Serag Eldin Ibrahim Ali Mustafa Elbehairi
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Serag Eldin Ibrahim Ali Mustafa Elbehairi

Associated Professor
King Khalid University, Saudi Arabia


Highest Degree
Ph.D. in Tissue Culture from Al-Azhar University, Egypt

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Area of Interest:

Cellular and Molecular Biology
100%
Molecular Biology
62%
3D Modeling
90%
Cancer Stem Cells
75%
Tissue Culture
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
41
Abstracts
2

Selected Publications

  1. Prakasha, G., H.D. Revanasiddappa, B. Jayalakshmi, B.T. Prabhakar and C. Shivamallu et al., 2023. Novel benzimidazole derived imine ligand and its Co(III) and Cu(II) complexes as anticancer agents: Chemical synthesis, DFT studies, in vitro and in vivo biological investigations. Pharmaceuticals, Vol. 16. 10.3390/ph16010125.
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  2. Gowtham, H.G., F. Ahmed, S. Anandan, C.S. Shivakumara and A. Bilagi et al., 2023. In silico computational studies of bioactive secondary metabolites from Wedelia trilobata against anti-apoptotic b-cell lymphoma-2 (Bcl-2) protein associated with cancer cell survival and resistance. Molecules, Vol. 28. 10.3390/molecules28041588.
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  3. Ghramh, H.A., S.A. Alrumman, I. Ahmad, A. Kalam and S.E.I. Elbehairi et al., 2023. Chemical characterization of honey and its effect (alone as well as with synthesized silver nanoparticles) on microbial pathogens’ and human cancer cell lines’ growth. Nutrients, Vol. 15. 10.3390/nu15030684.
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  4. Dharmashekar, C., B. Shreevatsa, A.S. Jain, B. Harendra and S. Pradeep et al., 2023. Evaluating the antimicrobial and anti-hemolytic activity of synthesized pseudopeptide against Leptospiral species: In silico and in vitro approach. Molecules, Vol. 28. 10.3390/molecules28031106.
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  5. Althobaiti, F., O.A.A. Ali, I. Kamal, M.Y. Alfaifi and A.A. Shati et al., 2023. New ionic liquid microemulsion-mediated synthesis of silver nanoparticles for skin bacterial infection treatments. Antibiotics, Vol. 12. 10.3390/antibiotics12020247.
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  6. AboElmaaty, S.A., A.A. Shati, M.Y. Alfaifi, S.E.I. Elbehairi and N.S. Sheraba et al., 2023. Biofilm inhibitory activity of actinomycete-synthesized AgNPs with low cytotoxic effect: Experimental and in silico study. Microorganisms, Vol. 11. 10.3390/microorganisms11010102.
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  7. Nazreen, S., A.S.A. Almalki, S.E.I. Elbehairi, A.A. Shati and M.Y. Alfaifi et al., 2022. Cell cycle arrest and apoptosis-inducing ability of benzimidazole derivatives: design, synthesis, docking, and biological evaluation. Molecules, Vol. 27. 10.3390/molecules27206899.
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  8. Nasr, A.M., Y.I. Mortagi, N.H. Abdul Elwahab, M.Y. Alfaifi and A.A. Shati et al., 2022. Upgrading the transdermal biomedical capabilities of thyme essential oil nanoemulsions using amphiphilic oligochitosan vehicles. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14071350.
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  9. Nasr, A.M., S.M. Aboelenin, M.Y. Alfaifi, A.A. Shati, S.E.I. Elbehairi, R.F.M. Elshaarawy and N.H.A. Elwahab, 2022. Quaternized chitosan thiol hydrogel-thickened nanoemulsion: A multifunctional platform for upgrading the topical applications of virgin olive oil. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14071319.
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  10. Murali, M., H.G. Gowtham, N. Shilpa, H.K.N. Krishnappa and A.E. Ledesma et al., 2022. Exploration of anti-HIV phytocompounds against SARS-CoV-2 main protease: Structure-based screening, molecular simulation, ADME analysis and conceptual DFT studies. Molecules, Vol. 27. 10.3390/molecules27238288.
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  11. Mokhtar, F.A., N.M. Selim, S.S. Elhawary, S.R.A. El Hadi and M.H. Hetta et al., 2022. Green biosynthesis of silver nanoparticles using Annona glabra and Annona squamosa extracts with antimicrobial, anticancer, apoptosis potentials, assisted by in silico modeling, and metabolic profiling. Pharmaceuticals, Vol. 15. 10.3390/ph15111354.
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  12. Hamdy, M.S., S.E.I. Elbehairi, A.A. Shati, H.S.M. Abd-Rabboh and M.Y. Alfaifi et al., 2022. Cytotoxic potential of bio-silica conjugate with different sizes of silver nanoparticles for cancer cell death. Materials, Vol. 15. 10.3390/ma15124074.
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  13. Gaikwad, K.D., P. Ubale, R. Khobragade, S. Deodware and P. Dhale et al., 2022. Preparation, characterization and in vitro biological activities of new diphenylsulphone derived schiff base ligands and their co(II) complexes. Molecules, Vol. 27. 10.3390/molecules27238576.
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  14. Deodware, S.A., U.B. Barache, P.C. Dhale, K.D. Gaikwad and C. Shivamallu et al., 2022. In vitro anticancer screening, molecular docking and antimicrobial studies of triazole-based nickel(II) metal complexes. Molecules, Vol. 27. 10.3390/molecules27196548.
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  15. Cai, Y., B. Karmakar, A.O. Babalghith, G.E.S. Batiha and H.S. AlSalem et al., 2022. Decorated Au NPs on lignin coated magnetic nanoparticles: Investigation of its catalytic application in the reduction of aromatic nitro compounds and its performance against human lung cancer. Int. J. Biol. Macromol., 223: 1067-1082.
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  16. Abdul-Hameed, Z.H., N.O. Bawakid, H.S. Alorfi, T.R. Sobahi and N.A. Alburae et al., 2022. Monoterpene indole alkaloids from the aerial parts of Rhazya stricta induce cytotoxicity and apoptosis in human adenocarcinoma cells. Molecules, Vol. 27. 10.3390/molecules27041422.
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  17. Abd-Rabboh, H.S.M., K.F. Fawy, M.S. Hamdy, S.E.I. Elbehairi and A.A. Shati et al., 2022. Valorization of rice husk and straw agriculture wastes of Eastern Saudi Arabia: Production of bio-based silica, lignocellulose, and activated carbon. Materials, Vol. 15. 10.3390/ma15113746.
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  18. Morsy, K., N. Sheraba, Y. Alhamhoom, S.B. Dajem and M. Al-Kahtani et al., 2021. Garlic oil as a fight against histological and oxidative stress abnormalities in Wistar rats after oral inoculation of Anisakis spp. Type II (L3) (Nematoda). Arquivo Bras. Med. Vet. Zootecnia, 73: 141-154.
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  19. Hussein, Y., S.A. Loutfy, E.A. Kamoun, S.H. El-Moslamy, E.M. Radwan and S.E.I. Elbehairi, 2021. Enhanced anti-cancer activity by localized delivery of curcumin form PVA/CNCs hydrogel membranes: Preparation and in vitro bioevaluation. Int. J. Bio. Macromol., 170: 107-122.
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  20. Elbehairi, S.E.I., M.Y. Alfaifi, A.A. Shati, U.A. Fahmy, B. Gorain and S. Md, 2021. Encapsulation of ellagic acid in di-block copolymeric micelle for non-small cell lung cancer therapy. Sci. Adv. Mater., 13: 66-72.
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  21. Althagbi, H.I., F. Budiyanto, A. Abdel-Lateff, K.O. Al-Footy and N.O. Bawakid et al., 2021. Antiproliferative isoprenoid derivatives from the red sea alcyonacean Xenia umbellata. Molecules, Vol. 26. 10.3390/molecules26051311.
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  22. Alam, M.M., S. Nazreen, A.S.A. Almalki, A.A. Elhenawy and N.I. Alsenani et al., 2021. Naproxen based 1,3,4-oxadiazole derivatives as EDFR inhibitors: Design, synthesis, anticancer, and computational studies. Pharmaceuticals, Vol. 14. 10.3390/ph14090870.
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  23. Ahmad, I., M.A. Mir, S. Srivastava, A.A. Shati and S.E.I. Elbehairi et al., 2021. Phytochemical screening and in-vitro antibacterial and anticancer activity of crude extract of Matricaria aurea. Curr. Pharm. Des., 27: 69-79.
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  24. Shati, A.A., M.A. Alkahtani, M.Y. Alfaifi, S.E.I. Elbehairi, F.G. Elsaid, R. Prasanna and M.A. Mir, 2020. Secondary metabolites of Saussurea costus leaf extract induce apoptosis in breast, liver, and colon cancer cells by caspase-3-dependent intrinsic pathway. BioMed Res. Int., 10.1155/2020/1608942.
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  25. Shadab , M.Y. Alfaifi, S.E.I. Elbehairi, A.A. Shati, U.A. Fahmy and N.A. Alhakamy, 2020. Ellagic acid loaded TPGS micelles for enhanced anticancer activities in ovarian cancer. Int. J. Pharmacol., 16: 63-71.
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  26. Motaal, A.A., H.H. Salem, D. Almaghaslah, A. Alsayari and A.B. Muhsinah et al., 2020. Flavonol glycosides: In vitro inhibition of DPPIV, aldose reductase and combating oxidative stress are potential mechanisms for mediating the antidiabetic activity of Cleome droserifolia. Molecules, Vol. 25. 10.3390/molecules25245864.
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  27. Moharram, B.A., A.A. Al-Doaiss, H.M. Al-Mahbashi, M.A. Al-Kahtani, M.A. Alfaifi, S.E.I. Elbehairi and R. Saif-Ali, 2020. Hepatoprotective, antioxidant and cytotoxic potential of Aloe niebuhriana latex extract from Yemen. Indian J. Pharm. Sci., 10.36468/pharmaceutical-sciences.675.
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  28. Mohammed, M.E.A., A.A. Shati, M.Y. Alfaifi, S.E.I. Elbehairi and M.A. Alshehri et al., 2020. Acacia honey from different altitudes: total phenols and flavonoids, laser-induced fluorescence (LIF) spectra, and anticancer activity. J. Int. Med. Res., Vol. 48. 10.1177/0300060520943451.
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  29. Elbehairi, S.E.I., M.Y. Alfaifi, A.A. Shati, M.A. Alshehri, R.F.M. Elshaarawy and H.S. Hafez, 2020. Role of Pd(II)–chitooligosaccharides–Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics. Chem. Biol. Drug Des., 96: 1148-1161.
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  30. Elbehairi, S.E.I., L.A. Ismail, M.Y. Alfaifi, R.F.M. Elshaarawy and H.S. Hafez, 2020. Chitosan nano-vehicles as biocompatible delivering tools for a new Ag(I)curcuminoid-Gboxin analog complex in cancer and inflammation therapy. Int. J. Bio. Macromol., 165: 2750-2764.
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  31. Alsayari, A., A.B. Muhsinah, Y.I. Asiri, M.Y. Alfaifi and S.E.I. Elbehairi et al., 2020. Synthesis of antimicrobial agents of tetra?substituted thiophenes from ethyl 5?(2?bromoacetyl)?4?phenyl?2?(phenylamino)thiophene?3?carboxylate. J. Heterocycl. Chem., 57: 2911-2922.
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  32. Alsayari, A., A.B. Muhsinah, Y.I. Asiri, J.A. Alshehri and Y.N. Mabkhot et al., 2020. Arylhydrazono/aryldiazenyl pyrazoles: green one-pot solvent-free synthesis and anticancer evaluation. Lett. Org. Chem., 17: 772-778.
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  33. Alfaifi, M.Y., A.A. Shati, S.E.I. Elbehairi, U.A. Fahmy, N.A. Alhakamy and S. Md, 2020. Development and evaluation of febuxostat loaded d-α-tocopheryl polyethylene glycol 1000 succinate micelles for lung cancer. Int. J. Pharmacol., 16: 422-429.
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  34. Alfaifi, M.Y., A.A. Shati, S.E.I. Elbehairi, U.A. Fahmy, N.A. Alhakamy and S. Md, 2020. Anti-tumor effect of PEG-coated PLGA nanoparticles of febuxostat on A549 non-small cell lung cancer cells. 3 Biotech, Vol. 10. 10.1007/s13205-020-2077-x.
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  35. Alfaifi, M.Y., A.A. Shati, M.A. Alshehri, S.E.I. Elbehairi, U.A. Fahmy and O.Y. Alshehri, 2020. Atorvastatin-TPGS-PLGA nanoparticles cytotoxicity augmentation against liver cancer HepG2 cells. Int. J. Pharmacol., 16: 79-86.
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  36. Alfaifi, M., A. Alsayari, N. Gurusamy, J. Louis and S.E. Elbehairi et al., 2020. Analgesic, anti-Inflammatory, cytotoxic activity screening and UPLC-PDA-ESI-MS metabolites determination of bioactive fractions of Kleinia pendula. Molecules, Vol. 25. 10.3390/molecules25020418.
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  37. Al-Hakimi, A.N., F. Alminderej, L. Aroua, S.K. Alhag and M.Y. Alfaifi et al., 2020. Design, synthesis, characterization of zirconium (IV), cadmium (II) and iron (III) complexes derived from Schiff base 2-aminomethylbenzimidazole, 2-hydroxynaphtadehyde and evaluation of their biological activity. Arabian J. Chem., 13: 7378-7389.
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  38. Ahmed, A.E., A. Alshehri, M.A. Al-Kahtani, S.E.I. Elbehairi and M.A. Alshehri et al., 2020. Vitamin E and selenium administration synergistically mitigates ivermectin and doramectin-induced testicular dysfunction in male Wistar albino rats. Biomed. Pharmacother., 10.1016/j.biopha.2020.109841.
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  39. Ahmed, A., M. Al-Kahtani, A. Khalil, A. Alshehri and A. Elghoneimy et al., 2020. Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectin. Vet. Med., 65: 71-83.
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  40. Abbas, A.M., M.A. Al-Kahtani, M.Y. Alfaifi, S.E.I. Elbehairi and M.O. Badry, 2020. Floristic diversity and phytogeography of JABAL fayfa: A subtropical dry zone, south-West Saudi Arabia. Diversity, 10.3390/d12090345.
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  41. Zamzami, T.A., H.M. Abdallah, I.A. Shehata, G.A. Mohamed and M.Y. Alfaifi et al., 2019. Macrochaetosides A and B, new rare sesquiterpene glycosides from Echinops macrochaetus and their cytotoxic activity. Phytochem. Lett., 30: 88-92.
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  42. Saleh, K.A., T.H. Albinhassan, S.E.I. Elbehairi, M.A. Alshehry and M.Y. Alfaifi et al., 2019. Cell cycle arrest in different cancer cell lines (liver, breast, and colon) induces apoptosis under the influence of the chemical content of aeluropus lagopoides leaf extracts. Molecules, Vol. 24 10.3390/molecules24030507.
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  43. Mostafa, Y., S. Alrumman, S. Alamri, M. Hashem and K. Al-izran et al., 2019. Enhanced production of glutaminase-free l-asparaginase by marine Bacillus velezensis and cytotoxic activity against breast cancer cell lines. Electron. J. Biotechnol., 42: 6-15.
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  44. Jabal, K.A., H.M. Abdallah, G.A. Mohamed, I.A. Shehata and M.Y. Alfaifi et al., 2019. Perisomalien A, a new cytotoxic scalarane sesterterpene from the fruits of Periploca somaliensis. Nat. Prod. Res., 34: 2167-2172.
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  45. Fouda, A., H.A. Abbas, E. Ahmed, A. Shati, M. Alfaifi and S. Elbehairi, 2019. Synthesis, in vitro antimicrobial and cytotoxic activities of some new Pyrazolo[1,5-a]pyrimidine derivatives. Molecules, Vol. 24. 10.3390/molecules24061080.
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  46. Elghamdi, A.A., H.M. Abdallah, I.A. Shehata, G.A. Mohamed and A.A. Shati et al., 2019. Cyclocuneatol and cuneatannin, new cycloartane triterpenoid and ellagitannin glycoside from Euphorbia cuneata. Chem. Select, 4: 12375-12379.
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  47. Banjar, M.F.S., G.A. Mohamed, I.A. Shehata, H.M. Abdallah and A.A. Shati et al., 2019. Cycloschimperols A and B, new cytotoxic cycloartane triterpenoids from Euphorbia schimperi. Phytochem. Lett., 32: 90-95.
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  48. Alrumman, S.A., Y.S. Mostafa, K.A. Al-Izran, M.Y. Alfaifi, T.H. Taha and S.E. Elbehairi, 2019. Production and anticancer activity of an L-Asparaginase from Bacillus licheniformis isolated from the Red Sea, Saudi Arabia. Sci. Rep., Vol. 9. 10.1038/s41598-019-40512-x.
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  49. Alfaifi, M.Y., S.E.I. Elbehairi, H.S. Hafez and R.F.M. Elshaarawy, 2019. Spectroscopic exploration of binding of new imidazolium-based palladium(II) saldach complexes with CT-DNA as anticancer agents against HER2/neu overexpression. J. Mol. Struct., 1191: 118-128.
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  50. Alfaifi, M.Y., M.A. ,E Zein, A.A. Shati, M.A. Alshehri, S.E.I. Elbehairi, H.S. Hafez and R.F.M. Elshaarawy, 2019. Synthesis, photophysical behavior and biomolecular reactivity of new triphenylphosphonium-based Pd(II)salphens as new anticancer candidates. J. Photochem. Photobiol. A: Chem., Vol. 385. 10.1016/j.jphotochem.2019.112083.
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