Dr. Jae Bong Park
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Dr. Jae Bong Park

Professor
Hallym University, South Korea


Highest Degree
Ph.D. in Biochemistry from Korea Advanced Institute of Science and Technology, South Korea

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Macrophages
90%
Tumors
75%
Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
73
Abstracts
0

Selected Publications

  1. Yu, S.B., Z. Umair, S. Kumar, U. Lee and S.H. Lee et al., 2016. xCyp26c Induced by Inhibition of BMP Signaling Is Involved in Anterior-Posterior Neural Patterning of Xenopuslaevis. Mol. Cells, 39: 352-357.
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  2. Kim, J.G., M.J. Kim, W.J. Choi, M.Y. Moon and H.J. Kim et al., 2016. Wnt3A Induces GSK-3B phosphorylation and B-catenin accumulation through RhoA/ROCK. J. Cell. Physiol., 10.1002/jcp.25572.
    CrossRef  |  Direct Link  |  
  3. Kim, J.G., H.J. Kwon, G. Wu, Y. Park and J.Y. Lee et al., 2016. RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-KB activation. Free Radical Biol. Med., 103: 57-68.
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  4. Jeon, H.Y., J.K. Kim, S.W. Ham, S.Y. Oh and J. Kim et al., 2016. Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. Tumour Biol., 37: 5857-5867.
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  5. Kim, E.J., S.O. Kim, X. Jin, S.W. Ham and J. Kim et al., 2015. Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1. Tumour Biol., 36: 2921-2928.
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  6. Yoon, J., J.H. Kim, S.Y. Lee, S. Kim, J.B. Park, J.Y. Lee and J. Kim, 2014. PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos. BMB Rep., 47: 673-678.
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  7. Yoon, J., J.H. Kim, S.C. Kim, J.B. Park, J.Y. Lee and J. Kim, 2014. PV.1 suppresses the expression of FoxD5b during neural induction in Xenopus embryos. Mol. Cells, 37: 220-225.
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  8. Kim, J.K., S.Y. Lee, C.W. Park, S.H. Park and J. Yin et al., 2014. Rab3a promotes brain tumor initiation and progression. Mol. Biol. Rep., 41: 5903-5911.
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  9. Kim, H.J., J.G. Kim, M.Y. Moon, S.H. Park and J.B. Park, 2014. IKB kinase Y/nuclear factor-KB modulator (NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated kinase (ROCK) to phosphorylate IKKB in response to transforming growth factor (TGF)-B1. J. Biol. Chem., 289: 1429-1440.
    CrossRef  |  Direct Link  |  
  10. Yoon, J., J.H. Kim, O.J. Lee, S.Y. Lee and S.H. Lee et al., 2013. AP-1(c-Jun/FosB) mediates xFoxD5b expression in Xenopus early developmental neurogenesis. Int. J. Dev. Biol. 57: 865-872.
    CrossRef  |  
  11. Moon, M.Y., H.J. Kim, Y. Li, J.G. Kim and Y.J. Jeon et al., 2013. Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides. Cell. Signalling, 25: 1861-1869.
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  12. Moon, M.Y., H.J. Kim, J.G. Kim, J.Y. Lee and J. Kim et al., 2013. Small GTPase Rap1 regulates cell migration through regulation of small GTPase RhoA activity in response to TGF-B1. J. Cell. Physiol., 228: 2119-2126.
    CrossRef  |  Direct Link  |  
  13. Lee, Y.J., B.H. Jeong, J.B. Park, H.J. Kwon, Y.S. Kim and I.S. Kwak, 2013. The prevalence of human endogenous retroviruses in the plasma of major burn patients. Burns, 39: 1200-1205.
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  14. Yi, L., J.G. Kim, H.J. Kim, M.Y. Moon and J.Y. Lee et al., 2012. Small GTPasesRap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages. Free Radical Biol. Med., 52: 1796-1805.
    CrossRef  |  Direct Link  |  
  15. Kim, J.S., I.G. Choi, B.C. Lee, J.B. Park and J.H. Kim et al., 2012. Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts. Mol. Cell Biochem., 365: 181-189.
    CrossRef  |  Direct Link  |  
  16. Kim, J.G., M.Y. Moon, H.J. Kim, Y. Li and D.K. Song et al., 2012. Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosans particles in macrophages. J. Biol. Chem., 287: 5145-5155.
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  17. Jeon, C.Y., M.Y. Moon, J.H. Kim, H.J. Kim and J.G. Kim et al., 2012. Control of neurite outgrowth by RhoA inactivation. J. Neurochem., 120: 684-698.
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  18. Heo, J.I., S.J. Oh, Y.J. Kho, J.H. Kim and H.J. Kang et al., 2012. ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage. Mol. Biol. Rep., 39: 8007-8014.
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  19. Yoon, J., J.H. Kim, O.J. Lee, S.B. Yu and J.I. Kim et al., 2011. xCITED2 Induces Neural Genes in Animal Cap Explants of Xenopus Embryos. Exp. Neurobiol., 20: 123-129.
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  20. Park, B.K., D. Kim, S. Cho, J.N. Seo and J.B. Park et al., 2011. Effects of lipopolysaccharide and CpG-DNA on burn-induced skin injury. BMB Rep., 44: 273-278.
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  21. Lee, S.Y., S.K. Lim, S.W. Cha, J. Yoon and S.H. Lee et al., 2011. Inhibition of FGF signaling converts dorsal mesoderm to ventral mesoderm in early Xenopus embryos. Differ., 82: 99-107.
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  22. Lee, S.Y., J. Yoon, H.S. Lee, Y.S. Hwang and S.W. Cha et al., 2011. The function of heterodimeric AP-1 comprised of c-Jun and c-Fos in activin mediated Spemann organizer gene expression. PLoS One, 10.1371/journal.pone.0021796.
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  23. Lee, H.S., S.Y. Lee, H. Lee, Y.S. Hwang and S.W. Cha et al., 2011. Direct response elements of BMP within the PV.1A promoter are essential for its transcriptional regulation during early Xenopus development. PLoS One, 10.1371/journal.pone.0022621.
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  24. Kim, J.S., E.J. Bak, B.C. Lee, Y.S. Kim, J.B. Park and I.G. Choi, 2011. Neuregulin induces HaCaT keratinocyte migration via Rac1-mediated NADPH-oxidase activation. J. Cell Physiol., 226: 3014-3021.
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  25. Heo, J.I., S.J. Oh, Y.J. Kho, J.H. Kim and H.J. Kang et al., 2011. ERK mediates anti-apoptotic effect through phosphorylation and cytoplasmic localization of p21Waf1/Cip1/Sdi in response to DNA damage in normal human embryonic fibroblast (HEF) cells. Mol. Biol. Rep., 38: 2785-2791.
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  26. Park, B.K., S. Lee, J.N. Seo, J.W. Rhee and J.B. Park et al., 2010. Protection of burn-induced skin injuries by the flavonoid kaempferol. BMB Rep., 43: 46-51.
    Direct Link  |  
  27. Oh, S.J., J.I. Heo, Y.J. Kho, J.H. Kim and H.J. Kang et al., 2010. Nitric oxide is an essential mediator for neuronal differentiation of rat primary cortical neuron cells. Exp. Neurobiol., 19: 83-89.
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  28. Jeon, C.Y., J.K. Jin, Y.H. Koh, W. Chun and I.G. Choi et al, 2010. Neurites from PC12 cells are connected to each other by synapse-like structures. Synapse, 64: 765-772.
  29. Jeon, C.Y., H.J. Kim, J.Y. Lee, J.B. Kim, S.C. Kim and J.B. Park, 2010. P190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells. Exp. Mol. Med., 42: 335-344.
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  30. Jeon, C.Y., H.J. Kim, H. Morii, N. Mori and J. Settleman et al., 2010. Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3. J. Cell. Physiol., 224: 786-794.
    CrossRef  |  Direct Link  |  
  31. Kim, M.J., K. Ahn, S.H. Park, H.J. Kang and B.G. Jang et al., 2009. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a. FEBS Lett., 583: 1183-1188.
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  32. Han, S.H., Y.E. Kim, J.A. Park, J.B. Park and Y.S. Kim et al., 2009. Expression of human beta-defensin-2 gene induced by CpG-DNA in human B cells. Biochem. Biophys. Res. Commun., 389: 443-448.
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  33. Kim, H.A., S.H. Jeon, G.Y. Deo, J.B. Park and P.H. Kim, 2008. TGF-B1 and IFN-Y stimulate mouse macrophages to express BAFF via different signaling pathways. J. LeukocBiol., 83: 1431-1439.
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  34. Jeon, Y.J., H.Y. Won, M.Y. Moon, W.H. Choi and C.H. Chang et al., 2008. Interaction of microglia and amyloid-B through B2-integrin is regulated by RhoA. Neurorep., 19: 1661-1665.
    CrossRef  |  Direct Link  |  
  35. Kim, R.J., H.A. Kim, J.B. Park, S.R. Park and S.H. Jeon et al., 2007. IL-4-induced AID expression and its relevance to IgA class switch recombination. Biochem. Biophys. Res. Commun., 361: 398-403.
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  36. Kim, M.J., S.J. Oh, S.H. Park, H.J. Kang and M.H. Won et al., 2007. Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging. Exp. Mol. Med., 39: 14-26.
    Direct Link  |  
  37. Kim, M.J., S.J. Oh, S.H. Park, H.J. Kang and M.H. Won et al., 2007. Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain. Apoptosis, 12: 707-718.
    CrossRef  |  Direct Link  |  
  38. Hwang, W.S., S.H. Park, H.S. Kim, H.J. Kang and M.J. Kim et al., 2007. Ascorbic acid extends replicative life span of human embryonic fibroblast by reducing DNA and mitochondrial damages. Nutr. Res. Pract., 1: 105-112.
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  39. Choi, S.H., G.Y. Seo, E.H. Nam, H.A. Kim, J.B. Park and P.H. Kim, 2007. Opposing effects of Arkadia and Smurf on TGF-B1-induced IgA isotype expression. Mol. Cells, 24: 283-287.
    Direct Link  |  
  40. Kim, J.S., J.G. Kim, C.Y. Jeon, M.Y. Moon and C.Y. Jeon et al., 2006. Transforming growth factor-B1 regulates macrophage migration via RhoA. Blood, 108: 1821-1829.
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  41. Heo, J.I., M.S. Lee, J.H. Kim, J.S. Lee and J. Kim et al., 2006. The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress. Exp. Mol. Med., 38: 295-301.
    Direct Link  |  
  42. Lim, D.Y., A.L. Tyner, J.B. Park, J.Y. Lee, Y.H. Choi and J.H.Y. Park, 2005. Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP/WAF1. J. Cell Physiol., 205: 107-113.
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  43. Kim, J.S., J.G. Kim, C.Y. Jeon, H.Y. Won and M.Y. Moon et al., 2005. Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages. Exp. Mol. Med., 37: 575-587.
    Direct Link  |  
  44. Kim, H.S., E.J. Yeo, S.H. Park, J.I. Park and S.C. Park et al., 2005. p21 is upregulated due to increased mRNA stability during hydroxyurea-induced scenescence of human fibroblasts. Mech. Ageing Dev., 126: 1255-1261.
  45. Jung, J.W., S.H. Jung, H.S. Kim, J.S. Yuk and J.B. Park et al., 2005. High throughput analysis of GST-fusion protein expression and activity-dependent protein interactions on GST-fusion protein arrays with a spectral surface plasmon resonance biosensor. Proteomics, 6: 1110-1120.
    CrossRef  |  Direct Link  |  
  46. Lee, S.Y., H.S. Lee, J.S. Moon, J.I. Kim and J.B. Park et al., 2004. Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development. Exp. Mol. Med., 36: 468-475.
    Direct Link  |  
  47. Kim, J.S., B.A. Diebold, J.I. Kim, J. Kim, J.Y. Lee and J.B. Park, 2004. Rho is involved in superoxide formation during phagocytosis of opsonized zymosans. J. Biol. Chem., 279: 21589-21597.
    CrossRef  |  Direct Link  |  
  48. Seo, J.Y., J.S. Kim, J.H. Ghang, T.C. Kang and J.G. Suh et al., 2003. Nerve growth factor induces proliferation of PC12 cells through Cdc42. Neurorep., 17: 1277-1281.
    Direct Link  |  
  49. Park, J.B., 2003. Phagocytosis induces superoxide formation and apoptosis in macrophages. Exp. Mol. Med., 35: 325-335.
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  50. Park, J., J.S. Kim, K.C. Jung, H.J. Lee and J.I. Kim et al., 2003. Exoenzyme tat-C3 inhibits association of zymosan particles, phagocytosis, adhesion, and complement binding in macrophage cells. Mol. Cells, 16: 216-223.
    Direct Link  |  
  51. Kim, J.S., H.Y. Kwon, W.H. Choi, C.Y. Jeon and J.I. Kim et al., 2003. Phagocytosis of serum- and IgG-opsonized zymosan particles induces apoptosis through superoxide but not nitric oxide in macrophage J774.A1. Exp. Mol. Med., 35: 211-221.
    CrossRef  |  Direct Link  |  
  52. Eum, W.S., M.Z. Li, G.S. Sin, S.Y. Choi, J.B. Park, J.Y. Lee and H.Y. Kwon, 2003. Dexamethasone-induced differentiation of pancreatic AR42J cell involves p21(waf1/cip1) and MAP kinase pathway. Exp. Mol. Med., 35: 379-384.
    CrossRef  |  Direct Link  |  
  53. Suh, J.G., S.J. An, J.B. Park, Z.Y. Ryoo and J.W. Lee et al., 2002. Transcortical alterations in Na(+)-K+ ATPase and microtubule-associated proteins immunoreactivity in the rat cortical atrophy model induced by hypoxic ischemia. Neural Plast., 9: 135-146.
    CrossRef  |  Direct Link  |  
  54. Park, J.B., J.S. Kim, J.Y. Lee, J.B. Kim, J.Y. Seo and A.R. Kim, 2002. GTP binds to Rab3A in a complex with Ca2+/calmodulin. Biochem. J., 362: 651-657.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Lee, H.S., M.J. Park, S.Y. Lee, Y.S. Hwang and H. Lee et al., 2002. Transcriptional regulation of Xbr-1a/Xvent-2 homeobox gene: analysis of its promoter region. Biochem. Biophys. Res. Commun., 298: 815-823.
    CrossRef  |  Direct Link  |  
  56. Kim, A.R., W.H. Choi, S.R. Lee, J.S. Kim and C.Y. Jeon et al., 2002. Phosphorylation of 46-kDa protein of synaptic vesicle membranes is stimulated by GTP and Ca2+/calmodulin. Exp. Mol. Med., 34: 434-443.
    CrossRef  |  Direct Link  |  
  57. Park, J.B., 2001. Regulation of GTP-binding state in RalA through Ca2+ and calmodulin. Exp. Mol. Med., 33: 54-58.
    CrossRef  |  Direct Link  |  
  58. Lee, S.R., A.R. Kim, J.S. Kim, J. Kim and J.Y. Lee et al., 2001. The proteins of synaptic vesicles membranes are affected during aging of rat brain. Exp. Mol. Med., 33: 220-225.
    CrossRef  |  Direct Link  |  
  59. Shin, J.Y., H.S. Kim, J. Park, J.B. Park and J.Y. Lee, 2000. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric. Cancer Res., 60: 262-265.
    PubMed  |  Direct Link  |