Dr. Gamal Abd-Elmegeed Abd-Elghany Aly
My Social Links

Dr. Gamal Abd-Elmegeed Abd-Elghany Aly

Professor
National Research Centre, Egypt

Highest Degree
Ph.D. in Science from Cairo University, Egypt

Share this Profile

Area of Interest:

Biomedical Sciences
100%
Medicinal Chemistry
62%
Antioxidant Agents
90%
Hormones
75%
Anticancer Activity
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
60
Abstracts
0

Selected Publications

  1. Nafie, M.S., M.A. Tantawy and G.A. Elmgeed, 2019. Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents. Steroids, Vol. 152. 10.1016/j.steroids.2019.108485.
    CrossRef  |  Direct Link  |  
  2. El-Kady, D.S., A.A. Abd Rabou, M.A. Tantawy, A.A.H. Abdel-Rahman, A.A.S. Abdel-Megeed, M.M. AbdElhalim and G.A. Elmegeed, 2019. Synthesis and evaluation of novel cholestanoheterocyclic steroids as anticancer agents. Applied Biochem. Biotechnol., 188: 635-662.
    CrossRef  |  Direct Link  |  
  3. Yahya, S.M., G.A. Elmegeed, M.S. Mohamed, R.M. Mohareb, M.M. Abd-Elhalim and G.H. Elsayed, 2018. The effect of newly synthesized heterosteroids on mirna34a, 98, and 214 expression levels in mcf-7 breast cancer cells. Indian J. Clin. Biochem., 33: 328-333.
    CrossRef  |  Direct Link  |  
  4. Elhinnawi, M.A., R.M. Mohareb, H.M. Rady, W.K. Khalil, M.M.A. Elhalim and G.A. Elmegeed, 2018. Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro. J. Steroid Biochem. Mol. Biol., 183: 125-136.
    CrossRef  |  Direct Link  |  
  5. Tantawy, M.A., M.S. Nafie, G.A. Elmegeed and I.A.I. Ali, 2017. Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs. Bioorg. Chem., 73: 128-146.
    CrossRef  |  Direct Link  |  
  6. Elhalim, M.M.A., N.S. Ismail, S.M. Yahya, Y.Y. Omar and A.A.A. Rabou et al., 2017. Synthesis, characterization and evaluation of cytotoxic effects of novel hybrid steroidal heterocycles as PEG based nanoparticles. Asian Pac. J. Cancer Prev., 18: 1937-1946.
    CrossRef  |  Direct Link  |  
  7. Elmegeed, G.A., S.M.M. Yahya, M.M. Abd-Elhalim, M.S. Mohamed, R.M. Mohareb and G.H. Elsayed, 2016. Evaluation of heterocyclic steroids and curcumin derivatives as anti-breast cancer agents: Studying the effect on apoptosis in MCF-7 breast cancer cells. Steroids, 115: 80-89.
    CrossRef  |  Direct Link  |  
  8. Elmegeed, G.A., H.H. Ahmed, M.A. Hashash, M.M. Abd-Elhalim and D.S. El-Kady, 2015. Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study. Steroids, 101: 78-89.
    CrossRef  |  Direct Link  |  
  9. Elmegeed, G.A. and W.W. Wardakhan, 2015. Synthesis of pregnene and androstane heterocyclic derivatives of potential pharmacological activity. Egypt. J. Chem., 48: 407-424.
  10. Ahmed, H.H., G.A. Elmegeed, M.A. Hashash, M.M. Abd-Elhalim and D.S. El-kady, 2015. Highlights on mechanisms of newly synthesized compounds targeting multiple systems provide a novel perspective on alzheimer's disease treatment. J. Chem. Pharm. Res., 7: 297-318.
  11. Younes, M.A., M.S. Hany and A.E. Gamal, 2014. Synthesis and antimicrobial evaluation of novel aminoheterocyclic steroids. Arch. Pharm. Chem. Life Sci., 346: 178-185.
  12. Mohareb, R.M., F. Al-Omran and R.A. Azzam, 2014. Heterocyclic ring extension of estrone: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives. Steroids, 84: 46-56.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Elmegeed, G.A., L.W. Jialin, N. David and L. Alicia, 2014. Synthesis of substrate analogs for study in sterol biosynthesis. Arch. Biochem. Biophys., 525: 11-19.
  14. Elmegeed, G.A., 2014. Novel approach of steroidal heterocyclic drugs. Acta Pharm., 32: 215-227.
  15. Nes, W.D., L. Jialin, A.E. Gamal, L.H. Alicia, A.N. Chizaram and K.C. Emily, 2013. Oriented synthesis and enzymatic evaluation of new fluro-sterols. Arch. Biochem. Biophys., 523: 78-91.
  16. Mohareb, R.M., W.W. Wagnat and A.E. Gamal, 2013. Synthesis and biological evaluation of tri-heterocycles incorporating pyrazoles bonded to steroids. Mol., 18: 47-56.
  17. Liu, J., A.E. Gamal, K.C. Emily and W.N. David, 2013. An effeicient approach to lactandrate analogues with a tricyclic framework. Arch. Pharm. Chem. Life Sci., 346: 512-527.
  18. Mohareb, R.M., W.W. Wardakhan, G.A. Elmegeed and R.M. Ashour, 2012. Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations. Steroids, 77: 1560-1569.
    CrossRef  |  Direct Link  |  
  19. Mohamed, N.R., M.M. Abdelhalim, Y.A. Khadrawy, G.A. Elmegeed and O.M.E. Abdel-Salam, 2012. One-pot three-component synthesis of novel heterocyclic steroids as a central antioxidant and anti-inflammatory agents. Steroids, 77: 1469-1476.
    CrossRef  |  Direct Link  |  
  20. Howard, A.L., L. Jialin, A.E. Gamal, K.C. Emily, S.G. Kalgi, A.N. Chizaram and W.N. David , 2012. Sterol C24-methyltransferase: Physio- and Stereo-chemical features of the sterol C3 group required for catalytic competence. Arch. Biochem. Biophys., 521: 43-50.
    CrossRef  |  Direct Link  |  
  21. Mohareb, R.M., H.H. Ahmed, G.A. Elmegeed, M.M. Abdelhalem and R. Wageh, 2011. Development of new indole-derived neuroprotective agents. Biooraganic Med. Chem., 19: 2966-2974.
    PubMed  |  Direct Link  |  
  22. Mohareb, R.M., G.A. Elmegeed, O.M.E. Abdel-Salam, S.H. Doss and M.G. William, 2011. Synthesis of modified steroids as a novel class of non-ulcerogenic, anti-inflammatory and anti-nociceptive agents. Steroids, 76: 1190-1203.
    PubMed  |  Direct Link  |  
  23. Mohareb, R.M., G.A. Elmegeed, A.R. Baiuomy, E.F. Eskander and M.G. William, 2011. Evaluation of anti‐inflammatory, anti‐nociceptive, and anti‐ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids. Archiv. Pharm., 344: 595-604.
    CrossRef  |  Direct Link  |  
  24. Elmegeed, G.A., W.K.B. Khalil, R.M. Mohareb, H.H. Ahmed, M.M. Abd-Elhalim and G.H. Elsayed, 2011. Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents. Bioorg. Med. Chem., 19: 6860-6872.
    CrossRef  |  Direct Link  |  
  25. Mohamed, N.R., G.A. Elmegeed, M.M. Abdelhalim and H.M. Rady, 2010. Facile synthesis and in vitro cytotoxic evaluation of novel thiadiazole, pyrazole, and dithiole-androstane derivatives. Phosphorus, Sulfur, Silicon, 185: 848-856.
    CrossRef  |  Direct Link  |  
  26. Elmegeed, G.A., A.R. Baiuomy, M.M. Abdelhalim and H.Y. Hana, 2010. Synthesis and antidepressant evaluation of five novel heterocyclic tryptophan‐hybrid derivatives. Arch. Pharm. Chem. Life Sci., 343: 261-267.
    CrossRef  |  Direct Link  |  
  27. Ahmed, H.H., G.A. Elmegeed, S.M. El-Sayed, M.M. Abd-Elhalim, W. Shousha and R.W. Shafic, 2010. Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats. Eur. J. Med. Chem., 45: 5452-5459.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Mohareb, R.M., S.H. Doss, G.A. Elmegeed and E.F. Eskander, 2009. Synthesis of novel hybrid steroids with potential biological activities: Synthesis of C-17-thiazole, isoxazole, pyrazole, thiophene and phthalazine derivatives of epi-androsterone. Curr. Top. Steroid Res., 6: 49-61.
  29. Mohareb, R.M., A.L. Nadia, A.M. Gamal and Y.H. Hanaa, 2009. Synthesis of unnatural tryptophan derivatives of potential biological activity. J. Chilean Chem. Soc., 54: 175-179.
  30. Elmegeed, G.A., M. El-Far, H. Mahrous and M.A. Tantawy, 2009. Aminothienoandrostane: Novel promising anti-tumor agent. Int. J. Med. Med. Sci., 1: 126-131.
    Direct Link  |  
  31. Elmegeed, G.A., E. Mohamed, M.R. Hanaa and A.T. Mohamed, 2009. Facile synthesis and biological evaluation of novel modified amino-steroids. J. Mansoura Univ., 36: 19-37.
  32. El-Far, M., G.A. Elmegeed, E.F. Eskander, H.M. Rady and M.A. Tantawy, 2009. Novel modified steroid derivatives of androstanolone as chemotherapeutic anti-cancer agents. Eur. J. Med. Chem., 44: 3936-3946.
    CrossRef  |  Direct Link  |  
  33. Ahmed, H.H., G.A. Elmegeed, E.S.M.E. Mahdy, W.G. Shousha and E.A.F. Mohamed, 2009. Efficacy of newly synthesized melatonin derivatives as antiosteoporotic agents in ovariectomized rats. J. Applied Sci. Res., 5: 263-282.
  34. Wardakhan, W.W., O.M. Abdel-Salam and G.A. Elmegeed, 2008. Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta pharm., 58: 1-14.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Hana, H.Y., W.K.B. Khalil, A.I. Elmakawy and G.A. Elmeeged, 2008. Androgenic profile and genotoxicity evaluation of testosterone propionate and novel synthesized heterocyclic steroids. J. Steroid Biochem. Mol. Biol., 110: 284-294.
    CrossRef  |  Direct Link  |  
  36. Gaara, A.H., M.I. Nassar, M. Younis, G.A. Elmegeed, T.J. Mabry and P.W. Pare, 2008. Biologically active polyphenolic compounds from Acacia ehrenbergiana. Rev. Latinoamer. Quim., 36: 52-59.
    Direct Link  |  
  37. Eskander, E.F., F.A. Aymen, A.E. Gamal and I.N. Mahmoud, 2008. Chemical constituents, biological activity and hormonal profile of Myristicafragrans. Egypt. Med. J. Nat. Res. Center, 7: 15-21.
  38. Elmegeed, G.A., W.K. Khalil, A.A. Raouf and M.M. Abd-Elhalim, 2008. Synthesis and in vivo anti-mutagenic activity of novel melatonin derivatives. Eur. J. Med. Chem., 43: 763-770.
    CrossRef  |  
  39. Ahmed, H.H., M.M. Abd Elhalim, G.A. Elmegeed and E.F. Eskander, 2008. Potential role of novel synthesized estrone derivatives in management of osteoporosis in ovariectomized rats. J. Applied Sci. Res., 4: 459-479.
  40. Elmegeed, G.A., A.R. Baiuomy and O.M. Abdel-Salam, 2007. Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues. Eur. J. Med. Chem., 42: 1285-1292.
  41. Abdelhamid, A.O., M.M. Abdelhalim and G.A. Elmegeed, 2007. New routes to steroidal heterocyclic derivatives: Synthesis of biologically active pyrazolyl‐ and isoxazolylpregnene derivatives. J. Heterocycl. Chem., 44: 7-11.
    CrossRef  |  Direct Link  |  
  42. Abdelhalim, M., M. El-Saidi, M.S. Rabie and G. Elmegeed, 2007. Synthesis of novel steroidal heterocyclic derivatives as antibacterial agents. Steroids, 72: 459-465.
    CrossRef  |  Direct Link  |  
  43. Wardakhan, W.W., G.A. Elmegeed and F.M. Manhi, 2005. Utility of 2-aminothiophene-3-carboxamide in the synthesis of biologically active, fused heterocyclic derivatives. Phosphorus, Sulfur, Silicon, 180: 125-140.
    CrossRef  |  Direct Link  |  
  44. Mohamed, N.R., G.A. Elmegeed, H.A. Abd-ElMalek and M. Younis, 2005. Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent. Steroids, 70: 131-136.
    CrossRef  |  Direct Link  |  
  45. Elmegeed, G.A., W.W. Wardakhan and A.R. Baiuomy, 2005. Synthesis of thiazolyl and thieno cholestane derivatives: A novel class of potent antiinflammatory steroids. Pharm. Int. J. Pharm. Sci., 60: 328-333.
    Direct Link  |  
  46. Elmegeed, G.A., H.H. Ahmed and J.S. Hussein, 2005. Novel synthesized aminosteroidal heterocycles intervention for inhibiting iron-induced oxidative stress. Eur. J. Med. Chem., 40: 1283-1294.
  47. Ahmed, H.H., G.A. Elmegeed and M.M. Abdelhalim, 2005. Synthesis and screening of certain new pyrazolo, pyrimidino and pyrido-androstane derivatives for androgenic and antiandrogenic activity. Bull. Fac. Pharm. Cairo Univ., 43: 147-159.
  48. Ahmed, H.H., F. Mannaa, G.A. Elmegeed and S.H. Doss, 2005. Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity. Bioorg. Med. Chem., 3: 1847-1857.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Elmegeed, G.A., W.W. Wardakhan, M. Younis and N.A. Louca, 2004. Synthesis and antimicrobial evaluation of some novel cholestane heterocyclic derivatives. Arch. Pharm. Chem. Life Sci., 337: 140-147.
    CrossRef  |  Direct Link  |  
  50. Elmegeed, G.A., 2004. Synthesis of novel pyrazolo, pyrimidino and pyrido androstane derivatives of pharmacological interest. Egypt. J. Chem., 47: 579-590.
  51. Younis, M., G.A. El-megeed and M.I. Nassar, 2003. Antimicrobial activities of acacia ehrenbergiana extracts and its nitrogen fixation ability. Egypt. J. Microbiol., 38: 195-204.
  52. Mohamed, N.R., G.A. Elmegeed and M. Younis, 2003. Studies on Organophosphorus Compounds VII1,2: Transformation of steroidal ketones with lawesson's reagent into thioxo and heterofused steroids. Phosphorus, Sulfur, Silicon, 178: 203-217.
    CrossRef  |  Direct Link  |  
  53. Doss, S.H., R.M. Mohareb, G.A. Elmegeed and N.A. Luoca, 2003. Synthesis and study of pigment aggregation response of some melatonin derivatives. Die Pharm. Int. J. Pharm. Sci., 58: 607-613.
    Direct Link  |  
  54. Doss, S.H., N.A. Louca, G.A. Elmegeed and R.M. Mohareb, 1999. Sultamo-steroid analogues, part VII: Synthesis of epi-androsterone derivatives with potential activity. Arch. Pharmacal Res., 22: 496-501.
    CrossRef  |  Direct Link  |