About
Professional Summary
Dr. Alaaeldin Ahmed Hamza, earned his PhD from Cairo University in Animal Physiology, is currently working as professor of Physiology in the National Organization for Drug Control and Research (NODCAR) Egypt. He is established scientist in the areas of liver toxicity, reproductive toxicity and liver cancer. For his highly cited publications he has ranked as the top scientists in United Arab Emirates institutions according to GSC public profiles 2017 and among the top 2% of researchers in the world by Stanford University in 2020. He has published more than 40 papers in different fields of pharmacology in many prestigious journal such as Hepatology, Scientific Report, Toxicology Letters, Toxicology, Food and Chemical Toxicology, Andrologia, Life Sciences and Molecules. His current Scopus H-index is 24 and his total citations are 2520. He is serving as a reviewer in Elsevier, Taylor, Springer and Wiley journals. He has been serving as an editorial board member of more than five international medical journals. He has participated in various national and international conferences. He has awarded the Best Individual Non Funded Research Project Award, the 9th Annual Research Conference, U.A.E. University, Al-Ain. April 21-23, 2008. ). He is member in National Committee for Biological Science. Egyptian Academy of Scientific Research and Technology. 22-10-2018-until now. He recognized as one of the best reviewers in Elsevier (2011& 2017). He is member in National Committee for Biological Science. Egyptian Academy of Scientific Research and Technology. 22-10-2018-until now. He recognized as one of the best reviewers in Elsevier (2011& 2017). His research focus areas are the development of animal models to study the protective effects of natural substances and antioxidant and oxidative stress induced by pharmacological agents such as anticancer drugs and pharmacological agents. For last 7 years, He was involved in developing in in vivo and enzyme assays in the field of cancer and oxidative stress researches. His experience has involved drug discovery, mechanism-of-action studies, biomarker development, cancer pharmacology in xenograft and chemical tumor models, pharmacology of stress response signaling. This has required a broad understanding of cancer biology and pharmacology.
Education
Academic Background
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Ph.D.
Cairo University, Egypt
Animal Physiology | Completed: 2004
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Ph.D.
Cairo University, Egypt
Pharmacology and Environmental Toxicology | Completed: 2004
Publications (40)
Selected Scholarly Contributions
Safranal Enhances the Efficacy of Praziquantel Against Schistosoma mansoni Infection and Alleviates Liver Fibrosis, Inflammation and Oxidative Stress in Mice
Azza Fahmy, Amany Mohammed Mohmmed Hegab, Hanan S. Mossalem, Samah Sulaiman Abuzahrah, Saud Omar Alafghani, Alaaeldin Ahmed Hamza, Nouf Juaid, Amr Amin
Journal of Xenobiotics
| Journal Article
2026
Withania somnifera Ameliorates Doxorubicin-Induced Nephrotoxicity and Potentiates Its Therapeutic Efficacy Targeting SIRT1/Nrf2, Oxidative Stress, Inflammation, and Apoptosis
Amany Mohammed Mohmmed Hegab, Soha Osama Hassanin, Reham Hassan Mekky, Samah Sulaiman Abuzahrah, Alaaeldin Ahmed Hamza, Iman M. Talaat, Amr Amin
Pharmaceuticals
| Journal Article
2025
Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against Breast Cancer
Soha Osama Hassanin, Amany Mohammed Mohmmed Hegab, Reham Hassan Mekky, Mohamed Adel Said, Mona G. Khalil, Alaaeldin Ahmed Hamza, Amr Amin
Marine Drugs
| Journal Article
2024
Combining Crocin and Sorafenib Improves Their Tumor-Inhibiting Effects in a Rat Model of Diethylnitrosamine-Induced Cirrhotic-Hepatocellular Carcinoma
Basma Awad, Alaaeldin Ahmed Hamza, Amna Al-Maktoum, Suhail Al-Salam, Amr Amin
Cancers
| Journal Article
2023
Biosynthesis and characterization of gold and copper nanoparticles from Salvadora persica fruit extracts and their biological properties.
ELhabal, S.F., H.M. Elwy, S. Hassanin, A.A. El-Rashedy, A.A. Hamza and M.A. Khasawneh,
Int. J. Nanomed.,
| Journal Article

Alaa Eldin Ahmed Hamza
2022
Polyphenolic-enriched olive leaf extract attenuated doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress and inflammation
Alaaeldin Ahmed Hamza, Soha Osama Hassanin, Salsabil Hamza, Ali Abdalla, Amr Amin
The Journal of Basic and Applied Zoology
| Journal Article
2021
Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats
Alaaeldin Ahmed Hamza, Mona Gamel Mohamed, Fawzy Mohamed Lashin, Amr Amin
The Journal of Basic and Applied Zoology
| Journal Article
2020
Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation
Alaaeldin Ahmed Hamza, Fawzy Mohamed Lashin, Mona Gamel, Soha Osama Hassanin, Youssef Abdalla, Amr Amin
Antioxidants
| Journal Article
2020
Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
Fadia S Youssef, Mohamed L Ashour, Hesham A El-Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B Singab, Michael Wink
Journal of Pharmacy and Pharmacology
| Journal Article
2020
Comments to the editor concerning the paper entitled “Mitochondrial dysfunction in diabetic cardiomyopathy: Effect of mesenchymal stem cell with PPAR-γ agonist or exendin-4” Mohamed Abd Elaziz Wassef et al.
Hamza, A.A.,
Exp. Clin. Endocrinol. Diabetes,
| Journal Article

Alaa Eldin Ahmed Hamza
2018
Radwan Salvia fruticosa-mediated antioxidant protection against oxidative stress in streptozotocin - induced diabetic rats.
Hamza, A.A., S.M. Ahmed, H.M. Elwy and O.K. Radwan,
Int. J. Pharm. Biol. Sci.,
| Journal Article

Alaa Eldin Ahmed Hamza
2016
Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line.
Heeba, G.H., A.A. Hamza and S.O. Hassanin,
Toxicol. Lett.,
| Journal Article

Alaa Eldin Ahmed Hamza
2016
Safranal ameliorates sodium valproate-induced liver toxicity in rats by targeting gene expression, oxidative stress and apoptosis.
Hamza, A.A., F. El Hodairy and A.M. Badawi,
J. Biomed. Pharm. Res.,
| Journal Article

Alaa Eldin Ahmed Hamza
2016
Saffron-based crocin prevents early lesions of liver cancer: In vivo, in vitro and network analyses.
Amin, A., A.A. Hamza, S. Daoud, K. Khazanehdari and A. Al Hrout et al.,
Recent Pat. Anti-Cancer Drug Discovery,
| Journal Article

Alaa Eldin Ahmed Hamza
2016
Fenugreek seed extract attenuates cisplatin‐induced testicular damage in wistar rats.
Hamza, A.A., H.M. Elwy and A.M. Badawi,
Andrologia,
| Journal Article

Alaa Eldin Ahmed Hamza
2016
Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats.
Heeba, G.H. and A.A. Hamza,
Life Sci.,
| Journal Article

Alaa Eldin Ahmed Hamza
2015
Selenium ameliorates isotretinoin-induced liver injury and dyslipidemia via antioxidant effect in rats.
Saied, N.M. and A.A. Hamza,
Toxicol. Mech. Methods,
| Journal Article

Alaa Eldin Ahmed Hamza
2014
Antioxidant activity and lipoxygenase inhibitory effect of Caralluma arabica and related polyphenolic constituents.
Khasawneh, M., H.M. Elwy, N.M. Fawzi, A.A. Hamza, A.R. Chevidenkandy and A.H. Hassan,
Am. J. Plant Sci.,
| Journal Article

Alaa Eldin Ahmed Hamza
2014
Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique.
Choi, Y.K., B.K. Poudel, N. Marasini, K.Y. Yang and J.W. Kim et al.,
Int. J. Pharm.,
| Journal Article

Alaa Eldin Ahmed Hamza
2012
Antioxidant, lipoxygenase and histone deacetylase inhibitory activities of Acridocarbus orientalis from Al Ain and Oman.
Ksiksi, T. and A.A. Hamza,
Mol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2012
Saffron: A potential candidate for a novel anti-cancer drug against hepatocellular carcinoma.
Amin, A., A. Hamza, K. Bajbouj, S.A. Ashraf and S. Daoud,
Hepatology,
| Journal Article

Alaa Eldin Ahmed Hamza
2011
Antioxidant activity, lipoxygenase inhibitory effect and polyphenolic compounds from Calotropis procera (Ait.) R. Br.
Khasawneh, M.A., H.M. Elwy, N.M. Fawzi, A.A. Hamza, A.R. Chevidenkandy and A.H. Hassan,
Res. J. Phytochem.,
| Journal Article

Alaa Eldin Ahmed Hamza
2011
The protective effects of ascorbic acid, cimetidine and nifidipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats.
Gaafa, K.M., M.M. Badawy and A.A. Hamza,
Drug Chem. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2011
Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk.) decne polyphenolic constituents.
Khasawneh, M.A., H.M. Elwy, A.A. Hamza, N.M. Fawzi and A.H. Hassan,
Mol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2011
Effect of licorice extract on the complications of diabetes nephropathy in rats.
Kataya, H.H., A.A. Hamza, G.A. Ramadan and M.A. Khasawneh,
Drug Chem. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2011
Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats.
Hamza, A.A.,
Food Chem. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2010
Herbal extracts counteract cisplatin-mediated cell death in rat testis.
Amin, A., A.A. Hamza, A. Kambal and S. Daoud,
Asian J. Androl.,
| Journal Article

Alaa Eldin Ahmed Hamza
2008
Apium graveolens modulates sodium valproate-induced reproductive toxicity in rats.
Hamza, A.A. and A. Amin,
J. Exp. Zool. Part A. Ecol. Genet. Physiol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
Protective effect of red cabbge (Brassica oleracea) on oxidative stress and experimental diabetic nephropathy in rats.
Kataya, H. and A. Hamza,
eCAM,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
Curcuma longa, Glycyrrhiza glabra and Moringa oleifera ameliorate diclofenac-induced hepatoxicity in rats.
Hamza, A.A.,
Am. J. Pharmacol. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
In vitro studies on the effect of phototoxicity of a new photosensitizer extracted from flowers and aerial parts of Cichorium pumilum.
Al-Akhras, M.A.H., A. Amin, K. Mohammad, F. Al-Haddad and A. Hamza,
Am. J. Pharmacol. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
Enhancement of dissolution amount and in vivo bioavailability of itraconazole by complexation with β-cyclodextrin using supercritical carbon dioxide.
Hassan, H.A., A.H. Al-Marzouqi, B. Jobe, A.A. Hamza and G.A. Ramadan,
J. Pharm. Biomed. Anal.,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.
Hamza, A.A., A. Amin and S. Daoud,
Cell Biol. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2007
Effects of roselle and ginger on cisplatin-induced reproductive toxicity in rats.
Amin, A. and A.A. Hamza,
Asian J. Andrology,
| Journal Article

Alaa Eldin Ahmed Hamza
2006
Spirulina protects against cadmium-induced hepatotoxicity in rats.
Amin, A., A.A Hamza, S. Daoud and W. Hamza,
Am. J. Pharmacol. Toxicol.,
| Journal Article

Alaa Eldin Ahmed Hamza
2006
Oxidative stress mediates drug-induced hepatotoxicity in rats: A possible role of DNA fragmentation.
Amin, A. and A.A. Hamza,
Toxicology,
| Journal Article

Alaa Eldin Ahmed Hamza
2005
Hepatoprotective effects of Hibiscus, Rosmarinus and salvia on azathioprine-induced toxicity in rats
Amin, A. and A.A. Hamza,
Life Sci.,
| Journal Article

Alaa Eldin Ahmed Hamza
2005
Pharmacokinetics of theophylline after administration of suppositories formulation.
Abou-Basha, L.I., L.F. Wahman, A. Hamza and H.Y. Aboul-Enein,
J. Immunoassay Immunochem.,
| Journal Article

Alaa Eldin Ahmed Hamza
2005
Selenium supplementation improves dyslipidemia, lipid peroxidation and impaired cardiac performance in preeclamptic rats.
El-Ridi, M.R., G.S.Y. Hanna and A. Hamza,
Minoufiya Med. J.,
| Journal Article

Alaa Eldin Ahmed Hamza
2003
Performance of submersible PV solar pumping systems under conditions in the Sudan.
Hamza, A.A. and A.Z. Taha,
Renewable Energy,
| Journal Article

Alaa Eldin Ahmed Hamza
1995