Dr. Gerald J. Wyckoff
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Dr. Gerald J. Wyckoff

Professor
University of Missouri, United States of America

Highest Degree
Ph.D. in Genetics from University of Missouri, United States of America

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Area of Interest:

Biomedical Sciences
100%
Genetic Analysis
62%
Bioinformatics
90%
Genotyping
75%
Computational Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Shortt, K., D.P. Heruth, N. Zhang, W. Wu and S. Singh et al., 2019. Identification of novel regulatory genes in APAP induced hepatocyte toxicity by a genome-wide CRISPR-Cas9 screen. Scient. Rep., Vol. 9. 10.1038/s41598-018-37940-6.
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  2. Zhang, L.Q., L. van Haandel, M. Xiong, P. Huang and D.P. Heruth et al., 2017. Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase. Cell Death Dis., Vol. 8. 10.1038/cddis.2017.132.
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  3. Xu, S., Z. He, Z. Guo, Z. Zhang and G.J. Wyckoff et al., 2017. Genome-wide convergence during evolution of mangroves from woody plants. Mol. Biol. Evol., 34: 1008-1015.
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  4. Ren, Q., C. Wang, M. Jin, J. Lan and T. Ye et al., 2017. Co-option of bacteriophage lysozyme genes by bivalve genomes. Open Biol., Vol. 7. 10.1098/rsob.160285.
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  5. Garcia, B.L., D.A. Skaff, A. Chatterjee, A. Hanning, J.K. Walker, G.J. Wyckoff and B.V. Geisbrecht, 2017. Identification of C3b-binding small-molecule complement inhibitors using cheminformatics. J. Immunol., 198: 3705-3718.
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  6. Sabbagh, U., S. Mullegama and G.J. Wyckoff, 2016. Identification and evolutionary analysis of potential candidate genes in a human eating disorder. BioMed Res. Int., Vol. 2016. 10.1155/2016/7281732.
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  7. Wyckoff, G.J. and D.A. Skaff, 2015. Big Data and Drug Discovery. In: Big Data Analysis for Bioinformatics and Biomedical Discoveries, Ye, S.Q. (Ed.). Chapman and Hall/CRC Press, Boca Raton, FL., USA., ISBN-13: 9781498724524, pp: 215-231.
  8. Skaff, D.A., W.J. McWhorter, B.V. Geisbrecht, G.J. Wyckoff and H.M. Miziorko, 2015. Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds. Arch. Biochem. Biophys., 566: 1-6.
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  9. VanNice, J.C., D.A. Skaff, A. Keightley, J.K. Addo, G.J. Wyckoff and H.M. Miziorko, 2014. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. J. Bacteriol., 196: 1055-1063.
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  10. Foy, S. and G. Wyckoff, 2014. Units: Universal true SDSA (Structure-Dependent Sequence Alignment). J. Data Mining Genom. Proteomics, Vol. 5. 10.4172/2153-0602.1000152.
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  11. VanNice, J.C., D.A. Skaff, G.J. Wyckoff and H.M. Miziorko, 2013. Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea. J. Bacteriol., 195: 3854-3862.
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  12. Zhang, Q., A. Solidar, N.J. Murgolo, W. Alkema and W. Ding et al., 2012. Selective constraint: A hallmark of genes successfully targeted for pharmaceutical development. Amer. J. Drug Discov. Develop., 2: 184-193.
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  13. O'Bleness, M.S., C.M. Dickens, L.J. Dumas, H. Kehrer-Sawatzki, G.J. Wyckoff and J.M. Sikela, 2012. Evolutionary history and genome organization of DUF1220 protein domains. G3: Genes Genomes Genet., 2: 977-986.
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  14. Moldover, B., A. Solidar, C. Montgomery, H. Miziorko, J. Murphy and G.J. Wyckoff, 2012. ChemVassa: A new method for identifying small molecule hits in drug discovery. Open Med. Chem. J., 6: 29-34.
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  15. Barta, M.L., N.E. Dickenson, M. Patil, A. Keightley and G.J. Wyckoff et al., 2012. The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins. J. Mol. Biol., 417: 395-405.
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  16. Yang, M. and G.J. Wyckoff, 2011. Detection of selection utilizing molecular phylogenetics: A possible approach. Genetica, 139: 639-648.
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  17. Yang, M., A. Solidar and G.J. Wyckoff, 2010. Novel method for discerning the action of selection during evolution. J. Biomed. Sci. Eng., 3: 109-113.
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  18. Wyckoff, G.J., A. Solidar and M.D. Yoden, 2010. Phosphatidylinositol transfer proteins: Sequence motifs in structural and evolutionary analyses. J. Biomed. Sci. Eng., 3: 65-67.
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  19. Nadeau, O.W., G.J. Wyckoff, J.E. Paschall, A. Artigues, J. Sage, M.T. Villar and G.M. Carlson, 2008. CrossSearch, a user-friendly search engine for detecting chemically cross-linked peptides in conjugated proteins. Mol. Cell. Proteomics, 7: 739-749.
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  20. Abdel-Rahman, S.M., N. Talib, A. Solidar, A.J. Nopper and G.J. Wyckoff, 2008. Examining Trichophyton tonsurans genotype and biochemical phenotype as determinants of disease severity in tinea capitis. Med. Mycol., 46: 217-223.
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  21. Starkweather, R., C.S. Barnes, G.J. Wyckoff and J.A. Keightley, 2007. Virtual polymorphism: Finding divergent peptide matches in mass spectrometry data. Anal. Chem., 79: 5030-5039.
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  22. Nadeau, O.W., D.W. Anderson, Q. Yang, A. Artigues and J.E. Paschall et al., 2007. Evidence for the location of the allosteric activation switch in the multisubunit phosphorylase kinase complex from mass spectrometric identification of chemically crosslinked peptides. J. Mol. Biol., 365: 1429-1445.
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  23. Vallender, E.J., J.E. Paschall, C.M. Malcom, B.T. Lahn and G.J. Wyckoff, 2006. SPEED: A molecular-evolution-based database of mammalian orthologous groups. Bioinformatics, 22: 2835-2837.
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  24. Popesco, M.C., E.J. MacLaren, J. Hopkins, L. Dumas and M. Cox et al., 2006. Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains. Science, 313: 1304-1307.
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  25. Wyckoff, G.J., C.M. Malcom, E.J. Vallender and B.T. Lahn, 2005. A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate. Trends Genet., 21: 381-385.
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  26. Tang, H., G.J. Wyckoff, J. Lu and C.I. Wu, 2004. A universal evolutionary index for amino acid changes. Mol. Biol. Evol., 21: 1548-1556.
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  27. Paschall, J.E., M.F. Oleksiak, J.D. VanWye, J.L. Roach and J.A. Whitehead et al., 2004. FunnyBase: A systems level functional annotation of Fundulus ESTs for the analysis of gene expression. BMC Genom., Vol. 5. 10.1186/1471-2164-5-96.
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  28. Dorus, S., P.D. Evans, G.J. Wyckoff, S.S. Choi and B.T. Lahn, 2004. Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nat. Genet., 36: 1326-1329.
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  29. Dorus, S., E.J. Vallender, P.D. Evans, J.R. Anderson and S.L. Gilbert et al., 2004. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell, 119: 1027-1040.
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  30. Malcom, C.M., G.J. Wyckoff and B.T. Lahn, 2003. Genic mutation rates in mammals: Local similarity, chromosomal heterogeneity and X-versus-autosome disparity. Mol. Biol. Evol., 20: 1633-1641.
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  31. Wyckoff, G.J., J. Li and C.I. Wu, 2002. Molecular evolution of functional genes on the mammalian Y chromosome. Mol. Biol. Evol., 19: 1633-1636.
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  32. Fay, J.C., G.J. Wyckoff and C.I. Wu, 2002. Testing the neutral theory of molecular evolution with genomic data from Drosophila. Nature, 415: 1024-1026.
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  33. Fay, J.C., G.J. Wyckoff and C.I. Wu, 2001. Positive and negative selection on the human genome. Genetics, 158: 1227-1234.
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  34. Wyckoff, G.J., W. Wang and C.I. Wu, 2000. Rapid evolution of male reproductive genes in the descent of man. Nature, 403: 304-309.
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