Dr. Pierri Ciro Leonardo
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Dr. Pierri Ciro Leonardo

professor of biochemistry and molecular modeling
University of Bari, Italy

Highest Degree
Ph.D. in Biochemical Pharmacology from University of Bari Aldo Moro, Italy

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Area of Interest:

Molecular Sciences
100%
Protein
62%
Protein Chemistry
90%
Molecular Microbiology
75%
Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
71
Abstracts
11

Selected Publications

  1. Pierri, C.L., 2020. Sars-CoV-2 spike protein: flexibility as a new target for fighting infection. Signal Transduction Targeted Ther., 10.1038/s41392-020-00369-3.
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  2. Mercurio, I., V. Tragni, F. Busto, A.D. Grassi and C.L. Pierri, 2020. Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ace2 receptor: from conformational changes to novel neutralizing antibodies. Cell. Mol. Life Sci., 10.1007/s00018-020-03580-1.
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  3. Menga, A., M. Serra, S. Todisco, C. Rierau2010Domingo and U. Ammarah et al., 2020. Glufosinate constrains synchronous and metachronous metastasis by promoting antiu2010tumor macrophages. EMBO Mol. Med., 10.15252/emmm.201911210.
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  4. Infantino, V., C.L. Pierri and V. Iacobazzi, 2020. Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target. Curr. Medic. Chem., 26: 7104-7116.
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  5. Amoedo, N.D., L. Dard, S. Sarlak, W. Mahfouf and W. Blanchard et al., 2020. Targeting human lung adenocarcinoma with a suppressor of mitochondrial superoxide production. Antioxid. Redox Signaling, 33: 883-902.
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  6. Trisolini, L., N. Gambacorta, R. Gorgoglione, M. Montaruli and L. Laera et al., 2019. Fad/nadh dependent oxidoreductases: from different amino acid sequences to similar protein shapes for playing an ancient function. J. Clin. Med., 10.3390/jcm8122117.
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  7. Laera, L., G. Punzi, V. Porcelli, N. Gambacorta and L. Trisolini et al., 2019. CRAT missense variants cause abnormal carnitine acetyltransferase function in an earlyu2010onset case of leigh syndrome. Hum. Mutat., 41: 110-114.
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  8. Itkis, Y., T. Krylova, N.L. Pechatnikova, A.D. Grassi and V.Y. Tabakov et al., 2019. A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion, 47: 10-17.
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  9. Favia, M., R. Fitak, L. Guerra, C.L. Pierri and B. Faye et al., 2019. Beyond the big five: investigating myostatin structure, polymorphism and expression in camelus dromedarius. Front. Genet., 10.3389/fgene.2019.00502.
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  10. Edvardson, S., C.M. Nicolae, G.J. Noh, J.E. Burton and G. Punzi et al., 2019. Heterozygous RNF13 gain-of-function variants are associated with congenital microcephaly, epileptic encephalopathy, blindness, and failure to thrive. Am. J. Hum. Genet., 104: 179-185.
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  11. Muzzachi, S., L. Guerra, N.A. Martino, M. Favia and G. Punzi et al., 2018. Effect of cariporide on ram sperm pH regulation and motility: possible role of NHE1. Reproduction, 155: 433-445.
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  12. Fabbri, A., S. Travaglione, Z. Maroccia, M. Guidotti and C. Pierri et al., 2018. The bacterial protein cnf1 as a potential therapeutic strategy against mitochondrial diseases: a pilot study. Int. J. Mol. Sci., 10.3390/ijms19071825.
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  13. Tavani, C., L. Bianchi, A.D. Palma, G.I. Passeri and G. Punzi et al., 2017. Nitro-substituted tetrahydroindolizines and homologs: design, kinetics, and mechanism of u03b1-glucosidase inhibition. Bioorg. Medic. Chem. Lett., 27: 3980-3986.
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  14. Punzi, G., V. Porcelli, M. Ruggiu, M.F. Hossain and A. Menga et al., 2017. SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex i deficiency. Hum. Mol. Genet., 27: 499-504.
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  15. Coccaro, N., C. Brunetti, G. Tota, C.L. Pierri and L. Anelli et al., 2017. A novel t(3;9)(q21.2; p24.3) associated with SMARCA2 and ZNF148 genes rearrangement in myelodysplastic syndrome. Leukemia Lymphoma, 59: 996-999.
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  16. Vozza, A., F. De Leonardis, E. Paradies, A. De Grassi and C.L. Pierri et al., 2016. Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim. Biophys. Acta Bioenerg., 1858: 137-146.
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  17. Todisco, S., M.A. Di Noia, A. Onofrio, G. Parisi and G. Punzi et al., 2016. Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays. Biochem. Pharmacol., 100: 112-132.
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  18. Pietropaolo, A., C.L. Pierri, F. Palmieri and M. Klingenberg, 2016. The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes. Biochim. Biophys. Acta Bioenerg., 1857: 772-781.
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  19. Pietropaolo, A., C.L. Pierri, F. Palmieri and M. Klingenberg, 2016. Dataset of the AAC2 conformations in the c-, intermediate- and m-states obtained from free-energy simulations. Data Brief, 7: 1355-1357.
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  20. Pierri, C.L., F. Bossis, G. Punzi, A. De Grassi, M. Cetrone, G. Parisi and D. Tricarico, 2016. Molecular modeling of antibodies for the treatment of TNFα-related immunological diseases. Pharmacol. Res. Perspect., Vol. 4. 10.1002/prp2.197.
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  21. Curcio, R., L. Muto, C.L. Pierri, A. Montalto and G. Lauria et al., 2016. New insights about the structural rearrangements required for substrate translocation in the bovine mitochondrial oxoglutarate carrier. Biochim. Biophys. Acta Proteins Proteomics, 1864: 1473-1480.
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  22. Cigliola, V., C. Populaire, C.L. Pierri, S. Deutsch and J.A. Haefliger et al., 2016. A variant of GJD2, encoding for connexin 36, alters the function of insulin producing β-cells. Plos One, Vol. 11. 10.1371/journal.pone.0150880.
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  23. Amoedo, N.D., G. Punzi, E. Obre, D. Lacombe, A. De Grassi, C.L. Pierri and R. Rossignol, 2016. AGC1/2, the mitochondrial aspartate-glutamate carriers. Biochim. Biophys. Acta Mol. Cell. Res., 1863: 2394-2412.
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  24. Shteyer, E., S. Edvardson, S.L. Wynia-Smith, C.L. Pierri and T. Zangen et al., 2015. Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. Gastroenterology, 148: 533-536.
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  25. Palmieri, E.M., I. Spera, A. Menga, V. Infantino and V. Porcelli et al., 2015. Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation. Biochim. Biophys. Acta Bioenerg., 1847: 729-738.
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  26. Marobbio, C.M., G. Punzi, C.L. Pierri, L. Palmieri, R. Calvello, M.A. Panaro and F. Palmieri, 2015. Pathogenic potential of SLC25A15 mutations assessed by transport assays and complementation of Saccharomyces cerevisiae ORT1 null mutant. Mol. Genet. Metab., 115: 27-32.
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  27. Pierri, C.L., F. Palmieri and A. De Grassi, 2014. Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers. Cell. Mol. Life Sci., 71: 349-364.
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  28. Onofrio, A., G. Parisi, G. Punzi, S. Todisco and M.A. Di Noia et al., 2014. Distance-dependent hydrophobic-hydrophobic contacts in protein folding simulations. Phys. Chem. Chem. Phys., 16: 18907-18917.
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  29. Gibellini, L., M. Pinti, F. Beretti, C.L. Pierri and A. Onofrio et al., 2014. Sirtuin 3 interacts with Lon protease and regulates its acetylation status. Mitochondrion, 18: 76-81.
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  30. Chaouch, A., V. Porcelli, D. Cox, S. Edvardson and P. Scarcia et al., 2014. Mutations in the mitochondrial citrate carrier SLC25A1 are associated with impaired neuromuscular transmission. J. Neuromuscular Dis., 1: 75-90.
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  31. Carrozzo, R., A. Torraco, G. Fiermonte, D. Martinelli and M. Di Nottia et al., 2014. Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2. Mitochondrion, 18: 49-57.
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  32. Bossis, F., A. De Grassi, L.L. Palese and C.L. Pierri, 2014. Prediction of high-and low-affinity quinol-analogue-binding sites in the aa3 and bo3 terminal oxidases from Bacillus subtilis and Escherichia coli. Biochem. J., 461: 305-314.
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  33. Ta-Shma, A., C.L. Pierri, P. Stepensky, A. Shaag, S. Zenvirt, O. Elpeleg and A.J. Rein, 2013. Isolated truncus arteriosus associated with a mutation in the plexin-D1 gene. Am. J. Med. Genet. Part A, 161: 3115-3120.
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  34. Regalado, A., C.L. Pierri, M. Bitetto, V.L. Laera and C. Pimentel et al., 2013. Characterization of mitochondrial dicarboxylate/tricarboxylate transporters from grape berries. Planta, 237: 693-703.
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  35. Lunetti, P., A.R. Cappello, R.M. Marsano, C.L. Pierri and C. Carrisi et al., 2013. Mitochondrial glutamate carriers from Drosophila melanogaster: Biochemical, evolutionary and modeling studies. Biochim. Biophys. Acta Bioenerg., 1827: 1245-1255.
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  36. Edvardson, S., V. Porcelli, C. Jalas, D. Soiferman and Y. Kellner et al., 2013. Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter. J. Med. Genet., 50: 240-245.
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  37. De Paola, D., E. Blanco, C.L. Pierri and G. Sonnante, 2012. Isolation and characterization of novel variants of BBI coding genes from the legume Lathyrus sativus. Plant Physiol. Biochem., 57: 45-53.
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  38. Agrimi, G., A. Russo, C.L. Pierri and F. Palmieri, 2012. The peroxisomal NAD+ carrier of Arabidopsis thaliana transports coenzyme A and its derivatives. J. Bioenergy Biomembr., 44: 333-340.
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  39. Palmieri, F., C.L. Pierri, A. De Grassi, A. Nunes-Nesi and A.R. Fernie, 2011. Evolution, structure and function of mitochondrial carriers: A review with new insights. Plant J., 66: 161-181.
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  40. Fiermonte, G., G. Parisi, D. Martinelli, F. De Leonardis and G. Torre et al., 2011. A new Caucasian case of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): A clinical, molecular and functional study. Mol. Genet. Metab., 104: 501-506.
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  41. Sonnante, G., R. D'Amore, E. Blanco, C.L. Pierri and M. De Palma et al., 2010. Novel hydroxycinnamoyl-coenzyme A quinate transferase genes from artichoke are involved in the synthesis of chlorogenic acid. Plant Physiol., 153: 1224-1238.
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  42. Pierri, C.L., G. Parisi and V. Porcelli, 2010. Computational approaches for protein function prediction: A combined strategy from multiple sequence alignment to molecular docking-based virtual screening. Biochim. Biophys. Acta Proteins Proteomics, 1804: 1695-1712.
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  43. Palmieri, F. and C.L. Pierri, 2010. Structure and function of mitochondrial carriers: Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett., 584: 1931-1939.
    PubMed  |  
  44. Palmieri, F. and C.L. Pierri, 2010. Mitochondrial metabolite transport. Essays Biochem., 47: 37-52.
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  45. Wibom, R., F.M. Lasorsa, V. Tohonen, M. Barbaro and F.H. Sterky et al., 2009. AGC1 deficiency associated with global cerebral hypomyelination. N. Engl. J. Med., 361: 489-495.
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  46. Tessa, A., G. Fiermonte, C. Dionisi-Vici, E. Paradies and M.R. Baumgartner et al., 2009. Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: A clinical, molecular and functional study. Hum. Mutat., 30: 741-748.
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  47. Pierri, C.L., A. De Grassi and A. Turi, 2008. Lattices for ab initio protein structure prediction. Proteins Struct. Funct. Bioinf., 73: 351-361.
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  48. Marobbio, C.M., G. Giannuzzi, E. Paradies, C.L. Pierri and F. Palmieri, 2008. α-isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. J. Biol. Chem., 283: 28445-28453.
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  49. Lauria, G., G. Lauria, P. Sanchez, B.M.D. Rocca and C.L. Pierri et al., 2008. Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling. Mol. Membr. Biol., 25: 236-244.
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