Dr. Eyad  Elkord
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Dr. Eyad Elkord

Associate Professor
United Arab Emirates University, UAE


Highest Degree
PostDoc Fellow in Human Immunology from University of Manchester, UK

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Biography

Dr Eyad Elkord has different positions as Associate Professor of Immunology at College of Medicine & Health Sciences-United Arab Emirates University, UAE; an Honorary Professor at the Institute of Cancer Sciences-University of Manchester, UK; and an Honorary Senior Lecturer at the School of Environment & Life Sciences-University of Salford, UK. He received his BSc in 1995 from Al-Quds University (Jerusalem, Palestine), M.Phil in 2001 from Bergen University (Norway) and PhD in Tumour Immunology in 2005 from University of Wales College of Medicine, Cardiff University (UK). He was a Postdoctoral Scientist (Jan 2005-Dec 2007) in the laboratory of Prof. Peter Stern at the Paterson Institute for Cancer Research, University of Manchester (UK). He then was promoted to a Research Fellow/Group Leader of the Clinical Immunotherapy Laboratory at the University of Manchester (Jan 2008-Nov 2010). He then undertook a faculty position as Lecturer with the School of Environment & Life Sciences, University of Salford (Dec 2010-July 2012), and was then promoted from August 2012 to a Senior Lecturer position. Dr Elkord is a member of scientific societies, including, British Society for Immunology, European Academy of Allergology and Clinical Immunology, Immunology Interest Group (National Institutes of Health) and European Macrophage and Dendritic Cell Society. He is a recipient of the Deans annual research prize, College of Science & Technology, University of Salford, UK for 2012 and an award of a certificate of achievement for publishing in top journals and bringing recognition to UAE University in May 2015. Dr Elkord is an editorial board member for peer-reviewed international journals such as BMC Cancer and Journal of Immunology Research. He is ad hoc reviewer to many international journals and well-known grant bodies including Medical Research Council, Wellcome Trust, Yorkshire Cancer Research, Leukaemia Lymphoma Research and Qatar Foundation. Dr Elkord’s research in the area of T regulatory cells is well recognized and as a result he has edited an eBook for Frontiers in Immunology in 2013. He is a contributing author to The Halifax Project task force focused on A Broad- Spectrum Integrative Design for Cancer Prevention and Therapy. He has presented his work in different national and international meetings and conferences. Dr Elkord has more than 45 publications in peer reviewed high-impact international journals (most of them as first or senior author) with more than 1220 citations and an h-index of 19 and M-index of 2.1.

Area of Interest:

Pharmacology and Toxicology
100%
Immunology
62%
Clinical Immunology
90%
Cancer
75%
Pharmacotherapy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Abd Al Samid, M., B. Chaudhary, Y.S. Khaled, B. Ammori and E. Elkord, 2016. Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients. Oncotarget, (In Press). 10.18632/oncotarget.7334.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Vinay, D.S., E.P. Ryan, G. Pawelec, W.H. Talib and J. Stagg et al., 2015. Immune evasion in cancer: Mechanistic basis and therapeutic strategies. Semin. Cancer Biol., 35: S185-S198.
    CrossRef  |  Direct Link  |  
  3. Toor, S.M. and E. Elkord, 2015. Myeloid-derived suppressor cells. eLS. 10.1002/9780470015902.a0024245.
    CrossRef  |  Direct Link  |  
  4. Elkord, E., M. Abd Al Samid and B. Chaudhary, 2015. Helios and not FoxP3, is the marker of activated Tregs expressing GARP/LAP. Oncotarget, 6: 20026-20036.
    CrossRef  |  Direct Link  |  
  5. Elkord, E., D.J. Burt, A. Sundstedt, O. Nordle, G. Hedlund and R.E. Hawkins, 2015. Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α. Oncotarget, 6: 4428-4439.
    CrossRef  |  Direct Link  |  
  6. Chaudhary, B. and E. Elkord, 2015. Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases. Expert Opin. Ther. Targets, 19: 147-161.
    CrossRef  |  Direct Link  |  
  7. Chaudhary, B. and E. Elkord, 2015. Downregulation of immunosuppressive environment in patients with chronic HBV hepatitis on maintained remission. Front. Immunol., Vol. 6. 10.3389/fimmu.2015.00052.
    CrossRef  |  Direct Link  |  
  8. Block, K.I., C. Gyllenhaal, L. Lowe, A. Amedei and A.R. Amin et al., 2015. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin. Cancer Biol., 35: S276-S304.
    CrossRef  |  Direct Link  |  
  9. Shablak, A., D.E. Gilham, R.E. Hawkins and E. Elkord, 2014. In vitro effect of IL-2 in combination with pazopanib or sunitinib on lymphocytes function and apoptosis of RCC cells. Expert Opin. Pharmacother., 15: 1489-1499.
    CrossRef  |  Direct Link  |  
  10. Khaled, Y.S., B.J. Ammori and E. Elkord, 2014. Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients. J. Immunol. Res., Vol. 2014. 10.1155/2014/879897.
    CrossRef  |  Direct Link  |  
  11. Kaimala, S., Y.A. Mohamed, N. Nader, J. Issac and E. Elkord et al., 2014. Salmonella-mediated tumor regression involves targeting of tumor myeloid suppressor cells causing a shift to M1-like phenotype and reduction in suppressive capacity. Cancer Immunol. Immunother., 63: 587-599.
    CrossRef  |  Direct Link  |  
  12. Elkord, E., 2014. Thymus-derived, peripherally derived and in vitro-induced T regulatory cells. Front. Immunol., Vol. 5. 10.3389/fimmu.2014.00017.
    CrossRef  |  Direct Link  |  
  13. Chaudhary, B., Y.S. Khaled, B.J. Ammori and E. Elkord, 2014. Neuropilin 1: Function and therapeutic potential in cancer. Cancer Immunol. Immunother., 63: 81-99.
    CrossRef  |  Direct Link  |  
  14. Chaudhary, B., M. Abd Al Samid, B.K. al-Ramadi and E. Elkord, 2014. Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer. Expert Opin. Biol. Ther., 14: 931-945.
    CrossRef  |  Direct Link  |  
  15. Khaled, Y.S., B.J. Ammori and E. Elkord, 2013. Myeloid-derived suppressor cells in cancer: Recent progress and prospects. Immunol. Cell Biol., 91: 493-502.
    CrossRef  |  Direct Link  |  
  16. Khaled, Y.S., E. Elkord and B.J. Ammori, 2012. Macrophage inhibitory cytokine-1: A review of its pleiotropic actions in cancer. Cancer Biomarkers, 11: 183-190.
    CrossRef  |  Direct Link  |  
  17. Jaggupilli, A. and E. Elkord, 2012. Significance of CD44 and CD24 as cancer stem cell markers: An enduring ambiguity. Clin. Dev. Immunol., Vol. 2012. 10.1155/2012/708036.
    CrossRef  |  Direct Link  |  
  18. Elkord, E., 2012. Comment on "Expression of helios in peripherally induced Foxp3+ regulatory T cells". J. Immunol., 189: 500-500.
  19. Elkord, E. and B.K. Al-Ramadi, 2012. Helios expression in FoxP3(+) T regulatory cells. Expert Opin. Biol. Ther., 12: 1423-1425.
  20. Castro, F.V., O.J. McGinn, S. Krishnan, G. Marinov and J. Li et al., 2012. 5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype. Leukemia, 26: 1487-1498.
    CrossRef  |  Direct Link  |  
  21. Khan, S., D.J. Burt, C. Ralph, F.C. Thistlethwaite, R.E. Hawkins and E. Elkord, 2011. Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cells. Clin. Immunol., 138: 85-96.
    CrossRef  |  Direct Link  |  
  22. Elkord, E., S. Sharma, D.J. Burt and R.E. Hawkins, 2011. Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs. Clin. Immunol., 140: 218-222.
    CrossRef  |  Direct Link  |  
  23. Elkord, E., 2011. Immunotherapy: What is its role in prostate cancer? Prostate Cancer Forum. .
    Direct Link  |  
  24. Elkord E. and D.J. Burt, 2011. Novel IFNγ ELISPOT assay for detection of functional carcinoembryonic antigen‐specific chimeric antigen receptor‐redirected T cells. Scand. J. Immunol., 74: 419-422.
    CrossRef  |  Direct Link  |  
  25. Sawan, S., D.J. Burt, P.L. Stern, C. Holland and E. Elkord, 2010. Circulating regulatory T cells in endometrial cancer: A role for age and menopausal status. Immunol. Invest., 40: 62-75.
    CrossRef  |  Direct Link  |  
  26. Ralph, C., E. Elkord, D.J. Burt, J.F. O'Dwyer and E.B. Austin et al., 2010. Modulation of lymphocyte regulation for cancer therapy: A phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clin. Cancer Res., 16: 1662-1672.
    CrossRef  |  Direct Link  |  
  27. Elkord E., E.M. Alcantar-Orozco, S.J. Dovedi, D.Q. Tran, R.E. Hawkins and D.E. Gilham, 2010. T regulatory cells in cancer: Recent advances and therapeutic potential. Expert Opin. Biol. Ther., 10: 1573-1586.
    CrossRef  |  Direct Link  |  
  28. Daayana, S., E. Elkord, U. Winters, M. Pawlita, R. Roden, P.L. Stern and H.C. Kitchener, 2010. Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial Neoplasia. Br. J. Cancer, 102: 1129-1136.
    CrossRef  |  Direct Link  |  
  29. Shablak, A., R.E. Hawkins, D.G. Rothwell and E. Elkord, 2009. T cell-based immunotherapy of metastatic renal cell carcinoma: Modest success and future perspective. Clin. Cancer Res., 15: 6503-6510.
    CrossRef  |  Direct Link  |  
  30. Elkord, E., A. Shablak, P.L. Stern and R.E. Hawkins, 2009. 5T4 as a target for immunotherapy in renal cell carcinoma. Expert Rev. Anticancer Ther., 9: 1705-1709.
    CrossRef  |  Direct Link  |  
  31. Elkord, E., A. Dangoor, D.J. Burt, T.D. Southgate and S. Daayana et al., 2009. Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4). Cancer Immunol. Immunother., 58: 1657-1667.
    CrossRef  |  Direct Link  |  
  32. Elkord, E., 2009. Frequency of human T regulatory cells in peripheral blood is significantly reduced by cryopreservation. J. Immunol. Methods, 347: 87-90.
    CrossRef  |  Direct Link  |  
  33. Winters, U., S. Daayana, J.T. Lear, A.E. Tomlinson, E. Elkord, P.L. Stern and H.C. Kitchener, 2008. Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia. Clin. Cancer Res., 14: 5292-5299.
    CrossRef  |  Direct Link  |  
  34. Thistlethwaite, F.C., E. Elkord, R.W. Griffiths, D.J. Burt and A.M. Shablak et al., 2008. Adoptive transfer of Treg depleted autologous T cells in advanced renal cell carcinoma. Cancer Immunol. Immunother., 57: 623-634.
    CrossRef  |  Direct Link  |  
  35. Elkord, E., R.E. Hawkins and P.L. Stern, 2008. Immunotherapy for gastrointestinal cancer: Current status and strategies for improving efficacy. Expert Opin. Biol. Ther., 8: 385-395.
    CrossRef  |  Direct Link  |  
  36. Elkord, E., D.J. Burt, J.W. Drijfhout, R.E. Hawkins and P.L. Stern, 2008. CD4+ T-cell recognition of human 5T4 oncofoetal antigen: Implications for initial depletion of CD25+ T cells. Cancer Immunol. Immunother., 57: 833-847.
    CrossRef  |  Direct Link  |  
  37. Elkord, E., A. Dangoor, N.L. Drury, R. Harrop and D.J. Burt et al., 2008. An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. J. Immunother., 31: 820-829.
    CrossRef  |  
  38. Elkord, E., 2008. Novel therapeutic strategies by regulatory T cells in allergy. Chem. Immunol. Allergy, 94: 150-157.
    CrossRef  |  Direct Link  |  
  39. Griffiths, R.W., E. Elkord, D.E. Gilham, V. Ramani, N. Clarke, P.L. Stern and R.E. Hawkins, 2007. Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival. Cancer Immunol. Immunother., 56: 1743-1753.
    CrossRef  |  Direct Link  |  
  40. Elkord, E., 2007. Immunology and immunotherapy approaches for prostate cancer. Prostate Cancer Prostatic Dis., 10: 224-236.
    CrossRef  |  Direct Link  |  
  41. Smyth, L.J., E. Elkord, T.E. Taher, H.R. Jiang and D.J. Burt et al., 2006. Cd8 T‐cell recognition of human 5T4 oncofetal antigen. Int. J. Cancer, 119: 1638-1647.
    CrossRef  |  Direct Link  |  
  42. Elkord, E., L. Hopcraft, D. Burt and P.L. Stern, 2006. Bead-isolated human CD4+CD25+ T regulatory cells are anergic and significantly suppress proliferation of CD4+CD25- T responder cells. Clin. Immunol., 120: 232-233.
  43. Elkord, E., A.W. Rowbottom, H. Kynaston and P.E. Williams, 2006. Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer. Clin. Immunol., 120: 91-98.
    CrossRef  |  Direct Link  |  
  44. Elkord, E., 2006. Role of regulatory T cells in allergy: Implications for therapeutic strategy. Inflammation Allergy Drug Targets, 5: 211-217.
    CrossRef  |  Direct Link  |  
  45. Elkord, E., P.E. Williams, H. Kynaston and A.W. Rowbottom, 2005. Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology, 114: 204-212.
    CrossRef  |  Direct Link  |  
  46. Elkord, E., P.E. Williams, H. Kynaston and A.W. Rowbottom, 2005. Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. Int. Immunol., 17: 1315-1325.
    CrossRef  |  Direct Link  |