Dr. Zhe-Sheng Jason Chen
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Dr. Zhe-Sheng Jason Chen

Professor
St. Johns University, USA


Highest Degree
Ph.D. in Cancer Pharmacology from Kagoshima University, Japan

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Biography

Dr. Zhe-Sheng Chen is currently working as Professor at St. Johns University, USA. He obtained his Ph.D. in Cancer Pharmacology from Kagoshima University, Japan. His area of interest related to Pharmacology and Toxicology. His area of expertise includes, Multidrug Resistance, ABC Transporters, and Tyrosine Kinase Inhibitors. He has 35 publications in journals.

Area of Interest:

Biomedical Sciences
100%
Chemotherapeutic Agents
62%
Multidrug Resistance
90%
Resistance Mechanisms
75%
Anticancer Drugs
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sun, Y.L., J.J. Chen, P. Kumar, K. Sodani and A. Patel et al., 2103. Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar. PLoS One, Vol. 8. 10.1371/journal.pone.0055576.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Zhang, Y.K., Y.J. Wang, P. Gupta and Z.S. Chen, 2015. Multidrug resistance proteins (MRPs) and cancer therapy. AAPS J., 17: 802-812.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Zhang, Y.K., H. Zhang, G.N. Zhang, Y.J. Wang and R.J. Kathawala et al., 2015. The reversal effect on ABCB1-mediated drug resistance by the semi-synthetic ocotillol analogues. Oncotarget, .
  4. Zhang, Y., Y.K. Zhang, Y.J. Wang, S.G. Vispute and S. Jain et al., 2015. Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance. Mar. Drugs, 13: 2267-2286.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Wei, L., J. Lu, H. Xu, A. Patel, Z.S. Chen and G. Chen, 2015. Silver nanoparticles: Synthesis, properties, and therapeutic applications. Drug Discovery Today, 20: 595-601.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Sui, H., H. Xu, Q. Ji, X. Liu and L. Zhou et al., 2015. 5-HTR1D promotes metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway in colorectal cancer. Oncotarget, .
  7. Singha, B., H.R. Gatla, S. Phyo, A. Patel, Z.S. Chen and I. Vancurova, 2015. IKK inhibition increases bortezomib effectiveness in ovarian cancer. Oncotarget, .
  8. Liu, D.L., Y.J. Li, D.H. Yang, C.R. Wang and J. Xu et al., 2015. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. Int. J. Oncol., 46: 2029-2038.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Kathawala, R.J., Y.J. Wang, S. Shukla, Y.K. Zhang and S. Alqahtani et al., 2015. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chin. J. Cancer, Vol. 34. 10.1186/s40880-015-0003-0.
    CrossRef  |  Direct Link  |  
  10. Kathawala, R.J., P. Gupta, C.R. Ashby and Z.S. Chen, 2015. The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade. Drug Resistance Updates, 18: 1-17.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Hasinoff, B.B., X. Wu, A.A. Yadav, D. Patel and H. Zhang et al., 2015. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu (II). Biochem. Pharmacol., 93: 266-276.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Zhang, H., Y.K. Zhang, Y.J. Wang, R.J. Kathawala and A. Patel et al., 2014. WHI‐P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci., 105: 1071-1078.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Zhang, H., Y.J. Wang, Y.K. Zhang, D.S. Wang and R.J. Kathawala et al., 2014. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Cancer Lett., 350: 61-68.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Zhang, H., R.J. Kathawala, Y.J. Wang, Y.K. Zhang and A. Patel et al., 2014. Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance. Int. J. Biochem. Cell Biol., 51: 111-119.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Zhang, H., A. Patel, S.L. Ma, X.J. Li and Y.K. Zhang et al., 2014. In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1. Br. J. Pharmacol., 171: 5845-5857.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Yao, N., D.L. Liu, Y.J. Li, Z.S. Chen and Z. Shi et al., 2014. B5H7, a Morpholine Derivative of 23-hydroxybetulinic acid, reverses doxorubicin resistance in HepG2/ADM. J. Cancer Res. Updates, 3: 59-66.
    CrossRef  |  
  17. Yan, X.J., L.H. Gong, F.Y. Zheng, K.J. Cheng, Z.S. Chen and Z. Shi, 2014. Triterpenoids as reversal agents for anticancer drug resistance treatment. Drug Discovery Today, 19: 482-488.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Xu, S., L. Pei, C. Wang, Y.K. Zhang and D. Li et al., 2014. Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates. ACS Med. Chem. Lett., 5: 797-802.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Wang, Y.J., Y.K. Zhang, R.J. Kathawala and Z.S. Chen, 2014. Repositioning of tyrosine kinase inhibitors as antagonists of ATP-binding cassette transporters in anticancer drug resistance. Cancers, 6: 1925-1952.
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  20. Wang, Y.J., R.J. Kathawala, Y.K. Zhang, A. Patel and P. Kumar et al., 2014. Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1. Biochem. Pharmacol., 90: 367-378.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Wang, J., Y.J. Wang, Z.S. Chen and C.H. Kwon, 2014. Synthesis and evaluation of sulfonylethyl-containing phosphotriesters of 3'-azido-3'-deoxythymidine as anticancer prodrugs. Bioorg. Med. Chem., 22: 5747-5756.
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  22. Wang, D.S., G.H. Rizwani, H. Guo, M. Ahmed and M. Ahmed et al., 2014. Annona squamosa Linn: Cytotoxic activity found in leaf extract against human tumor cell lines. Pak. J. Pharm. Sci., 27: 1559-1563.
    PubMed  |  Direct Link  |  
  23. Wang, D.S., A. Patel, S. Shukla, Y.K. Zhang and Y.J. Wang et al., 2014. Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2. Oncotarget, 5: 4529-4542.
    PubMed  |  Direct Link  |  
  24. Wang, D.S., A. Patel, H.M. Sim, Y.K. Zhang and Y.J. Wang et al., 2014. ARRY-334543 Reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member. J. Cell. Biochem. 10.1002/jcb.24787.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Tang, S.J., L.K. Chen, F. Wang, Y.K. Zhang and Z.C. Huang et al., 2014. CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochem. Pharmacol., 91: 144-156.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Sun, Y.L., P. Kumar, K. Sodani, A. Patel and Y. Pan et al., 2014. Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells. Oncol. Rep. 10.3892/or.2014.3002.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Sui, H., G.X. Cai, S.F. Pan, W.L. Deng and Y.W. Wang et al., 2014. miR200c attenuates P-gp-Mediated MDR and metastasis by targeting JNK2/c-jun signaling pathway in colorectal cancer. Mol. Cancer Ther., 13: 3137-3151.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Sodani, K., A.K. Tiwari, C.L. Dai, A.H. Abuznait and A. Patel et al., 2014. Sildenafil enhances the anticancer activity of paclitaxel in an ABCB1-mediated multidrug resistance xenograft mouse model. J. Cancer Res. Updates, 3: 169-173.
    Direct Link  |  
  29. Sodani, K., A. Patel, N. Anreddy, S. Singh and D.H. Yang et al., 2014. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochem. Pharmacol., 89: 52-61.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Singh, S., N.R. Prasad, E.E. Chufan, B.A. Patel and Y.J. Wang et al., 2014. Design and synthesis of human ABCB1 (P-Glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid. J. Med. Chem., 57: 4058-4072.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Minami, K., Y. Kamijo, Y. Nishizawa, S. Tabata and F. Horikuchi et al., 2014. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Res., 34: 4767-4773.
    PubMed  |  Direct Link  |  
  32. Liu, D.L., Y.J. Li, N. Yao, J. Xu and Z.S. Chen et al., 2014. Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina, reverses ABCB1-mediated multidrug resistance in HepG2/ADM and MCF-7/ADR cells. Eur. J. Pharmacol., 733: 34-44.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Kathawala, R.J., Y.J. Wang, C.R. Ashby Jr and Z.S. Chen, 2014. Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs. Chin. J. Cancer, 33: 223-230.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. Kathawala, R.J., L. Wei, N. Anreddy, K. Chen and A. Patel et al., 2014. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: A preclinical and pharmacokinetic study. Oncotarget, Vol. 6. .
    PubMed  |  Direct Link  |  
  35. Kathawala, R.J., K. Sodani, K. Chen, A. Patel and A.H. Abuznait et al., 2014. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: A preclinical study. Mol. Cancer Ther., 13: 714-723.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Kathawala, R.J., J.J. Chen, Y.K. Zhang, Y.J. Wang and A. Patel et al., 2014. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int. J. Oncol., 44: 1634-1642.
    CrossRef  |  Direct Link  |  
  37. Huang, X.C., X. Xiao, Y.K. Zhang, T.T. Talele, A.A. Salim, Z.S. Chen and R.J. Capon, 2014. Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Mar. Drugs, 12: 3818-3837.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Guo, H.Q., G.N. Zhang, Y.J. Wang, Y.K. Zhang and K. Sodani et al., 2014. β-elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncol. Rep., 31: 858-866.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Chen, G., R. Chen, C. Zou, D. Yang and Z.S. Chen, 2014. Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery. J. Mater. Chem. B, 2: 1327-1334.
    CrossRef  |  Direct Link  |  
  40. Anreddy, N., P. Gupta, R.J. Kathawala, A. Patel, J.N. Wurpel and Z.S. Chen, 2014. Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance. Molecules, 19: 13848-13877.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Anreddy, N., A. Patel, K. Sodani, R.J. Kathawala, E.P. Chen, J.N. Wurpel and Z.S. Chen, 2014. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharm. Sin. B, 4: 202-207.
    CrossRef  |  Direct Link  |  
  42. Zhao, X., C.L. Dai, S. Ohnuma, Y. Liang and W. Deng et al., 2013. Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2. Eur. J. Pharm. Sci., 49: 441-450.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Zhang, D.M., Y.J. Li, C. Shu, Z.X. Ruan and W.M. Chen et al., 2013. Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells. Anti-Cancer Drugs, 24: 441-454.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Zhang, D.M., C. Shu, J.J. Chen, K. Sodani and J. Wang et al., 2013. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Mol. Pharmaceutics, 9: 3147-3159.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Yang, D., R.J. Kathawala, E.E. Chufan, A. Patel, S.V. Ambudkar, Z.S. Chen and X. Chen, 2013. Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP). Future Oncol. 10.2217/fon.13.253.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Vispute, S.G., J.J. Chen, Y.L. Sun, K.S. Sodani and S. Singh et al., 2013. Vemurafenib (PLX4032, Zelboraf®), a BRAF inhibitor, modulates ABCB1-,ABCG2- and ABCC10-mediated multidrug resistance. J. Cancer Res., 2: 307-317.
    Direct Link  |  
  47. Tiwari, A.K., K. Sodani, C.L. Dai, A.H. Abuznait and S. Singh et al., 2013. Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Lett., 328: 307-317.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Tiwari, A.K. and Z.S. Chen, 2013. Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants. Front Pharmacol., Vol. 4. (In Press). 10.3389/fphar.2013.00082.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Qiu, J.G., X.L. Mei, Z.S. Chen and Z. Shi, 2013. Cytokine Detection by Flow Cytometry. In: Methods in Molecular Biology, Cytokine Bioassays, Vancurova, I. (Ed.). Springer, New York, USA.
  50. Patel, A., A.K. Tiwari, E.E. Chufan, K. Sodani and N. Anreddy et al., 2013. PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer Chemother Pharmacol., 72: 189-199.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Natarajan, K., J. Bhullar, S. Shukla, M. Burcu, Z.S. Chen, S.V. Ambudkar and M.R. Baer, 2013. The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms. Biochem. Pharmacol., 85: 514-524.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Liu, K.J., X.D. Su, J.D. Xie, X. Chen and F. Wang et al., 2013. Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo. Int. J. Cancer, 132: 224-235 .
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Huang, X.C., Y.L. Sun, A. Salim, Z.S. Chen and R.J. Capon, 2013. Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochem. Pharmacol., 85: 1257-1268.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Huang, X.C., P. Kumar, N. Anreddy, X. Xiao, D.H. Yang and Z.S. Chen, 2013. P-gp Inhibitory Activity from Marine Sponges, Tunicates and Algae. In: Anticancer Drugs from Marine Origin, Kim, S.K. (Ed.). Springer, New York, USA.
  55. He, D., X.Q. Zhao, X.G. Chen, Y. Fang and S. Singh et al., 2013. BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. PloS One, Vol. 8. 10.1371/journal.pone.0054181.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Guo, H.Q., D.S. Wang, G.H. Rizwani, M. Ahmed and M. Ahmed et al., 2013. Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro). Pak. J. Pharm. Sci., 26: 1151-1156.
    Direct Link  |  
  57. Deng, W., C.L. Dai, J.J. Chen, R. Kathawala, Y.L. Sun, H.F. Chen and Z.S. Chen, 2013. Tandutinib(MLN518) reverses multidrug resistance by inhibiting the efflux activity of the MRP7 (ABCC10). Oncol. Rep., 29: 2479-2485.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Deng, W., B. Hu, C.L. Dai, Y.J. Wang and H.F. Chen et al., 2013. Anticancer activity of oldenlandia diffusa and viola Philippica car. J. Cancer Res., 2: 87-94.
    Direct Link  |  
  59. Chen, J.J., A. Patel, K. Sodani, Z.J. Xiao and A.K. Tiwari et al., 2013. BBA, a Synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10). PLoS ONE, (In Press). 10.1371/journal.pone.0074573.
    CrossRef  |  PubMed  |  Direct Link  |  
  60. Chen, J., D.P. Brown, Y.J. Wang and Z.S. Chen, 2013. New phenstatin-fatty acid conjugates: Synthesis and evaluation. Bioorganic Med. Chem. Lett., 23: 5119-5122.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Zhao, X., J.D. Xie, X. Chen, H.M. Sim and X. Zhang et al., 2012. Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo and ex vivo. Mol. Pharmacol., 82: 47-58.
    CrossRef  |  PubMed  |  Direct Link  |  
  62. Tiwari, A.K., D.H. Yang and Z.S. Chen, 2012. Molecular Mechanisms of Metho-trexate Resistance. In: Methotrexate: Pharmacology, Clinical Uses and Adverse Effect, Castillo, V.S. and L.A. Moyano (Eds.) Nova Science Publishers, New York.
  63. Sun, Y.L., R.J. Kathawala, S. Singh, K. Zheng and T.T. Talele et al., 2012. Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Anti-Cancer Drugs, 23: 865-873.
    CrossRef  |  PubMed  |  Direct Link  |  
  64. Sun, Y.L., A. Patel, P. Kumar and Z.S. Chen, 2012. Role of ABC transporters in cancer chemotherapy. Chin. J. Cancer, 31: 51-57.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Sodani, K., A.K. Tiwari, S. Singh, A. Patel and Z.J. Xiao et al., 2012. GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochem. Pharmacol., 83: 1613-1622.
    CrossRef  |  PubMed  |  Direct Link  |  
  66. Sodani, K., A. Patel, R.J. Kathawala and Z.S. Chen, 2012. Multidrug resistance associated proteins in multidrug resistance. Chin. J Cancer, 31: 58-72.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Shukla, S., Z.S. Chen and S.V. Ambudkar, 2012. Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resistance Updates, 15: 70-80.
    CrossRef  |  PubMed  |  Direct Link  |  
  68. Shi, Z., W.M. Yang, L.P. Chen, D.H. Yang and Q. Zhou et al., 2012. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Res. Treatment, 135: 737-747.
    CrossRef  |  PubMed  |  Direct Link  |  
  69. Sen, R., K. Natarajan, J. Bhullar, S. Shukla and H.B. Fang et al., 2012. The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Mol. Cancer Ther., 11: 2033-2044.
    CrossRef  |  PubMed  |  Direct Link  |  
  70. Peng, X.X., A.K. Tiwari, H.C. Wu and Z.S. Chen, 2012. Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. Chin. J. Cancer, 31: 110-118.
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  71. Li, T.W., Y.C. Yang, C.M. Cheng, A.K. Tiwari and K. Sodani et al., 2012. N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents: Design, synthesis and biological evaluation. Bioorganic Med. Chem. Lett., 22: 7268-7274.
    CrossRef  |  PubMed  |  Direct Link  |  
  72. Li, T., Y. Yang, C. Cheng, A.K. Tiwari and K. Sodani et al., 2012. Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. Bioorg. Med. Chem., 22: 7268-7271.
    CrossRef  |  PubMed  |  Direct Link  |  
  73. Kumar, P., D.M. Zhang, K. Degenhardt and Z.S. Chen, 2012. Autophagy and transporter-based multi-drug resistance. Cells, 1: 558-575.
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  74. Kuang, Y.H., J. Patel, K. Sodani, C.P. Wu and L.Q. Liao et al., 2012. OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochem. Pharmacol., 84: 766-774.
    CrossRef  |  PubMed  |  Direct Link  |  
  75. Cheng, C., Z.G. Liu, H. Zhang, J.D. Xie and X.G. Chen et al., 2012. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an aurora kinase inhibitor CCT129202. Mol. Pharm., 9: 1971-1982.
    CrossRef  |  PubMed  |  Direct Link  |  
  76. Chen, J.J., Y.L. Sun, A.K. Tiwari, Z.J. Xiao and K. Sodani et al., 2012. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Sci., 103: 1531-1537.
    CrossRef  |  PubMed  |  Direct Link  |  
  77. Abraham, I., K. El Sayed, Z.S. Chen and H. Guo, 2012. Current status on marine products with reversal effect on cancer multidrug resistance. Mar. Drugs, 10: 2312-2321.
    CrossRef  |  PubMed  |  Direct Link  |  
  78. Yan, Y.Y., L.S. Zheng, X. Zhang, L.K. Chen and S. Singh et al., 2011. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Mol. Pharm., 8: 1687-1697.
    CrossRef  |  PubMed  |  Direct Link  |  
  79. Tiwari, K.A., K. Sodani, C.L. Dai, R.C. Ashby and Z.S. Chen, 2011. Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Curr. Pharmaceutical Biotechnol., 12: 570-594.
    CrossRef  |  PubMed  |  
  80. Shi, Z., A.K. Tiwari, S. Shukla, R.W. Robey and S. Singh et al., 2011. Sildenafil reverses ABCB1-and ABCG2-mediated chemotherapeutic drug resistance. Cancer Res., 71: 3029-3041.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Shi, Z., A.K. Tiwari, A.S. Patel, L.W. Fu and Z.S. Chen, 2011. Roles of sildenafil in enhancing drug sensitivity in cancer. Cancer Res., 71: 3735-3738.
    CrossRef  |  PubMed  |  Direct Link  |  
  82. Peng, X.X., Z. Shi, V.L. Damaraju, A.K. Tiwari and L.W. Fu et al., 2011. Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells. Oncol. Lett., 2: 549-556.
    CrossRef  |  PubMed  |  Direct Link  |  
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