Dr. Assaad Antoine Eid
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Dr. Assaad Antoine Eid

Associate Professor
American University of Beirut, Lebanon

Highest Degree
Ph.D. in Physiopathology from Universite Claude Bernard Lyon 1, France

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Area of Interest:

Biomedical Sciences
100%
Diabetic Nephropathy
62%
Predictive Oncology
90%
Drug Synthesis
75%
Cell Culture
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Noureldein, M.H. and A.A. Eid, 2018. Homeostatic effect of laughter on diabetic cardiovascular complications: The myth turned to fact. Diabetes Res. Clin. Pract., 135: 111-119.
  2. Hichor, M., V.K. Sundaram, S.A. Eid, R. Abdel-Rassoul and P.X. Petit et al., 2018. Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve. Scient. Rep., Vol. 8. 10.1038/s41598-018-20980-3.
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  3. Abdallah, M.S., C.R. Kennedy, J.S. Stephan, P.A. Khalil, M. Mroueh, A.A. Eid and W.H. Faour, 2018. Transforming growth factor-β1 and phosphatases modulate COX-2 protein expression and TAU phosphorylation in cultured immortalized podocytes. Inflammation Res., 67: 191-201.
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  4. Hichor, M., N.K. Sampathkumar, J. Montanaro, D. Borderie and P.X. Petit et al., 2017. Paraquat induces peripheral myelin disruption and locomotor defects: Crosstalk with LXR and Wnt pathways. Antioxid. redox signaling, 27: 168-183.
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  5. Hammoud, S.H., A.G. Omar, A.A. Eid and M.M. El-Mas, 2017. CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats. Toxicol. Applied Pharmacol., 334: 110-119.
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  6. Abou-El-Hassan, H., B. Dia, K. Choucair, S.A. Eid and F. Najdi et al., 2017. Traumatic brain injury, diabetic neuropathy and altered-psychiatric health: The fateful triangle. Med. Hypotheses, 108: 69-80.
    CrossRef  |  Direct Link  |  
  7. Abou Daher, A., T. El Jalkh, A.A. Eid, A. Fornoni, B. Marples and Y.H. Zeidan, 2017. Translational aspects of sphingolipid metabolism in renal disorders. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18122528.
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  8. Nassif, J., S.A. Abbasi, A. Nassar, A. Abu-Musa and A.A. Eid, 2016. The role of NADPH-derived reactive oxygen species production in the pathogenesis of endometriosis: A novel mechanistic approach. J. biol. regulators homeostatic Agents, 30: 31-40.
    Direct Link  |  
  9. Jurjus, A., A. Eid, S. Al Kattar, M.N. Zeenny and A. Gerges-Geagea et al., 2016. Inflammatory bowel disease, colorectal cancer and type 2 diabetes mellitus: The links. BBA Clin., 5: 16-24.
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  10. Eid, S., S. Boutary, K. Braych, R. Sabra and C. Massaad et al., 2016. MTORC2 signaling regulates Nox4-induced podocyte depletion in diabetes. Antioxid. Redox Signaling, 25: 703-719.
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  11. Eid, S., C. Massaad and A.A. Eid, 2016. Oxidative stress in diabetic neuropathy: Strategies for treatment. Diabetes Case Rep., Vol. 1. 10.4172/2572-5629.1000101.
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  12. Daoud, G., A. Monzer, H. Bahmad, F. Chamaa and L. Hamdar et al., 2016. Primary versus castration-resistant prostate cancer: Modeling through novel murine prostate cancer cell lines. Oncotarget, 7: 28961-28975.
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  13. Bouhadir, K.H., A. Koubeissi, F.A. Mohsen, M.D. El-Harakeh and R. Cheaib et al., 2016. Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu. II. Acylhydrazone-functionalized pyrimidines. Bioorg. Med. Chem. lett., 26: 1020-1024.
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  14. Altara, R., M. Manca, R. Sabra, A.A. Eid, G.W. Booz and F.A. Zouein, 2016. Temporal cardiac remodeling post-myocardial infarction: Dynamics and prognostic implications in personalized medicine. Heart Fail. Rev., 21: 25-47.
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  15. Mouhieddine, T.H., A. Nokkari, M.M. Itani, F. Chamaa and H. Bahmad et al., 2015. Metformin and ara-a effectively suppress brain cancer by targeting cancer stem/progenitor cells. Front. Neurosci., Vol. 9. 10.3389/fnins.2015.00442.
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  16. El-Achkar, G.A., M. Jouni, M.F. Mrad, T. Hirz and N. El Hachem et al., 2015. Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo. Eur. J. pharmacol., 750: 66-73.
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  17. Abou-Kheir, W., A. Eid, R. El-Merahbi, R. Assaf and G. Daoud, 2015. A unique expression of keratin 14 in a subset of trophoblast cells. PloS one, Vol. 10. 10.1371/journal.pone.0139939.
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  18. Tyan, P.I., A.H. Radwan, A. Eid, A.G. Haddad, D. Wehbe and A.T. Taher, 2014. Novel approach to reactive oxygen species in nontransfusion-dependent thalassemia. BioMed Res. Int., 10.1155/2014/350432.
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  19. Hussein, H., A. Eid, R. Maksoud, S. Jambart, Z. Zgheib et al., 2014. Estrogens control inflammation in experimental colitis. J. boil. Regulators Homeostatic Agents, 28: 213-224.
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  20. El-Merahbi, R., Y.N. Liu, A. Eid, G. Daoud and L. Hosry et al., 2014. Berberis libanotica ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells. PLoS One, Vol. 9. 10.1371/journal.pone.0112453.
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  21. Eid, S., C. Abdul-Massih, C.M. El-Khuri, A. Hamdy, A. Rashid and A.A. Eid, 2014. New mechanistic insights in the development of diabetic nephropathy: Role of cytochromes P450 and their metabolites. J. Endocr Disord, 1: 1-6.
  22. Anwar, M.A., W.A. Kheir, S. Eid, J. Fares, X. Liu, A.H. Eid and A.A. Eid, 2014. Colorectal and prostate cancer risk in diabetes: Metformin, an actor behind the scene. J. Cancer, 5: 736-744.
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  23. Nayak, B.K., D. Feliers, S. Sudarshan, W.E. Friedrichs and R.T. Day et al., 2013. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene, 32: 3147-3155.
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  24. Nassif, J., S. Mattar, A.M. Abu and A. Eid, 2013. Endometriosis and cancer: what do we know. Minerva Ginecol., 65: 167-179.
    Direct Link  |  
  25. Lee, D.Y., F. Wauquier, A.A. Eid, L.J. Roman and G. Ghosh-Choudhury, 2013. Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin ii role of mitochondrial reactive oxygen species. J. Biol. Chem., 288: 28668-28686.
    Direct Link  |  
  26. Ford, B.M., A.A. Eid, M. Gooz, J.L. Barnes, Y.C. Gorin and H.E. Abboud, 2013. ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. Am. J. Physiol. Renal Physiol., 305: F323-F332.
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  27. Eid, S., W. Abou-Kheir, R. Sabra, G. Daoud and A. Jaffa, 2013. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. J Biol Regul Homeost Agents, 27: 693-703.
  28. Eid, S., R. Maalouf, A.A. Jaffa, J. Nassif and A. Hamdy et al., 2013. 20-HETE and EETs in diabetic nephropathy: A novel mechanistic pathway. PLoS One, Vol. 8. 10.1371/journal.pone.0070029.
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  29. Eid, A.A., D.Y. Lee, L.J. Roman, K. Khazim and Y. Gorin, 2013. Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression. Mol. Cell. Boil., 33: 3439-3460.
    Direct Link  |  
  30. Eid, A.A., B.M. Ford, B. Bhandary, R.C. Cavaglieri and K. Block et al., 2013. Mammalian target of rapamycin regulates nox4-mediated podocyte depletion in diabetic renal injury. Diabetes, 62: 2935-2947.
    CrossRef  |  Direct Link  |  
  31. Eid, A.A., A. Koubeissi, R. Bou-Mjahed, N. Al Khalil and M. Farah et al., 2013. Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu. Bioorg. Med. Chem. Let., 23: 174-178.
    CrossRef  |  Direct Link  |  
  32. Mrad, M.F., C.A. Mouawad, M. Al‐Hariri, A.A. Eid, J. Alam and A. Habib, 2012. Statins modulate transcriptional activity of heme‐oxygenase‐1 promoter in NIH 3T3 Cells. J. Cell. Biochem., 113: 3466-3475.
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  33. Jaffa, M.A., F. Kobeissy, M. Al Hariri, H. Chalhoub, A. Eid, F.N. Ziyadeh and A.A. Jaffa, 2012. Global renal gene expression profiling analysis in B2-kinin receptor null mice: Impact of diabetes. PloS one, Vol. 7. 10.1371/journal.pone.0044714.
    CrossRef  |  Direct Link  |  
  34. Fitzgerald, J.P., B. Nayak, K. Shanmugasundaram, W. Friedrichs and S. Sudarshan et al., 2012. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6-and 8-production. PloS one, Vol. 7. 10.1371/journal.pone.0030712.
    CrossRef  |  Direct Link  |  
  35. Maalouf, R.M., A.A. Eid, Y.C. Gorin, K. Block and G.P. Escobar et al., 2011. Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes. Am. J. Physiol. Cell Physiol., 302: C597-C604.
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  36. Eid, A.A., B.M. Ford, K. Block, B.S. Kasinath and Y. Gorin et al., 2010. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J. Biol. Chem., 285: 37503-37512.
    Direct Link  |  
  37. Block, K., Y. Gorin, D.D. New, A. Eid and T. Chelmicki et al., 2010. The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin. Am. J. Pathol., 176: 2447-2455.
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  38. Eid, A.A., Y. Gorin, B.M. Fagg, R. Maalouf, J.L. Barnes, K. Block and H.E. Abboud, 2009. Mechanisms of podocyte injury in diabetes: Role of cytochrome P450 and NADPH oxidases. Diabetes, 58: 1201-1211.
    CrossRef  |  Direct Link  |  
  39. Block, K., A. Eid, K.K. Griendling, D.Y. Lee, Y. Wittrant and Y. Gorin, 2008. Nox4 nad (p) h oxidase mediates src-dependent tyrosine phosphorylation of pdk-1 in response to angiotensin II role in mesangial cell hypertrophy and fibronectin expression. J. Biol. Chem., 283: 24061-24076.
    Direct Link  |  
  40. Eid, A., S. Bodin, B. Ferrier, H. Delage and M. Boghossian et al., 2006. Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats. J. Am. Soc. Nephrol., 17: 398-405.
    Direct Link  |  
  41. Eid, A., G. Baverel and B. Ferrier, 2006. Effect of type 2 diabetes on renal metabolism. Diabetes Metab., 42: 98-103.
  42. Guitton, J., A. Conjard, A. Eid, M. Martin and M. Boghossian et al., 2005. Identification of novel targets of cephaloridine in rabbit renal proximal tubules synthesizing glutamine from alanine. Arch. Toxicol., 79: 587-594.
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