Roland Eghoghosoa Akhigbe
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Roland Eghoghosoa Akhigbe

Researcher
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria; Reproductive Medicine and Toxicology Laboratory, Oasis of Grace Hospital, Ota efun, Nigeria

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Biography

Dr. AKHIGBE Roland Eghoghosoa is a physician and Physiologist with keen interest in Reproductive Medicine (Andrology), Endocrinology and Metabolism and Toxicology. He has worked on the role of oxidative stress in the pathogenesis of various oathological conditions. He has published over 50 papers in peer-reviewed journals with 43 in Scopus, and 35 indexed in Pubmed, with over 914 citations.

Area of Interest:

Molecular Sciences
100%
Oxidative Stress and Antioxidants
62%
Molecular Toxicology
90%
Reproductive Medicine
75%
Endocrinology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Saka, W.A., R.E. Akhigbe, A.O. Abidoye, O.S. Dare and A.O. Adekunle, 2021. Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats. Biomed. Pharmacother., Vol. 138. 10.1016/j.biopha.2021.111443.
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  2. Hamed, M.A., G.O. Aremu and R.E. Akhigbe, 2021. Concomitant administration of HAART aggravates anti-Koch-induced oxidative hepatorenal damage via dysregulation of glutathione and elevation of uric acid production. Biomed. Pharmacother., Vol. 137. 10.1016/j.biopha.2021.111309.
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  3. Akhigbe, R.E., M.A. Hamed and A.F. Odetayo, 2021. HAART and anti‐Koch’s impair sexual competence, sperm quality and offspring quality when used singly and in combination in male wistar rats. Andrologia, Vol. 53. 10.1111/and.13951.
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  4. Akhigbe, R.E., L.O. Ajayi and A.F. Ajayi, 2021. Codeine exerts cardiorenal injury via upregulation of adenine deaminase/xanthine oxidase and caspase 3 signaling. Life Sci., Vol. 273. 10.1016/j.lfs.2020.118717.
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  5. Akhigbe, R. and A. Ajayi, 2021. The impact of reactive oxygen species in the development of cardiometabolic disorders: A review. Lipids Health Dis., Vol. 20. 10.1186/s12944-021-01435-7.
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  6. Saka, W.A., T.E. Ayoade, T.M. Akhigbe and R.E. Akhigbe, 2020. Moringa oleifera seed oil partially abrogates 2,3-dichlorovinyl dimethyl phosphate (Dichlorvos)-induced cardiac injury in rats: evidence for the role of oxidative stress. J. Basic Clin. Physiol. Pharmacol., 32: 237-246.
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  7. Oluwole, D.T., R.E. Akhigbe and A.F. Ajayi, 2020. Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: an experimental study in rats. Andrologia, Vol. 53. 10.1111/and.13931.
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  8. Akhigbe, R.E., L.O. Ajayi, A.A. Adelakun, O.S. Olorunnisola and A.F. Ajayi, 2020. Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis. Mol. Biol. Rep., 47: 9521-9530.
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  9. Akhigbe, R.E. and M.A. Hamed, 2020. Possible links between COVID-19 and male fertility. Asian Pac. J. Reprod., 9: 211-214.
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  10. Ajayi, A.F. and R.E. Akhigbe, 2020. The physiology of male reproduction: impact of drugs and their abuse on male fertility. Andrologia, 10.1111/and.13672.
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  11. Ajayi, A.F. and R.E. Akhigbe, 2020. Staging of the estrous cycle and induction of estrus in experimental rodents: An update. Fertil. Res. Pract., Vol. 6. 10.1186/s40738-020-00074-3.
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  12. Ajayi, A.F. and R.E. Akhigbe, 2020. Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis. Redox Rep., 25: 33-40.
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  13. Ajayi, A.F. and R.E. Akhigbe, 2020. In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway. Heliyon, Vol. 6. 10.1016/j.heliyon.2020.e05589.
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  14. Ajayi, A.F. and R.E. Akhigbe, 2019. Assessment of sexual behaviour and fertility indices in male rabbits following chronic codeine use. Andrology, 8: 509-515.
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