Dr. Lorenzo Jose Fraile Sauce
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Dr. Lorenzo Jose Fraile Sauce

Research Scientist
Universitat de Lleida, Spain

Highest Degree
Ph.D. in Veterinary Sciences from Universidad de Zaragoza, Spain

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Biography

Dr. Lorenzo Jose Fraile Sauce is currently working as Lecturer at University of Lleida Spain. He has completed his Ph.D. in Veterinary Sciences from Universidad de Zayragoza, Spain. His main area of interest focuses on Pharmacology and Toxicology and Animal and Veterinary Sciences. His area of expertise includes Epidemiology, Veterinary science, Pharmacology, Pharmacokineticsl, PK/PD models, Infectious Diseases, Vaccinology, Immune response, Antimicrobials, Treatment, Pig Medicine, Pig production, Animal Science Immunology, Vaccine, and Animal production. He has published b79 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Immunology
62%
Veterinary Microbiology
90%
Vaccine
75%
Immunopathology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Vilaró, A., E. Novell, V. Enrique-Tarancon, J. Balielles, L. Migura-García and L. Fraile, 2022. Antimicrobial susceptibility testing of porcine bacterial pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family. Antibiotics, Vol. 11. 10.3390/antibiotics11050638.
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  2. Uruén, C., C. García, L. Fraile, J. Tommassen and J. Arenas, 2022. How Streptococcus suis escapes antibiotic treatments. Vet Res., Vol. 53. 10.1186/s13567-022-01111-3 .
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  3. Ruiz, M., A. Puig, M. Bassols, L. Fraile and R. Armengol, 2022. Influenza D virus: A review and update of its role in bovine respiratory syndrome. Viruses, Vol. 14. 10.3390/v14122717 .
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  4. Puig, A., M. Ruiz, M. Bassols, L. Fraile and R. Armengol, 2022. Technological tools for the early detection of bovine respiratory disease in farms. Animals, Vol. 12. 10.3390/ani12192623 .
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  5. Laghouaouta, H., L. Fraile, R. Suárez-Mesa, R. Ros-Freixedes, J. Estany and R.N. Pena, 2022. A genome-wide screen for resilient responses in growing pigs. Genet. Sel. Evol., Vol. 54. 10.1186/s12711-022-00739-1 .
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  6. Guitart-Matas, J., N. Gonzalez-Escalona, M. Maguire, A. Vilaró, J. Martinez-Urtaza, L. Fraile and L. Migura-Garcia, 2022. Revealing genomic insights of the unexplored porcine pathogen Actinobacillus pleuropneumoniae using whole genome sequencing. Microbiol. Spectr., 10.1128/spectrum.01185-22 .
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  7. Armengol, R., L. Fraile and A. Bach, 2022. Key performance indicators used by dairy consultants during the evaluation of reproductive performance in a first visit. Front. Vet. Sci., Vol. 9. 10.3389/fvets.2022.871079 .
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  8. Montaner-Tarbes, S., L. Fraile, M. Montoya and H.D. Portillo, 2021. Exosome-based vaccines: pros and cons in the world of animal health. Viruses, Vol. 13. 10.3390/v13081499.
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  9. Laghouaouta, H., R.N. Pena, R. Ros-Freixedes, J. Reixach and M. Díaz et al., 2021. A methodology to quantify resilience in growing pigs. Animals, Vol. 11. 10.3390/ani11102970.
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  10. Gonzalez, R., L. Elvira, C. Carbonell, G. Vertenten and L. Fraile, 2021. The specific immune response after vaccination against neonatal calf diarrhoea differs between apparent similar vaccines in a case study. Vaccines, Vol. 9. 10.3390/ani11051238.
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  11. Garrido, V., L. Migura-García, I. Gaitán, A. Arrieta-Gisasola, I. Martínez-Ballesteros, L. Fraile and M.J. Grilló, 2021. Prevalence of Salmonella in free-range pigs: risk factors and intestinal microbiota composition. Foods, Vol. 10. 10.3390/foods10061410.
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  12. Colomer, M.À., A. Margalida, F. Alòs, P. Oliva-Vidal, A. Vilella and L. Fraile, 2021. Modeling of vaccination and contact tracing as tools to control the COVID-19 outbreak in Spain. Vaccines, Vol. 9. 10.3390/vaccines9040386.
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  13. Blanco-Fuertes, M., F. Correa-Fiz, L. Fraile, M. Sibila and V. Aragon, 2021. Altered nasal microbiota composition associated with development of polyserositis by Mycoplasma hyorhinis. Pathogens, Vol. 10. 10.3390/pathogens10050603.
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  14. Baliellas, J., E. Novell, V. Enric-Tarancón, C. Vilalta and L. Fraile, 2021. Porcine reproductive and respiratory syndrome surveillance in breeding herds and nurseries using tongue tips from dead animals. Vet. Sci., Vol. 8. 10.3390/vetsci8110259.
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  15. Armengol, R., M. Bassols and L. Fraile, 2021. A cow-calf farming system fully adapted to elevation and harsh conditions in andorra (Europe). Animals, 10.3390/ani11030611.
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  16. Abella, G., A. Pagu00e8s-Bernaus, J. Estany, R.N. Pena, L. Fraile and L.M. Plu00e0-Aragonu00e9s, 2021. Using PRRSV-resilient sows improve performance in endemic infected farms with recurrent outbreaks. Animals, 10.3390/ani11030740.
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  17. Abella, G., A. Pages-Bernaus, J. Estany, R.N. Pena, L. Fraile and L.M. Pla-Aragones, 2021. Using PRRSV-resilient sows improve performance in endemic infected farms with recurrent outbreaks. Animals, 10.3390/ani11030740.
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  18. Vilaró, A., E. Novell, V. Enrique-Tarancón, J. Balielles, C. Vilalta, S. Martinez and L.J.F. Sauce, 2020. Antimicrobial susceptibility pattern of porcine respiratory bacteria in Spain. Antibiotics, Vol. 9. 10.3390/antibiotics9070402.
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  19. Vilaru00f3, A., E. Novell, V. Enrique-Tarancu00f3n, J. Balielles, E. Alluu00e9 and L. Fraile, 2020. Antimicrobial stewardship for respiratory pathogens in swine. Antibiotics, 10.3390/antibiotics9110727.
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  20. Vidaña, B., P. Martínez-Orellana, J. Martorell, M. Baratelli and J. Martínez et al., 2020. Differential viral-host immune interactions associated with oseltamivir-resistant H275Y and wild-type H1N1 A(pdm09) influenza virus pathogenicity. Viruses, Vol. 12. 10.3390/v12080794.
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  21. Petrocchi-Rilo, M., C.B. Gutiu00e9rrez-Martu00edn, E. Pu00e9rez-Fernu00e1ndez, A. Vilaru00f3, L. Fraile and S. Martu00ednez-Martu00ednez, 2020. Antimicrobial resistance genes in porcine pasteurella multocida are not associated with its antimicrobial susceptibility pattern. Antibiotics, 10.3390/antibiotics9090614.
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  22. Laplana, M., J. Estany, L.J. Fraile and R.N. Pena, 2020. Resilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows. Animals, Vol. 10. 10.3390/ani10050902.
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  23. Fraile, L., N. Fernández, R.N. Pena, S. Balasch and G. Castellà et al., 2020. A probabilistic Poisson-based model to detect PRRSV recirculation using sow production records. Preventive Vet. Med., Vol. 177. 10.1016/j.prevetmed.2020.104948.
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  24. Colomer, M.A., A. Margalida and L. Fraile, 2020. Vaccination is a suitable tool in the control of Aujeszky’s disease outbreaks in pigs using a population dynamics P systems model. Animals, Vol. 10. 10.3390/ani10050909.
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  25. Armengol, R. and L. Fraile, 2020. Feeding calves with pasteurized colostrum and milk has a positive long-term effect on their productive performance. Animals, Vol. 10. 10.3390/ani10091494.
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  26. Alba-Casals, A., E. Allue, V. Tarancon, J. Baliellas, E. Novell, S. Napp and L. Fraile, 2020. Near real-time monitoring of clinical events detected in swine herds in Northeastern Spain. Front. Vet. Sci., Vol. 7. 10.3389/fvets.2020.00068.
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  27. Pena, Fernández, Blasco-Felip, Fraile and Estany, 2019. Genetic markers associated with field PRRSV-induced abortion rates. Viruses, Vol. 11. 10.3390/v11080706.
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  28. Montaner-Tarbes, S., H.A. Del Portillo, M. Montoya and L. Fraile, 2019. Key gaps in the knowledge of the porcine respiratory reproductive syndrome virus (PRRSV). Front. Vet. Sci., Vol. 6. 10.3389/fvets.2019.00038.
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  29. Montaner-Tarbes, Pujol, Jabbar, Hawes and Chapman et al., 2019. Serum-derived extracellular vesicles from African swine fever virus-infected pigs selectively recruit viral and porcine proteins. Viruses, Vol. 11. 10.3390/v11100882.
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  30. Garrido, V., S. Sánchez, B.S. Román, L. Fraile, L. Migura-García and M.J. Grilló, 2019. Salmonella infection in mesenteric lymph nodes of breeding sows. Foodborne Pathog. Dis., 17: 411-417.
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  31. Fraile, L., A. Arcas, L.M. Jiménez, J. Mallo and R. Armengol, 2019. Treatment with etamsylate reduces haemolactia in lactating dairy cows. J. Dairy Res., 86: 193-195.
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  32. Figueras-Gourgues, S., L. Fraile, J. Segalés, I. Hernández-Caravaca and R. López-Úbeda et al., 2019. Effect of Porcine circovirus 2 (PCV-2) maternally derived antibodies on performance and PCV-2 viremia in vaccinated piglets under field conditions. Porc. Health Manag., Vol. 5. 10.1186/s40813-019-0128-7.
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  33. Crisci, E., L. Fraile and M. Montoya, 2019. Cellular innate immunity against PRRSV and swine influenza viruses. Vet. Sci., Vol. 6. 10.3390/vetsci6010026.
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  34. Colomer, M.À., A. Margalida and L. Fraile, 2019. Improving the management procedures in farms infected with the Porcine Reproductive and Respiratory Syndrome virus using PDP models. Sci. Rep., Vol. 9. 10.1038/s41598-019-46339-w.
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  35. Bello, J.M., G. Chacón, R. Pueyo, R. Lechuga and L. Marco et al., 2019. Antimicrobial susceptibility of Mannheimia haemolytica and Pasteurella multocida isolated from ovine respiratory clinical cases in Spain and Portugal. Small Ruminant Res., 178: 85-93.
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  36. Abella, G., E. Novell, V. Tarancon, L. Varona, R.N. Pena, J. Estany and L. Fraile, 2019. Identification of resilient sows in porcine reproductive and respiratory syndrome virus–infected farms1. J. Anim. Sci., 97: 3228-3236.
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  37. Soler, C., T. Goossens, A. Bermejo, L. Migura-García, A. Cusco, O. Francino and L. Fraile, 2018. Digestive microbiota is different in pigs receiving antimicrobials or a feed additive during the nursery period. PLoS ONE, Vol. 13. 10.1371/journal.pone.0197353.
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  38. Montaner-Tarbes, S., E. Novell, V. Tarancón, F.E. Borrás, M. Montoya, L. Fraile and H.A. Del Portillo, 2018. Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from porcine respiratory and reproductive virus infections. Sci Rep., Vol. 8. 10.1038/s41598-018-36141-5.
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  39. Cameron-Veas, K., L. Fraile, S. Napp, V. Garrido, M.J. Grilló and L. Migura-Garcia, 2018. Multidrug resistant Salmonella enterica isolated from conventional pig farms using antimicrobial agents in preventative medicine programmes. Vet. J., 234: 36-42.
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  40. Armengol, R. and L. Fraile, 2018. Descriptive study for culling and mortality in five high-producing Spanish dairy cattle farms (2006–2016). Acta Vet. Scand., Vol. 60. 10.1186/s13028-018-0399-z.
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  41. Henriquez-Rodriguez, E., R.N. Pena, A.R. Seradj, L. Fraile, P. Christou, M. Tor and J. Estany, 2017. Carotenoid intake and SCD genotype exert complementary effects over fat content and fatty acid composition in Duroc pigs1. J. Anim. Sci., 95: 2547-2557.
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  42. Garcia-Morante, B., J. Segalés, L. Fraile, G. Llardén, T. Coll and M. Sibila, 2017. Potential use of local and systemic humoral immune response parameters to forecast Mycoplasma hyopneumoniae associated lung lesions. PLoS ONE, Vol. 12. 10.1371/journal.pone.0175034.
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  43. Cabezón, O., S. Muñoz-González, A. Colom-Cadena, M. Pérez-Simó and R. Rosell et al., 2017. African swine fever virus infection in Classical swine fever subclinically infected wild boars. BMC Vet. Res., Vol. 13. 10.1186/s12917-017-1150-0.
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  44. Bohórquez, J.A., S. Defaus, S. Muñoz-González, M. Perez-Simó and R. Rosell et al., 2017. A bivalent dendrimeric peptide bearing a T-cell epitope from foot-and-mouth disease virus protein 3A improves humoral response against classical swine fever virus. Virus Res., 238: 8-12.
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  45. Rocadembosch, J., J. Amador, J. Bernaus, J. Font and L.J. Fraile, 2016. Production parameters and pig production cost: temporal evolution 2010–2014. Porc. Health Manag., Vol. 2. 10.1186/s40813-016-0027-0.
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  46. Montaner-Tarbes, S., F.E. Borrás, M. Montoya, L. Fraile and H.A. Del Portillo, 2016. Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins. Vet. Res., Vol. 47. 10.1186/s13567-016-0345-x.
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  47. Marco-Ramell, A., L. Arroyo, R. Peña, R. Pato and Y. Saco et al., 2016. Biochemical and proteomic analyses of the physiological response induced by individual housing in gilts provide new potential stress markers. BMC Vet. Res., Vol. 12. 10.1186/s12917-016-0887-1.
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  48. Garcia-Morante, B., J. Segalés, L. Fraile, A. Pérez de Rozas, H. Maiti, T. Coll and M. Sibila, 2016. Assessment of Mycoplasma hyopneumoniae-induced pneumonia using different lung lesion scoring systems: a comparative review. J. Comp. Pathol., 154: 125-134.
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  49. Feng, H., J. Segalés, L. Fraile, S. López-Soria and M. Sibila, 2016. Effect of high and low levels of maternally derived antibodies on porcine circovirus type 2 (PCV2) infection dynamics and production parameters in PCV2 vaccinated pigs under field conditions. Vaccine, 34: 3044-3050.
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  50. Correa-Fiz, F., L. Fraile and V. Aragon, 2016. Piglet nasal microbiota at weaning may influence the development of Glässers disease during the rearing period. BMC Genomics, Vol. 17. 10.1186/s12864-016-2700-8.
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  51. Cameron-Veas, K., M.A. Moreno, L. Fraile and L. Migura-Garcia, 2016. Shedding of cephalosporin resistant Escherichia coli in pigs from conventional farms after early treatment with antimicrobials. Vet. J., 211: 21-25.
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  52. Armengol, R. and L. Fraile, 2016. Colostrum and milk pasteurization improve health status and decrease mortality in neonatal calves receiving appropriate colostrum ingestion. J. Dairy Sci., 99: 4718-4725.
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  53. Torres, F., R. Santamaria, M. Jimenez, R. Menjón and A. Ibanez et al., 2015. Pharmacokinetics of tildipirosin in pig tonsils. J. Vet. Pharmacol. Therap., 39: 199-201.
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  54. Solórzano, A., E. Foni, L. Córdoba, M. Baratelli and E. Razzuoli et al., 2015. Cross-species infectivity of H3N8 influenza virus in an experimental infection in swine. J. Virol., 89: 11190-11202.
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  55. Munoz-Gonzaez, S., N. Ruggli, R. Rosell, L. Josue Perez, and M.T. Frias-Leuporea et al., 2015. Postnatal persistent infection with classical swine fever virus and its immunological implications. PLoS One, 10: 1-22.
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  56. Martinez-Orellana, P., J. Martorell, B. Vidana , N. Majo, A. Falcon et al., 2015. Clinical response to pandemic H1N1 influenza virus from a fatal and mild case in ferrets. Virol.J., 12: 48-57.
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  57. Glòria Abella, Ramona N. Pena, Carmina Nogareda, R. Armengol and A. Vidal et al., 2015. A WUR SNP is associated with European porcine reproductive and respiratory virus syndrome resistance and growth performance in pigs. Res. Vet. Sci., 104: 117-122.
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  58. Fraile, L., Y. Saco. L. Grau-Roma, M. Nofrarias and S. Lopez-Soria et al., 2015. Serum haptoglobin dynamics in pigs vaccinated or not vaccinated against porcine circovirus type 2. Porcine Health Manag., Vol.1. 10.1186/2055-5660-1-3.
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  59. Fraile, L., J. Segales, G. Tico, S. Lopez-Soria and O. Valero et al., 2015. Virological and serological characterization of vaccinated and non-vaccinated piglet subpopulations coming from vaccinated and non-vaccinated sows. Prev. Vet. Med., 119: 153-161.
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  60. Dieste-Perez, L., L. Fraile, M.J. de Miguel, M. Barberan, J.M. Blasco and M. Munoz, 2015. Studies on a suitable antibiotic therapy for treating swine brucellosis. J. Vet. Pharmacol. Ther., 38: 357-364.
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  61. Crisci, E., L. Fraile, R. Novellas, Y. Espada and R. Cabezon et al., 2015. In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells. Mol. Immunol., 63: 343-354.
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  62. Cano, G., M. Hows, R. Janes, A. Morillo and L. Fraile , 2015. Dose dependent penetration of tulathromycin in pig tonsils. Pharmacologia, 6: 110-113.
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  63. Cameron-Veas, K., M. Sola-Gines, M.A. Moreno, L. Fraile and L. Migura-Garcia, 2015. Impact of the use of β-lactam antimicrobials on the emergence of Escherichia coli isolates resistant to cephalosporins under standard pig-rearing conditions. Appl. Environ. Microbiol., 81: 1782-1787.
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  64. Cameron-Veas K., M. Sola-Gines, M.A. Moreno, L. Fraile and L. Migura, 2015. Impact of the use of beta-lactam antimicrobials on the emergence of Escherichia coli resistant to cephalosporins under standard pig rearing conditions. Appl.Environ. Microbiol., 81: 1782-1787.
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  65. Armengol, R. and L. Fraile, 2015. Comparison of two treatment strategies for cows with metritis in high-risk lactating dairy cows. Theriogenology, 83: 1344-1351.
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  66. Vilalta, C., H. Giboin, M. Schneider, F. El Garch and L. Fraile, 2014. Pharmacokinetic/pharmacodynamic evaluation of marbofloxacin in the treatment of Haemophilus parasuis and Actinobacillus pleuropneumoniae infections in nursery and fattener pigs using Monte Carlo simulations. J. Vet. Pharmacol. Ther., 37: 542-549.
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  67. Tarradas, J., M.E. de la Torre, R. Rosell, L.J. Perez and J. Pujols et al., 2014. The impact of CSFV on the immune response to control infection. Virus Res., 185: 82-91.
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  68. Sibila, M., V. Aragon, L. Fraile and J. Segales, 2014. Comparison of four lung scoring systems for the assessment of the pathological outcomes derived from Actinobacillus pleuropneumoniae experimental infections. BMC Vet. Res., 10: 165-165.
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  69. Pileri, E., M. Cortey, F. Rodriguez, M. Sibila, L. Fraile and J. Segales, 2014. Comparison of the immunoperoxidase monolayer assay and three commercial ELISAs for detection of antibodies against porcine circovirus type 2. Vet. J., 201: 429-432.
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  70. Garcia-Migura, L., R.S. Hendriksen, L. Fraile and F.M. Aarestrup, 2014. Antimicrobial resistance of zoonotic and commensal bacteria in Europe: The missing link between consumption and resistance in veterinary medicine. Vet. Microbiol., 170: 1-9.
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  71. Dieste-Perez, L., L. Fraile, M.J. de Miguel, M. Barberan, J.M. Blasco and M. Munoz, 2014. Studies on a suitable antibiotic therapy for treating swine brucellosis. J. Vet. Pharmacol. Ther. 10.1111/jvp.12189.
    CrossRef  |  PubMed  |  Direct Link  |  
  72. Crisci, E., L. Fraile, S. Valentino, L. Martinez-Guino, B. Bottazzi, A. Mantovani and M. Montoya, 2014. Immune characterization of long pentraxin in pigs. Vet. Microbiol., 168: 185-192.
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  73. Baratelli, M., L. Cordoba, L.J. Perez, J. Maldonado, L. Fraile, J.I. Nunez and M. Montoya, 2014. Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007 Res. Vet. Sci., 96: 380-388.
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  74. Sibila, M., L. Fraile, G. Tico, S. Lopez-Soria and M. Nofrarias et al., 2013. Humoral response and colostral antibody transfer following one-dose pre-mating vaccination of sows against porcine circovirus type-2. Vet. J., 197: 881-883.
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  75. Mussa, T., M. Ballester, E. Silva-Campa, M. Baratelli and N. Busquets et al., 2013. Infection by swine, human or avian influenza viruses differentially activates porcine dendritic cells cytokine profile. Vet. Immunol. Immunopathol., 154: 25-35.
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  76. Crisci, E., T. Mussa, L. Fraile and M. Montoya, 2013. Review: Influenza virus in pigs. Mol. Immunol., 55: 200-211.
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  77. Crisci, E., L. Fraile, S. Valentino, L. Martinez-Guino, B. Bottazzi, A. Mantovani and M. Montoya, 2013. Immune characterization of long pentraxin 3 in pigs infected with influenza virus. Vet. Microbiol., 10.1016/j.vetmic.2013.10.004.
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  78. Crisci, E., T. Mussa, L. Fraile and M. Montoya, 2013. Review on influenza virus in pigs. Mol. Immunol., 55: 200-211.
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  79. Baratelli, M., L. Cordoba, L.J. Perez, J. Maldonado, L. Fraile, J.I. Nunez and M. Montoya, 2013. Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007. Res. Vet. Sci., 10.1016/j.rvsc.2013.12.006.
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  80. Vilalta,C., T. Alcala, R. Lopez-Jimenez, M. Nofrarias and S. Lopez-Soria et al., 2012. Clinical efficacy of acetyl salicylic acid as an adjunct to the antibacterial treatment of porcine respiratory disease complex. J. Swine Health Prod., 20: 10-16.
  81. Vilalta, C., N. Galofre, V. Aragon, A.M. Perez de Rozas and L. Fraile, 2012. Effect of marbofloxacin on Haemophilus parasuis nasal carriage. Vet. Microbiol., 159: 123-129.
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  82. Tarradas, J., M. Monso, L. Fraile, B.G. de la Torre and M. Munoz et al., 2012. A T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs. Vet. Immunol. Immunopathol., 150: 36-46.
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  83. Nieto, D., M. Aramouni, M. Sibila, L. Fraile, T. Kekarainen and J. Segales, 2012. Lack of effect of piglet vaccination against Porcine circovirus type 2 (PCV2) on serum viral loads of Torque teno sus virus 2 (TTSuV2). Vet. Microbiol., 157: 8-12.
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  84. Mussa, T., C. Rodriguez-Carino, A. Sanchez-Chardi, M. Baratelli and M. Costa-Hurtado et al., 2012. Differential interactions of virulent and non-virulent H. parasuis strains with naive or swine influenza virus pre-infected dendritic cells. Vet. Res., Vol. 43. 10.1186/1297-9716-43-80.
    CrossRef  |  
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  125. Fraile, L.J., J.J. Aramayona, M.A. Bregante, M.A. Garcia and A.R. Abadia, 1996. Deacetylation of diltiazem by several rabbit tissues. Pharm. Res., 13: 1875-1880.
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