-840.
    CrossRef  |  PubMed  |  
  39. Yuan, W., Y. Geng, F. Wu, Y. Liu, M. Guo, H. Zhao and T. Jin, 2009. Preparation of polysaccharide glassy microparticles with stabilization of proteins. Int. J. Pharm., 366 : 154-159.
    CrossRef  |  PubMed  |  
  40. Yuan, W., F. Wu, M. Guo and T. Jin, 2009. Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion. Eur. J. Pharm. Sci., 36: 212-218.
    CrossRef  |  PubMed  |  
  41. Yuan, W., F. Wu and T. Jin, 2009. Microencapsulation of protein-loaded polysaccharide particles within poly(D,L-lactic-co-glycolic acid) microspheres using S/O/W: Characterization and release studies. Polym. Adv. Technol., 20: 834-842.
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  42. Yang, S., W. Yuan and T. Jin, 2009. Formulating protein therapeutics into particulate forms. Expert Opin. Drug Deliv., 6: 1123-1133.
    CrossRef  |  PubMed  |  
  43. Xu, L., F. Wu, W. Yuan and T. Jin, 2008. Controlled-release implant system formulated using biodegradable hemostatic gauze as Scaffold. Int. J. Pharm., 355: 249-258.
    CrossRef  |  PubMed  |  
  44. Jin, T., J. Zhu, F. Wu, W. Yuan, L.L. Geng and H. Zhu, 2008. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J. Control Release, 128: 50-59.
    CrossRef  |  PubMed  |  
  45. Geng, Y., W. Yuan, F. Wu, J. Chen, M. He and T. Jin, 2008. Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation. J. Control Release, 130: 259-265.
    CrossRef  |  PubMed  |  
  46. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. Preparation of dextran glassy particles through freezing-induced phase separation. Int. J. Pharm., 339: 76-83.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. An effective approach to prepare uniform protein-Zn2+ nanoparticles under mild conditions. Nanotechnology, Vol. 18. 10.1088/0957-4484/18/14/145601.
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