Dr. Osama Abdelhakim Aly Ahmed
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Dr. Osama Abdelhakim Aly Ahmed

Associate Professor
King Abdulaziz University, Kingdom of Saudi Arabi

Highest Degree
Ph.D. in Pharmacy from University of Bath, England

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Analysis
62%
Drug Design
90%
Drug Delivery
75%
Industrial Pharmacy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Osman, A.M.M., H.S. Al-Johani, F.O. Kamel, O.A.H.A. Ahmed, E.A. Huwait and M.M. Sayed-Ahmed, 2020. 5-fluorouracil and simvastatin loaded solid lipid nanoparticles for effective treatment of colorectal cancer cells. Int. J. Pharmacol., 16: 205-213.
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  2. Murad, H., O. Ahmed, T. Ghabrah and M. Gari, 2020. Telmisartan self-nanoemulsifying drug delivery system, compared with standard telmisartan, more effectively improves hepatic fibrosis in rats. Dose-Response, 10.1177/1559325820982190.
    CrossRef  |  Direct Link  |  
  3. Hosny, K.M., R.H. Bahmdan, N.A. Alhakamy, M.A. Alfaleh, O.A. Ahmed and M.H. Elkomy, 2020. Physically optimized nano-lipid carriers augment raloxifene and vitamin D oral bioavailability in healthy humans for management of osteoporosis. J. Pharm. Sci., 109: 2145-2155.
    CrossRef  |  Direct Link  |  
  4. Fahmy, U.A., H.M. Aldawsari, S.M. Badr-Eldin, O.A.A. Ahmed and N.A. Alhakamy et al., 2020. The encapsulation of febuxostat into emulsomes strongly enhances the cytotoxic potential of the drug on HCT 116 colon cancer cells. Pharm., Vol. 12. 10.3390/pharmaceutics12100956.
    CrossRef  |  Direct Link  |  
  5. El-Say, K.M., T.A. Ahmed, O.A.A. Ahmed and H. Elimam, 2020. Enhancing the hypolipidemic effect of simvastatin in poloxamer-induced hyperlipidemic rats via liquisolid approach: pharmacokinetic and pharmacodynamic evaluation. AAPS Pharm. Sci. Tech., 10.1208/s12249-020-01754-5.
    CrossRef  |  Direct Link  |  
  6. Basahih, T.S., A.A. Alamoudi, K.M. El-Say, N.A. Alhakamy and O.A.A. Ahmed, 2020. Improved transmucosal delivery of glimepiride via unidirectional release buccal film loaded with vitamin E TPGS-based nanocarrier. Dose-Response, 10.1177/1559325820945164.
    CrossRef  |  Direct Link  |  
  7. Alhakamy, N.A., U.A. Fahmy, S.M. Badr-Eldin, O.A.A. Ahmed and H.Z. Asfour et al., 2020. Optimized icariin phytosomes exhibit enhanced cytotoxicity and apoptosis-inducing activities in ovarian cancer cells. Pharm., Vol. 12. 10.3390/pharmaceutics12040346.
    CrossRef  |  Direct Link  |  
  8. Alhakamy, N.A., U.A. Fahmy, O.A.A. Ahmed, G. Caruso and F. Caraci et al., 2020. Chitosan coated microparticles enhance simvastatin colon targeting and pro-apoptotic activity. Marine Drugs, Vol. 18. 10.3390/md18040226.
    CrossRef  |  Direct Link  |  
  9. Alhakamy, N.A., U.A. Fahmy, O.A.A. Ahmed, E.A. Almohammadi and S.A. Alotaibi et al., 2020. Development of an optimized febuxostat self-nanoemulsified loaded transdermal film: In-vitro, ex-vivo and in-vivo evaluation. Pharm. Dev. Technol., 25: 326-331.
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  10. Alhakamy, N.A., S.M. Badr-Eldin, U.A. Fahmy, N.K. Alruwaili and Z.A. Awan et al., 2020. Thymoquinone-loaded soy-phospholipid-based phytosomes exhibit anticancer potential against human lung cancer cells. Pharm., 10.3390/pharmaceutics12080761.
    CrossRef  |  Direct Link  |  
  11. Alhakamy, N.A., S.M. Badr-Eldin, O.A.A. Ahmed, A.A. Halwani and H.M. Aldawsari et al., 2020. Optimized ellagic acidu2013ca pectinate floating beads for gastroprotection against indomethacin-induced gastric injury in rats. Biomolecules, 10.3390/biom10071006.
    CrossRef  |  Direct Link  |  
  12. Alhakamy, N.A., O.A.A. Ahmed, M. Kurakula, G. Caruso and F. Caraci et al., 2020. Chitosan-based microparticles enhance ellagic acidu2019s colon targeting and proapoptotic activity. Pharmaceutics, 10.3390/pharmaceutics12070652.
    CrossRef  |  Direct Link  |  
  13. Alhakamy, N.A., A.L. Alaofi, O.A.A. Ahmed, U.A. Fahmy and S. Md et al., 2020. Development of lipid membrane based assays to accurately predict the transfection efficiency of cell-penetrating peptide-based gene nanoparticles. Int. J. Pharmaceutics, Vol. 580. 10.1016/j.ijpharm.2020.119221.
    CrossRef  |  Direct Link  |  
  14. Aldawsari, H.M., U.A. Fahmy, F. Abd-Allah and O.A.A. Ahmed, 2020. Formulation and optimization of avanafil biodegradable polymeric nanoparticles: A single-dose clinical pharmacokinetic evaluation. Pharmaceutics, Vol. 12. 10.3390/pharmaceutics12060596.
    CrossRef  |  Direct Link  |  
  15. Ahmed, O.A.A., U.A. Fahmy, S.M. Badr-Eldin, H.M. Aldawsari and Z.A. Awan et al., 2020. Application of nanopharmaceutics for flibanserin brain delivery augmentation via the nasal route. Nanomaterials, 10.3390/nano10071270.
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  16. Ahmed, O.A.A., U.A. Fahmy, R. Bakhaidar, M.A. El-Moselhy and S.Z. Okbazghi et al., 2020. Omega-3 self-nanoemulsion role in gastroprotection against indomethacin-induced gastric injury in rats. Pharmaceutics, Vol. 12. 10.3390/pharmaceutics12020140.
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  17. Ahmed, O.A.A., A.S. Azhar, M.M. Tarkhan, K.S. Balamash and H.M. El-Bassossy, 2020. Antiglycation activities and common mechanisms mediating vasculoprotective effect of quercetin and chrysin in metabolic syndrome. Evidence-Based Compl. Alt. Med., 10.1155/2020/3439624.
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  18. Ahmed, O.A.A. and S.M. Badr-Eldin, 2020. Biodegradable self-assembled nanoparticles of peg-plga amphiphilic diblock copolymer as a promising stealth system for augmented vinpocetine brain delivery. Int. J. Pharmaceutics, 10.1016/j.ijpharm.2020.119778.
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  19. Ahmed, O.A.A. H.M. El-Bassossy, A.S. Azhar, M.M. Tarkhan and M.M. El-Mas, 2020. Interference with AGEs formation and AGEs-induced vascular injury mediates curcumin vascular protection in metabolic syndrome. Sci. Rep., 10: 1-10.
  20. Ahmed, O.A., U.A. Fahmy, R. Bakhaidar, M.A. El-Moselhy and M.A. Alfaleh et al., 2020.

    Pumpkin oil-based nanostructured lipid carrier system for antiulcer effect in NSAID-induced gastric ulcer model in rats

    . Int. J. Nanomed., Volume 15: 2529-2539.
    CrossRef  |  Direct Link  |  
  21. Fahmy, U.A., O.A.A. Ahmed and N.A. Alhakamy, 2019. Augmentation of alendronate cytotoxicity against breast cancer cells by complexation with trans-activating regulatory protein. Int. J. Pharmacol., 15: 731-737.
    CrossRef  |  Direct Link  |  
  22. El-Say, K.M., O.A.A. Ahmed, H.M. Aldawsari, and S.M. Badr-Eldin, 2019. Influence of different variables on the dissolution behavior of carvedilol from liquisolid compacts using response surface methodology. Dig. J. Nanomater. Biostructures, 14: 879-894.
  23. El-Say, K.M., O.A.A. Ahmed, A.I. Mohamed, M.K. Safo and A.S.M. Omar, 2019. Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation. Int. J. Nanomed., 14: 7461-7473.
    CrossRef  |  Direct Link  |  
  24. Alhakamy, N.A., U.A. Fahmy and O.A.A. Ahmed, 2019. Attenuation of benign prostatic hyperplasia by optimized tadalafil loaded pumpkin seed oil-based self nanoemulsion: in vitro and in vivo evaluation. Pharmaceutics, 10.3390/pharmaceutics11120640.
    CrossRef  |  Direct Link  |  
  25. Alhakamy, N.A., O.A.A. Ahmed, H.M. Aldawsari, M.Y. Alfaifi, B.G. Eid, A.B. Abdel-Naim and U.A. Fahmy, 2019. Encapsulation of lovastatin in zein nanoparticles exhibits enhanced apoptotic activity in HepG2 cells. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20225788.
    CrossRef  |  Direct Link  |  
  26. Al-Gethmy, H.A., U.A. Fahmy, N.A. Alhakamy, O. Ahmed and K.M. El-Say, 2019. Optimization of the factors affecting the absorption of vardenafil from oral disintegrating tablets: A clinical pharmacokinetic investigation. Pharmaceutics, Vol. 11, No. 1. 10.3390/pharmaceutics11010011.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Ahmed, T.A., K.M. El-Say, O.A.A. Ahmed and B.M. Aljaeid, 2019. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel. Int. J. Nanomed., Volume 14: 5555-5567.
    CrossRef  |  Direct Link  |  
  28. Ahmed, O.A.A., K.M. El-Say, B.M. Aljaeid, S.M. Badr-Eldin and T.A. Ahmed, 2019. Optimized vinpocetine-loaded vitamin e D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: In vitro and ex vivo studies. Int. J. Nanomed., 14: 33-43.
    CrossRef  |  Direct Link  |  
  29. Ahmed, O.A.A. and S.M. Badr-Eldin, 2019. Development of an optimized avanafil-loaded invasomal transdermal film: Ex vivo skin permeation and in vivo evaluation. Int. J. Pharmaceutics, Vol. 570. 10.1016/j.ijpharm.2019.118657.
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