Dr. Weiguo  Zou
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Dr. Weiguo Zou

Post-doctoral Fellow
Harvard School of Public Health, USA


Highest Degree
Ph.D. in Biochemistry and Molecular Biology from Institute of Biochemistry and Cell Biology, China

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Area of Interest:

Molecular Sciences
100%
Gene Therapy
62%
Biochemistry
90%
Molecular Biology
75%
Cancer
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Shim, J.H., M.B. Greenblatt, M. Xie, M.D. Schneider and W. Zou et al., 2009. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J., 28: 2028-2041.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Zou, W., J.H. Kim, A. Handidu, X. Li and K.I. Kim et al., 2007. Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 Usp18 deficient macrophages. Biochem. Biophys. Res. Commun., 356: 193-199.
    PubMed  |  
  3. Zou, W., J. Wang and D.E. Zhang, 2007. Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. Biochem. Biophys. Res. Commun., 354: 321-327.
    PubMed  |  Direct Link  |  
  4. Okumura, F., W. Zou and D.E. Zhang, 2007. ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21: 255-260.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Zou, W. and D.E. Zhang, 2006. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J. Biol. Chem., 281: 3989-3994.
    CrossRef  |  PubMed  |  
  6. Wang, B., W. Zou, W. Liu and X. Liu, 2006. The lower cytotoxicity of cinnamomin (a type II RIP) is due to its B-chain. Arch. Biochem. Biophys., 451: 91-96.
    PubMed  |  Direct Link  |  
  7. Malakhova, O.A., K.I. Kim, J.K. Luo, W. Zou and K.G. Kumar et al., 2006. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J., 25: 2358-2367.
    PubMed  |  Direct Link  |  
  8. Kim, K.I., M. Yan, O. Malakhova, J.K. Luo and M.F. Shen et al., 2006. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol. Cell. Biol., 26: 472-479.
    PubMed  |  Direct Link  |  
  9. Zhang, Z.L., W.G. Zou, J.H. Wang, J.F. Gu and Y.K. Dang et al., 2005. Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble Flt-1. Mol. Ther., 11: 553-562.
    CrossRef  |  Direct Link  |  
  10. Liu, X., S. Qiu, W. Zou, Z. Pei and J. Gu et al., 2005. Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol. Ther., 11: 531-541.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Giannakopoulos, N.V., J. Luo, V. Papov, W. Zou and D.J. Lenschow et al., 2005. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem. Biophys. Res. Commun., 336: 496-506.
    PubMed  |  Direct Link  |  
  12. Zou, W., C. Luo, Z. Zhang, J. Liu and J. Gu et al., 2004. A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent. Oncogene, 23: 457-464.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Pei, Z., L. Chu, W. Zou, Z. Zhang and S. Qiu et al., 2004. An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology, 39: 1371-1381.
    PubMed  |  Direct Link  |  
  14. Zhang, Z.L., W.G. Zou, C.X. Luo, B. Li and J.H. Wang et al., 2003. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res., 13: 481-489.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Zou, W., J. Zeng, M. Zhuo, W. Xu, L. Sun, J. Wang and X. Liu, 2002. Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J. Neurosci. Res., 67: 837-843.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Zou, W., D. Wang, M. Lang, D. Jin and D. Xu et al., 2002. Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. J. Surg. Res., 103: 121-126.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Liu, J., W. Zou, M. Lang, J. Luo and L. Sun et al., 2002. Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int. J. Oncol., 21: 661-666.
    PubMed  |  Direct Link  |  
  18. Zou, W., M. Yan, W. Xu, H. Huo, L. Sun, Z. Zheng and X. Liu, 2001. Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J. Neurosci. Res., 64: 646-653.
    PubMed  |  Direct Link  |