Dr. Hongyan Qin
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Dr. Hongyan Qin

Associate Professor
First Hospital of Lanzhou University, China

Highest Degree
Ph.D. in Pharmacology from Hong Kong Baptist University, China

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacology
62%
Medical Microbiology
90%
Pharmaceutical Analysis
75%
Basic Medical Science
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wong, H.L.X., H.Y. Qin, S.W. Tsang, X. Zuo and S. Che et al., 2019. Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Commun., 10: 1-14.
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  2. Qin, H.Y., K.H. Zang, X. Zuo, X.A. Wu and Z.X. Bian, 2019. Quercetin attenuates visceral hypersensitivity and 5-hydroxytryptamine availability in postinflammatory irritable bowel syndrome rats: Role of enterochromaffin cells in the colon. J. Med. Food, 22: 663-671.
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  3. Qin, H.Y., J.X. Kou, Z. Rao, G.Q. Zhang, X.H. Wang, L.P. Bai and Y.H. Wei, 2019. N-acetyltransferase activity assay and inhibitory compounds screening by using living human hepatoma heparg cell model. Int. J. Pharmacol., 15: 229-237.
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  4. Chow, C.F.W., S. Che, H.Y. Qin, H.Y. Kwan, Z.X. Bian and H.L.X. Wong, 2019. From psychology to physicality: How nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle, 18: 1824-1829.
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  5. Zhang F, L. Xi, Y. Duan, H. Qin and M. Wei et al., 2018. The ileum-liver farnesoid x receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats. Eur. J. Pharm. Sci., 123: 404-415.
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  6. Rao, Z., F. Zhang, X.Y. Zhang, G.Q. Zhang and Y.R. Ma et al., 2018. Multicomponent determination of traditional Chinese medicine preparation yin‐zhi‐huang injection by LC–MS/MS for screening of its potential bioactive candidates using HepaRG cells. Biomed. Chromatogr., Vol. 32. 10.1002/bmc.4057.
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  7. Ma, Y.R., Y. Zhou, J. Huang, H.Y. Qin and P. Wang et al., 2018. The urinary excretion of metformin, ceftizoxime and ofloxacin in high serum creatinine rats: Can creatinine predict renal tubular elimination? Life Sci., 196: 110-117.
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  8. Kou, W., H. Qin, S. Hanif and X. Wu, 2018. Nephrotoxicity evaluation on cisplatin combined with 5-HT3 receptor antagonists: A retrospective study. Biomed. Res. Int., Vol. 2018. 10.1155/2018/1024324.
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  9. Zhang, F., H. Qin, Y. Zhao, Y. Wei, L. Xi, Z. Rao and X. Wu., 2017. Effect of cholecystectomy on bile acids as well as relevant enzymes and transporters in mice: Implication for pharmacokinetic changes of rifampicin. Eur. J. Pharm. Sci., 96: 141-153.
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  10. Shi, A.X., Y. Zhou, X.Y. Zhang, Y.S. Zhao, H.Y. Qin, Y.P. Wang and X.A. Wu, 2017. Irinotecan-induced bile acid malabsorption is associated with down-regulation of ileal Asbt (Slc10a2) in mice. Eur. J. Pharm. Sci., 102: 220-229.
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  11. Duan, H., S. Lu, H. Qin, C. Gao and X. Bai et al., 2017. Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. Int. J. Pharm., 516: 214-224.
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  12. Zhou, L., Y. Song, J. Zhao, H. Qin, G. Zhang, Y. Zhou and X.A. Wu, 2016. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp and Oatp1a4 in liver. Pharm. Biol., 54: 931-937.
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  13. Zhang, G., J. Zhu, Y. Zhou, Y. Wei, L. Xi, H. Qin and X.A. Wu, 2016. Hesperidin alleviates oxidative stress and upregulates the multidrug resistance protein 2 in isoniazid and rifampicin‐induced liver injury in rats. J. Biochem. Mol. Toxicol., 30: 342-349.
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  14. Wang, X.D., Z. Rao, H.Y. Qin, G.Q. Zhang and Y.R. Ma et al., 2016. Effect of hesperidin on the pharmacokinetics of CPT‐11 and its active metabolite SN‐38 by regulating hepatic Mrp2 in rats. Biopharm. Drug Dispos., 37: 421-432.
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  15. Ma, Y.R., H.Y. Qin, Y.W. Jin, J. Huang, M. Han, X.D. Wang and X.A. Wu, 2016. Gender-related differences in the expression of organic cation transporter 2 and its role in urinary excretion of metformin in rats. Eur. J. Drug metab. Pharmacokinet., 41: 559-565.
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  16. Ma, Y.R., A.X. Shi, H.Y. Qin, T. Zhang, Y.F. Wu and G.Q. Zhang, 2016. Metoprolol decreases the plasma exposure of metformin via the induction of liver, kidney and muscle uptake in rats. Biopharm. Drug Disposit., 97: 511-521.
  17. Kai-hong, Z., S. Yun-yun, Z. Xiao, R. Zhi and Q. Hong-yan, 2016. Oridonin alleviates visceral hyperalgesia in a rat model of postinflammatory irritable bowel syndrome: Role of colonic enterochromaffin cell and serotonin availability. J. Med. Food, 19: 586.-592.
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  18. Duan, H., S. Lu, C. Gao, X. Bai and H. Qin et al., 2016. Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflammed colon. Colloids Surf. B Biointerfaces, 145: 510-519.
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  19. Zhou, Y., G.Q. Zhang, Z. Rao, Y. Yang and Q. Zhou et al., 2015. Increased brain uptake of venlafaxine loaded solid lipid nanoparticles by overcoming the efflux function and expression of P-gp. Arch. Pharm. Res., 38: 1325-1335.
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  20. Zhang, G., Y. Zhou, Z. Rao, H. Qin and Y. Wei et al., 2015. Effect of yin-zhi-huang on up-regulation of Oatp2, Ntcp, and Mrp2 proteins in estrogen-induced rat cholestasis. Pharm. Biol., 53: 319-325.
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  21. Zang, K.H., Z. Rao, G.Q. Zhang and H.Y. Qin, 2015. Anticolitis activity of chinese herbal formula yupingfeng powder via regulating colonic enterochromaffin cells and serotonin. Indian J. Pharmacol., 47: 632-637.
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  22. Shao, Y.Y., J. Huang, Y.R. Ma, M. Han, K. Ma, H.Y. Qin and X.A. Wu, 2015. Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats. Can. J. Physiol. Pharmacol., 93: 633-639.
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  23. Rao, Z., Y.R., Ma, H.Y. Qin, Y.F. Wang and Y.H. Wei et al., 2015. Development of a LC‐MS/MS method for simultaneous determination of metoprolol and its metabolites, α‐hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: Application to the herb-drug interaction study of metoprolol and breviscapine. Biomed. Chromatogr., 29: 1453-1460.
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  24. Rao, Z., H. Qin, Y. Wei, Y. Zhou, G. Zhang, F. Zhang and X.A. Wu, 2014. Development of a dynamic multiple reaction monitoring method for determination of digoxin and six active components of Ginkgo biloba leaf extract in rat plasma. J. Chromatogr. B, 959: 27-35.
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  25. Qin, H.Y., C.W. Cheng, X.D. Tang and Z.X. Bian, 2014. Impact of psychological stress on irritable bowel syndrome. World J. Gastroenterol., 20: 14126-14131.
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  26. Xiao, H.T., S.W. Tsang, H.Y. Qin, F.F.K. Choi and Z.J. Yang et al., 2013. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J. Ethnopharmacol., 149: 499-505.
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  27. Qin, H.Y., H.T. Xiao, J.C.Y. WU, B.M. Berman, J.J. Sung and Z.X. Bian, 2012. Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats World J. Gastroenterol., 18: 2481-2492.
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  28. Qin, H.Y., H.T. Xiao, F.P. Leung, J.C.Y. Wu and J.J.Y. Sung et al., 2012. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing colonic EC cell hyperplasia and serotonin availability. Evid. Based Complement. Altern. Med., Vol. 2012. 10.1155/2012/239638.
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  29. Qin, H.Y., Wu, J.C., X.D. Tong , J.J.Y. Sung , H.X. Xu and Z.X. Bian, 2011. Systematic review of animal models of post-infectious/post inflammatory irritable. J. Gastroenterol., 46: 164-174.
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  30. Luo, J.L., H.Y. Qin, C.K. Wong, S.Y. Tsang, Y. Huang and Z.X. Bian, 2011. Enhanced excitability and down-regulated voltage-gated potassium channels in colonic drg neurons from neonatal maternal separation rats. J. Pain, 12: 600-609.
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  31. Bian, Z.X., H.Y. Qin, S.L. Tian and S.D. Qi, 2011. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: Differences between proximal and distal colon in rats. Stress: Int. J. Biol. Stress, 14: 448-458.
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  32. Qin, H.Y., J.L. Luo, S.D. Qi, H.X. Xu, J.J.Y. Sung and Z.X. Bian, 2010. Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon. Eur. J. Pharmacol., 647: 75-83.
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  33. Wei, Y.H., J.Q. He, H.Y. Qin, X.A. Wu and X.J. Yao, 2009. Determination of ferruginol in rat plasma via high‐performance liquid chromatography and its application in pharmacokinetics study. Biomed. Chromatogr., 23: 1116-1120.
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  34. Zhao, G., W. Du, Y. Wei, H. Qin and X. Wu, 2008. An HPLC method for the determination and pharmacokinetic study of lehmannine in rat plasma. Biomed. Chrom., 22 : 1149-1154.
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  35. Du, W., Y.H. Wei, G. Zhao, H.Y. Qin and X.A. Wu, 2008. Determination of tanshinone i in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. J. Chromatogr. Sci., 46: 730-734.
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