Dr. Walid Al-Achkar
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Dr. Walid Al-Achkar

Research Scientist
Atomic Energy Commission of Syria, Syria

Highest Degree
Ph.D. in Biology from Atomic Energy Commission of Syria, Syria

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Area of Interest:

Molecular Sciences
100%
Genetics
62%
Genomics
90%
Cytogenetics
75%
Molecular Genetics
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
92
Abstracts
1

Selected Publications

  1. Walid, A.A., A.H. Bassel, B. Ali and F. Moassass, 2017. First report of prevalence c. IVS1+1G> A and del (GJB6-13S1854) mutations in Syrian families with non-syndromic sensorineural hearing loss. Int. J. Pediatr. Otorhinolaryngology, 92: 82-87.
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  2. Wafa, A., M. As` sad, T. Liehr, A. Aljapawe and W.A. Achkar, 2016. A new complex karyotype in a unique de novo myelodysplastic syndrome case involving ten chromosomes and monoallelic loss of TP53. Gene Rep., 4: 208-212.
    Direct Link  |  
  3. Wafa, A., F. Moassass, T. Liehr, A. Aljapawe and W. Al Achkar, 2016. Partial Trisomy 1q21-qter and Partial Monosomy 7q21-qter Due to a Derivative Chromosome 7 in Myelodysplastic Syndrome Associated with Squamous Cell Carcinoma: Case Report. Case Rep. Clin. Med., 5: 518-527.
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  4. Wafa, A., F. Moassass, T. Liehr, A. Al-Ablog and W. Al-Achkar, 2016. Acute promyelocytic leukemia with the translocation t (15; 17)(q22; q21) associated with t (1; 2)(q42~ 43; q11. 2~ 12): a case report. J. Med. Case Rep., .
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  5. Wafa, A., F. Moassaa, T. Liehr, S. Bhatt, A. Aljapawe and W. Al Achkar, 2016. A high complex karyotype involving eleven chromosomes including three novel chromosomal aberrations and monoallelic loss of TP53 in case of follicular lymphoma transformed into B-cell lymphoblastic leukemia. Mol. Cytogenetics, .
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  6. Al-Achkar, W., A. Wafa, S. Ammar, F. Moassass and R.A. Jarjour, 2016. Association of Methylenetetrahydrofolate Reductase C677T and A1298C Gene Polymorphisms With Recurrent Pregnancy Loss in Syrian Women. Reprod. Sci., .
  7. Wafa, A., M. Asa`ad, A. Ikhtiar, T. Liehr and W. Al Achkar, 2015. Deletion 9p23 to 9p11. 1 as sole additional abnormality in a Philadelphia positive chronic myeloid leukemia in blast crisis: a rare event. Mol. Cytogenetics, .
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  8. Al-ajoury, R., E. Kassem, B. Al-halabi, F. Moassess and W. Al-achkar, 2015. Investigation of some genetic variations in BMP15 accompanied with premature ovarian failure (POF) in Syrian women. Middle East Fertil. Soc. J., 20: 91-96.
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  9. Al-Ajoury, R., E. Kassem, B. Al-Halabi, F. Moassess and W. Al-Achkar, 2015. Mutations Analysis of the Growth Differentiation Factor 9 Gene in Syrian Women with Ovarian Failure. Int. J Hum. Genet., 15: 139-144.
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  10. Al-Achkar, W., F. Moassass, N. Youssef and A. Wafa, 2015. Correlation of p210 BCR-ABL transcript variants with clinical, parameters and disease outcome in 45 chronic myeloid leukemia patients. J. BUON, 21: 444-449.
  11. Al-Achkar, W., F. Moassass, A. Al-Ablog, T. Liehr, X. Fan and A. Wafa, 2015. Chromosomal aberration leads to recurrent pregnancy loss and partial trisomy of 5p12-15.3 in the offspring: report of a Syrian couple and review of the literature. National J. Andrology, 21: 219-224.
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  12. Walid, A.A., A. Wafa, M.A.K. Othman, F. Moassass, A. Aljapawe and T. Liehr, 2014. An adult B-cell precursor acute lymphoblastic leukemia with multiple secondary cytogenetic aberrations. Molecular Cytogenetics, .
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  13. Wafa, A., A. Aljapawe, M.A. Othman, T. Liehr, E. Alhourani and W. Al Achkar, 2014. Do novo del (9)(p13) in a childhood T-cell prolymphocytic leukemia as sole abnormality. Exp. Hematol. Oncol., .
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  14. Okada, Y., D. Diogo, J.D. Greenberg, F. Mouassess and W.A. Achkar, et al., 2014. Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PloS one, .
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  15. Murad, H., F. Moassas, R. Jarjour, Y. Mukhalalaty and W. Al Achkar, 2014. Prenatal Molecular Diagnosis of β-Thalassemia and Sickle Cell Anemia in the Syrian Population. Hemoglobin, 38: 390-393.
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  16. Madania, A., I. Ghoury, W. Al Ashkar, S. Nweder and H. Zarzour, 2014. Frequency of HLA-A alleles in the Syrian population genotyped by sequence-based typing. Int. J. Immunogenet., 41: 378-383.
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  17. Jarjour, R.A., H. Murad, F. Moasses and W. Al-Achkar, 2014. Molecular update of β-thalassemia mutations in the syrian population: identification of rare β-thalassemia mutations. Hemoglobin, 38: 272-276.
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  18. Al-Achkar, W., G. Azeiz, F. Moassass and A. Wafa, 2014. Influence of CYP1A1, GST polymorphisms and susceptibility risk of chronic myeloid leukemia in Syrian population. Med. Oncol., 31: 1-5.
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  19. Al-Achkar, W., F. Moassass, A. Ikhtiar, T. Liehr, M.A.K. Othman and A. Wafa, 2014. Hyperdiploidy associated with T315I mutation in BCR-ABL kinase domain in an accelerated phase-chronic myeloid leukemia case. Mol. Cytogenetics, .
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  20. Al-Achkar, W., A. Aljapawe, T. Liehr and A. Wafa, 2014. De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncol. Lett., 7: 787-790.
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  21. Murad, H., A. Dabboul, F. Moassas, D. Alasmar and W. Al-Achkar, 2013. Mutation spectrum of phenylketonuria in Syrian population: genotype-phenotype correlation. Gene, 528: 241-247.
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  22. Al-achkar, W., A. Aljapawe, M.A.K. Othman and A. Wafa, 2013. A de novo acute myeloid leukemia (AML-M4) case with a complex karyotype and yet unreported breakpoints. Molecular Cytogenetics, .
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  23. Al-Achkar, W., A. Wafa, M. Assaad, C. Ehlers and T. Liehr, 2013. A unique case of female pseudohermaphroditism with 21-hydroxylase deficiency and small supernumerary marker chromosome 7. Mol. Med. Rep., 7: 1545-1548.
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  24. Al-Achkar, W., A. Wafa, F. Moassass, E. Klein and T. Liehr, 2013. Multiple copies of BCR-ABL fusion gene on two isodicentric Philadelphia chromosomes in an imatinib mesylate-resistant chronic myeloid leukemia patient. Oncol Lett. 5: 1579-1582.
    PubMed  |  
  25. Al-Achkar, W., A. Wafa, A. Ikhtiar and T. Liehr, 2013. Three-way Philadelphia translocation t(9;10;22)(q34;p11.2;q11.2) as a secondary abnormality in an imatinib mesylate-resistant chronic myeloid leukemia patient. Oncol. Lett., 5: 1656-1658.
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  26. Al-Achkar, W., A. Wafa, A. Aljapawe, M.A.K. Othman and T. Liehr, 2013. A novel cytogenetic abnormality r(7)(::p11.2->q36.3::) in a Philadelphia-positive chronic myeloid leukemia case. Case Rep. Clin. Med., 2: 517-520 .
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  27. Al-Achkar, W., A. Wafa, A. Al-Ablog, F. Moassass and T. Liehr, 2013. Molecular cytogenetic characterization of an inv(Y)(p11.2q11.221~q11.222) in a syrian family. Balkan J. Med. Genet., 16: 73-76.
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  28. Al-Achkar, W., A. Wafa and F. Moassass, 2013. Cytogenetic abnormalities and Y-chromosome microdeletions in infertile Syrian males. Biomed. Rep., 1: 275-279.
    PubMed  |  
  29. Al-Achkar, W., A. Aljapawe, S. Almedani, T. Liehr and A Wafa, 2013. A novel cytogenetic abnormality t(7;8)(p11.2:q11.2) and a four-way Philadelphia translocation in an imatinib mesylate-resistant chronic myeloid leukemia patient. Oncol. Lett., 5: 617-620.
    PubMed  |  
  30. Al-Achkar W., A. Wafa and T. Liehr, 2013. A new t(9;11;20;22)(q34;p11.2;q11.21;q11) in a Philadelphia-positive chronic myeloid leukemia case. Oncol. Lett., 5: 605-608.
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  31. Al Achkar, W., A. Wafa, A. Aljapawe, M.A. Othman, E. Alhourani and T. Liehr, 2013. Acquired del (9)(p22. 3) in a primary plasma cell leukemia. Mol. Cytogenetics, .
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  32. Achkar, W.A., F. Moassass, A.I.M.A. Othman, T. Liehr and A. Wafa, 2013. Cytogenetic Evolution in a Patient with Chronic developing a Secondary Acute Myelogenous Leukemia Subtype M5 Resistant to Imatinib Mesylate Therapy. J. Leukemia, .
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  33. Al-achkar, W., A. Wafa, F. Moassass and M.A.K. Othman, 2012. A novel dic (17; 18)(p13. 1; q11. 2) with loss of TP53 and BCR/ABL rearrangement in an Imatinib resistant chronic myeloid leukemia. Molecular Cytogenetics, .
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  34. Al-Achkar, W., A. Wafa, T. Liehr, E. Klein and F. Moassass, 2012. Detailed analysis of an idic(Y)(q11.21) in a mosaic karyotype. Mol. Med. Rep., 6: 293-296.
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  35. Al-Achkar, W., A. Wafa, F. Moassass and T. Liehr, 2012. A unique cytogenetic abnormality, t(2;7)(p13.1;p21.3), in a Philadelphia-positive chronic myeloid leukemia. Oncol. Lett., 4: 209-212.
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  36. Al-Achkar, W., A. Wafa, F. Moassass and T. Liehr et al., 2012. A chronic myeloid leukemia case with a unique variant Philadelphia translocation: t(9;22;21)(q34;q11;p12). Oncol Lett. 3: 1027-1029.
    PubMed  |  
  37. Achilli, A., A. Olivieri, P. Soares, H. Lancioni and B.H. Kashani et al., 2012. Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domestication. Proc. Nati. Acad. Sci. USA, 109: 2449-2454.
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  38. Al-Achkar, W., F. Moassass, B. Al-Halabi and A. Al-Ablog, 2011. Mutations of the connexin 26 gene in families with non-syndromic hearing loss. Mol. Med. Rep., 4: 331-335.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Al-Achkar, W., A. Wafa, E. Klein and A. Aljapawe, 2011. Biclonal myelodysplastic syndrome involving six chromosomes and monoallelic loss of RB1-A rare case. Molecular Cytogenetics, .
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  40. Al-Achkar, W., A. Wafa and T. Liehr, 2011. Complex translocation involving four chromosomes in a novel philadelphia-positive chronic myeloid leukemia case. Oncol. Lett., 2: 273-276.
    PubMed  |  
  41. Al-Achkar, W., A. Wafa and R.A. Jarjour, 2011. A new case of de novo translocation (12;17;18)(q21.2;q22;q21.1) and cranio-cerebello-cardiac (3c) syndrome. Am. J. Med. Genet. Part A, 155: 648-651.
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  42. Al-Achkar, W., T. Liehr and A. Wafa, 2010. Insertion of the 3' ABL region into the long arm of chromosome 1 in a philadelphia chromosome-negative chronic myeloid leukemia case. Oncol. Lett., 1: 951-954.
    PubMed  |  
  43. Al-Achkar, W., A. Wafa, M. Manvelyan, A. Ikhtiar and T. Liehr, 2010. De novo translocation involving two chromosomes in adult prolymphocytic leukemia-A rare case. Leukemia Res., 34: e345-e347.
  44. Al-Achkar, W., A. Wafa, H. Mkrtchyan, F. Moassass and T. Liehr, 2010. A unique complex translocation involving six different chromosomes in a case of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and adverse prognosis. Oncol. Lett., 1: 801-804.
    PubMed  |  
  45. Al-Achkar, W., A. Wafa, H. Mkrtchyan, F. Moassass and T. Liehr, 2010. A rare case of philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17). Oncol. Lett., 1: 793-795.
    PubMed  |  Direct Link  |  
  46. Al-Achkar, W., A. Wafa, B.Y. Ali, M. Manvelyan and T. Liehr, 2010. A rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-ABL e13a3 transcript and complex translocation involving four different chromosomes. Oncol. Lett., 1: 797-800.
    PubMed  |  
  47. Al-Achkar, W., A. Wafa and S. Almedani, 2010. BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome. Oncol. Lett., 1: 445-447.
    PubMed  |  
  48. Al Achkar, W., A. Wafa, H. Mkrtchyan, F. Moassass and T. Liehr, 2010. A rare case of chronic myeloid leukemia with secondary chromosomal changes including partial trisomy 17q21 to 17qter and partial monosomy of 16p13. 3. Mol. Cytogenetics, .
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  49. Al Achkar, W., A. Wafa, F. Moassass and T. Liehr, 2010. Partial trisomy 9p22 to 9p24. 2 in combination with partial monosomy 9pter in a Syrian girl. Molecular Cytogenetics, .
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  50. Al Achkar, W., A. Wafa, H. Mkrtchyan, F. Moassass and T. Liehr, 2009. Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report. Mol. Cytogenetics, .
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  51. Al-Achkar, W., A. Wafa and M.S. Nweder, 2007. A complex translocation t(5;9;22) in Philadelphia cells involving the short arm of chromosome 5 in a case of chronic myelogenous leukemia. J. Exp. Clin. Cancer Res., 26: 411-415.
    PubMed  |  Direct Link  |  
  52. Druker, B.J., C.L. Sawyers, H. Kantarjian, D.J. Resta and S.F. Reese et al., 2001. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med., 344: 1038-1042.
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  53. Mohammad, O., A.A. Walid and K. Ghada, 1995. Chromosomal aberrations in human lymphocytes from two groups of workers occupationally exposed to pesticides in Syria. Environ. Res., 70: 24-29.
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  54. Sabatier, L., F. Hoffschir, W. Al-Achkar, C. Turleau and J. Grouchy et al., 1989. The decrease of catalase or esterase D activity in patients with microdeletions of 11p or 13q does not increase their radiosensitivity. Ann. Genet., 32: 144-148.
    PubMed  |  
  55. Lefrancois, D., W. Al-Achkar, A. Aurias, J. Couturier and A.M. Dutrillaux et al., 1989. Chromosomal aberrations induced by low-dose γ-irradiation study of R-banded chromosomes of human lymphocytes. Mutat. Res., 212: 167-172.
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  56. Al-Achkar, W., L. Sabatier, and B. Dutrillaux, 1989. How are sticky chromosomes formed? Ann. Genet., 32: 10-15.
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  57. Prieur, M., W. Al-Achkar, A. Aurias, J. Couturier and A.M. Dutrillaux et al., 1988. Acquired chromosome rearrangements in human lymphocytes: effect of aging. Hum. Genet., 79: 147-150.
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  58. Al-Achkar, W., L. Sabatier and B. Dutrillaux, 1988. Transmission of radiation-induced rearrangements through cell divisions. Mutat. Res., 198: 191-198.
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  59. Al-Achkar, W., L. Sabatier and B. Dutrillaux, 1988. Influence of time and cell cycle phase on radiation-induced chromosome lesions. Ann. Genet., 31: 87-90.
    PubMed  |  
  60. Sabatier, L., W. Al-Achkar, F. Hoffschir, C. Luccioni and B. Dutrillaux, 1987. Qualitative study of chromosomal lesions induced by neutrons and neon ions in human lymphocytes at G0 phase. Mutat. Res., 178: 91-97.
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  61. Dutrillaux, B., W.A. Achkar, R. Aledo, A. Aurias and J. Couturier et al., 1987. Isoacentric and isocentric chromosomes originating after deletions of human chromosomes. Hum. Genet., 76: 244-247.
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  62. Marlhens, F., W. Al-Achkar, A. Aurias, J. Couturier and A.M. Dutrillaux et al., 1986. The rate of chromosome breakage is age dependent in lymphocytes of adult controls. Hum. Genet., 73: 290-297.
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  63. Dutrillaux, B., L. Sabatier, W. Al-Achkar, M. Muleris and A. Aurias et al., 1986. Radiation induced inversions in human somatic cells. Ann. Genet., 29: 189-194.
    PubMed  |